EKS-GAG-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NEK	340.4	8.2E-102	8	269	262

Status

Unreviewed

Ensembl Protein

ENSGALP00000016000

UniProt Accession

F1NI69;

Protein Name

Protein Synonyms/Alias

Gene Name

NEK2

Gene Synonyms/Alias

NEK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000009854	ENSGALP00000016000	ENSGALT00000016017

Organism

Gallus gallus

Functional Description

Protein Length

444

Protein Sequence
(FASTA)

MPSRPEDYEV LLTIGAGSYG KCRKVRRKAD GKILVWKELD YGSMTETEKQ MLVSEVNLLR 60

ELRHPNIVRY HDRIIDRSST TLYIVMEYCD GGDLASLIAR CTRDRHYLEE SFVLRVLTQL 120

TLALKECHRR SDGGVTVHRD LKPANVFLDG KQNVKLGDFG LARILHHDTS FAKTFVGTPY 180

YMSPEQINHM SYNEKSDIWS LGCLLYELCA LTPPFTAYNQ KELAEKIREG KFRRIPYRYS 240

EQLNELLKEM LNLKDYCRPS VEDILQHPLI ADLVAEEQRK NPDKRGRRSG DPERVQHSDA 300

PVNELKLKEQ QLHEREQAIK DREQRLEQRE RELCVRERLA EDKLARAEKL MRNYSLYKQQ 360

RTLSSVDGPD NALLLPFSTT KKKVHFGGSE EDGMPSVNVE NYPLSKGKCS DLKRRLYAAN 420

LRAQALCELE KNYQLKSRQI LGMR 444

Nucleotide Sequence
(FASTA)

ATGCCCAGCC GGCCCGAGGA CTACGAGGTG CTGCTCACCA TCGGCGCCGG CTCCTACGGC 60

AAGTGCCGCA AGGTGCGGCG CAAGGCCGAC GGCAAGATCC TAGTATGGAA GGAACTCGAC 120

TACGGCTCCA TGACGGAGAC GGAGAAGCAG ATGCTCGTTT CGGAGGTAAA TCTGCTCCGC 180

GAGCTGCGAC ACCCCAACAT CGTCCGCTAC CACGACCGCA TCATCGACCG GAGCAGCACC 240

ACCCTCTACA TCGTGATGGA GTACTGCGAC GGGGGCGACC TGGCCAGCCT CATCGCGCGC 300

TGCACCAGGG ACAGACACTA CTTGGAAGAA AGCTTTGTTC TCCGAGTACT GACTCAGCTG 360

ACGTTGGCCT TGAAGGAGTG CCATAGGCGG AGTGATGGCG GAGTCACTGT ACACCGTGAC 420

TTAAAACCAG CGAATGTCTT CCTGGATGGC AAGCAGAATG TTAAACTTGG AGATTTTGGA 480

CTGGCTCGAA TATTGCATCA CGACACCAGC TTTGCCAAAA CTTTTGTTGG AACCCCATAC 540

TATATGTCTC CAGAGCAAAT TAACCACATG TCATACAACG AAAAATCTGA CATTTGGTCT 600

CTAGGATGTC TTCTATATGA GTTATGTGCT CTCACGCCTC CATTTACAGC TTACAACCAG 660

AAGGAGTTGG CAGAAAAGAT AAGGGAGGGG AAGTTCAGAC GAATACCGTA TCGTTACTCA 720

GAGCAATTGA ACGAACTTCT CAAAGAGATG CTGAACTTAA AGGATTATTG CCGACCTTCT 780

GTTGAAGATA TTCTGCAGCA TCCCTTGATA GCAGATTTAG TGGCAGAAGA ACAGAGAAAA 840

AATCCTGATA AAAGAGGCCG GAGATCAGGA GACCCAGAGA GGGTGCAGCA TTCGGATGCT 900

CCGGTGAATG AACTGAAGCT GAAGGAGCAA CAACTACATG AAAGAGAGCA AGCCATTAAG 960

GACAGAGAGC AACGATTGGA GCAGAGAGAA CGGGAACTCT GTGTTCGAGA GAGACTGGCA 1020

GAGGACAAAC TTGCTAGAGC TGAAAAATTG ATGAGGAACT ACAGTCTCTA CAAACAGCAG 1080

AGGACATTAT CTTCTGTAGA TGGCCCAGAT AATGCACTCC TGCTCCCCTT TTCTACAACC 1140

AAGAAGAAGG TCCACTTTGG TGGAAGTGAA GAGGATGGTA TGCCTTCTGT TAACGTGGAG 1200

AACTATCCCC TTTCGAAAGG GAAATGCTCT GATCTCAAAA GACGCCTATA TGCTGCAAAT 1260

CTACGAGCTC AAGCACTGTG TGAACTGGAA AAGAACTATC AACTAAAGAG CAGACAAATC 1320

TTGGGCATGC GCTGA 1335

Domain Profile

S: 1     yevlkkiGrGsfgevlkvrkksdkkllvlKeikleeldekerqklvkevsllkqlkHpni  60

         yevl +iG+Gs+g+++kvr+k+d+k lv+Ke+++++++e+e+q+lv+ev+ll++l+Hpni

Q: 8     YEVLLTIGAGSYGKCRKVRRKADGKILVWKELDYGSMTETEKQMLVSEVNLLRELRHPNI  67

         999*********************************************************

S: 61    veyyesfe..eneelyivmeyceggdLsqlikeqkekkklleEktvlkilvqlllalkkl  118

         v+y+++++  + ++lyivmeyc+ggdL++li + ++++++leE+ vl++l+ql+lalk++

Q: 68    VRYHDRIIdrSSTTLYIVMEYCDGGDLASLIARCTRDRHYLEESFVLRVLTQLTLALKEC  127

         ******65478899**********************************************

S: 119   Hek....kilHRDlkpaNifltkkevvklgDfGlaklleskielaktlvGtpyYlsPEvl  174

         H++      +HRDlkpaN+fl+ k++vklgDfGla++l++++++akt+vGtpyY+sPE++

Q: 128   HRRsdggVTVHRDLKPANVFLDGKQNVKLGDFGLARILHHDTSFAKTFVGTPYYMSPEQI  187

         *88777678***************************************************

S: 175   eekpYneksDiWslgCvlyelcaLkkpFeaknllelvlkivegklepvpekyseelkeli  234

         ++ +YneksDiWslgC+lyelcaL++pF+a n +el++ki egk++++p +yse+l+el+

Q: 188   NHMSYNEKSDIWSLGCLLYELCALTPPFTAYNQKELAEKIREGKFRRIPYRYSEQLNELL  247

         ************************************************************

S: 235   esllkvdpekrpsveeilkkpl  256

         +++l+ ++  rpsve+il++pl

Q: 248   KEMLNLKDYCRPSVEDILQHPL  269

         *******************987

Domain Sequence
(FASTA)

YEVLLTIGAG SYGKCRKVRR KADGKILVWK ELDYGSMTET EKQMLVSEVN LLRELRHPNI 60

VRYHDRIIDR SSTTLYIVME YCDGGDLASL IARCTRDRHY LEESFVLRVL TQLTLALKEC 120

HRRSDGGVTV HRDLKPANVF LDGKQNVKLG DFGLARILHH DTSFAKTFVG TPYYMSPEQI 180

NHMSYNEKSD IWSLGCLLYE LCALTPPFTA YNQKELAEKI REGKFRRIPY RYSEQLNELL 240

KEMLNLKDYC RPSVEDILQH PL 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000794	; C:condensed nuclear chromosome
GO:0000776	; C:kinetochore
GO:0030496	; C:midbody
GO:0000922	; C:spindle pole
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0051299	; P:centrosome separation
GO:0000070	; P:mitotic sister chromatid segregation
GO:0043392	; P:negative regulation of DNA binding
GO:0046777	; P:protein autophosphorylation
GO:0051988	; P:regulation of attachment of spindle microtubules to kinetochore

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013