EKS-GAG-00125
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00125
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR555.41.9E-167485761277
StatusUnreviewed
Ensembl ProteinENSGALP00000015441
UniProt AccessionF1NEE9;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000009495ENSGALP00000037940ENSGALT00000038732
ENSGALG00000009495ENSGALP00000015442ENSGALT00000015458
ENSGALG00000009495ENSGALP00000015441ENSGALT00000015457
OrganismGallus gallus
Functional Description
Protein Length825
Protein Sequence
(FASTA)
MVSWDSGCLI CLVVVTMAGL SLARPSFNLV VEDATLEPEE PPTKYQISQP DVHSALPGEP 60
LELRCQLKDA VMISWTKDGV PLGPDNRTVI IGEYLQIKDA SPRDSGLYAC TAIRTLDSDT 120
LYFIVNVTDA LSSGDDEDDN DGSEDFVNDS NQMRAPYWTH TDKMEKRLHA VPAANTVKFR 180
CPAMGNPTPT MRWLKNGKEF KQEHRIGGYK VRNQHWSLIM ESVVPSDKGN YTCIVENQYG 240
SINHTYHLDV VERSPHRPIL QAGLPANASA VVGGDVEFVC KVYSDAQPHI QWIKHVERNG 300
SKYGPDGLPY LQVLKHSGIN SSNAEVLTLY NVTEADAGEY ICKVSNYIGE ANQSAWLSVL 360
PSLQAPEKEK EFPTSPDYLE IAIYCIGVFL IACMVLTVIL CRMKNTTKKP DFSSQPAVHK 420
LTKRIPLRRQ ITSVSADSSS SMNSNTPLVR ITTRLSSTAD APMLAGVSEY ELPEDPKWEF 480
PRDKLTLGKP LGEGCFGQVV MAEAVGIDKD RPKEAVTVAV KMLKDDATEK DLSDLVSEME 540
MMKMIGKHKN IINLLGACTQ DGPLYVIVEY ASKGNLREYL RARRPPGMEY SFDINRVPEE 600
QMTFKDLVSC TYQLARGMEY LASQKCIHRD LAARNVLVTE NNVMKIADFG LARDINNIDY 660
YKKTTNGRLP VKWMAPEALF DRVYTHQSDV WSFGVLMWEI FTLGGSPYPG IPVEELFKLL 720
KEGHRMDKPA NCTNELYMMM RDCWQAVPSQ RPTFKQLVED LDRILTLTTN EEYLDLSGPL 780
EQYSPSYPDT RSSCSSGDDS VFSPDPMPYE PCLPKYQHMN GSVKT 825
Nucleotide Sequence
(FASTA)
ATGGTCAGCT GGGATTCGGG TTGCCTTATC TGCCTGGTGG TGGTCACCAT GGCTGGACTT 60
TCCCTGGCTC GACCGTCATT TAACTTAGTT GTTGAAGATG CCACTTTGGA ACCCGAAGAG 120
CCGCCAACCA AATACCAAAT CTCTCAGCCA GATGTACACT CTGCACTTCC AGGAGAACCA 180
CTTGAGTTGC GCTGTCAATT GAAAGACGCC GTCATGATCA GTTGGACTAA GGATGGGGTC 240
CCCTTGGGGC CCGACAATAG GACAGTGATT ATTGGGGAGT ACTTACAAAT TAAAGATGCT 300
TCACCCAGAG ATTCGGGCCT CTATGCTTGC ACTGCTATTA GGACCCTAGA CAGTGATACT 360
CTGTACTTCA TTGTAAATGT TACAGATGCT CTTTCTTCTG GGGATGATGA AGATGACAAT 420
GATGGGTCTG AGGACTTTGT GAATGACAGC AACCAGATGA GGGCGCCCTA TTGGACACAC 480
ACAGACAAAA TGGAGAAAAG GTTACACGCA GTGCCAGCAG CAAACACTGT CAAGTTTCGT 540
TGCCCAGCCA TGGGAAACCC AACACCAACC ATGAGATGGC TGAAAAATGG GAAAGAGTTT 600
AAACAAGAAC ATCGTATTGG CGGCTATAAG GTCCGCAACC AGCACTGGAG TCTCATCATG 660
GAGAGCGTAG TCCCATCCGA CAAAGGAAAT TACACGTGCA TCGTGGAAAA CCAGTATGGC 720
TCCATCAACC ACACTTACCA TCTCGATGTT GTCGAGCGAT CACCGCACAG GCCCATCCTC 780
CAGGCTGGCC TTCCAGCAAA CGCCTCGGCT GTAGTCGGAG GTGATGTCGA GTTTGTCTGC 840
AAAGTCTACA GTGATGCTCA ACCCCACATT CAGTGGATAA AACACGTAGA GAGGAATGGC 900
AGTAAATACG GACCAGATGG ACTGCCTTAC CTTCAGGTTT TAAAGCATTC GGGGATAAAT 960
AGTTCCAATG CTGAAGTGCT GACACTGTAC AATGTGACAG AGGCGGACGC TGGAGAATAT 1020
ATTTGTAAGG TCTCCAATTA TATAGGGGAG GCCAACCAGT CTGCCTGGCT CTCTGTTCTG 1080
CCGAGTTTAC AAGCTCCTGA AAAGGAAAAG GAATTTCCCA CATCTCCAGA CTACCTGGAA 1140
ATAGCAATTT ACTGCATAGG GGTCTTCCTG ATCGCCTGCA TGGTGCTGAC AGTCATCCTG 1200
TGCCGCATGA AGAACACCAC CAAGAAGCCT GACTTCAGCA GCCAGCCCGC TGTCCACAAG 1260
CTGACAAAGC GAATCCCTCT GCGCAGACAG ATTACATCTG TGTCAGCTGA CTCAAGCTCC 1320
TCCATGAACT CCAACACGCC TCTGGTGAGG ATAACTACAC GCCTCTCCTC CACTGCTGAT 1380
GCCCCAATGC TGGCAGGGGT CTCGGAATAT GAACTGCCAG AGGATCCAAA ATGGGAGTTT 1440
CCAAGGGATA AGCTGACGCT GGGTAAACCC CTGGGGGAAG GCTGCTTTGG GCAAGTGGTG 1500
ATGGCTGAAG CGGTGGGGAT TGACAAAGAC CGGCCCAAAG AAGCAGTGAC TGTGGCAGTG 1560
AAGATGCTGA AAGATGATGC TACGGAAAAG GATCTATCCG ACCTGGTGTC AGAGATGGAG 1620
ATGATGAAGA TGATTGGGAA ACATAAAAAT ATCATCAATC TTCTTGGAGC CTGTACCCAG 1680
GATGGTCCGC TGTATGTGAT TGTAGAATAT GCTTCCAAAG GAAACCTGCG TGAGTACCTG 1740
CGAGCACGCC GCCCTCCTGG GATGGAATAC TCCTTTGATA TTAACAGGGT CCCAGAGGAG 1800
CAGATGACAT TCAAGGACTT GGTATCCTGC ACGTACCAGT TGGCAAGAGG CATGGAGTAC 1860
TTGGCTTCAC AAAAATGTAT CCACCGAGAC CTAGCTGCAA GAAATGTTTT GGTAACTGAA 1920
AATAACGTCA TGAAAATAGC AGACTTCGGT TTAGCCAGAG ACATCAACAA TATAGATTAT 1980
TATAAAAAGA CTACTAATGG ACGGCTTCCA GTAAAGTGGA TGGCTCCAGA AGCTCTGTTT 2040
GACAGAGTTT ACACACACCA AAGCGACGTA TGGTCATTTG GTGTGCTAAT GTGGGAGATC 2100
TTCACCTTAG GAGGATCGCC CTACCCAGGA ATCCCAGTGG AGGAACTTTT TAAGCTGCTT 2160
AAAGAAGGGC ACCGAATGGA TAAACCTGCC AACTGCACCA ATGAACTCTA CATGATGATG 2220
AGAGATTGCT GGCAGGCTGT GCCTTCACAA AGACCAACTT TTAAACAGTT GGTAGAAGAC 2280
TTGGATCGGA TCCTTACTCT CACAACTAAC GAGGAGTATC TGGACCTCAG CGGACCTCTG 2340
GAGCAGTATT CACCTAGCTA CCCTGACACC AGGAGTTCGT GTTCTTCAGG TGATGACTCT 2400
GTTTTTTCTC CTGATCCAAT GCCTTATGAA CCCTGTCTTC CCAAGTACCA ACACATGAAT 2460
GGGAGCGTTA AAACATGA 2478
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkd++k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 485   LTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  544
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s d ++++eeq+t+
Q: 545   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTF  604
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 605   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  664
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 665   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  724
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct+ely++mr+cw+a++s+rptfkqlvedl
Q: 725   RMDKPANCTNELYMMMRDCWQAVPSQRPTFKQLVEDL  761
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDRPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSFDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTN ELYMMMRDCW QAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAJ-00155
EKS-CAF-00154
EKS-CAP-00147
EKS-DAR-00432
EKS-DRM-00071
EKS-EQC-00145
EKS-FEC-00140
EKS-GAM-00078
EKS-GAA-00175
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LAC-00158
EKS-LOA-00149
EKS-MAM-00147
EKS-MOD-00147
EKS-MUM-00151
EKS-MUP-00151
EKS-NOL-00141
EKS-ORN-00182
EKS-ORC-00138
EKS-ORL-00170
EKS-OTG-00152
EKS-PAT-00137
EKS-PES-00132
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
EKS-TAR-00191
EKS-TEN-00183
EKS-XET-00137
EKS-XIM-00176
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0045165; P:cell fate commitment
GO:0007267; P:cell-cell signaling
GO:0050673; P:epithelial cell proliferation
GO:0008285; P:negative regulation of cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0035265; P:organ growth
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0051781; P:positive regulation of cell division
GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010518; P:positive regulation of phospholipase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0046777; P:protein autophosphorylation
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453; P:regulation of cell fate commitment
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014; P:regulation of multicellular organism growth
GO:0051150; P:regulation of smooth muscle cell differentiation
GO:0008589; P:regulation of smoothened signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013