EKS-GAG-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	315.4	3.4E-94	4	254	251

Status

Unreviewed

Ensembl Protein

ENSGALP00000018527

UniProt Accession

E1BWJ2;

Protein Name

Protein Synonyms/Alias

Gene Name

STK36

Gene Synonyms/Alias

STK36;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000011371	ENSGALP00000018527	ENSGALT00000018550
ENSGALG00000011371	ENSGALP00000018526	ENSGALT00000018549
ENSGALG00000011371	ENSGALP00000027456	ENSGALT00000027508
ENSGALG00000011371	ENSGALP00000032441	ENSGALT00000033081

Organism

Gallus gallus

Functional Description

Protein Length

1328

Protein Sequence
(FASTA)

MERYHVLEVI GEGSFGRVYK GRRRCSAQVV ALKFIPKVGR SEKELKNLQR EIEIMRGLHH 60

PNIIQMLDSF ETDKEVVMVT DYAEGELFQI LEDDGSLPED QVQTIAAQLV SALYYLHSHR 120

ILHRDMKPQN ILLGKDGVIK LCDFGFARAM SIHTMVLTSI KGTPLYMSPE LVEERPYDHT 180

ADLWSVGCIL YELFMGTPPF YTSSIFQLVS LIVKDPVKWP KAISPAFKSF LQGLLMKDPH 240

QRLSWPELLS HPFVAGRVTV IDDTEEHGIS NPFTTKLSPE LQALKEQQAH SLAPRSGQSR 300

ILRKARQKMA EEAQKKVEKS VGFSGLHPMV MSKEGLLNGT EAALEEEVEL PPSFKEKKSG 360

VLQGKNSMAE WQLKEPPPSP REHSITQDYE REFPQPEAPL QLAVGKAELR GRQSIKAVDL 420

ESEEQESDEE WQHLIEATEP LAMQLSTPLS LLRDPAFRHR VQARLAESAQ QVLEGMLEGA 480

SHLRPVLRVV GNLLATRCDS ELLNLFCQEL SLPLSLLHLA KQMLESGSTR QQPWCITVLT 540

DLIMVTTVYF SSECNLEKSG QDSLQTIQES ANHFLALLPD LLAEPADSEM RLCQQSLLCF 600

TLLCESLDAM CPSISAPFYA SLREENEPLL DRLLQGLISE QPALQGATME AKSAHDQRQC 660

VADLCTAALA AACSIPLAQS SCRETKQQVA QEIAGKLMDG ECQQLGKLLG RLEHPNCSLN 720

VLKILYTCCY ASPSLCQHLG RSQQVWDFLM QLSKGKVPMA EVTRKVACEA SLYLLALLTL 780

QPQASPSRLE EVVTLALDVL TQSPVISVVG AAAFLLTQLD QRGVPVALQG KEILPAVTNA 840

LMEPAELHFS LPMGAGLYDG IIFLLLKLLA QEDVAVEQSF AASELWNVVW HCVPAVLCMG 900

SSGAALEGDS PGAGPPVAEP DWSLLSPQGT LLFLSLALLI FTRETHRCLP QLTQSRGVFM 960

VMLKTLLSPR FLACLAQTQA GENGEAELIP AVVIQACQLL CFPFALDVDE DTIALVIEAV 1020

RDSQIPPQLL QVCCHHLPFS DTELPMSLLC RLVVSDEQVT DQIAREAATS EHIIAYLSTV 1080

LFSGSLTLTT DLLSLLTHVA RTCPEHLPFL QRILGGSDMS YQALTHLLSH QEHPIRAKTC 1140

NLLGNLLRHS HGFPQVLQNQ PGLLESLLVC LADEDEAVRK AASFAVGNAA YHESSPAGTL 1200

GRAVPRLTQL LSDRQAKTRC NAASALGNLG RRSAELGELL IESGAPRILL EMACRDPQAS 1260

VREGALMALR AVSQHPGIQQ VLLSLRATDQ LAALAGGDSW TTAGGSPRPS SARHCQKLIR 1320

LLTPLQST 1328

Nucleotide Sequence
(FASTA)

ATGGAGAGGT ACCACGTGCT GGAGGTGATC GGAGAAGGCT CCTTCGGACG AGTTTACAAG 60

GGGCGGCGGA GGTGCAGCGC GCAGGTGGTG GCTCTGAAAT TCATCCCCAA GGTGGGGCGG 120

TCTGAGAAGG AGCTGAAGAA CCTGCAGCGG GAAATTGAGA TTATGAGAGG TCTCCATCAC 180

CCTAACATCA TTCAGATGCT TGACAGCTTT GAGACTGACA AAGAGGTGGT GATGGTGACT 240

GACTATGCAG AGGGGGAGCT ATTCCAGATC CTGGAGGACG ATGGGAGTTT GCCCGAGGAC 300

CAGGTCCAGA CCATAGCTGC CCAGCTGGTC TCTGCTCTCT ATTACCTGCA CTCCCACCGC 360

ATCTTGCACC GTGACATGAA ACCCCAGAAC ATCCTGCTGG GCAAAGATGG TGTCATCAAG 420

CTCTGTGACT TCGGGTTTGC ACGTGCCATG AGCATCCACA CCATGGTGCT GACTTCCATC 480

AAGGGCACTC CACTGTACAT GTCCCCTGAG TTGGTGGAGG AGCGGCCATA TGACCACACA 540

GCAGACCTGT GGTCTGTGGG CTGCATCCTG TATGAACTGT TCATGGGCAC ACCTCCCTTC 600

TACACAAGCA GCATCTTCCA GCTTGTCAGC CTCATTGTCA AGGACCCTGT CAAATGGCCT 660

AAGGCCATAA GCCCAGCCTT CAAGAGCTTC CTGCAGGGGC TGCTAATGAA GGACCCCCAC 720

CAGCGCCTGT CATGGCCAGA GCTGCTCTCC CACCCCTTTG TTGCTGGACG GGTTACTGTG 780

ATTGATGACA CAGAAGAGCA TGGGATCTCA AACCCCTTCA CCACCAAGCT GTCCCCAGAG 840

CTACAGGCCC TGAAGGAGCA GCAAGCCCAT TCTCTGGCCC CTAGGAGTGG CCAGTCCAGG 900

ATCCTGAGAA AGGCTCGGCA GAAGATGGCT GAGGAGGCAC AGAAAAAGGT GGAGAAAAGT 960

GTGGGATTCT CTGGACTGCA CCCCATGGTT ATGTCAAAGG AGGGGCTCTT AAATGGGACT 1020

GAGGCAGCCC TTGAGGAGGA GGTGGAGCTA CCACCATCCT TCAAAGAGAA GAAATCTGGT 1080

GTCCTGCAAG GAAAGAACAG CATGGCAGAG TGGCAACTGA AGGAGCCTCC TCCCAGCCCA 1140

CGGGAGCACA GCATCACACA AGATTATGAG CGGGAGTTTC CCCAGCCAGA AGCACCTCTG 1200

CAGCTTGCTG TTGGCAAAGC AGAGCTCCGA GGCAGGCAAA GCATCAAGGC TGTGGACCTG 1260

GAGAGTGAGG AGCAGGAGAG TGATGAGGAG TGGCAACACC TGATCGAGGC CACAGAGCCC 1320

TTGGCCATGC AGCTGAGCAC CCCTCTTAGC CTCCTGAGGG ACCCAGCCTT CCGGCACCGT 1380

GTCCAAGCCC GGCTTGCAGA ATCTGCTCAG CAAGTGCTGG AAGGGATGCT TGAGGGAGCC 1440

TCCCATCTCC GTCCTGTGCT TCGCGTTGTG GGAAATCTCC TGGCTACCCG CTGTGACTCT 1500

GAGCTGCTGA ACCTCTTTTG CCAAGAGCTG AGCTTGCCAT TGTCCCTGCT GCATCTGGCC 1560

AAGCAGATGC TGGAGAGTGG CAGCACCAGG CAGCAGCCCT GGTGTATCAC AGTGCTGACA 1620

GACCTCATCA TGGTGACCAC AGTTTACTTC AGCAGTGAAT GCAACCTGGA GAAGAGTGGG 1680

CAGGACAGCC TACAGACCAT CCAGGAGAGT GCCAACCACT TCCTAGCCTT GCTGCCAGAT 1740

TTGCTGGCCG AGCCAGCTGA CAGTGAAATG AGACTCTGCC AGCAAAGCCT CCTGTGCTTT 1800

ACCCTGCTCT GTGAGAGCCT GGATGCGATG TGCCCCTCTA TCTCTGCCCC CTTCTATGCC 1860

AGCCTGCGAG AGGAGAATGA GCCCCTGCTG GACAGACTCC TTCAGGGATT GATCTCTGAG 1920

CAACCTGCTC TGCAAGGTGC AACAATGGAG GCCAAGTCAG CTCATGACCA GAGACAATGC 1980

GTGGCAGACC TTTGTACGGC TGCACTGGCA GCTGCCTGCA GCATCCCCCT GGCACAGAGC 2040

AGCTGTCGGG AAACCAAGCA GCAGGTTGCT CAGGAGATAG CTGGAAAGCT GATGGATGGC 2100

GAGTGCCAGC AGCTTGGGAA GCTGCTGGGG AGGCTGGAGC ACCCAAATTG CTCCTTGAAT 2160

GTTCTCAAGA TCCTCTACAC TTGCTGCTAT GCCAGCCCGA GTCTGTGCCA GCACCTGGGG 2220

AGGAGCCAGC AAGTATGGGA TTTCCTTATG CAGCTCTCAA AGGGCAAGGT CCCCATGGCA 2280

GAGGTGACTC GGAAGGTGGC CTGTGAGGCC TCCCTATACC TGCTGGCCCT GCTTACCCTG 2340

CAGCCCCAGG CCTCTCCTTC CAGGCTGGAG GAGGTGGTTA CCCTGGCCTT GGATGTGCTC 2400

ACTCAGTCTC CTGTCATCTC TGTTGTGGGT GCTGCAGCAT TCCTCCTGAC ACAGCTTGAC 2460

CAGCGTGGGG TGCCAGTGGC ACTTCAGGGA AAAGAAATCT TACCAGCAGT GACAAATGCA 2520

CTGATGGAGC CTGCTGAGCT GCACTTCTCG CTGCCTATGG GTGCTGGTCT CTATGACGGG 2580

ATCATTTTCC TCCTGTTGAA GCTGCTTGCA CAGGAAGATG TGGCTGTGGA GCAGAGCTTT 2640

GCTGCCTCAG AGTTGTGGAA CGTGGTGTGG CACTGTGTTC CTGCAGTGCT TTGCATGGGC 2700

AGCAGTGGGG CAGCACTGGA GGGAGACAGC CCAGGGGCAG GGCCCCCTGT GGCAGAGCCA 2760

GACTGGAGCC TTCTCTCCCC TCAAGGCACA CTGCTTTTCT TAAGCCTGGC CCTCTTAATC 2820

TTCACTCGTG AGACCCACCG GTGCCTGCCT CAGCTCACCC AGTCCCGAGG TGTCTTCATG 2880

GTGATGCTGA AGACACTGCT GTCCCCTCGC TTCCTGGCGT GTCTGGCACA GACGCAAGCA 2940

GGGGAGAATG GAGAGGCTGA GCTCATCCCA GCTGTAGTGA TCCAGGCCTG CCAGCTCCTC 3000

TGTTTTCCTT TTGCCCTGGA CGTGGATGAA GACACCATAG CATTAGTCAT CGAGGCAGTG 3060

AGAGACTCCC AGATCCCTCC CCAGCTACTG CAGGTCTGCT GTCACCATCT GCCTTTCTCA 3120

GACACTGAGC TCCCCATGAG CCTCTTATGC CGCCTTGTTG TGTCCGATGA GCAGGTCACA 3180

GACCAAATAG CAAGGGAGGC TGCCACCTCA GAGCACATCA TTGCCTACTT GAGTACTGTG 3240

TTGTTTTCAG GCAGCCTCAC ACTCACAACT GACCTCCTGT CTCTCTTGAC TCATGTGGCT 3300

CGGACCTGTC CGGAGCACCT GCCCTTTCTC CAGAGGATTT TAGGGGGTTC AGATATGTCC 3360

TACCAGGCAC TGACCCACCT ACTCAGCCAC CAGGAACACC CCATACGAGC CAAAACCTGC 3420

AATCTGCTGG GCAACCTGCT CCGACACAGC CACGGCTTTC CCCAGGTGCT GCAGAACCAG 3480

CCTGGCTTAC TGGAGAGCCT GCTGGTGTGC CTGGCTGATG AGGATGAGGC TGTGCGCAAG 3540

GCAGCCAGCT TTGCGGTGGG TAATGCTGCT TATCACGAGT CCTCCCCAGC CGGGACTCTG 3600

GGCAGGGCCG TGCCCAGGCT GACGCAGCTG CTGAGTGACC GGCAGGCCAA GACACGCTGC 3660

AATGCGGCCT CAGCCCTGGG CAACTTGGGC CGGCGCTCAG CAGAGCTCGG GGAGTTGCTC 3720

ATCGAAAGCG GGGCCCCCCG CATCCTCCTG GAGATGGCCT GCCGGGACCC CCAGGCCAGC 3780

GTGCGGGAGG GAGCACTCAT GGCTCTGCGC GCTGTCAGCC AGCACCCTGG GATACAGCAG 3840

GTGTTGCTGT CCCTCAGGGC CACTGACCAG CTGGCTGCAC TGGCCGGCGG TGACTCCTGG 3900

ACCACGGCTG GGGGCAGCCC CCGGCCTTCA TCTGCACGCC ACTGCCAGAA GCTCATCCGC 3960

CTCCTCACAC CCCTGCAGAG CACCTGA 3987

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen  59

         y++ e iG+Gsf+ vykgr r+ ++qvvA+k++ k ++ +k+l+nl++ei+i++ l+h+n

Q: 4     YHVLEVIGEGSFGRVYKGR-RRCSAQVVALKFIPKVGRsEKELKNLQREIEIMRGLHHPN  62

         8899***************.99999*************9*********************

S: 60    ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki  119

         i+++ld++et+kev++v++y++ g+L ++l+++++L+ed+v+++++ql+sal++Lhs++i

Q: 63    IIQMLDSFETDKEVVMVTDYAE-GELFQILEDDGSLPEDQVQTIAAQLVSALYYLHSHRI  121

         **********************.*************************************

S: 120   vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesma.atlkGsplYmaPEvvk  178

         +hrD+kPqniLl         k++ +kl+dFg+ar+++ ++m  +++kG+plYm+PE+v+

Q: 122   LHRDMKPQNILLG--------KDGVIKLCDFGFARAMSIHTMVlTSIKGTPLYMSPELVE  173

         *************........89*******************99****************

S: 179   eqqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdl  238

         e+ yd++aDlWS+G+ilyel++G+pPf+++si++Lv+ i k++v   ++pk is+ +k++

Q: 174   ERPYDHTADLWSVGCILYELFMGTPPFYTSSIFQLVSLIVKDPV---KWPKAISPAFKSF  230

         ********************************************...*************

S: 239   lqsLLqrdpkkRisfeelfahpfl  262

         lq+LL +dp++R+s+ el++hpf+

Q: 231   LQGLLMKDPHQRLSWPELLSHPFV  254

         **********************96

Domain Sequence
(FASTA)

YHVLEVIGEG SFGRVYKGRR RCSAQVVALK FIPKVGRSEK ELKNLQREIE IMRGLHHPNI 60

IQMLDSFETD KEVVMVTDYA EGELFQILED DGSLPEDQVQ TIAAQLVSAL YYLHSHRILH 120

RDMKPQNILL GKDGVIKLCD FGFARAMSIH TMVLTSIKGT PLYMSPELVE ERPYDHTADL 180

WSVGCILYEL FMGTPPFYTS SIFQLVSLIV KDPVKWPKAI SPAFKSFLQG LLMKDPHQRL 240

SWPELLSHPF V 251

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007228	; P:positive regulation of hh target transcription factor activity
GO:0045880	; P:positive regulation of smoothened signaling pathway

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR000225	; Armadillo.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00185	; ARM; 3.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013