EKS-GAG-00002
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00002
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph519.01.7E-156565822258
StatusUnreviewed
Ensembl ProteinENSGALP00000037020
UniProt AccessionF1NSE6;
Protein Name
Protein Synonyms/Alias Ephrin type-A receptor 5;
Gene NameEPHA5
Gene Synonyms/Alias EPHA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000011680ENSGALP00000037019ENSGALT00000037813
ENSGALG00000011680ENSGALP00000037020ENSGALT00000037814
ENSGALG00000011680ENSGALP00000019068ENSGALT00000019091
OrganismGallus gallus
Functional Description
Protein Length927
Protein Sequence
(FASTA)
APIHTYQVCK VMEQNQNNWL LTSWISNEGA SRIFIELKFT LRDCNSLPGG LGTCKETFNM 60
YYFESDDEDG RNIRENQYIK IDTIAADESF TELDLGDRVM KLNTEVRDVG PLTKKGFYLA 120
FQDVGACIAL VSVRVYYKKC PSVIRNLARF PDTITGADSS QLLEVSGVCV NHSVTDEAPK 180
MHCSAEGEWL VPIGKCLCKA GYEEKNNTCQ VCRPGFFKAS PHSPSCSKCP PHSYTLDEAS 240
TSCLCEEHYF RRESDPPTMA CTRPPSAPRS AISNVNETSV FLEWIPPADT GGRKDVSYYI 300
ACKKCNSHSG LCEACGSHVR YLPQQTGLKN TSVMMVDLLA HTNYTFEIEA VNGVSDQNPG 360
ARQFVSVNVT TNQAAPSPVS SVKKGKITKN SISLSWQEPD RPNGIILEYE IKYFEKGWEK 420
DQETSYTIIK SKETAITADG LKPGSAYVFQ IRARTAAGYG GFSRRFEFET SPVSVAASSD 480
QSQIPIIVVS VTVGVILLAV VIGFLLSGRR CGYSKAKQDP EEEKMHFHNG HIKLPGVRTY 540
IDPHTYEDPN QAVHEFAKEI EASCITIERV IGAGEFGEVC SGRLKLQGKR EFPVAIKTLK 600
VGYTEKQRRD FLGEASIMGQ FDHPNIIHLE GVVTKSKPVM IVTEYMENGS LDTFLKKNDG 660
QFTVIQLVGM LRGIASGMKY LSDMGYVHRD LAARNILINS NLVCKVSDFG LSRVLEDDPE 720
AAYTTRGGKI PIRWTAPEAI AFRKFTSASD VWSYGIVMWE VMSYGERPYW EMTNQDVIKA 780
VEEGYRLPSP MDCPAALYQL MLDCWQKDRN SRPKFDEIVS MLDKLIRNPS SLKTLVNASS 840
RVSNLLVEHS PVGSGAYRSV GEWLEAIKMG RYTEIFMENG YSSMDSVAQV TLEDLRRLGV 900
TLVGHQKKIM NSLQEMKVQL VNGMVPL 927
Nucleotide Sequence
(FASTA)
GCTCCGATAC ACACATACCA AGTATGCAAG GTAATGGAAC AGAATCAGAA CAACTGGCTT 60
CTGACCAGCT GGATCTCTAA TGAAGGGGCA TCCCGCATCT TCATTGAACT CAAATTCACC 120
CTGAGGGACT GTAACAGCCT TCCAGGAGGA CTTGGGACTT GCAAGGAGAC TTTTAACATG 180
TACTACTTTG AGTCAGATGA TGAAGATGGG AGGAACATCA GAGAGAATCA GTACATCAAG 240
ATAGATACCA TTGCTGCTGA TGAGAGCTTC ACGGAGTTGG ACCTCGGCGA CAGAGTTATG 300
AAGTTAAACA CAGAAGTGAG AGATGTTGGG CCTCTAACAA AAAAAGGATT TTACCTTGCT 360
TTTCAGGATG TGGGCGCCTG CATTGCCCTG GTCTCTGTGC GTGTGTACTA CAAGAAATGC 420
CCATCAGTGA TCCGCAACCT GGCACGCTTT CCAGATACCA TCACAGGAGC AGATTCCTCA 480
CAGCTGCTAG AAGTGTCAGG CGTCTGTGTC AACCACTCAG TGACTGATGA GGCACCAAAG 540
ATGCACTGCA GTGCTGAGGG AGAATGGCTG GTGCCCATCG GGAAGTGTTT GTGCAAGGCA 600
GGGTACGAGG AGAAGAACAA CACCTGCCAA GTATGCAGAC CTGGGTTCTT CAAAGCTTCA 660
CCCCACAGTC CATCCTGCAG CAAATGTCCC CCTCACAGCT ACACGCTTGA TGAAGCATCC 720
ACATCTTGCC TGTGTGAAGA GCACTATTTT AGGAGAGAAT CAGACCCACC TACAATGGCC 780
TGTACAAGAC CCCCCTCTGC TCCTCGGAGT GCCATCTCAA ATGTTAACGA GACTAGTGTC 840
TTTCTGGAAT GGATTCCCCC TGCTGATACT GGTGGAAGGA AAGATGTGTC TTATTATATT 900
GCATGCAAGA AGTGCAACTC ACACTCAGGT CTGTGCGAGG CATGTGGCAG TCATGTCAGG 960
TACCTCCCCC AGCAAACCGG CCTGAAAAAC ACCTCTGTCA TGATGGTGGA TCTGCTTGCT 1020
CATACAAACT ATACCTTTGA AATTGAGGCA GTGAATGGAG TGTCCGACCA GAACCCTGGA 1080
GCCCGGCAGT TTGTGTCTGT AAATGTAACC ACAAACCAGG CAGCACCTTC TCCAGTCAGT 1140
AGTGTGAAAA AAGGGAAGAT AACTAAAAAT AGCATCTCCC TTTCCTGGCA GGAGCCAGAT 1200
CGACCCAACG GCATCATCCT GGAATACGAA ATCAAATATT TTGAAAAGGG TTGGGAAAAG 1260
GACCAGGAGA CAAGCTACAC CATCATCAAA TCCAAAGAGA CCGCAATTAC GGCAGATGGC 1320
TTGAAACCAG GCTCAGCGTA CGTCTTCCAG ATCCGAGCCC GGACAGCTGC TGGCTACGGT 1380
GGCTTCAGTC GAAGATTTGA GTTTGAAACC AGCCCAGTGT CAGTAGCTGC ATCCAGTGAC 1440
CAGAGCCAGA TTCCTATAAT TGTTGTGTCT GTAACAGTGG GAGTTATTCT GCTGGCTGTT 1500
GTTATCGGTT TCCTTCTCAG TGGAAGGCGC TGTGGCTACA GCAAGGCTAA ACAAGACCCA 1560
GAAGAAGAAA AGATGCATTT TCATAATGGC CACATTAAAC TGCCTGGTGT AAGAACCTAC 1620
ATTGATCCCC ACACCTATGA GGACCCTAAT CAAGCTGTCC ACGAGTTTGC CAAGGAAATA 1680
GAAGCTTCGT GCATAACCAT CGAGAGAGTT ATCGGAGCTG GTGAATTTGG AGAAGTCTGC 1740
AGTGGACGGC TGAAACTGCA GGGAAAACGC GAGTTTCCAG TGGCTATCAA AACCCTGAAG 1800
GTGGGCTACA CAGAGAAGCA AAGGCGAGAT TTCCTGGGAG AAGCGAGCAT CATGGGGCAG 1860
TTCGACCACC CCAACATCAT CCACCTGGAA GGTGTCGTCA CAAAAAGCAA ACCTGTAATG 1920
ATAGTAACGG AATACATGGA AAATGGTTCT CTGGATACAT TTTTAAAGAA GAACGATGGG 1980
CAGTTCACGG TCATTCAGCT GGTCGGGATG CTGCGAGGCA TCGCATCAGG GATGAAGTAC 2040
CTGTCTGACA TGGGTTACGT ACACAGAGAC CTCGCTGCCA GGAATATCCT CATCAACAGC 2100
AACTTAGTCT GCAAGGTGTC TGACTTTGGC CTCTCCAGAG TCCTAGAAGA TGATCCTGAA 2160
GCAGCGTACA CAACCAGGGG AGGGAAGATC CCCATCCGAT GGACGGCACC TGAAGCAATC 2220
GCCTTCCGCA AATTCACGTC GGCCAGCGAT GTGTGGAGCT ACGGCATTGT GATGTGGGAA 2280
GTGATGTCCT ATGGCGAGAG ACCTTACTGG GAAATGACAA ACCAAGATGT GATTAAAGCC 2340
GTGGAGGAAG GCTATCGCCT GCCAAGTCCC ATGGACTGCC CTGCTGCTCT CTACCAGTTG 2400
ATGCTTGACT GCTGGCAGAA AGACCGCAAC AGCAGGCCCA AGTTTGATGA AATTGTCAGC 2460
ATGTTGGACA AGCTCATCCG TAACCCAAGC AGCTTGAAGA CGTTGGTTAA TGCATCGAGC 2520
AGAGTATCAA ATTTGTTGGT AGAACACAGT CCAGTGGGGA GCGGTGCCTA CAGGTCAGTG 2580
GGTGAGTGGC TGGAAGCCAT CAAAATGGGT CGATACACCG AGATTTTCAT GGAGAATGGA 2640
TACAGTTCGA TGGATTCTGT GGCTCAGGTG ACCCTAGAGG ATTTGAGGCG GCTGGGAGTG 2700
ACACTTGTTG GTCACCAGAA GAAGATAATG AACAGCCTTC AAGAGATGAA GGTCCAGTTG 2760
GTGAATGGGA TGGTGCCATT GTAA 2784
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++ie+viGaGefGevcsGrlkl+gkre +vaiktlk g+tekqrrdfl easi+Gqfdhp
Q: 565   ITIERVIGAGEFGEVCSGRLKLQGKREFPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  624
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtkskpvmivteymeng+ld+fl+k+dgqftviqlvgmlrGiasgmkylsdm
Q: 625   NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGMKYLSDM  684
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaia+rk
Q: 685   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK  744
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpyw+m+nqdvika+eegyrlp+pmdcpaalyqlmldc
Q: 745   FTSASDVWSYGIVMWEVMSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC  804
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkf++ivs+l
Q: 805   WQKDRNSRPKFDEIVSML  822
         ***************986
Domain Sequence
(FASTA)
ITIERVIGAG EFGEVCSGRL KLQGKREFPV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60
NIIHLEGVVT KSKPVMIVTE YMENGSLDTF LKKNDGQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAFRK 180
FTSASDVWSY GIVMWEVMSY GERPYWEMTN QDVIKAVEEG YRLPSPMDCP AALYQLMLDC 240
WQKDRNSRPK FDEIVSML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00005
EKS-BOT-00003
EKS-CAJ-00003
EKS-CAF-00002
EKS-CAP-00002
EKS-DAR-00003
EKS-EQC-00002
EKS-GAA-00010
EKS-GOG-00011
EKS-ICT-00003
EKS-LAC-00007
EKS-LOA-00003
EKS-MAM-00003
EKS-MAE-00001
EKS-MOD-00003
EKS-MUP-00005
EKS-MYL-00007
EKS-NOL-00003
EKS-ORN-00010
EKS-ORA-00002
EKS-ORC-00005
EKS-ORL-00011
EKS-OTG-00008
EKS-PAT-00004
EKS-PES-00002
EKS-POA-00003
EKS-PTV-00002
EKS-SAH-00003
EKS-SOA-00001
EKS-SUS-00010
EKS-TAG-00002
EKS-XIM-00009
Gene Ontology
GO:0030425; C:dendrite
GO:0009897; C:external side of plasma membrane
GO:0005887; C:integral to plasma membrane
GO:0043025; C:neuronal cell body
GO:0048471; C:perinuclear region of cytoplasm
GO:0005791; C:rough endoplasmic reticulum
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0032314; P:regulation of Rac GTPase activity
KEGG
gga:395997;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013