EKS-GAG-00405

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00405

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	390.5	2.9E-117	10	265	256

Status

Unreviewed

Ensembl Protein

ENSGALP00000017170

UniProt Accession

F1NLC9;

Protein Name

Protein Synonyms/Alias

TBC domain-containing protein kinase-like protein;

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000010564	ENSGALP00000017170	ENSGALT00000017190

Organism

Gallus gallus

Functional Description

Protein Length

885

Protein Sequence
(FASTA)

MGASTFFASA LPHDVCGSNG LPLTPNSIKI LGRFQILKTI THPRLCQYVD ITRGKHERLV 60

VAAEHCENSL EDLLREGKPV SSSRILCIAY EVLQGLQYMN KHGMVHRALS PRNILLDRKG 120

HVKLAKFGLY HMTAQGVDVD FPIGYPSYLA PEVIAQGMVK PSDHTQCEKP LPSGPKSDLW 180

SLGIILFELC VGRKLFQTLE IAERLKFVIT LGYVDDIVTV LAEEHGCLDI IKDLSENVIT 240

LLKKCLTFQP SKRPTPEELM HDHLFSEVSL AYPPFHKPAG LFSSSPRCAD LTLPEDISQL 300

CKDEDNDYLA ERSIEEVYYL WCLAGGDLEK ELVNKEIIRS KPPVCTLPNF VLEDGESFGQ 360

GRDRSSLLDD TTVTLSLCQL RNRLKDVGGE AFYPLLEDDQ STLPHSNSSS ELSAAANLPL 420

IIRERDTEYQ LNRIVLFDRL LKAYPYKKNQ IWKEARVDIP PLLRGITWAA LLGVEGAIQA 480

KYDAIDKDTP IPTDRQIEVD IPRCHQYDEL LSSPEGHAKF RRVLKAWVVS HPDLVYWQGL 540

DSLCAPFLYL NFNNEALAYA CMSAFIPKYL YNFFLKDNSH VIQEYLTVFS QMIAFHDPEL 600

SNHLNEIGFI PDLYAIPWFL TMFTHVFPLH KIFHLWDTLL LGNSSFPFCI GVAILQQLRD 660

RLLANGFNEC ILLFSDLPEI DIERCVRESI NLFRWTPKSA TYRQYAQPPR QANESNGTRS 720

SMSCFSVDYQ EAPRGDLSRD SIKLDDLKAE VSPRISAEDL IDLCELTGPS HSKTPIKKTK 780

SSKPKLLVVD IRNSEDFNRG HISGSINVPF ASAFTAEGDL IQCPATATLQ SFKGRVVVIV 840

GNAVKNTAAF AAHLVKSKYP RVCILDGGIN KIKPTGLLTV PSPQI 885

Nucleotide Sequence
(FASTA)

ATGGGTGCTT CCACCTTCTT TGCCTCGGCT CTTCCACATG ATGTCTGTGG AAGTAATGGC 60

CTCCCTCTGA CACCCAACTC CATCAAAATT CTAGGGAGGT TTCAAATCCT TAAAACAATC 120

ACCCATCCTA GACTTTGCCA GTATGTTGAT ATTACCAGAG GTAAACATGA GAGACTGGTT 180

GTGGCTGCTG AACACTGTGA AAATAGTCTG GAAGATTTGC TACGAGAGGG AAAACCAGTC 240

AGTTCCTCAA GGATTTTGTG CATTGCATAC GAGGTTCTGC AAGGTTTGCA GTATATGAAC 300

AAACATGGAA TGGTCCACCG AGCACTCTCC CCTCGCAATA TACTTTTGGA TCGAAAGGGA 360

CACGTCAAGT TGGCTAAATT TGGACTTTAC CATATGACTG CTCAGGGTGT TGATGTTGAT 420

TTTCCTATAG GGTACCCATC TTATCTGGCA CCTGAAGTAA TTGCGCAGGG AATGGTCAAA 480

CCAAGTGATC ATACTCAGTG TGAGAAGCCT CTGCCTTCTG GCCCTAAATC AGATCTCTGG 540

TCTCTTGGCA TAATACTATT TGAGCTTTGT GTGGGGAGAA AATTGTTCCA GACTTTGGAG 600

ATTGCAGAAA GATTAAAATT TGTAATTACA CTAGGCTATG TAGATGATAT TGTAACTGTA 660

TTAGCTGAAG AACACGGTTG CCTTGATATT ATTAAGGATC TTTCTGAAAA TGTCATAACT 720

CTGCTGAAAA AATGCCTTAC ATTCCAACCT TCTAAGAGGC CAACTCCAGA GGAATTGATG 780

CATGACCATT TGTTCAGTGA AGTATCTTTG GCATACCCTC CCTTTCACAA ACCTGCTGGA 840

CTGTTCTCAT CCTCTCCGAG GTGTGCTGAC TTAACACTGC CTGAAGACAT AAGTCAGTTA 900

TGCAAAGATG AAGATAACGA TTACCTAGCA GAAAGATCAA TTGAAGAGGT TTATTATCTC 960

TGGTGTCTGG CTGGAGGAGA CTTAGAGAAA GAACTTGTCA ACAAGGAAAT TATTCGATCA 1020

AAACCACCTG TCTGTACGCT TCCCAACTTT GTGTTAGAAG ATGGTGAAAG CTTTGGGCAA 1080

GGACGAGATA GAAGTTCCCT TCTAGATGAC ACAACTGTGA CTTTGTCTCT GTGCCAGCTC 1140

CGAAATAGAC TGAAAGATGT TGGTGGGGAA GCGTTTTATC CATTACTTGA AGATGACCAG 1200

TCAACTTTAC CTCATTCAAA TAGCAGTAGT GAGCTGTCTG CAGCTGCCAA TCTACCTCTG 1260

ATCATCCGGG AGAGGGACAC AGAGTATCAG CTAAACAGAA TTGTTCTGTT TGACAGGCTG 1320

TTGAAGGCCT ACCCATATAA GAAAAACCAG ATCTGGAAAG AAGCCAGAGT TGACATCCCT 1380

CCTCTCCTGA GAGGCATAAC CTGGGCTGCT CTGTTGGGTG TTGAGGGTGC CATTCAAGCA 1440

AAATACGATG CCATTGATAA AGACACACCG ATTCCTACAG ACAGACAAAT TGAAGTTGAT 1500

ATTCCTCGTT GCCATCAGTA TGATGAATTG CTGTCATCAC CAGAGGGTCA TGCAAAGTTT 1560

AGACGGGTAT TGAAGGCCTG GGTTGTTTCC CATCCTGACT TGGTCTACTG GCAAGGTCTC 1620

GATTCTCTTT GTGCACCATT CCTATACTTG AATTTTAACA ATGAAGCTCT GGCATATGCC 1680

TGCATGTCTG CTTTTATACC TAAGTATTTG TATAACTTCT TTCTGAAGGA TAATTCTCAT 1740

GTTATCCAAG AGTACCTAAC GGTGTTTTCT CAGATGATTG CATTCCATGA TCCGGAGCTG 1800

AGCAACCACC TTAATGAAAT TGGTTTTATT CCCGATCTCT ATGCTATTCC GTGGTTTCTT 1860

ACAATGTTTA CACATGTCTT TCCTTTGCAT AAAATTTTTC ACTTGTGGGA TACATTGTTG 1920

CTTGGAAATT CCTCCTTCCC GTTCTGCATT GGGGTGGCTA TACTTCAACA ACTGAGAGAT 1980

CGTCTTCTTG CAAATGGATT CAATGAATGC ATTCTCCTTT TTTCAGACTT ACCAGAGATT 2040

GACATTGAGC GTTGTGTTCG TGAGTCAATC AACCTGTTTC GCTGGACCCC AAAGAGTGCT 2100

ACATACAGGC AATATGCACA GCCTCCTCGG CAAGCCAATG AGAGCAATGG CACAAGAAGT 2160

TCAATGTCCT GCTTTTCTGT AGATTATCAG GAAGCACCTA GAGGTGACCT GTCTAGGGAT 2220

TCTATCAAGT TGGATGACCT GAAGGCAGAG GTGTCACCAC GGATTTCAGC AGAAGATCTG 2280

ATTGATCTTT GTGAATTGAC AGGACCAAGT CATTCCAAAA CACCTATAAA GAAAACAAAG 2340

TCTAGCAAGC CAAAGTTGCT GGTGGTGGAC ATCCGTAACA GTGAAGACTT TAACCGTGGC 2400

CACATCTCTG GCAGCATCAA TGTCCCATTT GCATCAGCAT TTACTGCAGA AGGCGATCTC 2460

ATCCAGTGCC CAGCAACTGC CACGCTCCAG AGCTTTAAAG GAAGAGTTGT AGTGATTGTA 2520

GGAAATGCAG TGAAGAACAC AGCTGCTTTT GCAGCTCATC TGGTGAAGAG CAAGTACCCA 2580

CGGGTCTGCA TCCTAGATGG AGGAATCAAC AAGATCAAAC CAACTGGTCT CCTCACTGTT 2640

CCTTCTCCAC AAATATAA 2658

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+di+rgkher++v aeh+e s

Q: 10    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDITRGKHERLVVAAEHCENS  69

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+e+kpvs s +l+iayevl+gl+y+nkh++vhral+p++illdrkg+ vkLak+G

Q: 70    LEDLLREGKPVSSSRILCIAYEVLQGLQYMNKHGMVHRALSPRNILLDRKGH-VKLAKFG  128

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G dvdfpigy+sylaPe+i+q+          +k+l++++ksD WsLg+il+e

Q: 129   LYHMTAQGVDVDFPIGYPSYLAPEVIAQGmvkpsdhtqCEKPLPSGPKSDLWSLGIILFE  188

         ************************************9999********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf+ l+++erlk++ +l+ vd+ + +laee++cldiik+l e+++ llkkCLt+

Q: 189   LCVGRKLFQTLEIAERLKFVITLGYVDDIVTVLAEEHGCLDIIKDLSENVITLLKKCLTF  248

         ************************************************************

S: 232   lpskRpspdellkekvf  248

          pskRp+p+el++++ f

Q: 249   QPSKRPTPEELMHDHLF  265

         *************9876

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DITRGKHERL VVAAEHCENS 60

LEDLLREGKP VSSSRILCIA YEVLQGLQYM NKHGMVHRAL SPRNILLDRK GHVKLAKFGL 120

YHMTAQGVDV DFPIGYPSYL APEVIAQGMV KPSDHTQCEK PLPSGPKSDL WSLGIILFEL 180

CVGRKLFQTL EIAERLKFVI TLGYVDDIVT VLAEEHGCLD IIKDLSENVI TLLKKCLTFQ 240

PSKRPTPEEL MHDHLF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013