EKS-GAG-00227
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00227
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK441.42.1E-132196524329
StatusUnreviewed
Ensembl ProteinENSGALP00000019093
UniProt AccessionE1BUN6;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK3
Gene Synonyms/Alias HIPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000011695ENSGALP00000019093ENSGALT00000019117
OrganismGallus gallus
Functional Description
Protein Length1194
Protein Sequence
(FASTA)
MASQVLVYPP YVYQTQSSAF CSVKKLKLEP SSCVYHERAY PQIYVNGKNF GISPHRVSTF 60
LQTKNPFDRP RGQNVLLQSN AVALKNIAGA TKALAAQAQQ AQLEAPRSGT QGSRADILEG 120
PQRCGLKRKS EELDNQSSTM QIVDELSILP AMLQTNVGNP VTVVTTAATS KQTGTSGDGD 180
YQLVQHEVLC SVKNTYEVLD FLGRGTFGQV VKCWKRGTNE IVAIKILKNH PSYARQGQIE 240
VSILARLSTE NADEFNFVRA YECFQHRNHT CLVFEMLEQN LYDFLKQNKF SPLQLKVIRP 300
ILQQVATALK KLKSLGLIHA DLKPENIMLV DPVRQPYRVK VIDFGSASHV SKTICSTYLQ 360
SRYYRAPEII LGLPFCEAID MWSLGCVIAE LFLGWPLYPG ALEYDQIRYI SQTQGLPGEQ 420
LLSMGTKTAR FFCRETDAPY SSWRLKTLEE HEAETGMKSK EARKYIFNSL DDIVHVNMVM 480
DLEGSDLLAE KADRREFVSL LKKMLLIDAD LRITPAETLN HSFVTMKHLL DFPHSNQVKS 540
CFHIMDVCKC RSNLYDLSNR NKTSLMRPVA SGSAANLTAS FTKIGPLRSQ ALTASAHSVL 600
HQGIPLQAGT AQFGCSDIFQ QTLIICPPTL QGITTNHSKP TSFSLRVDNA VPLVTQAHAI 660
QPLQIRAGIL SQTWSNHTQQ ILVPAWQQVA PVAAPATSLA SDPVAGPQRL GDWGKMITQG 720
THYNSVMPQP LLTHQITFSA PQPISVGIAH VVWPQPAATK RNKLCQNRSN ALQNTNIQNS 780
ALISPKIINL KAVKRISCIE AQDNHNSDGQ ESNCCEASVR LEPDSSLSNK QRQAIFIAGS 840
PSPAVSVITI SSDTDEDDLG QTRSLRECKG SLDCEACQNT LNIDRVCSLS SQDSTLSTSS 900
SGQSSPSPCK RSNSMSDDEQ ESGCDTVDGS PTSDSSGHDS PFVEDGFVAN TNKNKEARAS 960
VNSETKSAVC TVVVPPMSLE NRLRLDEQMV NTEDATCQPL KNGRSVLGRK TQSSAVGNRQ 1020
QKLASAFHQQ HLNFSQVQHF GSAPQEWNGN YAHRRQQAYI PASVASHAFS LPQGSPNPTT 1080
VHAHLSGSTH LGGQPAILPY PSSAPLSTAA PVAHLLASPC TSRPLLQHPT YNISHPSGIV 1140
HQVPVGINPR LLPSPTIHQT QYKPIFPPHS YIAASPAYTG FPLSPTKLSQ YPFM 1194
Nucleotide Sequence
(FASTA)
ATGGCCTCAC AAGTCTTGGT CTATCCACCA TATGTTTATC AAACCCAGTC AAGTGCCTTT 60
TGTAGTGTGA AAAAACTCAA ACTAGAACCA AGCAGTTGTG TGTACCACGA AAGAGCCTAC 120
CCACAAATCT ATGTGAATGG TAAAAACTTT GGAATCTCTC CCCACAGGGT TAGTACTTTC 180
CTTCAGACTA AAAACCCATT TGACAGACCT CGAGGACAGA ACGTTTTGTT GCAGTCAAAT 240
GCTGTTGCTT TAAAAAATAT TGCAGGTGCT ACAAAAGCGT TAGCGGCGCA GGCGCAGCAA 300
GCTCAGTTGG AAGCACCTCG GAGTGGGACA CAAGGAAGCA GAGCAGATAT ACTGGAAGGA 360
CCCCAGCGAT GTGGATTGAA GCGTAAGAGT GAAGAGCTAG ATAATCAAAG CAGCACGATG 420
CAGATTGTTG ATGAACTGTC CATATTGCCT GCGATGTTGC AAACCAATGT AGGAAACCCA 480
GTGACAGTTG TGACAACTGC TGCAACTTCA AAACAAACTG GTACAAGCGG AGATGGAGAC 540
TACCAGCTGG TACAGCATGA GGTTTTGTGC TCGGTGAAAA ATACTTATGA GGTTCTTGAT 600
TTCCTTGGGC GAGGGACCTT CGGTCAAGTG GTGAAGTGCT GGAAAAGGGG GACAAATGAG 660
ATTGTGGCAA TCAAAATCTT GAAGAATCAT CCTTCGTACG CACGCCAAGG ACAAATAGAA 720
GTGAGCATAT TAGCGAGACT AAGTACTGAA AATGCTGATG AATTCAATTT TGTGAGAGCC 780
TACGAATGCT TTCAGCATCG TAACCATACT TGTCTGGTTT TCGAGATGTT GGAACAGAAT 840
TTATATGACT TCCTGAAGCA AAACAAATTC AGCCCTCTGC AACTGAAAGT AATACGGCCT 900
ATTCTACAAC AGGTGGCCAC TGCACTGAAA AAACTAAAAA GTCTTGGTTT AATCCACGCT 960
GACCTCAAAC CAGAGAACAT TATGTTGGTG GATCCCGTTC GGCAGCCTTA CCGGGTTAAA 1020
GTAATAGATT TTGGGTCTGC CAGCCATGTA TCAAAGACTA TTTGTTCAAC CTATTTACAA 1080
TCCCGGTATT ATAGAGCACC AGAGATCATA CTGGGATTGC CGTTTTGTGA AGCCATAGAC 1140
ATGTGGTCAT TAGGGTGTGT GATTGCAGAG CTGTTCCTTG GATGGCCACT GTACCCAGGA 1200
GCACTGGAAT ATGACCAGAT TCGTTACATT TCTCAGACTC AAGGTTTGCC AGGAGAACAG 1260
TTGTTAAGCA TGGGGACGAA AACTGCAAGA TTTTTCTGTA GAGAAACAGA TGCACCATAT 1320
TCTAGTTGGA GATTAAAGAC TTTGGAAGAG CACGAGGCAG AGACAGGTAT GAAGTCTAAA 1380
GAGGCCAGGA AGTATATTTT CAACAGTTTG GATGATATAG TGCATGTGAA CATGGTGATG 1440
GATTTGGAAG GAAGTGACCT GTTGGCAGAG AAGGCAGACA GGAGGGAATT TGTCAGTCTG 1500
TTGAAGAAAA TGTTGCTGAT TGATGCCGAT TTAAGAATCA CTCCAGCTGA GACACTGAAC 1560
CATTCTTTTG TTACCATGAA GCACCTCCTC GATTTTCCTC ATAGCAACCA AGTGAAGTCC 1620
TGTTTTCACA TCATGGATGT TTGCAAATGC AGATCAAACT TATATGACCT AAGCAACCGC 1680
AATAAAACAT CGCTTATGAG ACCAGTTGCC TCAGGCAGTG CAGCTAATCT GACTGCAAGC 1740
TTCACCAAAA TTGGCCCGTT AAGAAGCCAG GCTTTAACTG CGTCTGCCCA CTCAGTTTTA 1800
CACCAAGGAA TCCCACTGCA GGCAGGAACT GCTCAGTTTG GTTGCAGTGA CATTTTCCAG 1860
CAGACACTGA TTATATGTCC TCCGACTCTT CAAGGAATTA CTACAAACCA TAGTAAACCC 1920
ACAAGTTTCT CCCTGAGGGT GGACAACGCA GTTCCGTTGG TGACCCAGGC CCATGCAATT 1980
CAGCCACTAC AGATTCGAGC AGGAATCCTT TCTCAGACAT GGTCAAACCA CACCCAGCAA 2040
ATCCTGGTTC CTGCGTGGCA GCAAGTGGCA CCAGTGGCAG CCCCTGCAAC ATCTCTAGCT 2100
TCTGATCCTG TGGCTGGCCC ACAGAGGCTT GGAGACTGGG GGAAGATGAT TACCCAGGGC 2160
ACTCATTACA ACTCAGTGAT GCCGCAGCCT CTTTTAACCC ATCAAATAAC CTTTTCTGCC 2220
CCACAGCCAA TTAGTGTGGG CATTGCACAT GTTGTCTGGC CTCAGCCTGC AGCTACCAAG 2280
AGGAATAAAC TGTGTCAGAA CAGGAGCAAT GCGTTGCAAA ATACCAATAT CCAAAATTCA 2340
GCCTTGATAT CTCCAAAGAT AATTAACCTG AAGGCTGTAA AGAGAATAAG CTGTATAGAA 2400
GCACAGGACA ATCATAACTC AGATGGACAG GAGAGTAACT GCTGCGAAGC GTCGGTCAGG 2460
CTGGAACCTG ATTCATCTCT TTCCAACAAG CAGCGACAGG CTATCTTCAT CGCGGGCTCC 2520
CCCAGCCCTG CAGTCAGTGT GATCACCATC AGCAGCGACA CGGATGAAGA TGACTTAGGT 2580
CAAACACGTT CTCTGAGAGA GTGCAAAGGT AGCCTTGACT GTGAAGCCTG CCAAAATACT 2640
CTGAATATTG ACCGTGTATG TTCTCTAAGC AGTCAAGATA GCACTCTGAG CACGAGCTCC 2700
TCGGGACAGT CTAGTCCATC TCCTTGCAAG AGATCCAACA GTATGTCAGA TGATGAACAG 2760
GAAAGTGGAT GTGATACGGT GGATGGTTCC CCAACTTCAG ACTCTTCAGG ACATGACAGC 2820
CCGTTTGTAG AAGATGGCTT TGTAGCTAAT ACCAACAAAA ATAAGGAAGC AAGAGCATCA 2880
GTTAATTCCG AAACCAAATC AGCTGTTTGC ACAGTAGTGG TTCCACCAAT GAGTCTTGAA 2940
AACAGATTAC GTCTTGACGA ACAGATGGTG AACACAGAAG ATGCTACTTG TCAGCCATTG 3000
AAAAATGGTC GGTCTGTCCT GGGAAGAAAA ACCCAGTCTT CTGCTGTGGG AAACCGTCAG 3060
CAAAAACTGG CATCAGCATT CCATCAGCAA CATTTAAACT TCAGCCAGGT GCAGCACTTC 3120
GGATCTGCGC CGCAGGAATG GAATGGAAAC TACGCTCATC GAAGGCAGCA GGCCTACATC 3180
CCAGCAAGCG TTGCCAGTCA CGCTTTCTCC CTTCCACAAG GAAGTCCAAA CCCCACTACC 3240
GTGCACGCGC ATCTCTCTGG AAGCACCCAC CTGGGAGGAC AGCCTGCTAT TCTTCCGTAC 3300
CCATCGTCAG CACCCCTTAG TACTGCTGCA CCCGTTGCCC ACCTCCTTGC TTCGCCATGT 3360
ACCTCAAGAC CCTTACTGCA ACATCCAACG TACAACATAT CTCACCCCAG TGGTATAGTT 3420
CACCAAGTTC CAGTTGGCAT AAATCCCCGT CTCTTACCTT CCCCAACCAT TCATCAGACT 3480
CAGTACAAAC CAATTTTTCC ACCACATTCG TACATTGCAG CATCACCTGC TTACACGGGA 3540
TTTCCATTGA GTCCAACAAA ACTCAGCCAG TACCCATTTA TGTGA 3585
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevl+++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 196   YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ENADE  254
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         +n+vr++e+f++rnh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aLk+Lk+
Q: 255   FNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLQLKVIRPILQQVATALKKLKS  314
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs++ ++ty+qsr+YraPEiilgl+
Q: 315   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKTICSTYLQSRYYRAPEIILGLP  374
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG+ e+dq+++i++++glp e+ll+ ++k+ +ff  
Q: 375   FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLSMGTKTARFFcr  434
         **********************************************************99
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
          t+  ++ ++lkt          ks++++k+++n  +++ ++++ ++ e ++ l+ek+d+
Q: 435   eTDAPYSSWRLKTLeeheaetgmKSKEARKYIFNSLDDIVHVNMVMDLEGSDLLAEKADR  494
         888899999999999********************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + f++llk+ml +d++ Ritp+e+l+h+fv
Q: 495   ReFVSLLKKMLLIDADLRITPAETLNHSFV  524
         99***************************7
Domain Sequence
(FASTA)
YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTENADEF 60
NFVRAYECFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLQL KVIRPILQQV ATALKKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKTIC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGEQLLSMG TKTARFFCRE 240
TDAPYSSWRL KTLEEHEAET GMKSKEARKY IFNSLDDIVH VNMVMDLEGS DLLAEKADRR 300
EFVSLLKKML LIDADLRITP AETLNHSFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00252
EKS-ANC-00259
EKS-BOT-00270
EKS-CAJ-00276
EKS-CAF-00277
EKS-CAP-00305
EKS-DAR-00610
EKS-DIO-00021
EKS-EQC-00262
EKS-FEC-00256
EKS-GAA-00333
EKS-GOG-00269
EKS-HOS-00276
EKS-ICT-00259
EKS-LAC-00281
EKS-LOA-00280
EKS-MAM-00272
EKS-MEG-00215
EKS-MOD-00267
EKS-MUM-00301
EKS-MUP-00267
EKS-MYL-00272
EKS-NOL-00247
EKS-ORN-00349
EKS-ORA-00234
EKS-ORC-00255
EKS-ORL-00325
EKS-OTG-00276
EKS-PAT-00255
EKS-PES-00240
EKS-POA-00260
EKS-RAN-00285
EKS-SAH-00254
EKS-SUS-00232
EKS-TAG-00285
EKS-TAR-00346
EKS-VIP-00012
EKS-XET-00344
EKS-XIM-00341
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009299; P:mRNA transcription
GO:0043508; P:negative regulation of JUN kinase activity
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013