EKS-GAG-00239

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00239

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	371.0	4.4E-111	233	526	294

Status

Unreviewed

Ensembl Protein

ENSGALP00000019666

UniProt Accession

E1BQF4;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC424261

Gene Synonyms/Alias

LOC424261;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000012055	ENSGALP00000019666	ENSGALT00000019692

Organism

Gallus gallus

Functional Description

Protein Length

567

Protein Sequence
(FASTA)

MGCRRRPGLL SLLLLSFSCC ASARRSLKTN LCKWCDSTPP ACEREVCYSN CNLNSYCEDP 60

FEICVAIWRQ DNDSIRISTL CHNPHRPIEN LMVPNYNTSR CIMTHQPSED GIIYICGCVD 120

EQECNDKLIF ENHTNGYSML QSKEVIPVAA ISLLPPLLVA VMITVIFYLC RTQKQRKRAK 180

SWVGKQGQGP ALPEPGRAAE RDEKLSVLMD DGPAAMNATC ANSLNHNTEL LPIELDEMVG 240

KGQFAEVWRA KLNHSSSGQY ETVAVKIFPC EEYSSWKNES QIFTDASLKH DSVLQFLTAE 300

DRGSGPRREY WLITAYHSRG NLKDYLSRHI LSWMDLQKMA GSLVNGVAHL HSDYTACGRP 360

KIPIAHRDIK STNILVKNEQ ECVICDFGIA IRLDPSLTAD DFANSGQVGT ARYMAPEVLE 420

SRVNLEDLES FKQMDVYSMA LVLWEMASRC EVVGEVKNYE LPFGSKVQEQ PCVDTMRDIV 480

LHGRGRPEIP SSWLVHQGMR FLCDTITECW DHDPEARLTA HCVAERFNLM AQMDCDDILN 540

NNTDNEVGKT ASAGGEQRDN DGSRSAP 567

Nucleotide Sequence
(FASTA)

ATGGGTTGCC GGAGGAGACC GGGTCTGCTT TCCTTGCTGC TGCTGTCCTT CTCCTGCTGT 60

GCCAGCGCGC GCCGCAGCCT GAAGACCAAC CTGTGCAAGT GGTGCGACTC CACGCCGCCG 120

GCCTGCGAGC GGGAGGTGTG CTACAGCAAC TGCAACCTCA ACTCCTACTG CGAGGACCCC 180

TTTGAGATCT GCGTGGCCAT ATGGAGGCAG GACAACGACA GCATCAGGAT CAGCACACTC 240

TGCCACAACC CCCACCGCCC CATAGAGAAC CTCATGGTCC CCAACTACAA CACCTCGCGC 300

TGCATCATGA CCCACCAGCC CAGCGAGGAT GGCATCATCT ACATCTGTGG CTGCGTGGAT 360

GAGCAGGAGT GCAATGATAA GCTTATCTTC GAAAATCATA CCAATGGCTA CTCCATGCTG 420

CAGAGCAAGG AGGTCATCCC GGTGGCCGCC ATCAGCCTCC TGCCGCCGTT GCTGGTGGCA 480

GTGATGATCA CCGTCATCTT CTACCTCTGC CGCACACAGA AGCAACGCAA GAGGGCCAAG 540

AGCTGGGTTG GGAAGCAGGG ACAGGGTCCA GCACTGCCAG AGCCGGGCAG GGCTGCCGAG 600

CGGGACGAGA AGCTGTCTGT GCTGATGGAT GATGGCCCGG CCGCCATGAA TGCCACCTGC 660

GCCAACAGCC TCAACCACAA CACCGAGCTG CTGCCCATCG AGCTGGACGA GATGGTAGGC 720

AAGGGGCAGT TTGCGGAGGT GTGGAGGGCT AAGCTGAACC ACAGCAGCTC AGGGCAGTAC 780

GAGACGGTGG CGGTGAAGAT CTTTCCCTGT GAGGAGTATT CTTCCTGGAA GAACGAGAGC 840

CAGATCTTCA CGGACGCCAG CCTCAAGCAT GACAGTGTCC TGCAATTCCT CACGGCTGAG 900

GACAGGGGTT CGGGGCCACG CAGAGAGTAC TGGCTCATCA CCGCCTACCA CAGCAGGGGC 960

AACCTCAAGG ACTATCTCTC CAGACACATC CTGAGCTGGA TGGACCTGCA AAAAATGGCG 1020

GGGTCGCTGG TGAACGGGGT GGCCCACCTC CACAGCGATT ACACCGCCTG CGGCCGGCCG 1080

AAAATCCCCA TTGCCCACCG GGACATCAAA AGCACCAACA TCCTGGTGAA GAACGAGCAG 1140

GAGTGCGTGA TCTGTGACTT CGGCATTGCC ATACGCCTTG ACCCCTCACT GACGGCAGAT 1200

GACTTTGCTA ACAGCGGGCA AGTGGGCACT GCCAGGTACA TGGCTCCAGA GGTCCTGGAG 1260

TCCAGGGTGA ACCTGGAAGA TCTGGAGTCT TTCAAGCAGA TGGACGTCTA CTCCATGGCC 1320

CTTGTTCTGT GGGAGATGGC CTCCAGATGT GAAGTGGTGG GAGAGGTAAA GAATTACGAG 1380

CTGCCTTTTG GGTCAAAAGT GCAGGAGCAG CCCTGTGTGG ACACCATGAG AGACATCGTG 1440

CTGCATGGCA GAGGGCGGCC TGAGATCCCT AGCAGCTGGC TGGTGCACCA GGGGATGCGC 1500

TTCCTGTGCG ACACCATCAC GGAGTGCTGG GACCACGACC CCGAGGCTCG CCTCACCGCA 1560

CACTGCGTGG CCGAGCGCTT CAACCTGATG GCGCAGATGG ATTGCGACGA CATCCTCAAC 1620

AACAACACGG ACAACGAGGT CGGCAAAACA GCCTCTGCGG GCGGGGAGCA GCGGGACAAC 1680

GACGGGAGCA GGAGTGCGCC GTGA 1704

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l e++gkG+++eVw+akl++      e+vAvKif+ e+ +swk+E++i++   l+h++

Q: 233   IELDEMVGKGQFAEVWRAKLNHsssgqyETVAVKIFPCEEYSSWKNESQIFTDASLKHDS  292

         6899****************999999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         +lqf++a+ + ++ + e++l+t+yh +g+L dyL+r++l++ +l ++a sl++G+ahLH+

Q: 293   VLQFLTAEDRGSGPRREYWLITAYHSRGNLKDYLSRHILSWMDLQKMAGSLVNGVAHLHS  352

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         +  + +g+ K  iaHRD+ks Nilvk+++ c+i+D+G+a++l+ + ++ d a++ qvGt

Q: 353   DY-TACGRPKIPIAHRDIKSTNILVKNEQECVICDFGIAIRLDPSLTADDFANSGQVGTA  411

         *5.66799****************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+d+e+fk++DvYs++LvlWE+asRce   +ev++y+lpf ++v+++

Q: 412   RYMAPEVLESRVNLEDLESFKQMDVYSMALVLWEMASRCEV-VGEVKNYELPFGSKVQEQ  470

         ****************************************9.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P+++ m+++v++ + rP+ip++w  ++ ++ l+++++ecWd+dpeaRlta++v++r

Q: 471   PCVDTMRDIVLHGRGRPEIPSSWLVHQGMRFLCDTITECWDHDPEARLTAHCVAER  526

         *****************************************************987

Domain Sequence
(FASTA)

IELDEMVGKG QFAEVWRAKL NHSSSGQYET VAVKIFPCEE YSSWKNESQI FTDASLKHDS 60

VLQFLTAEDR GSGPRREYWL ITAYHSRGNL KDYLSRHILS WMDLQKMAGS LVNGVAHLHS 120

DYTACGRPKI PIAHRDIKST NILVKNEQEC VICDFGIAIR LDPSLTADDF ANSGQVGTAR 180

YMAPEVLESR VNLEDLESFK QMDVYSMALV LWEMASRCEV VGEVKNYELP FGSKVQEQPC 240

VDTMRDIVLH GRGRPEIPSS WLVHQGMRFL CDTITECWDH DPEARLTAHC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013