EKS-GAG-00139
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00139
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb479.62.5E-144382647266
StatusUnreviewed
Ensembl ProteinENSGALP00000018680
UniProt AccessionF1P1H2;
Protein Name
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000011473ENSGALP00000018680ENSGALT00000018703
OrganismGallus gallus
Functional Description
Protein Length708
Protein Sequence
(FASTA)
EEGIVKEIDI SHHVKEGFEK ADPSQFELLK VLGQGSYGKV FLVRKIKGSD AGQLYAMKVL 60
KKATLKVRDR VRSKMERDIL AEVNHPFIVK LHYAFQTEGK LYLILDFLRG GDLFTRLSKE 120
VMFTEEDVKF YLAELALALD HLHGLGIIYR DLKPENILLD EEGHIKITDF GLSKEAIDHD 180
KRAYSFCGTI EYMAPEVVNR RGHTQSADWW SFGVLMFEML TGSLPFQGKD RKETMALILK 240
AKLGMPQFLS IEAQSLLRAL FKRNPSNRLG AGFDGVEEIK RHPFFITIDW NKLYRKEIKP 300
PFKPAVGRPE DTFHFDPEFT SRTPTDSPGV PPSANAHHLF RGFSFVASNL VQEPAQQDVH 360
KITVHPIVQQ LHGNNIHFTD GYEIKEDIGI GSYSVCKRCV HKATETEFAV KIIDKSKRDP 420
SEEIEILLRY GQHPNIITLK DVYDDGKYVY LVMELMRGGE LLDRILQQKC FSEREASAVL 480
CTITRTVDYL HSQGVSITFL VLVVHRDLKP SNILYMDESG NPDSIRICDF GFAKQLRAEN 540
GLLMTPCYTA NFVAPEVLKR QGYDAACDIW SLGILLYTML AGFTPFANGP DDTPEEILAR 600
IGSGKYALTG GNWDSVSDTA KDIVSKMLHV DPHQRLTAVQ VLRHPWIVNR EYLSQNQLSR 660
QDVHLVKGAM AATYFALNRT PQAPRLEPVL SSNLAQRRGM KRLTSTRL 708
Nucleotide Sequence
(FASTA)
GAAGAAGGTA TTGTGAAGGA AATAGACATC AGTCACCATG TGAAGGAAGG TTTTGAAAAA 60
GCAGATCCTT CTCAATTTGA GCTGCTGAAA GTATTAGGAC AAGGTTCATA TGGAAAGGTG 120
TTTCTAGTGA GGAAGATCAA AGGATCTGAT GCAGGTCAGC TTTATGCCAT GAAGGTACTT 180
AAGAAAGCAA CTCTGAAAGT TCGGGATCGG GTACGGTCGA AAATGGAGAG AGATATTTTG 240
GCAGAAGTCA ATCATCCTTT CATAGTCAAG CTTCATTATG CATTTCAGAC AGAGGGGAAG 300
TTGTATCTAA TACTAGACTT CCTGCGGGGA GGAGACCTTT TCACAAGACT CTCCAAAGAG 360
GTGATGTTTA CAGAAGAGGA TGTCAAGTTC TACTTAGCTG AGCTGGCCTT GGCTTTAGAC 420
CACCTCCACG GGCTTGGAAT TATTTACAGG GATCTAAAAC CAGAAAACAT TCTTCTTGAT 480
GAAGAGGGCC ACATAAAGAT AACAGATTTT GGTCTGAGTA AAGAAGCCAT CGACCATGAC 540
AAGAGAGCGT ACTCGTTCTG TGGGACAATA GAGTATATGG CCCCAGAGGT GGTCAACCGC 600
AGAGGACACA CTCAGAGCGC CGACTGGTGG TCTTTTGGTG TGCTCATGTT TGAGATGCTG 660
ACAGGATCAT TACCATTCCA GGGAAAAGAC AGAAAGGAGA CGATGGCTCT TATACTCAAA 720
GCCAAACTGG GAATGCCACA GTTCTTGAGC ATAGAAGCCC AGAGCCTGCT GCGAGCCCTC 780
TTCAAAAGGA ACCCATCCAA CAGACTAGGT GCTGGATTCG ATGGAGTGGA AGAAATTAAA 840
CGTCACCCTT TCTTTATTAC TATAGACTGG AACAAACTGT ACAGAAAAGA AATCAAGCCG 900
CCTTTCAAGC CTGCAGTGGG ACGGCCAGAA GACACTTTTC ATTTTGATCC GGAGTTCACA 960
TCTCGGACCC CCACGGATTC CCCAGGTGTT CCTCCAAGTG CCAATGCTCA TCATCTTTTC 1020
AGAGGGTTCA GCTTTGTTGC CTCTAACTTG GTGCAGGAGC CTGCACAGCA GGATGTGCAC 1080
AAAATCACCG TTCATCCAAT TGTGCAGCAA TTACATGGAA ACAATATTCA CTTTACAGAT 1140
GGATATGAGA TCAAGGAGGA CATAGGAATT GGCTCCTATT CAGTGTGCAA GAGATGTGTT 1200
CATAAAGCAA CAGAAACAGA GTTTGCTGTG AAGATAATTG ACAAGAGCAA GAGAGACCCC 1260
TCTGAAGAAA TAGAGATTCT CTTGCGATAT GGACAGCATC CAAACATCAT TACTCTTAAA 1320
GATGTCTATG ATGATGGGAA ATACGTGTAC CTGGTGATGG AGTTGATGCG GGGAGGAGAG 1380
CTCCTGGACC GCATTCTTCA GCAGAAGTGT TTTTCAGAGC GAGAGGCCAG CGCTGTGCTG 1440
TGCACTATCA CAAGGACTGT GGACTACCTG CACTCCCAGG GGGTAAGCAT TACTTTTTTG 1500
GTTCTCGTGG TGCACCGAGA TTTGAAGCCA AGTAATATCC TCTACATGGA TGAGTCAGGA 1560
AACCCAGACT CCATCAGGAT CTGTGACTTT GGCTTTGCCA AGCAACTGAG AGCAGAGAAT 1620
GGGCTGCTCA TGACTCCCTG CTACACGGCC AACTTTGTCG CCCCTGAGGT CCTTAAGCGC 1680
CAAGGTTACG ATGCAGCCTG TGACATCTGG AGCTTGGGGA TCCTGTTGTA CACAATGCTG 1740
GCAGGGTTCA CTCCTTTTGC AAATGGGCCA GATGACACCC CAGAGGAGAT TCTGGCCAGG 1800
ATTGGCAGTG GCAAATACGC ACTTACCGGA GGAAACTGGG ATTCAGTATC GGATACTGCG 1860
AAGGATATTG TGTCTAAGAT GCTTCACGTA GACCCTCATC AGCGTCTCAC AGCAGTTCAA 1920
GTGTTAAGAC ATCCATGGAT AGTGAACAGG GAGTATCTGT CTCAAAATCA ACTCAGCAGA 1980
CAGGATGTTC ACCTGGTGAA GGGTGCAATG GCAGCCACTT ACTTTGCTTT AAACCGAACA 2040
CCTCAGGCAC CAAGGCTGGA GCCTGTATTA TCCTCCAACC TGGCTCAGCG GAGGGGCATG 2100
AAAAGACTTA CCTCAACCAG ATTGTAG 2127
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+G Gsysvckrcvhkat++efavkiidkskrd+seeieillry+qhpni+tlkd
Q: 382   YEIKEDIGIGSYSVCKRCVHKATETEFAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  441
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGv......  114
         vyddgkyvylv+el++GGelldri+++k+fsereasa+l+t++++v+ylh+qGv      
Q: 442   VYDDGKYVYLVMELMRGGELLDRILQQKCFSEREASAVLCTITRTVDYLHSQGVsitflv  501
         *****************************************************5555555
S: 115   ..vhrdlkpenilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrq  172
           vhrdlkp+nily+des+n++si+i+dfGfak++raengll+tpcyt+nfvapevlkrq
Q: 502   lvVHRDLKPSNILYMDESGNPDSIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ  561
         559*********************************************************
S: 173   GydeacdlwslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeak  232
         Gyd+acd+wslG+llytmlaG++pfangp+dt+eeila+i++Gk++l G++wdsvs++ak
Q: 562   GYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALTGGNWDSVSDTAK  621
         ************************************************************
S: 233   dlvsklltvdpakrlkleqllkhswl  258
         d+vsk+l+vdp++rl++ q+l+h+w+
Q: 622   DIVSKMLHVDPHQRLTAVQVLRHPWI  647
         *************************8
Domain Sequence
(FASTA)
YEIKEDIGIG SYSVCKRCVH KATETEFAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKYVYL VMELMRGGEL LDRILQQKCF SEREASAVLC TITRTVDYLH SQGVSITFLV 120
LVVHRDLKPS NILYMDESGN PDSIRICDFG FAKQLRAENG LLMTPCYTAN FVAPEVLKRQ 180
GYDAACDIWS LGILLYTMLA GFTPFANGPD DTPEEILARI GSGKYALTGG NWDSVSDTAK 240
DIVSKMLHVD PHQRLTAVQV LRHPWI 266
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-XET-00150
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013