EKS-GAG-00026

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00026

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	336.7	1.2E-100	871	1143	273

Status

Unreviewed

Ensembl Protein

ENSGALP00000017948

UniProt Accession

F1NMJ9;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000011031	ENSGALP00000032304	ENSGALT00000032943
ENSGALG00000011031	ENSGALP00000017948	ENSGALT00000017969
ENSGALG00000011031	ENSGALP00000037165	ENSGALT00000037961
ENSGALG00000011031	ENSGALP00000037164	ENSGALT00000037960
ENSGALG00000011031	ENSGALP00000037163	ENSGALT00000037959

Organism

Gallus gallus

Functional Description

Protein Length

1152

Protein Sequence
(FASTA)

MQYLNVKEDC KAMAFCAKMR STKKSEVNLE AQHQGLEVLF YLQDKSPICY TSGEFTSEEL 60

CIEAAQKCSI SPLCHNLFAL FDENRRLWYA PNQVFKIDEK TSQRLYYRMR YYFTNWHGTS 120

ENEPSVWRHS PKKSKNSYDK KLAPEGTPIL DANSLEYIFA QGQYDLVKGL APIRDPKNDQ 180

EVHEIENECL GMAVLAISHY AIKKNVKLPE LPKDISYKHY IPETLNKTIR QRNFLTRIRI 240

NNVFKHFLKE FNNKTICDSS VSPRDLKVKY LSTMETLTKY YGAEIFETSS LLISSESEIN 300

RFNCGDGEII PLYEVIVTGN NGIQWRLKPS SVQTEKKKKS DGKIKKDEDR YKTRDLWNNF 360

SYFPEITHIV IKESTVSINK QDNKKMELKL SSHDEALSFA SLIDGYFRLT ADAHHYLCTD 420

VAPPLIEHNI KNGCHGPICT EYAINKLRQE GNEAGMYVLR WSCTNFNHIL MTVTCLEGPE 480

MINNSVQYKN FQIEVKKGGY FLHGSNRSFA SLKELMDHLK GQILRTDNIS FTLKRCCQPK 540

PREISNLLVA TKKAQECQPA YHLGQLSFHR IRKEEIMQGE HLGRGTRTQI YSGILNYKDD 600

ENEGYQNEKE IKVLLKVLDP SHRDISLASA FFEAASMMRQ VSHKHIVFLH GVCVRDLENI 660

MVEEFVEFGP LDLFMHRKSE LLTTPWKFNV AKQLASALSY LEDKDLVHGN VCTKNILLAR 720

EGIDTEYGPF IKLSDPGIPI TVLSRQECVE RIPWIAPECV EDSKNLSIAA DKWSFGTTLW 780

EICYNGETPL KDKTLAEKER FYEGHFMLIT PSCKELADLM KQCMNYDPHQ RPFFRAIMRD 840

INKLEEQNPD IVSEKKPVTE VDPTLFEKRF LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ 900

VAVKSLKPES GGNHIADLKK EIEILRNLYH ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL 960

KEYLPRNKNK INLKQLLRYA VQICKGMDYL GSRQYVHRDL AARNVLVESE NRVKIGDFGL 1020

TKAIETDKEY YTVKDDLDSP VFWYAPECLI QSKFYIASDV WSFGVTLYEL LTYCDSESSP 1080

MTEFLKMIGP TQGQMTVARL VRVLQEEKRL PRPPNCPEEI DQLMRKCWIF KHDKRTTFHN 1140

LIQGFETIMS KM 1152

Nucleotide Sequence
(FASTA)

ATGCAGTATC TAAACGTAAA AGAAGACTGC AAAGCCATGG CTTTCTGTGC AAAAATGAGG 60

AGCACGAAGA AGAGCGAAGT AAACTTGGAA GCTCAGCACC AGGGCTTAGA GGTACTCTTC 120

TACCTGCAAG ATAAAAGCCC CATTTGTTAT ACCAGTGGCG AGTTTACCTC TGAGGAGCTG 180

TGCATCGAAG CTGCCCAGAA GTGCTCTATA TCTCCTCTGT GCCATAATCT CTTTGCACTG 240

TTTGATGAGA ACAGAAGGCT CTGGTATGCA CCAAACCAGG TCTTTAAGAT AGATGAAAAA 300

ACATCGCAAC GGCTCTATTA TCGAATGAGA TACTACTTCA CAAACTGGCA TGGGACTAGT 360

GAAAACGAAC CCTCGGTGTG GAGGCATTCC CCAAAGAAGT CAAAGAACTC TTATGACAAG 420

AAGCTGGCGC CAGAAGGAAC CCCAATCCTG GATGCAAACT CATTGGAGTA CATCTTTGCA 480

CAGGGTCAGT ATGACTTAGT GAAGGGACTG GCACCAATCC GTGACCCTAA AAATGATCAA 540

GAAGTTCATG AAATTGAAAA TGAGTGTCTG GGAATGGCTG TGCTTGCAAT CTCTCACTAT 600

GCTATCAAGA AAAATGTGAA GCTGCCAGAG CTGCCCAAAG ATATCAGTTA CAAACATTAT 660

ATTCCTGAAA CGTTGAACAA GACCATCAGG CAGAGGAATT TCCTAACCAG GATTCGGATA 720

AATAACGTTT TCAAGCATTT CCTCAAGGAG TTCAACAATA AAACCATTTG TGACAGTAGT 780

GTGTCTCCAC GCGATCTGAA AGTTAAATAC TTATCAACAA TGGAGACTTT GACTAAATAT 840

TATGGAGCAG AAATTTTTGA GACTTCATCT CTGCTTATTT CATCCGAGAG TGAAATAAAT 900

AGATTTAATT GTGGAGACGG TGAGATCATT CCGCTCTATG AAGTCATCGT GACAGGAAAC 960

AATGGAATCC AGTGGAGGCT CAAGCCAAGT TCTGTGCAGA CAGAGAAGAA GAAAAAGTCT 1020

GATGGCAAAA TCAAAAAGGA TGAAGATAGA TACAAAACCC GAGATTTGTG GAACAATTTT 1080

TCCTATTTTC CTGAAATCAC TCACATTGTC ATCAAGGAGT CTACAGTTAG CATTAACAAG 1140

CAGGATAACA AAAAGATGGA ATTAAAACTG TCCTCACATG ATGAAGCTCT GTCATTTGCA 1200

TCATTGATAG ATGGATACTT CAGACTTACA GCAGATGCCC ACCATTATCT CTGCACAGAT 1260

GTGGCTCCCC CACTGATTGA ACACAACATA AAGAATGGTT GCCATGGACC CATTTGCACT 1320

GAATATGCCA TCAACAAACT GCGACAGGAA GGGAATGAAG CAGGAATGTA TGTGCTGAGG 1380

TGGAGCTGCA CAAACTTTAA CCACATCCTC ATGACAGTGA CTTGTCTCGA AGGCCCAGAG 1440

ATGATAAATA ATTCAGTCCA GTACAAGAAC TTCCAGATTG AGGTGAAGAA AGGAGGGTAC 1500

TTCCTACATG GCTCAAACAG GTCTTTTGCA TCCTTGAAAG AGTTGATGGA TCACCTGAAA 1560

GGACAAATCC TTCGCACAGA CAACATCAGC TTCACACTGA AGAGATGCTG CCAACCAAAG 1620

CCAAGAGAAA TCTCCAACTT GCTGGTTGCA ACCAAGAAGG CTCAGGAATG CCAGCCTGCT 1680

TATCATCTAG GGCAGCTGAG CTTCCATCGA ATCCGCAAAG AAGAAATAAT GCAGGGTGAA 1740

CACCTTGGAA GAGGGACAAG AACACAGATT TACTCAGGGA TTCTCAACTA CAAAGATGAT 1800

GAGAATGAAG GATATCAAAA CGAAAAAGAG ATTAAAGTGC TCCTCAAAGT TTTGGACCCC 1860

AGTCACAGAG ATATTTCTTT GGCAAGTGCC TTCTTTGAAG CAGCAAGTAT GATGAGGCAG 1920

GTTTCTCATA AGCACATCGT CTTCCTCCAT GGAGTCTGCG TCCGTGACTT AGAAAATATC 1980

ATGGTTGAAG AATTCGTTGA ATTTGGGCCT CTGGATTTGT TTATGCATCG AAAAAGTGAA 2040

CTCCTGACAA CTCCCTGGAA ATTCAACGTA GCCAAGCAAC TTGCAAGTGC GCTGAGCTAC 2100

CTGGAGGATA AGGATTTGGT ACATGGAAAC GTGTGTACTA AAAACATCCT ACTGGCAAGA 2160

GAGGGAATTG ACACCGAATA TGGCCCTTTC ATAAAGCTGA GCGACCCAGG AATACCAATA 2220

ACTGTGCTGT CCAGACAAGA ATGCGTGGAG CGAATCCCCT GGATTGCACC CGAATGTGTT 2280

GAAGACTCAA AAAATTTAAG CATTGCAGCA GATAAGTGGA GCTTTGGTAC AACACTGTGG 2340

GAAATCTGCT ATAATGGAGA AACACCGCTG AAAGACAAGA CGTTGGCAGA GAAGGAAAGG 2400

TTCTACGAAG GGCATTTCAT GTTGATAACA CCATCGTGCA AGGAACTAGC TGACCTGATG 2460

AAACAGTGCA TGAACTATGA CCCCCACCAG AGACCCTTCT TCAGAGCTAT CATGAGAGAC 2520

ATCAACAAAC TGGAGGAGCA AAACCCCGAT ATCGTCTCGG AGAAGAAGCC TGTTACAGAG 2580

GTCGATCCCA CACTCTTCGA AAAACGGTTC TTAAAGAGAA TCCGTGATTT GGGAGAGGGC 2640

CACTTTGGAA AGGTTGAACT CTGCAGATAC GATCCAGAAG GTGACAATAC AGGAGAACAA 2700

GTGGCAGTTA AATCTCTGAA GCCGGAGAGT GGAGGGAATC ACATTGCTGA TCTCAAGAAG 2760

GAAATAGAAA TCTTGAGGAA TCTGTATCAT GAGAACATTG TCAAGTATAA GGGAATTTGC 2820

ACAGAAGATG GAGGAAATGG GATTAAACTC ATCATGGAAT TTCTTCCTTC TGGGAGCTTA 2880

AAGGAGTATC TGCCACGAAA CAAGAACAAA ATCAATCTCA AACAACTTCT CAGATATGCA 2940

GTTCAGATCT GCAAGGGGAT GGACTACTTG GGCTCCCGTC AGTATGTGCA CCGTGACTTA 3000

GCAGCAAGAA ATGTCCTTGT TGAAAGTGAG AACAGAGTGA AAATTGGAGA TTTTGGTCTC 3060

ACCAAAGCCA TTGAGACCGA TAAGGAGTAC TACACTGTCA AAGACGACCT CGACAGCCCT 3120

GTATTTTGGT ATGCTCCAGA ATGCTTGATT CAGAGTAAGT TTTACATCGC CTCAGATGTG 3180

TGGTCTTTTG GAGTGACGCT GTATGAACTG CTCACCTACT GCGATTCGGA GTCCAGCCCA 3240

ATGACAGAGT TCCTGAAGAT GATTGGCCCC ACGCAGGGCC AGATGACAGT AGCACGGCTC 3300

GTGCGTGTCC TACAAGAAGA GAAGCGTTTG CCACGTCCAC CCAACTGCCC AGAGGAGATC 3360

GACCAGCTGA TGAGGAAATG CTGGATATTC AAGCACGATA AGCGGACGAC CTTTCACAAC 3420

CTGATTCAAG GGTTTGAAAC GATTATGAGC AAGATGTAA 3459

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 871   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  930

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+++k++++l++ll +a q++k+m+YL

Q: 931   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPRNKNKINLKQLLRYAVQICKGMDYL  990

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++ ds+++w+

Q: 991   GSRQYVHRDLAARNVLVESENR------VKIGDFGLTKAIETDkEYYTVKDDLDSPVFWY  1044

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtlyellt c++++sp    l++++++       r++++

Q: 1045  APECLIQSK-FYIASDVWSFGVTLYELLTyCDSESSPmtefLKMIGPTqgqmtvaRLVRV  1103

         *********.*******************************99999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+e+ +lm++c+  + ++r++F+++++

Q: 1104  LQEEKRLPRPPnCPEEIDQLMRKCWIFKHDKRTTFHNLIQ  1143

         *************************************986

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPRNKNK INLKQLLRYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE NRVKIGDFGL TKAIETDKEY YTVKDDLDSP VFWYAPECLI 180

QSKFYIASDV WSFGVTLYEL LTYCDSESSP MTEFLKMIGP TQGQMTVARL VRVLQEEKRL 240

PRPPNCPEEI DQLMRKCWIF KHDKRTTFHN LIQ 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013