EKS-GAG-00221

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00221

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	381.9	1.7E-114	12	265	254

Status

Unreviewed

Ensembl Protein

ENSGALP00000016553

UniProt Accession

E1C1M7;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000010195	ENSGALP00000016553	ENSGALT00000016572

Organism

Gallus gallus

Functional Description

Protein Length

968

Protein Sequence
(FASTA)

MATCIGETIE DFKVGNLLGK GSFAGVYRAV SLKTGLEVAI KMIDKKAMHK VGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DSNYVYLILE MCHNGEMSRY IKNRKKPFSE DEARHFLHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTSNMNV KIADFGLATQ LKMPHEKHYT MCGTPNYISP 180

EIATRSPHGL ESDVWSLGCM FYTLLIGKPP FDTDTVKNTL NKVVLADYEM PAFLSREAQD 240

LIHKLLRKNP ADRLSLSSVL DHPFMSRCSS ARSKDSGTSE DSMDSGNATI STTFTGSSSI 300

STSGCLKEKK KLLVGQPLPN KITFFPKNKN PSNASSVDGS GSFHQWGIQG KEMGTSGRGR 360

VMQLAEERPH SRYLRRAHSS DRSGTSHSQT QGISNIMERC HSLELLSKPR GGTRENTECF 420

SPANSYTDMG EIFKEKTSGS SGSFEGQISP PVKDQPHSNF LYPMKPPFGL LEQKSQAETM 480

QQWLGNMQTN AQLRPPEDLT GNGNAHGGFR YHLDVQQDAS RNGWNTLKDI RNHDASHDCS 540

HSLNQRNPNK HISEVLCQSE KVPSSSRGLW PASEQNQAWG KEPPAHQKPT LRSVVSPLSA 600

YRLKPIRQKT KNAVVSILDT GEVCMEFIKE HHSQEFVKEV LRISCDGNTI AVYHPNEGRG 660

FLLDDRPPIP PEDSCMYNFD NLPEKYWKKY QYAAKFVQLV RTKTPKVTFY TRYAKCMLME 720

NSPPADVEVC FYDGAKIHKT AGITRVIEKS GKSFTLKGDN ETGLKKEMQV YMDHANEGHR 780

ICLALESAIL EEEKRSENVP FFPIIVGRKP GNTESPKALL PLLDNTTCSK EVTALDRNTA 840

ASSTPVQTLN CTPVVSYEKS TFMANATESP CSSVHQTECS PNSAQLLKSV FVKNVGWASQ 900

LTSGAVWVQF NDGSQLVAQA GVSSITYTSP DGQTTRYGEN DKLPEYIKEK LHCLSSILVM 960

FTNPTGPH 968

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGCGA GACGATAGAG GACTTCAAGG TGGGGAACCT CCTGGGAAAG 60

GGCTCCTTTG CCGGGGTCTA CAGAGCGGTA TCCCTGAAAA CCGGCCTGGA AGTGGCTATC 120

AAAATGATAG ACAAAAAAGC CATGCACAAA GTGGGAATGG TACAAAGGGT TCAGAACGAG 180

GTGAAAATAC ATTGTCAGCT AAAGCATCCA TCTATCCTTG AGCTTTATAA CTATTTTGAA 240

GATAGCAACT ATGTGTACTT GATACTTGAA ATGTGTCACA ATGGTGAAAT GAGCAGATAC 300

ATAAAGAATA GAAAGAAACC CTTTTCAGAA GATGAAGCCC GACACTTCTT GCATCAAATT 360

ATCACGGGTA TGCTGTATCT TCATTCTCAT GGAATACTGC ATCGGGACCT CACCCTTTCC 420

AATCTCTTAC TCACCAGTAA CATGAACGTC AAGATTGCTG ATTTTGGACT AGCAACTCAG 480

TTGAAAATGC CTCATGAAAA GCATTATACC ATGTGTGGAA CTCCTAATTA CATTTCACCA 540

GAGATAGCCA CGAGGAGTCC ACATGGACTT GAGTCTGATG TATGGTCTTT GGGCTGCATG 600

TTTTACACTC TTCTTATTGG AAAGCCACCT TTTGACACCG ACACGGTGAA GAACACGCTG 660

AATAAAGTAG TATTAGCAGA TTACGAAATG CCAGCCTTTT TGTCCAGAGA GGCACAAGAC 720

CTTATACATA AATTACTTCG CAAAAACCCA GCAGATCGTT TGAGTCTTTC CTCTGTGTTG 780

GATCATCCTT TTATGTCCAG GTGTAGCTCT GCACGGAGCA AAGATTCAGG GACTTCAGAA 840

GATTCCATGG ACAGTGGAAA TGCTACCATC TCTACCACTT TTACAGGCTC TTCCAGCATC 900

AGTACCAGCG GCTGCTTGAA AGAAAAGAAG AAGCTGTTAG TGGGACAGCC GCTCCCAAAT 960

AAAATTACCT TTTTTCCTAA AAACAAGAAT CCCAGTAATG CTTCATCTGT AGATGGGAGT 1020

GGTTCTTTTC ATCAGTGGGG AATTCAAGGG AAAGAAATGG GCACAAGTGG CAGGGGAAGA 1080

GTCATGCAAC TTGCCGAAGA GAGACCACAT TCCCGCTACC TCCGAAGAGC GCACTCCTCA 1140

GATAGGTCTG GCACATCGCA CAGTCAGACT CAAGGAATAT CAAATATTAT GGAGAGGTGT 1200

CACTCCCTGG AACTGCTTTC CAAGCCTAGA GGAGGAACGA GGGAAAACAC AGAATGCTTT 1260

TCGCCTGCAA ACAGCTATAC TGACATGGGA GAAATATTTA AGGAAAAGAC TTCTGGTAGT 1320

TCTGGTTCTT TTGAAGGGCA GATATCTCCA CCTGTAAAAG ACCAACCACA CTCAAATTTT 1380

CTCTATCCAA TGAAGCCCCC TTTTGGTTTG TTAGAGCAGA AGTCCCAGGC TGAAACCATG 1440

CAGCAGTGGC TTGGAAACAT GCAGACAAAT GCTCAGCTGA GACCACCTGA AGACCTGACT 1500

GGCAATGGTA ATGCACACGG AGGCTTTCGG TATCATCTGG ATGTGCAGCA AGATGCATCG 1560

AGAAATGGAT GGAACACCTT AAAGGATATA CGGAATCATG ATGCATCCCA TGATTGTTCA 1620

CATTCTTTAA ATCAGAGAAA CCCAAACAAA CATATATCCG AAGTTCTCTG CCAATCTGAA 1680

AAAGTTCCGT CATCTTCACG TGGCCTTTGG CCAGCTTCAG AACAAAACCA AGCGTGGGGC 1740

AAAGAACCAC CGGCACATCA GAAACCTACG CTGCGAAGTG TAGTATCGCC TCTCAGTGCT 1800

TACAGGCTAA AACCAATCAG GCAAAAAACA AAAAATGCAG TGGTGAGCAT TCTAGATACT 1860

GGGGAGGTGT GTATGGAGTT TATAAAAGAA CACCATTCAC AAGAATTTGT GAAAGAAGTC 1920

CTCAGAATAT CTTGTGATGG AAATACGATT GCGGTTTATC ACCCGAATGA AGGAAGAGGC 1980

TTCCTTCTTG ACGACAGGCC ACCCATTCCT CCTGAAGACA GCTGTATGTA TAATTTTGAC 2040

AACTTGCCAG AAAAGTACTG GAAAAAGTAC CAGTATGCAG CCAAGTTTGT GCAGTTAGTG 2100

AGAACAAAAA CCCCCAAAGT CACATTCTAC ACAAGATATG CCAAGTGCAT GTTGATGGAA 2160

AATTCACCTC CTGCAGATGT TGAAGTATGT TTTTATGATG GAGCAAAGAT CCACAAGACA 2220

GCTGGTATAA CTCGTGTGAT TGAAAAATCA GGGAAATCCT TCACTTTGAA AGGAGACAAT 2280

GAAACAGGTT TGAAGAAAGA AATGCAAGTA TATATGGATC ATGCAAATGA GGGACATCGC 2340

ATATGCCTTG CACTGGAATC TGCTATTCTG GAAGAAGAAA AAAGGAGCGA AAATGTTCCA 2400

TTTTTTCCAA TAATTGTTGG AAGAAAACCT GGCAATACTG AATCTCCAAA GGCTCTACTG 2460

CCTCTGTTGG ACAACACCAC CTGTTCAAAA GAAGTTACGG CACTGGATAG AAATACAGCT 2520

GCCAGTTCTA CTCCAGTTCA AACTCTGAAC TGTACTCCTG TGGTGTCATA TGAAAAGTCT 2580

ACGTTTATGG CCAATGCTAC TGAAAGTCCC TGCTCCTCTG TTCATCAGAC AGAATGCAGC 2640

CCAAATTCAG CTCAACTTTT AAAATCAGTC TTTGTGAAAA ATGTTGGTTG GGCTTCGCAG 2700

CTGACCAGCG GAGCAGTATG GGTTCAATTT AATGATGGAT CCCAACTGGT AGCCCAAGCA 2760

GGTGTTTCTT CTATCACTTA CACCTCTCCA GATGGCCAGA CAACTCGGTA TGGAGAAAAT 2820

GATAAGTTGC CAGAATACAT CAAAGAGAAG TTGCACTGTC TGTCTTCTAT TCTTGTGATG 2880

TTTACCAACC CAACTGGTCC CCACTGA 2907

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++ +l+t+ ++a+k+++k++++k  + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAVSLKTGLEVAIKMIDKKAMHKVGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vyl+le+c+++++ +++k+r k+++e e+r++l+qi++g++ylh++

Q: 72    ILELYNYFEDSNYVYLILEMCHNGEMSRYIKNRkKPFSEDEARHFLHQIITGMLYLHSHG  131

         *******************************99899************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l+++++vki+dfGlat+l++++e+++t+cGtPnyi+Pe+++++ h+le

Q: 132   ILHRDLTLSNLLLTSNMNVKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRSPHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+GkPPf+t+++k+t++k++ a+y++P+ ls+ea++li+kll+k+P+

Q: 192   SDVWSLGCMFYTLLIGKPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHKLLRKNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAVS LKTGLEVAIK MIDKKAMHKV GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED SNYVYLILEM CHNGEMSRYI KNRKKPFSED EARHFLHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTSNMNVK IADFGLATQL KMPHEKHYTM CGTPNYISPE IATRSPHGLE 180

SDVWSLGCMF YTLLIGKPPF DTDTVKNTLN KVVLADYEMP AFLSREAQDL IHKLLRKNPA 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013