EPS-GAG-00035

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAG-00035

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	86.0	3.6E-24	54	333	280

Status

Unreviewed

Ensembl Protein

ENSGALP00000019817

UniProt Accession

E1C0Y2;

Protein Name

Protein Synonyms/Alias

Gene Name

TAB1

Gene Synonyms/Alias

TAB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000012150	ENSGALP00000019817	ENSGALT00000019844
ENSGALG00000012150	ENSGALP00000019827	ENSGALT00000019854
ENSGALG00000012150	ENSGALP00000037089	ENSGALT00000037882

Organism

Gallus gallus

Functional Description

Protein Length

437

Protein Sequence
(FASTA)

MAAQRRSLLQ SEQQPSWTDD LPSCHLSGVG SAPNRSYSAD GKGTEGHPLE DNWLKFRSEN 60

NCYLYGVFNG YDGNRVTNFV GQRLSAELLL GQLHADHSDA DVRRVLLQAF DVVERSFLES 120

IDDALAEKAS LQSQLPEGVP HHQLPPQYQK IVERLKVVEQ EISGGAMAIV AVVLNNKLYI 180

ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRFSQ LGLDAGKIKQ VGTIRGQEST 240

RRIGDYKVKY GYTDIELLSA AKSKPIIAEP EIHGGHSLDG VTGFLVLMSE GLYKALEAAH 300

GPGQANQEIA AMIATEFAKQ TSLDAVAQAV VDRVKRIHCD TFASGGERSK FCPRHEDMTL 360

LVRNFGYPLG EMSQPTLTPT QGGRVYPVSV PYSSSQSTSK TSVTLSLVMP SQGQMVNGAH 420

SSSWMKPPPP SLTKAPL 437

Nucleotide Sequence
(FASTA)

ATGGCGGCGC AGAGGAGGAG TCTGCTGCAG AGTGAACAGC AGCCCAGCTG GACAGATGAC 60

TTACCGTCCT GCCATCTCTC GGGGGTGGGC TCAGCTCCAA ACCGTTCCTA CAGTGCTGAC 120

GGCAAGGGTA CAGAGGGTCA CCCCTTGGAA GATAACTGGT TGAAATTCAG GAGTGAGAAC 180

AACTGCTACC TCTATGGTGT CTTCAATGGC TATGATGGCA ACCGAGTCAC CAACTTTGTG 240

GGCCAGAGGC TGTCTGCAGA ATTGCTGCTG GGCCAGCTGC ACGCAGATCA CAGTGATGCT 300

GATGTGCGCC GAGTTCTGCT GCAGGCATTT GATGTGGTAG AAAGAAGTTT CTTGGAGTCT 360

ATTGATGATG CTTTGGCAGA GAAGGCCAGC CTGCAGTCCC AGCTGCCAGA GGGTGTTCCT 420

CACCACCAGC TGCCTCCTCA ATACCAGAAG ATCGTGGAGA GATTGAAAGT TGTAGAGCAG 480

GAGATCTCTG GAGGAGCCAT GGCCATTGTG GCTGTTGTTC TCAACAATAA GCTCTATATC 540

GCCAATGTTG GTACCAATCG TGCACTATTG TGTAAGTCCA CAGTGGATGG GCTGCAGGTG 600

ACTCAGCTAA ACGTGGACCA CACGACAGAG AACGAGGATG AACTTTTTCG CTTCTCTCAG 660

CTGGGCTTGG ATGCAGGGAA GATAAAACAA GTGGGCACTA TCCGTGGGCA GGAAAGCACT 720

CGGCGCATTG GAGACTACAA AGTCAAATAT GGCTATACTG ATATTGAACT GCTCAGCGCT 780

GCTAAATCTA AGCCTATTAT AGCAGAGCCT GAAATCCATG GAGGGCACTC ACTGGATGGA 840

GTGACTGGCT TCTTGGTGCT TATGTCTGAA GGGCTTTACA AAGCTCTGGA GGCAGCTCAT 900

GGGCCTGGGC AGGCCAACCA GGAAATTGCA GCCATGATAG CCACAGAGTT TGCCAAGCAG 960

ACATCGCTGG ATGCTGTGGC CCAGGCTGTA GTGGACCGGG TTAAACGGAT CCACTGTGAC 1020

ACTTTTGCCA GTGGTGGGGA ACGGTCCAAG TTCTGTCCCC GCCATGAAGA CATGACCCTG 1080

CTTGTGAGGA ATTTTGGCTA TCCCTTGGGT GAAATGAGTC AGCCCACGCT AACACCAACA 1140

CAAGGGGGCC GTGTCTACCC AGTCTCTGTG CCATATTCCA GCTCCCAAAG CACGAGCAAA 1200

ACGAGCGTCA CGCTGTCTCT TGTCATGCCT TCCCAAGGCC AGATGGTCAA TGGTGCTCAC 1260

AGCAGCTCAT GGATGAAGCC ACCCCCACCC TCACTAACCA AAGCCCCACT GTGA 1314

Domain Profile

S: 26    lkspekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaFls  85

         lk +++++  +++gv++G  g++v++f+ ++l+  l       + ++++v+++l +aF

Q: 54    LKFRSENN-CYLYGVFNGYDGNRVTNFVGQRLSAELLLGQLHADHSDADVRRVLLQAFDV  112

         55555555.69*********************97666555558999**************

S: 86    tdeel...................................kvleeksldidksGstavva  110

         +++ +                                   + l+ + +++ + G+ a va

Q: 113   VERSFlesiddalaekaslqsqlpegvphhqlppqyqkivERLKVV-EQEISGGAMAIVA  171

         ******************************9999998553333333.3444499******

S: 111   likdsklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvilk  163

         ++ ++kly+anvG  ra+Lc++  +   + +l +dH++++edEl R ++ g   g++ +

Q: 172   VVLNNKLYIANVGTNRALLCKSTvDglqVTQLNVDHTTENEDELFRFSQLGldaGKIKQV  231

         ********************9663366699*********************977777776

S: 164   dgaRvlGvLavsRalGdlylk..............pyvtpePevts.hrltsedefliLa  208

             + G  + +R +Gd+++k              + +++ePe++  h l+  + fl+L

Q: 232   G--TIRG-QESTRRIGDYKVKygytdiellsaaksKPIIAEPEIHGgHSLDGVTGFLVLM  288

         5..7778.489***********************999*******95488999999*****

S: 209   sDGlwdvvs........neeavslvrdvlekkeaeqeaakkLvkl  245

         s Gl++ ++        n+e+ +++     k+++++++a+ +v++

Q: 289   SEGLYKALEaahgpgqaNQEIAAMIATEFAKQTSLDAVAQAVVDR  333

         ******986333333335666666655555677777777777765

Domain Sequence
(FASTA)

LKFRSENNCY LYGVFNGYDG NRVTNFVGQR LSAELLLGQL HADHSDADVR RVLLQAFDVV 60

ERSFLESIDD ALAEKASLQS QLPEGVPHHQ LPPQYQKIVE RLKVVEQEIS GGAMAIVAVV 120

LNNKLYIANV GTNRALLCKS TVDGLQVTQL NVDHTTENED ELFRFSQLGL DAGKIKQVGT 180

IRGQESTRRI GDYKVKYGYT DIELLSAAKS KPIIAEPEIH GGHSLDGVTG FLVLMSEGLY 240

KALEAAHGPG QANQEIAAMI ATEFAKQTSL DAVAQAVVDR 280

Keyword

Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0003824	; F:catalytic activity
GO:0019209	; F:kinase activator activity
GO:0000185	; P:activation of MAPKKK activity
GO:0008152	; P:metabolic process
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR008253	; Marvel.
IPR021128	; MARVEL-like_dom.
IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF01284	; MARVEL; 1.
PF00481	; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

PS51225

; MARVEL; 1.

Prints

Created Date

20-Feb-2013