EKS-GAG-00237

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00237

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	389.8	7.9E-117	219	511	293

Status

Reviewed

Ensembl Protein

ENSGALP00000036894

UniProt Accession

Q90999;

Protein Name

TGF-beta receptor type-2

Protein Synonyms/Alias

TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II;

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000011442	ENSGALP00000036894	ENSGALT00000037689
ENSGALG00000011442	ENSGALP00000036896	ENSGALT00000037691
ENSGALG00000011442	ENSGALP00000018634	ENSGALT00000018657

Organism

Gallus gallus

Functional Description

Transmembrane serine/threonine kinase forming with theTGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways (By similarity).

Protein Length

541

Protein Sequence
(FASTA)

MCSCTGEECN DVLIFSANRF REHGLQLPRL CKFCDIKATT CSNQDQCTSN CNITSICEKN 60

NEVCAAVWRR NDENVTLETI CHDPQKRLYG HMLDDSSSEQ CVMKEKKDDG GLMFMCSCTG 120

EECNDVLIFS AKEKDEISKV TIISLVPLLV ISVAVIVIFY AYRTHKKRKL NKAWEKNVKP 180

KKHKDCSDVC AIMLDDDHSD ISSTCANNIN HNTELLPIEL DIVVGKGRFA EVYKAKLKQN 240

TSEQYETVAV KIFPYEEYAS WKTEKDIFSD VNLKHENILQ FLTAEERKTD LGKQYWLITA 300

FHARGNLQEY LTRHIISWED LWKLGGSLAR GIAHLHSDHT PCGRPKTPIV HRDLKSSNIL 360

VKNDLTCCLC DFGLSLRLDP SLSVDDLANS GQVGTARYMA PEVLESRMNL ENMESFKQTD 420

VYSMALVLWE MTSRCNGVGE VKEYEPPFGS KVREHPCVES MKDNVLRDRG RPEIPSSWLN 480

HQGIQMVCET LIECWDHDPE ARLTAQCVAE RFSEFKHHDK LSGRSCSEEK IPEDGSVTTA 540

K 541

Nucleotide Sequence
(FASTA)

ATGTGTTCCT GTACAGGTGA AGAGTGCAAC GATGTTCTTA TTTTTTCTGC AAACAGATTT 60

AGGGAACATG GACTGCAATT GCCCAGGCTA TGCAAATTCT GTGACATTAA GGCAACAACG 120

TGCTCAAACC AAGATCAGTG CACGAGCAAC TGCAACATCA CTTCTATCTG TGAGAAGAAT 180

AACGAAGTCT GTGCAGCTGT ATGGAGACGG AATGATGAAA ATGTGACGTT AGAAACAATC 240

TGCCATGATC CCCAGAAAAG GCTGTATGGT CACATGTTGG ATGACTCCAG CTCAGAGCAG 300

TGTGTGATGA AGGAAAAGAA GGATGATGGG GGACTGATGT TCATGTGTTC CTGTACAGGT 360

GAAGAGTGCA ACGATGTTCT TATTTTTTCT GCAAAGGAGA AAGATGAAAT TTCCAAAGTC 420

ACAATCATAA GTCTTGTCCC TTTATTGGTG ATTTCTGTTG CTGTGATTGT TATCTTTTAT 480

GCCTACCGCA CTCACAAGAA GAGGAAGCTC AACAAGGCCT GGGAGAAGAA TGTCAAGCCC 540

AAGAAACATA AAGACTGCAG TGATGTTTGT GCCATTATGT TGGATGATGA CCACTCAGAC 600

ATCAGCTCTA CCTGTGCCAA CAACATCAAC CACAACACAG AATTGCTGCC CATTGAACTG 660

GACATTGTTG TTGGCAAAGG AAGGTTTGCT GAAGTGTATA AAGCCAAATT GAAGCAAAAC 720

ACATCTGAGC AGTATGAAAC TGTGGCAGTA AAGATCTTCC CCTATGAAGA ATATGCCTCC 780

TGGAAGACCG AGAAAGACAT TTTTTCAGAT GTAAATCTTA AGCATGAGAA CATCCTCCAA 840

TTCTTGACCG CAGAGGAGCG TAAGACAGAT CTTGGTAAAC AGTATTGGTT GATCACTGCC 900

TTCCATGCTA GAGGAAACTT GCAGGAATAC CTCACACGGC ATATTATCAG CTGGGAAGAC 960

CTCTGGAAAC TGGGAGGATC CTTGGCCCGA GGGATTGCCC ATCTGCACAG TGATCATACA 1020

CCTTGTGGTC GCCCTAAAAC CCCTATTGTG CACAGAGACC TAAAGAGTTC CAACATCCTG 1080

GTGAAAAATG ATTTAACTTG CTGTCTCTGT GACTTTGGGT TATCCCTGAG GCTGGACCCT 1140

TCTCTCTCTG TGGATGACTT GGCCAACAGT GGTCAGGTTG GCACAGCAAG GTACATGGCC 1200

CCTGAGGTTC TGGAGTCCAG GATGAACCTT GAGAACATGG AGTCCTTTAA ACAAACAGAT 1260

GTGTACTCCA TGGCTTTGGT CCTCTGGGAA ATGACATCTC GCTGTAATGG TGTTGGAGAA 1320

GTGAAAGAGT ATGAGCCCCC ATTCGGCTCT AAAGTGCGAG AGCATCCCTG CGTGGAAAGC 1380

ATGAAGGACA ATGTCCTAAG AGACAGAGGG CGACCCGAGA TCCCCAGCTC CTGGCTTAAC 1440

CATCAGGGCA TCCAGATGGT GTGCGAGACC CTTATCGAGT GCTGGGACCA CGACCCCGAG 1500

GCTCGGCTCA CGGCGCAATG CGTGGCGGAG CGCTTCAGCG AGTTCAAGCA CCACGACAAG 1560

CTCTCAGGGA GAAGCTGTTC GGAGGAGAAG ATCCCCGAGG ACGGCTCCGT GACCACCGCC 1620

AAGTAG 1626

Domain Profile

S: 2     klleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrheni  55

         +l  ++gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ v+l+heni

Q: 219   ELDIVVGKGRFAEVYKAKLKQntseqyETVAVKIFPYEEYASWKTEKDIFSDVNLKHENI  278

         67779***************99999999********************************

S: 56    lqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHee  115

         lqf++a+++++d+ ++++l+t++h +g+L++yL+r+++++e+l +l  sla+G+ahLH++

Q: 279   LQFLTAEERKTDLGKQYWLITAFHARGNLQEYLTRHIISWEDLWKLGGSLARGIAHLHSD  338

         ************************************************************

S: 116   ivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkR  175

          ++ +g+ K  i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt R

Q: 339   -HTPCGRPKTPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPSLSVDDLANSGQVGTAR  397

         .8999*******************************************************

S: 176   YmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdP  235

         YmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc+   +ev+ey++pf ++v+++P

Q: 398   YMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNG-VGEVKEYEPPFGSKVREHP  456

         ****************************************.999****************

S: 236   sleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++e+mk+ v++++ rP+ip++w +++ +++++++l ecWd+dpeaRlta++v++r

Q: 457   CVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLIECWDHDPEARLTAQCVAER  511

         ****************************************************987

Domain Sequence
(FASTA)

ELDIVVGKGR FAEVYKAKLK QNTSEQYETV AVKIFPYEEY ASWKTEKDIF SDVNLKHENI 60

LQFLTAEERK TDLGKQYWLI TAFHARGNLQ EYLTRHIISW EDLWKLGGSL ARGIAHLHSD 120

HTPCGRPKTP IVHRDLKSSN ILVKNDLTCC LCDFGLSLRL DPSLSVDDLA NSGQVGTARY 180

MAPEVLESRM NLENMESFKQ TDVYSMALVL WEMTSRCNGV GEVKEYEPPF GSKVREHPCV 240

ESMKDNVLRD RGRPEIPSSW LNHQGIQMVC ETLIECWDHD PEARLTAQCV AER 293

Keyword

3D-structure; Apoptosis; ATP-binding; Cell membrane; Complete proteome; Differentiation; Disulfide bond; Glycoprotein; Growth regulation; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0050431	; F:transforming growth factor beta binding
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0060317	; P:cardiac epithelial to mesenchymal transition
GO:0001775	; P:cell activation
GO:0016477	; P:cell migration
GO:0009790	; P:embryo development
GO:0001654	; P:eye development
GO:0030324	; P:lung development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0030335	; P:positive regulation of cell migration
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0010718	; P:positive regulation of epithelial to mesenchymal transition
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0040008	; P:regulation of growth
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

gga:396399

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013