EKS-GAG-00344

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00344

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	334.8	4.6E-100	193	459	267

Status

Unreviewed

Ensembl Protein

ENSGALP00000015600

UniProt Accession

E1C1A7;

Protein Name

Protein Synonyms/Alias

Gene Name

IRAK4

Gene Synonyms/Alias

IRAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000009586	ENSGALP00000015599	ENSGALT00000015615
ENSGALG00000009586	ENSGALP00000015600	ENSGALT00000015616

Organism

Gallus gallus

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MSQPVTAATY VRSLRYGLLR QLADLLDPQE GWKRLAAAIT DPAGDSRYSQ AHIRRFEAFV 60

QMGKSPTCEL LYDWGTTNCT VGDLVDLLIR NQFLAPASLL LPEAVGMAQE VTLPLSSQET 120

LPVCEKQQPI QEKEVTSVKP VLSQNTEKQP SAPPCLSQEI SSTQSSNTDF HNFWFHDLES 180

VTNNFDERPE SAGGNKLGEG GFGIVFKGYI NGRNVAVKKL AAVVDVSAQD LKQQFDQEIE 240

IMAKCKHENL VELLGFSSDG AQPCLVYEYM PNGSLLDRLA CLDGTPPISW NTRCEIAQGT 300

ANGINFLHDN NHIHRDIKSA NILLTDTYVP KISDFGLARA SVTFTRTIMT DRVVGTAAYM 360

APEALRGEIT PKSDIFSFGV VLLEVITGLP PVDENREPQL LLSIKDEIED EEATIEDYVD 420

VKMSDWDATS VHKMYSLADQ CLNEKKNRRP NMKMVQQYLQ EIKT 464

Nucleotide Sequence
(FASTA)

ATGAGCCAAC CGGTCACCGC CGCCACCTAC GTCCGCAGCC TGCGCTACGG GCTGCTGAGG 60

CAGCTGGCCG ACCTCCTGGA CCCGCAGGAG GGCTGGAAGC GGCTGGCCGC GGCCATCACC 120

GACCCGGCCG GCGACAGCAG ATACAGCCAG GCGCACATCA GGAGATTTGA AGCGTTTGTG 180

CAAATGGGGA AGAGTCCCAC GTGTGAATTG CTTTATGACT GGGGAACAAC AAATTGTACG 240

GTTGGTGACC TTGTGGATCT GCTGATTAGG AACCAGTTTC TGGCACCAGC AAGTCTTTTG 300

CTTCCAGAAG CTGTCGGGAT GGCACAAGAA GTTACGTTAC CTCTTTCTTC ACAGGAAACT 360

TTGCCTGTAT GTGAGAAACA ACAGCCTATA CAGGAAAAAG AAGTGACATC TGTAAAGCCT 420

GTTTTGTCTC AGAACACAGA GAAGCAACCT TCAGCCCCTC CATGTTTAAG TCAAGAAATC 480

AGCAGCACAC AGTCTAGTAA CACAGATTTC CACAATTTTT GGTTTCACGA CTTGGAAAGT 540

GTTACAAATA ATTTTGATGA ACGACCAGAA TCAGCTGGAG GAAATAAGCT GGGGGAAGGT 600

GGCTTTGGCA TTGTGTTCAA AGGCTACATC AATGGCAGAA ACGTGGCTGT CAAGAAACTT 660

GCTGCTGTGG TTGATGTTAG TGCACAGGAT TTGAAACAGC AGTTTGATCA AGAAATAGAA 720

ATTATGGCAA AGTGTAAACA TGAAAATCTG GTAGAATTGC TTGGTTTCTC AAGTGATGGT 780

GCTCAGCCCT GTTTGGTGTA TGAATACATG CCCAATGGTT CGCTGCTTGA CAGACTTGCT 840

TGTCTGGATG GCACTCCACC TATTTCTTGG AACACAAGGT GTGAAATTGC TCAAGGTACT 900

GCGAATGGCA TCAACTTTCT GCATGACAAT AATCATATTC ACAGAGACAT TAAAAGTGCA 960

AATATCTTAT TAACTGATAC GTATGTGCCC AAAATTTCGG ACTTTGGACT TGCAAGAGCA 1020

TCAGTAACAT TCACACGAAC CATCATGACA GACAGAGTTG TGGGAACAGC AGCCTATATG 1080

GCACCTGAAG CTCTGCGAGG AGAAATAACG CCTAAATCCG ATATCTTCAG CTTTGGGGTA 1140

GTCTTACTAG AAGTAATAAC AGGTCTGCCA CCAGTAGACG AAAACCGGGA GCCACAGTTA 1200

CTGTTAAGTA TCAAGGATGA AATTGAGGAT GAGGAGGCGA CTATAGAGGA TTATGTTGAC 1260

GTAAAGATGA GTGACTGGGA TGCAACTTCA GTTCATAAAA TGTACTCACT TGCTGATCAG 1320

TGTCTGAATG AGAAAAAAAA CAGGAGGCCA AACATGAAGA TGGTCCAGCA GTATTTACAA 1380

GAGATAAAAA CGTGA 1395

Domain Profile

S: 3     ednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnile  62

          +n++geGgfg v++g +++ +vavkkl++ +d+s + lkq+f++E++++a+++H+n++e

Q: 193   GGNKLGEGGFGIVFKGYINGRNVAVKKLAAVVDVSAQDLKQQFDQEIEIMAKCKHENLVE  252

         579*********************************************************

S: 63    llgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeasp  122

         llg+s+++ ++cLvY+ym+nGsL drL c +g++p+sW++R++i++Gta++i+fLH++

Q: 253   LLGFSSDGAQPCLVYEYMPNGSLLDRLACLDGTPPISWNTRCEIAQGTANGINFLHDN--  310

         **********************************************************..

S: 123   slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeefir  182

         ++ih+diksaNiLL ++  pK++Dfglar   +s   ++t++ t++v+gt+aY+++e++r

Q: 311   NHIHRDIKSANILLTDTYVPKISDFGLAR---ASVTFTRTIM-TDRVVGTAAYMAPEALR  366

         *****************************...8888999999.*****************

S: 183   vgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfldkka  242

          g++t k+D++SfG+VllEv+tGl+ vde+r+++ L+ + k+eie+e+  ++e+++d k+

Q: 367   -GEITPKSDIFSFGVVLLEVITGLPPVDENREPQLLLSI-KDEIEDEE-ATIEDYVDVKM  423

         .************************************99.********.899********

S: 243   gkleeellealielalaclaekakkrPtmsqvlell  278

         ++ + ++++++++la +cl+ek+++rP+m+ v+++l

Q: 424   SDWDATSVHKMYSLADQCLNEKKNRRPNMKMVQQYL  459

         *********************************987

Domain Sequence
(FASTA)

GGNKLGEGGF GIVFKGYING RNVAVKKLAA VVDVSAQDLK QQFDQEIEIM AKCKHENLVE 60

LLGFSSDGAQ PCLVYEYMPN GSLLDRLACL DGTPPISWNT RCEIAQGTAN GINFLHDNNH 120

IHRDIKSANI LLTDTYVPKI SDFGLARASV TFTRTIMTDR VVGTAAYMAP EALRGEITPK 180

SDIFSFGVVL LEVITGLPPV DENREPQLLL SIKDEIEDEE ATIEDYVDVK MSDWDATSVH 240

KMYSLADQCL NEKKNRRPNM KMVQQYL 267

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway

KEGG

InterPros

IPR011029	; DEATH-like.
IPR017428	; Interleukin-1_rcpt-assoc_kin4.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013