EKS-GAG-00146
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00146
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC455.09.4E-137281541261
StatusUnreviewed
Ensembl ProteinENSGALP00000016228
UniProt AccessionF1NG47;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCE
Gene Synonyms/Alias PRKCE;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000010000ENSGALP00000016228ENSGALT00000016247
OrganismGallus gallus
Functional Description
Protein Length610
Protein Sequence
(FASTA)
SSVSAPKDNE ERVFRERMRP RKRQGAVRRR VHQVNGHKFM ATYLRQPTYC SHCRDFIWGV 60
IGKQGYQCQV CTCVVHKRCH ELIITKCAGL KKQETHDEQV GSQRFSVNMP HKFSIHNYKV 120
PTFCDHCGSL LWGLLRQGLQ CKVCKMNVHR RCETNVAPNC GVDARGIAKV LADLGVTPDK 180
ITNSGQRRKK LIAGAENQQP VPGSTSSEED RSKSAPTSPC DQEIKELENN IRKALSFDNR 240
GEEHRATATT SADNQLNKPG ENGENGEVKQ AQTKRIGLEE FNFIKVLGKG SFGKVMLAEL 300
KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP YLTQLYCCFQ TKDRLFFVME 360
YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG VIYSDLNSGN ILLDAEGHCK 420
LAAFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS VDWWALGVLM YEMMAGQPPF 480
EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPN KRLGCVASQN GEDAIKQHPF 540
FKEIDWVLLE QRKIKPPFKP RIKTKRDVNN FDQDFTREEP VLTLVDETII KQINQEEFKG 600
FSYFGEELLP 610
Nucleotide Sequence
(FASTA)
TCTTCTGTTT CAGCACCCAA AGACAATGAA GAACGTGTAT TTCGGGAACG GATGCGCCCC 60
AGAAAGCGGC AGGGTGCTGT ACGACGCAGA GTACATCAGG TCAATGGACA CAAGTTTATG 120
GCCACCTATC TTAGACAACC AACATACTGT TCACACTGCA GAGATTTTAT ATGGGGTGTA 180
ATAGGAAAAC AGGGATACCA ATGTCAAGTT TGCACTTGTG TAGTCCACAA GAGATGCCAT 240
GAACTTATAA TAACGAAGTG TGCTGGCTTA AAAAAACAGG AAACCCACGA TGAGCAAGTG 300
GGATCTCAGC GTTTCAGTGT CAACATGCCT CACAAATTTA GCATTCACAA TTACAAAGTG 360
CCCACCTTCT GTGACCACTG TGGTTCATTG CTCTGGGGTC TTTTGAGACA AGGTTTACAA 420
TGCAAAGTTT GCAAGATGAA TGTACATCGA CGCTGTGAAA CAAATGTGGC ACCAAACTGT 480
GGAGTGGATG CTAGAGGCAT AGCTAAAGTT CTTGCTGATC TTGGAGTCAC TCCAGATAAG 540
ATCACTAATA GTGGGCAGAG GAGGAAAAAG CTAATTGCAG GTGCAGAGAA TCAGCAACCA 600
GTTCCTGGAA GCACATCATC AGAAGAAGAT AGGTCAAAGT CAGCACCGAC TTCTCCATGT 660
GATCAAGAAA TCAAAGAGCT GGAAAACAAC ATTAGGAAAG CATTATCATT TGACAACCGG 720
GGAGAAGAGC ACAGGGCAAC TGCTACAACA TCGGCAGACA ACCAGCTTAA CAAACCCGGG 780
GAGAATGGTG AAAATGGGGA GGTCAAACAA GCACAGACCA AGCGAATAGG CCTTGAGGAG 840
TTCAACTTCA TCAAAGTATT AGGGAAAGGC AGCTTTGGCA AGGTAATGTT AGCTGAGCTA 900
AAAGGAAAAG ATGAAGTATA TGCAGTGAAA GTCTTAAAAA AAGATGTCAT ACTTCAAGAT 960
GATGACGTAG ACTGCACAAT GACAGAAAAG AGAATTCTGG CGTTAGCACG GAAACATCCA 1020
TACCTAACAC AACTTTACTG CTGCTTCCAG ACAAAGGACC GCCTCTTTTT CGTCATGGAA 1080
TATGTAAATG GAGGAGACCT AATGTTTCAA ATCCAGCGCT CACGCAAATT TGACGAACCT 1140
CGATCCCGCT TTTATGCAGC AGAGGTCACA TCAGCACTCA TGTTTCTTCA CCAACATGGC 1200
GTCATCTACA GTGATTTAAA TTCTGGAAAT ATTCTTCTGG ATGCAGAAGG CCACTGTAAA 1260
CTGGCTGCCT TTGGGATGTG CAAAGAAGGG ATTCTGAATG GAGTGACCAC CACAACCTTC 1320
TGTGGTACAC CTGACTATAT AGCTCCAGAG ATCCTCCAGG AATTAGAATA TGGCCCTTCA 1380
GTAGACTGGT GGGCTCTGGG TGTTCTCATG TACGAAATGA TGGCTGGGCA ACCCCCCTTT 1440
GAAGCTGACA ATGAAGACGA TCTCTTTGAA TCCATCCTTC ACGATGATGT CTTATATCCA 1500
GTCTGGCTCA GTAAAGAAGC AGTCAGCATT CTAAAAGCAT TCATGACAAA AAATCCAAAT 1560
AAACGACTTG GCTGTGTGGC ATCACAAAAT GGGGAAGATG CGATTAAGCA GCATCCGTTT 1620
TTCAAGGAAA TTGACTGGGT TCTTCTAGAA CAAAGGAAAA TCAAGCCACC CTTCAAACCT 1680
CGGATTAAAA CCAAAAGGGA TGTAAATAAC TTTGATCAAG ACTTTACACG AGAAGAGCCG 1740
GTATTAACTC TAGTGGATGA GACAATTATA AAACAAATCA ATCAAGAAGA ATTTAAAGGG 1800
TTCTCTTATT TTGGAGAAGA GCTACTGCCA TAG 1833
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+++kvlGkGsfgkv+laelk++de+ya+kvlkkdv+lqdddv++t++ekr+lala+k+p
Q: 281   FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP  340
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g
Q: 341   YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHG  400
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         +iy dl   n+lldaeGh+kla fG+cke+il+g tt+tfcGtPdyiaPeil+e eyg s
Q: 401   VIYSDLNSGNILLDAEGHCKLAAFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPS  460
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+ilk+++tk+p+
Q: 461   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPN  520
         ************************************************************
S: 241   krlGv..keegeedikehaff  259
         krlG+  +++ge++ik+h+ff
Q: 521   KRLGCvaSQNGEDAIKQHPFF  541
         *****6559***********9
Domain Sequence
(FASTA)
FNFIKVLGKG SFGKVMLAEL KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP 60
YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG 120
VIYSDLNSGN ILLDAEGHCK LAAFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS 180
VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPN 240
KRLGCVASQN GEDAIKQHPF F 261
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00162
EKS-ANC-00164
EKS-BOT-00170
EKS-CAE-00130
EKS-CAJ-00174
EKS-CAF-00177
EKS-CAP-00170
EKS-CIS-00205
EKS-DAR-00463
EKS-DRM-00083
EKS-FEC-00160
EKS-GAA-00205
EKS-GOG-00168
EKS-HOS-00176
EKS-ICT-00165
EKS-LOA-00169
EKS-MAM-00168
EKS-MEG-00135
EKS-MIM-00077
EKS-MUM-00175
EKS-MUP-00174
EKS-MYL-00179
EKS-NOL-00163
EKS-ORN-00215
EKS-ORC-00157
EKS-ORL-00201
EKS-OTG-00176
EKS-PAT-00161
EKS-PES-00150
EKS-POA-00166
EKS-RAN-00165
EKS-SUS-00146
EKS-TAG-00198
EKS-TAR-00222
EKS-TAS-00059
EKS-TEN-00214
EKS-XET-00158
EKS-XIM-00208
EKS-SCP-00081
Gene Ontology
GO:0005829; C:cytosol
GO:0005783; C:endoplasmic reticulum
GO:0005794; C:Golgi apparatus
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004699; F:calcium-independent protein kinase C activity
GO:0008047; F:enzyme activator activity
GO:0035276; F:ethanol binding
GO:0046872; F:metal ion binding
GO:0030546; F:receptor activator activity
GO:0071361; P:cellular response to ethanol
GO:0071456; P:cellular response to hypoxia
GO:0035556; P:intracellular signal transduction
GO:0002281; P:macrophage activation involved in immune response
GO:0030838; P:positive regulation of actin filament polymerization
GO:0071777; P:positive regulation of cell cycle cytokinesis
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:2001031; P:positive regulation of cellular glucuronidation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0010763; P:positive regulation of fibroblast migration
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032024; P:positive regulation of insulin secretion
GO:0050996; P:positive regulation of lipid catabolic process
GO:0043410; P:positive regulation of MAPK cascade
GO:0070257; P:positive regulation of mucus secretion
GO:0032230; P:positive regulation of synaptic transmission, GABAergic
GO:0090303; P:positive regulation of wound healing
GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0051209; P:release of sequestered calcium ion into cytosol
GO:0043278; P:response to morphine
GO:0035669; P:TRAM-dependent toll-like receptor 4 signaling pathway
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013