EKS-GAG-00055
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00055
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK353.86.8E-10613300288
StatusUnreviewed
Ensembl ProteinENSGALP00000015412
UniProt AccessionQ90771;
Protein Name
Protein Synonyms/Alias Cyclin-dependent kinase;
Gene Namecdk6
Gene Synonyms/Alias cdk6; CDK6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000009476ENSGALP00000015412ENSGALT00000015428
OrganismGallus gallus
Functional Description
Protein Length326
Protein Sequence
(FASTA)
MDKDGTNLAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTS EEGMPLSTIR 60
EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 120
TIKDMMLQLF RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV 180
VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GNSDVDQLGK IFDVIGLPEE 240
EDWPNDVALP RNAFASRPAQ PIEKFVPDID DMGKDLLLKC LAFNPAKRIS AYAALSHPYF 300
HDLEKCKENL DSHMSSSQNS SEVNAS 326
Nucleotide Sequence
(FASTA)
ATGGACAAGG ACGGCACCAA CCTGGCCGAC CAGCAGTATG AGTGCGTGGC TGAGATCGGC 60
GAGGGAGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAATGGCGG CCGCTTCGTG 120
GCGCTGAAGC GGGTGCGGGT GCAGACCAGC GAGGAGGGCA TGCCGCTGTC CACCATCCGG 180
GAGGTGGCCG TCCTGAGGCA CCTGGAGACC TTCGAGCACC CCAACGTGGT CAGATTGTTT 240
GATGTGTGCA CCGTGTCACG AACAGACAGA GAAACCAAGT TAACGTTGGT GTTTGAACAT 300
GTGGATCAAG ACTTGACTAC TTACTTGGAT AAAGTTCCAG AGCCTGGAGT GCCTACTGAA 360
ACTATAAAGG ATATGATGCT TCAGCTGTTT CGGGGACTGG ATTTTCTGCA TTCACATCGT 420
GTGGTGCATC GGGACCTGAA ACCCCAGAAT ATCCTTGTAA CCAGCAGTGG GCAGATAAAG 480
TTAGCTGACT TTGGACTTGC ACGAATCTAC AGTTTTCAGA TGGCTCTTAC ATCAGTGGTT 540
GTTACTTTGT GGTATAGAGC TCCTGAAGTT TTGCTTCAGT CCAGCTATGC AACACCAGTT 600
GATCTTTGGA GTGTTGGTTG CATATTTGCA GAAATGTTCC GTCGAAAACC ACTCTTCCGT 660
GGAAATTCAG ATGTTGATCA GCTAGGAAAA ATCTTTGATG TAATTGGACT CCCAGAAGAA 720
GAGGACTGGC CTAATGATGT GGCCCTTCCA AGAAATGCTT TTGCTTCCAG ACCCGCACAA 780
CCTATTGAAA AATTTGTACC AGATATTGAT GACATGGGCA AAGACTTGCT TCTTAAATGC 840
TTAGCGTTCA ATCCAGCCAA GAGAATATCT GCCTATGCTG CCCTGTCTCA CCCCTATTTC 900
CATGATCTGG AGAAATGCAA GGAGAATCTG GACTCTCACA TGTCATCCAG CCAAAACTCC 960
AGTGAGGTGA ACGCATCATA A 981
Domain Profile
S: 1     yeklekigeGtygkvykakd.ketgevvAlKkirlekekegvpitalrEisllkel...k  56
         ye++++igeG+ygkv+ka+d k+ g++vAlK++r+++++eg+p +++rE+++l++l   +
Q: 13    YECVAEIGEGAYGKVFKARDlKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLetfE  72
         899*****************888999*****************************98889
S: 57    hknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112
         h+n+v+L +v++     +++kl+Lvfe+++qdL+++l+k ++ ++++e++k ++lql++g
Q: 73    HPNVVRLFDVCTvsrtDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMLQLFRG  132
         ************99855569****************************************
S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelL  172
         l++lHs++++HRDlKpqN+L++++g++klaDfGlar +s ++  +t++vvTlwYraPe+L
Q: 133   LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVL  191
         *****************************************99.****************
S: 173   lgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklp  232
         l++ +Y t vD+Wsvgci+ae+++rkplf+g+s++dql +if+++g p+e++wp+   lp
Q: 192   LQS-SYATPVDLWSVGCIFAEMFRRKPLFRGNSDVDQLGKIFDVIGLPEEEDWPNDVALP  250
         *88.5*******************************************************
S: 233   eykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         +   +f +++++ +++ v+++++ + dll k+la++p+kRisa +al+h+yf
Q: 251   RN--AFASRPAQPIEKFVPDIDDMGKDLLLKCLAFNPAKRISAYAALSHPYF  300
         95..59999999***************************************9
Domain Sequence
(FASTA)
YECVAEIGEG AYGKVFKARD LKNGGRFVAL KRVRVQTSEE GMPLSTIREV AVLRHLETFE 60
HPNVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLDKV PEPGVPTETI KDMMLQLFRG 120
LDFLHSHRVV HRDLKPQNIL VTSSGQIKLA DFGLARIYSF QMALTSVVVT LWYRAPEVLL 180
QSSYATPVDL WSVGCIFAEM FRRKPLFRGN SDVDQLGKIF DVIGLPEEED WPNDVALPRN 240
AFASRPAQPI EKFVPDIDDM GKDLLLKCLA FNPAKRISAY AALSHPYF 288
KeywordATP-binding; Complete proteome; Cyclin; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00064
EKS-ANC-00063
EKS-BOT-00069
EKS-CAJ-00065
EKS-CAF-00073
EKS-CAP-00067
EKS-CII-00028
EKS-CIS-00069
EKS-DAR-00082
EKS-DRM-00032
EKS-ECT-00043
EKS-EQC-00067
EKS-ERE-00036
EKS-FEC-00067
EKS-GAM-00030
EKS-GAA-00084
EKS-GOG-00073
EKS-HOS-00071
EKS-ICT-00064
EKS-LAC-00069
EKS-LOA-00067
EKS-MAM-00067
EKS-MAE-00028
EKS-MEG-00052
EKS-MIM-00032
EKS-MOD-00066
EKS-MUM-00071
EKS-MUP-00071
EKS-MYL-00072
EKS-NOL-00064
EKS-OCP-00043
EKS-ORN-00088
EKS-ORA-00061
EKS-ORC-00065
EKS-ORL-00078
EKS-OTG-00072
EKS-PAT-00061
EKS-PES-00062
EKS-PEM-00037
EKS-POA-00064
EKS-PRC-00041
EKS-PTV-00061
EKS-RAN-00064
EKS-SAH-00064
EKS-SOA-00030
EKS-SUS-00062
EKS-TAG-00057
EKS-TAR-00088
EKS-TAS-00027
EKS-TEN-00090
EKS-TUT-00063
EKS-XET-00063
EKS-XIM-00088
Gene Ontology
GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0001726; C:ruffle
GO:0005524; F:ATP binding
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0043697; P:cell dedifferentiation
GO:0000080; P:G1 phase of mitotic cell cycle
GO:0045786; P:negative regulation of cell cycle
GO:2000773; P:negative regulation of cellular senescence
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045638; P:negative regulation of myeloid cell differentiation
GO:0045668; P:negative regulation of osteoblast differentiation
GO:0007219; P:Notch signaling pathway
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0010628; P:positive regulation of gene expression
GO:0045646; P:regulation of erythrocyte differentiation
KEGG
gga:420558;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013