EKS-GAG-00222

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00222

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	469.3	6.9E-141	147	460	314

Status

Reviewed

Ensembl Protein

ENSGALP00000016084

UniProt Accession

Q5ZIU3;

Protein Name

Dual specificity tyrosine-phosphorylation-regulated kinase 2

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2; RCJMB04_23i19;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000009901	ENSGALP00000016084	ENSGALT00000016103

Organism

Gallus gallus

Functional Description

Serine/threonine-protein kinase involved in the controlof mitotic transition and the regulation of cellular growth and/or development (By similarity).

Protein Length

526

Protein Sequence
(FASTA)

MNEHLHVGSH GQIQVQQLFE DNSNKRTVLT TQPNGLTTLG KSGLPVVQDR QSESAHRRQG 60

SSSSLKSTDG TGKVKASVMT PEQAMKQYMQ KLTTFEHNEI FGYTEIYFLG PNAKKRQGVI 120

GGPNNCGYDD DQGSYIQVPH DHIAYRYEVL KVIGKGSFGQ VVKAYDHKMH QHVALKMVRN 180

EKRFHRQAAE EIRILEHLRK QDKDNNMNVI HMLENFTFRS HICMTFELLS MNLYELIKKN 240

KFQGFSLPLV RKFAHSILQC LDALHKNRII HCDLKPENIL LKQQGRSGIK VIDFGSSCYE 300

HQRVYTYIQS RFYRAPEVIL GARYGMPIDM WSLGCILAEL LTGYPLLPGE DEGDQLACMI 360

ELLGMPSPKL LDSSKRAKNF VSSKGYPRYC TITTLSDGSI ILNGGRSRRG KLRGPPESRE 420

WGNALKGCDD PLFLDFLKQC LEWDPAIRMT PSQALRHPWL RRRLPKPPTG EKASAKRITE 480

STGAITSISK LPPTSSSASK LRTNLAQMTD ANGNIQQRTV LPKLVS 526

Nucleotide Sequence
(FASTA)

ATGAATGAGC ACCTCCATGT TGGTAGCCAT GGACAAATCC AGGTTCAACA ACTGTTTGAA 60

GATAATAGTA ACAAGAGGAC GGTTCTGACA ACACAGCCGA ATGGACTTAC AACGCTAGGC 120

AAATCTGGAT TGCCAGTGGT TCAGGACAGA CAGTCAGAGA GTGCTCACAG ACGACAAGGG 180

AGCTCCAGCT CTTTAAAATC TACAGATGGA ACAGGGAAGG TGAAAGCCTC CGTTATGACA 240

CCAGAGCAGG CAATGAAGCA ATACATGCAA AAACTAACAA CTTTTGAACA TAATGAGATT 300

TTTGGCTACA CTGAAATATA CTTTTTGGGT CCAAATGCAA AGAAGCGGCA AGGTGTGATT 360

GGTGGTCCAA ACAATTGCGG GTATGATGAT GACCAGGGGT CGTACATACA AGTACCCCAC 420

GATCATATTG CATACAGATA TGAAGTCCTG AAAGTTATCG GGAAAGGAAG CTTTGGGCAG 480

GTGGTGAAAG CCTACGATCA CAAGATGCAT CAACACGTGG CACTAAAAAT GGTGAGAAAT 540

GAAAAGCGTT TCCACCGCCA AGCTGCGGAA GAAATTAGGA TTCTGGAGCA TCTCCGGAAA 600

CAAGACAAGG ATAACAACAT GAATGTTATT CACATGTTGG AAAACTTCAC ATTCCGCAGC 660

CATATCTGCA TGACATTTGA ATTGCTGAGC ATGAACCTGT ATGAATTAAT AAAGAAGAAC 720

AAGTTTCAGG GCTTTAGCCT GCCTTTGGTC CGCAAGTTTG CCCACTCCAT TTTACAGTGC 780

TTGGATGCTT TGCACAAAAA CAGAATTATC CACTGTGACC TTAAACCTGA GAACATTCTG 840

TTAAAGCAAC AGGGCCGAAG TGGTATCAAA GTGATCGATT TTGGCTCGAG TTGTTACGAG 900

CATCAGCGTG TCTACACTTA CATTCAGTCA CGTTTTTATC GCGCGCCTGA AGTCATCCTT 960

GGTGCTCGTT ACGGGATGCC CATCGATATG TGGAGCTTGG GATGTATTCT AGCAGAGCTT 1020

CTCACCGGCT ATCCACTTTT ACCTGGAGAA GATGAAGGAG ACCAGCTGGC TTGTATGATT 1080

GAGCTGTTGG GCATGCCTTC CCCAAAACTT TTAGATTCAT CCAAGCGAGC CAAAAACTTT 1140

GTGAGCTCTA AGGGTTATCC CCGCTACTGC ACCATCACAA CCTTGTCCGA TGGTTCTATA 1200

ATACTGAACG GTGGACGCTC TCGGAGGGGA AAATTACGCG GCCCACCAGA GAGCAGAGAA 1260

TGGGGTAACG CATTAAAGGG GTGCGACGAT CCCCTGTTCC TTGACTTTTT AAAACAGTGT 1320

TTAGAATGGG ATCCTGCTAT CCGAATGACA CCCAGCCAGG CTTTGCGACA TCCCTGGCTA 1380

AGGCGACGGT TGCCGAAGCC TCCGACTGGG GAGAAGGCCT CAGCAAAGAG AATTACAGAG 1440

AGCACTGGTG CTATAACGTC GATTTCCAAG TTACCTCCAA CTTCAAGCTC AGCTTCAAAA 1500

CTGAGGACTA ATTTGGCACA GATGACAGAT GCCAATGGGA ATATTCAGCA AAGAACAGTA 1560

TTGCCAAAAC TCGTTAGCTG A 1581

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 147   YEVLKVIGKGSFGQVVKAYDHKMHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNN  206

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+fr+h+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 207   MNVIHMLENFTFRSHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  266

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y

Q: 267   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  325

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+

Q: 326   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSPKLLDSSKRAKNFVSSKG  385

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y++ t+ sd + +l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp

Q: 386   YPRYCTITTLSDGSIILNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP  445

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp++al+hp++

Q: 446   AIRMTPSQALRHPWL  460

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKMHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNN 60

MNVIHMLENF TFRSHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SPKLLDSSKR AKNFVSSKGY 240

PRYCTITTLS DGSIILNGGR SRRGKLRGPP ESREWGNALK GCDDPLFLDF LKQCLEWDPA 300

IRMTPSQALR HPWL 314

Keyword

Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Manganese; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0030529	; C:ribonucleoprotein complex
GO:0000151	; C:ubiquitin ligase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0042771	; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725	; P:positive regulation of glycogen biosynthetic process
GO:0007224	; P:smoothened signaling pathway

KEGG

gga:427864

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013