EKS-GAG-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	482.1	3.7E-145	446	704	259

Status

Unreviewed

Ensembl Protein

ENSGALP00000017721

UniProt Accession

E1C4W9;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000010909	ENSGALP00000017721	ENSGALT00000017742

Organism

Gallus gallus

Functional Description

Protein Length

755

Protein Sequence
(FASTA)

MGNASMKHKH LRQPDRHVAN LALGCASHRV LELEKELKRK DEELQEGQSL VAELQEQLSV 60

QTKVIAELTK ELQSKCIQLN KLQDVINTQG EHSLQPSPFR VTPKNQISAD RRKGAKEGVS 120

AEPTTQLYDS SKQARFSFEK SRVRKDSSEK KLITDALNKN QFLKRLEPQQ IREMVECMYE 180

RTFQQGSYVI RQGEPGNHIF VLKEGRLEVF QQNKLLSSIP VWTAFGELAI LYNCTRTASV 240

KAITNVKTWA LDREVFQNIM RVTAQTRQEQ YRNFLRSVSL LKNLPEDKLT KIMDCLEVEY 300

YNKGDYVIRE GEEGNTFFII AKGKVKVTQS TADHSQPQLI KNLHKGDYFG EKALISDDVR 360

SANVIADEYD VECLVIDRDT FNQTVGTYEE LQTYLEGYVA NLARADEKRH AKRRSFCGQS 420

TKEVSLEMIQ LKEKVAQFPS SPFQNLEVVT TLGVGGFGRV ELVKVKNENV AFAMKCIKKK 480

HVVDTKQQEH IYSEKKILEQ ICSPFIVKLY RTFKDSKYVY MLLEACLGGE LWSLLRDRGC 540

FDEPTTKFCV GCVTEALDYL HHIGIVYRDL KPENLILDAE GYIKLVDFGF AKKIGSGQKT 600

WTFCGTPEYV APEVILSKGH DFSVDFWSLG ILVYELLTGS PPFSGADQMT TYNLILKGIE 660

KLDFPRTITR RPEDLIRRLC RQNPTERLGN LRNGINDIKK HRWLNGFNWD GLKLRKLASP 720

LKRELSGPTD YSYFDSYPPE EGMPPDELSG WDKDF 755

Nucleotide Sequence
(FASTA)

ATGGGGAATG CATCAATGAA ACACAAACAC CTGAGGCAGC CAGACAGACA CGTAGCAAAC 60

CTAGCTCTTG GTTGTGCTAG CCACAGGGTG CTTGAACTGG AAAAGGAGCT GAAAAGAAAA 120

GATGAAGAGT TGCAAGAGGG TCAAAGTCTT GTTGCTGAGC TTCAGGAGCA GCTGTCTGTG 180

CAGACTAAGG TCATCGCAGA ACTCACCAAG GAACTTCAGA GCAAGTGCAT ACAGCTGAAC 240

AAGCTGCAGG ATGTTATTAA CACTCAAGGA GAACACTCTC TTCAGCCTTC TCCATTTAGA 300

GTGACTCCAA AGAATCAAAT CTCTGCTGAC AGGAGGAAAG GAGCTAAGGA GGGTGTATCT 360

GCAGAGCCAA CAACACAGCT CTATGATTCC AGCAAACAAG CTAGATTTTC CTTTGAAAAA 420

TCAAGGGTCC GAAAGGATTC CAGTGAGAAA AAGCTCATCA CGGATGCCCT GAATAAAAAT 480

CAGTTTTTGA AGAGACTGGA ACCTCAGCAG ATCCGAGAGA TGGTGGAATG TATGTACGAG 540

AGGACTTTCC AGCAGGGGAG CTATGTCATC AGACAAGGAG AGCCAGGCAA TCACATTTTT 600

GTCCTCAAAG AGGGCAGACT GGAAGTCTTC CAGCAGAATA AACTGCTCTC CTCCATACCT 660

GTGTGGACAG CGTTTGGTGA ACTGGCCATT TTATACAACT GCACGCGGAC GGCTTCCGTG 720

AAAGCAATCA CCAATGTTAA AACATGGGCA CTGGACAGAG AAGTGTTTCA AAACATCATG 780

AGAGTGACAG CACAGACAAG ACAAGAACAG TACAGAAACT TTCTTAGAAG TGTGTCCCTC 840

TTAAAAAACT TGCCAGAAGA TAAACTGACC AAAATCATGG ACTGCCTGGA GGTGGAGTAC 900

TATAACAAAG GAGATTATGT TATTCGGGAA GGAGAAGAGG GAAATACCTT CTTTATAATA 960

GCAAAAGGAA AGGTAAAGGT TACCCAGAGT ACTGCAGATC ACTCACAGCC TCAGCTGATT 1020

AAAAATCTGC ATAAAGGAGA TTACTTTGGA GAAAAGGCCC TCATTAGTGA TGATGTCAGA 1080

TCAGCAAATG TTATTGCGGA TGAATATGAC GTGGAGTGCC TCGTTATAGA TAGAGACACA 1140

TTTAATCAAA CTGTTGGAAC TTATGAGGAG TTACAAACCT ACCTTGAGGG TTATGTGGCT 1200

AATCTGGCCC GGGCTGATGA AAAGCGACAT GCCAAAAGAA GATCCTTCTG TGGACAGTCA 1260

ACCAAAGAGG TGTCTTTGGA AATGATACAG CTGAAGGAGA AAGTAGCCCA GTTCCCTTCT 1320

TCCCCATTCC AGAATTTAGA AGTTGTCACA ACTCTCGGTG TTGGTGGGTT CGGAAGGGTT 1380

GAACTTGTTA AGGTAAAAAA TGAGAATGTG GCTTTTGCTA TGAAGTGTAT AAAGAAGAAA 1440

CATGTAGTGG ACACCAAACA ACAAGAGCAT ATATATTCTG AAAAGAAAAT CCTTGAGCAG 1500

ATATGTTCTC CTTTCATTGT GAAACTGTAT CGCACATTCA AGGATAGTAA GTATGTGTAC 1560

ATGCTGCTGG AGGCTTGCCT TGGTGGGGAG TTGTGGAGCT TGCTGAGAGA CAGAGGCTGC 1620

TTTGATGAAC CCACTACAAA GTTCTGTGTT GGCTGTGTGA CAGAGGCTTT GGACTATCTA 1680

CATCACATAG GAATTGTCTA CAGAGACTTG AAGCCAGAAA ACTTAATTTT GGATGCTGAA 1740

GGGTATATAA AATTGGTTGA TTTTGGATTT GCAAAAAAGA TCGGATCAGG GCAGAAAACC 1800

TGGACGTTCT GTGGAACCCC TGAGTATGTT GCTCCAGAAG TCATTCTGAG TAAGGGCCAT 1860

GACTTCAGTG TGGATTTTTG GTCCCTTGGG ATTCTTGTGT ATGAACTCCT TACTGGCAGT 1920

CCACCGTTCT CTGGGGCTGA TCAGATGACA ACCTATAATT TGATTCTAAA AGGCATTGAA 1980

AAGCTGGATT TTCCGAGAAC AATAACAAGG CGGCCTGAGG ATTTGATCCG CAGACTCTGC 2040

AGGCAGAACC CAACAGAAAG ATTAGGCAAT CTGAGGAATG GAATTAATGA CATTAAGAAG 2100

CACAGGTGGT TGAATGGTTT TAACTGGGAT GGTCTGAAAC TGAGGAAATT AGCATCACCT 2160

TTAAAAAGAG AGTTGTCTGG ACCAACTGAT TACAGCTACT TTGACAGCTA TCCACCTGAA 2220

GAGGGAATGC CTCCAGACGA ACTTTCTGGC TGGGACAAGG ATTTCTGA 2268

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l+v++tlgvggfgrvelvkvk+ e+ afa+k++kkkh+vdtkqqeh++sek+ile+++s+

Q: 446   LEVVTTLGVGGFGRVELVKVKN-ENVAFAMKCIKKKHVVDTKQQEHIYSEKKILEQICSP  504

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw++lrdrg fd+ t+kf+v+cv+eal+ylh+ +

Q: 505   FIVKLYRTFKDSKYVYMLLEACLGGELWSLLRDRGCFDEPTTKFCVGCVTEALDYLHHIG  564

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         i+yrdlkpenl+ld+egy+klvdfgfakk++sg+ktwtfcgtpeyvape+il kghd+sv

Q: 565   IVYRDLKPENLILDAEGYIKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILSKGHDFSV  624

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+kl++pr+it+++edli++lcr+np

Q: 625   DFWSLGILVYELLTGSPPFSGADQMTTYNLILKGIEKLDFPRTITRRPEDLIRRLCRQNP  684

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+l++gi+dikkh+w+

Q: 685   TERLGNLRNGINDIKKHRWL  704

         *******************7

Domain Sequence
(FASTA)

LEVVTTLGVG GFGRVELVKV KNENVAFAMK CIKKKHVVDT KQQEHIYSEK KILEQICSPF 60

IVKLYRTFKD SKYVYMLLEA CLGGELWSLL RDRGCFDEPT TKFCVGCVTE ALDYLHHIGI 120

VYRDLKPENL ILDAEGYIKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LSKGHDFSVD 180

FWSLGILVYE LLTGSPPFSG ADQMTTYNLI LKGIEKLDFP RTITRRPEDL IRRLCRQNPT 240

ERLGNLRNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013