EKS-GAG-00247
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00247
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/IKK432.29.3E-1309295287
StatusUnreviewed
Ensembl ProteinENSGALP00000015982
UniProt AccessionE1C581;
Protein Name
Protein Synonyms/Alias
Gene NameTBK1
Gene Synonyms/Alias TBK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000009840ENSGALP00000015982ENSGALT00000015999
OrganismGallus gallus
Functional Description
Protein Length731
Protein Sequence
(FASTA)
MQSTSNYLWL LSDILGQGAT ANVFRGRHKK TGDLYAVKVF NSISFLRPVD VQMREFEVLT 60
KLNHKNIVKL FAIEEETTTR HKVLVMEFCP CGSLYTVLEE PSNAFGLPES EFLIVLRDVV 120
KVAGMNHLRE NGIVHRDIKP GNIMRVIGED GQSVYKLTDF GAARELEDDE QFVSLYGTEE 180
YLHPDMYERA VLRKEHQKKY GATVDLWSIG VTFYHAATGS LPFRPFEGPR RNKEVMYKII 240
TGKPSGAISG IQKAANGPIE WSWEMPISCS LSKGLQVLLT PVLANILEAD QEKCWGFDQF 300
FAETSDILHR IIIHIFSLQQ MTLHKVYIHS YNTAAIFHEL VYKQTKIPSQ NQELIYEGRR 360
LILEPGRLAQ HFPRTTEENP IFVVSREAVN IVGLVYEEVL LPKVHQRYDL DGDASMAKEV 420
TRIVCYACRV ANSLLLYQEL MRRGIRWLIE IIKDDYNEMV HKKTEVVIRL DFCSRNIEKA 480
EKIYENLMQI NLESSEVDEI SEINTKLLRL SSSQGTIETS LQDIKTKLSP GGLLADTWAN 540
QEGTHPRDRN SERLQTLLSA ITDIYYQFKK DKQERRLAYN EEQIHKFDKQ KLYLHATKAI 600
ALFKDECVSK YDAFLDKAED WTRKMLHTRK QLLALTNQCF DIEEEVSKYQ DYINELQDAL 660
PQKMFAASTG MKHTMNTVYP SSNTLVEMTL GMKKLKEEME GVVKELAENN HILERFGALT 720
ADGGLRNVDC I 731
Nucleotide Sequence
(FASTA)
ATGCAGAGCA CCTCGAATTA CCTCTGGCTG TTGTCTGACA TTCTAGGACA AGGAGCTACT 60
GCAAATGTTT TCCGGGGACG ACATAAGAAA ACTGGGGATT TGTATGCTGT CAAAGTATTT 120
AACAGTATAA GTTTCCTTCG CCCCGTGGAT GTTCAGATGC GAGAGTTTGA AGTGTTGACG 180
AAACTGAATC ATAAAAACAT TGTCAAGTTG TTTGCTATTG AGGAAGAGAC AACAACTAGG 240
CACAAAGTGC TCGTTATGGA GTTTTGTCCG TGTGGAAGTC TATATACAGT TCTAGAGGAA 300
CCATCCAATG CCTTTGGTTT GCCAGAATCG GAGTTCTTAA TTGTGTTGAG AGATGTAGTT 360
AAAGTGGCTG GGATGAATCA TCTCCGGGAA AATGGAATAG TGCACCGTGA CATCAAACCA 420
GGCAACATCA TGCGTGTTAT AGGTGAAGAT GGTCAGTCTG TTTACAAACT GACAGACTTC 480
GGTGCTGCGA GGGAGCTTGA AGATGATGAA CAGTTTGTTT CTCTCTACGG CACAGAGGAG 540
TATTTACATC CTGATATGTA TGAGCGAGCA GTTTTGAGGA AAGAGCATCA GAAAAAGTAC 600
GGAGCCACAG TTGATCTGTG GAGTATAGGG GTGACCTTTT ACCATGCTGC AACAGGGAGC 660
TTGCCTTTCC GACCCTTTGA AGGACCTCGT AGAAACAAGG AAGTGATGTA TAAAATAATC 720
ACTGGGAAGC CTTCTGGTGC TATTTCTGGA ATACAGAAGG CAGCAAACGG ACCAATTGAG 780
TGGAGCTGGG AGATGCCTAT TTCTTGCAGT CTTTCCAAGG GTCTGCAGGT ACTGCTCACA 840
CCTGTCCTTG CAAATATTCT GGAAGCAGAC CAGGAGAAAT GCTGGGGCTT CGATCAGTTC 900
TTTGCAGAGA CGAGTGACAT ATTGCACCGG ATAATAATCC ACATCTTTTC ACTCCAGCAG 960
ATGACCTTGC ACAAAGTCTA TATTCACAGC TATAATACAG CTGCTATATT TCATGAGTTG 1020
GTCTACAAAC AGACAAAGAT ACCATCTCAG AATCAAGAAC TTATATACGA AGGTCGGCGT 1080
TTGATACTAG AGCCTGGCAG ACTGGCACAA CACTTCCCCA GAACTACTGA GGAGAATCCT 1140
ATCTTTGTAG TAAGCAGAGA GGCTGTGAAC ATTGTTGGAT TAGTCTACGA AGAAGTTTTG 1200
CTTCCTAAAG TGCATCAACG TTATGACTTG GATGGGGATG CCAGTATGGC TAAAGAAGTA 1260
ACACGTATCG TATGTTATGC CTGTAGAGTT GCCAATTCTT TGCTACTTTA CCAGGAGCTG 1320
ATGCGAAGAG GAATACGATG GCTAATTGAA ATAATCAAGG ATGATTACAA TGAAATGGTT 1380
CATAAAAAGA CTGAGGTTGT CATCAGACTG GATTTCTGCA GCAGAAACAT TGAAAAAGCA 1440
GAGAAAATAT ATGAGAATTT GATGCAGATC AACTTGGAAT CATCAGAAGT GGATGAAATT 1500
TCAGAGATAA ACACGAAATT GTTGCGTCTC TCCAGCTCCC AGGGCACAAT AGAAACAAGT 1560
CTTCAAGATA TCAAAACCAA ACTTTCTCCT GGTGGTTTAC TGGCTGACAC CTGGGCGAAT 1620
CAAGAAGGCA CACATCCGAG AGACAGAAAT TCTGAAAGGC TGCAGACACT GCTATCTGCA 1680
ATCACAGATA TTTATTATCA GTTCAAAAAA GACAAACAAG AACGAAGGCT TGCCTATAAT 1740
GAAGAACAAA TTCACAAGTT TGACAAGCAG AAGCTGTATT TGCACGCTAC CAAAGCCATA 1800
GCTCTGTTCA AAGATGAATG TGTCAGCAAG TACGATGCAT TTCTGGACAA GGCTGAGGAC 1860
TGGACAAGGA AAATGCTTCA CACAAGGAAG CAGTTGCTAG CTCTCACCAA CCAATGTTTT 1920
GATATTGAAG AAGAAGTATC CAAATACCAG GATTATATAA ATGAGTTACA AGATGCTCTG 1980
CCTCAGAAAA TGTTTGCAGC TTCCACTGGG ATGAAACATA CCATGAATAC AGTTTATCCA 2040
AGTTCAAACA CATTAGTAGA AATGACTCTT GGTATGAAGA AACTAAAGGA GGAAATGGAA 2100
GGGGTTGTTA AAGAGCTGGC TGAGAACAAT CATATTTTGG AAAGATTTGG TGCTTTGACT 2160
GCAGATGGTG GCCTGAGGAA TGTGGACTGT ATCTAA 2196
Domain Profile
S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60
         W l+++LG+Ga++nv+++r+kktg+ +avkv++++s+lrp++vq+re+evl klnhkniv
Q: 9     WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNSISFLRPVDVQMREFEVLTKLNHKNIV  68
         999*********************************************************
S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvv..agl  118
         kl+++eee   +++r+kvlv+e+C +G+l++vLeep+na+GL+ese+l+vL+dvv  ag+
Q: 69    KLFAIEEE---TTTRHKVLVMEFCPCGSLYTVLEEPSNAFGLPESEFLIVLRDVVkvAGM  125
         ********...*******************************************73369*
S: 119   ryLrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPe  178
         ++Lren+ivhRD+kP+ni++++gedg+s+ykltD+Gaarel+dde++vsl+GteeYl+P+
Q: 126   NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD  185
         ************************************************************
S: 179   lye........qkkytatvDlWsiGvllyeaitGslPflpfegprr....lykkitkkpa  226
         +ye        qkky+atvDlWsiGv++y+a+tGslPf+pfegprr    +yk+it kp+
Q: 186   MYEravlrkehQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRnkevMYKIITGKPS  245
         ************************************************************
S: 227   kaiagteka.ngevefssslPlsaslssglqeklekllanllevdeekrw  275
         +ai+g +ka ng++e+s ++P+s+sls+glq  l+++lan+le+d+ek+w
Q: 246   GAISGIQKAaNGPIEWSWEMPISCSLSKGLQVLLTPVLANILEADQEKCW  295
         ********99***************************************9
Domain Sequence
(FASTA)
WLLSDILGQG ATANVFRGRH KKTGDLYAVK VFNSISFLRP VDVQMREFEV LTKLNHKNIV 60
KLFAIEEETT TRHKVLVMEF CPCGSLYTVL EEPSNAFGLP ESEFLIVLRD VVKVAGMNHL 120
RENGIVHRDI KPGNIMRVIG EDGQSVYKLT DFGAARELED DEQFVSLYGT EEYLHPDMYE 180
RAVLRKEHQK KYGATVDLWS IGVTFYHAAT GSLPFRPFEG PRRNKEVMYK IITGKPSGAI 240
SGIQKAANGP IEWSWEMPIS CSLSKGLQVL LTPVLANILE ADQEKCW 287
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00276
EKS-ANC-00284
EKS-BOT-00294
EKS-CAJ-00300
EKS-CAF-00300
EKS-CAP-00328
EKS-CII-00172
EKS-CIS-00060
EKS-DAR-00643
EKS-DRM-00150
EKS-EQC-00285
EKS-FEC-00282
EKS-GAM-00187
EKS-GAA-00362
EKS-GOG-00293
EKS-HOS-00300
EKS-ICT-00277
EKS-LAC-00307
EKS-LOA-00305
EKS-MAM-00297
EKS-MEG-00235
EKS-MUM-00325
EKS-MUP-00291
EKS-MYL-00295
EKS-NOL-00270
EKS-ORN-00380
EKS-ORA-00260
EKS-ORC-00275
EKS-ORL-00355
EKS-OTG-00299
EKS-PAT-00278
EKS-PES-00261
EKS-PEM-00163
EKS-POA-00286
EKS-PTV-00050
EKS-RAN-00309
EKS-SAH-00276
EKS-TAG-00309
EKS-TAR-00383
EKS-TEN-00379
EKS-VIP-00025
EKS-XET-00366
EKS-XIM-00372
Gene Ontology
GO:0005524; F:ATP binding
GO:0003676; F:nucleic acid binding
GO:0051219; F:phosphoprotein binding
GO:0004672; F:protein kinase activity
GO:0002218; P:activation of innate immune response
GO:0050830; P:defense response to Gram-positive bacterium
GO:0010629; P:negative regulation of gene expression
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032727; P:positive regulation of interferon-alpha production
GO:0045359; P:positive regulation of interferon-beta biosynthetic process
GO:0032728; P:positive regulation of interferon-beta production
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013