EPS-GAG-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAG-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	287.0	1.7E-85	23	289	267

Status

Unreviewed

Ensembl Protein

ENSGALP00000019417

UniProt Accession

E1BVM8;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000011917	ENSGALP00000019417	ENSGALT00000019443

Organism

Gallus gallus

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPNGL DGWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT SNQDFKGPDG PPSVESVKSG IRTGFLQIDE HMRVISEKKH 120

GADRSGSTAV GVMISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VYEIERSEED DQFIILACDG 240

IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE IVDTCLYKGS RDNMSVILIC FPNAPKVSPE 300

AVKREAELDK YLESRVEEII KKQGEGVPDL VHVMRTLATE SIPNLPPGGE LASKRSVIEA 360

VYNRLNPYRN DDTDSASTDD MW 382

Nucleotide Sequence
(FASTA)

ATGGGAGCAT TTTTAGACAA GCCAAAGATG GAGAAGCATA ATGCCCAAGG GCAAGGGAAT 60

GGGCTTCGTT ATGGTCTGAG TAGTATGCAA GGCTGGCGAG TCGAAATGGA GGATGCACAT 120

ACAGCTGTGA TTGGTTTGCC AAATGGACTT GATGGATGGT CATTTTTTGC TGTATACGAT 180

GGGCACGCTG GATCACAGGT TGCCAAGTAC TGCTGTGAGC ATTTATTAGA TCACATCACA 240

AGCAACCAGG ATTTTAAAGG GCCAGATGGG CCACCATCTG TGGAAAGTGT AAAGAGTGGC 300

ATCAGAACAG GTTTTCTGCA AATTGATGAA CACATGAGAG TCATCTCTGA GAAGAAACAT 360

GGTGCAGACA GAAGTGGGTC AACAGCTGTG GGTGTCATGA TTTCTCCCCA ACATACATAC 420

TTCATCAACT GTGGAGACTC AAGAGGTTTA CTTTGTAGAA ACAGGAAGGT TCACTTCTTC 480

ACACAGGATC ACAAACCAAG CAACCCACTG GAGAAAGAGC GTATACAGAA TGCAGGCGGC 540

TCTGTGATGA TTCAGCGTGT GAATGGCTCT CTTGCTGTTT CAAGGGCACT CGGGGACTTT 600

GATTACAAAT GTGTCCATGG GAAAGGTCCT ACAGAACAGC TAGTCTCTCC AGAGCCTGAA 660

GTTTATGAAA TTGAGAGATC AGAAGAAGAT GATCAGTTCA TCATACTGGC TTGCGATGGT 720

ATCTGGGATG TTATGGGAAA TGAAGAGCTC TGTGACTTTG TAAGATCCAG ACTTGAAGTC 780

ACTGATGACC TTGAGAAAGT TTGCAATGAG ATAGTTGACA CCTGCTTGTA CAAGGGAAGT 840

CGAGACAACA TGAGTGTGAT ACTGATCTGT TTTCCGAATG CACCAAAGGT ATCACCGGAG 900

GCGGTGAAAA GAGAGGCAGA GTTGGACAAG TACCTGGAAA GCAGAGTAGA AGAGATCATA 960

AAGAAGCAGG GTGAAGGAGT GCCAGACTTA GTCCACGTGA TGCGTACGTT AGCAACTGAG 1020

AGCATCCCAA ACCTCCCGCC AGGGGGTGAA TTGGCAAGCA AACGGAGTGT AATTGAAGCT 1080

GTTTATAACA GACTGAACCC CTACAGGAAT GATGATACTG ATTCTGCCTC AACTGATGAT 1140

ATGTGGTAA 1149

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t+   ++  p+  d ++ff+vyDGh+gs+vak+c e+l +++

Q: 23    RYGLSSMQGWRVEMEDAHTA---VIGLPNGLDGWSFFAVYDGHAGSQVAKYCCEHLLDHI  79

         69****************98...5555555666***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         + + +    ++ ++ + vk+ ++++Fl++de+++v++ek++  d+sGstav ++i++++

Q: 80    TSNQDfkgpDGPPSVESVKSGIRTGFLQIDEHMRVISEKKHGADRSGSTAVGVMISPQHT  139

         ***998888888999*********************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcrn+k++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 140   YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  196

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev+++++++ed+ f+iLa+DG+wdv+ nee++++vr+

Q: 197   LGDFDYKcvhgkgpteQLVSPEPEVYEIERSEEDDqFIILACDGIWDVMGNEELCDFVRS  256

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +le +++++++++++v+++l +gs+dn+s+i++

Q: 257   RLEVTDDLEKVCNEIVDTCLYKGSRDNMSVILI  289

         ****************************99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPNGLDG WSFFAVYDGH AGSQVAKYCC EHLLDHITSN 60

QDFKGPDGPP SVESVKSGIR TGFLQIDEHM RVISEKKHGA DRSGSTAVGV MISPQHTYFI 120

NCGDSRGLLC RNRKVHFFTQ DHKPSNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVY EIERSEEDDQ FIILACDGIW DVMGNEELCD FVRSRLEVTD 240

DLEKVCNEIV DTCLYKGSRD NMSVILI 267

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004871	; F:signal transducer activity
GO:0010991	; P:negative regulation of SMAD protein complex assembly
GO:0030512	; P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0030177	; P:positive regulation of Wnt receptor signaling pathway
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

gga:423525

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013