EKS-GAG-00233

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00233

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	449.8	4.2E-135	204	491	288

Status

Unreviewed

Ensembl Protein

ENSGALP00000036862

UniProt Accession

F1NIC3;

Protein Name

Protein Synonyms/Alias

Bone morphogenetic protein receptor type-1B;

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000012216	ENSGALP00000019925	ENSGALT00000019952
ENSGALG00000012216	ENSGALP00000036862	ENSGALT00000037656

Organism

Gallus gallus

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MPLLSSSKLS VESRKEDGEG TAPAPPQKKL SCQCHHHCPE DSVNSTCSTD GYCFTIIEED 60

DSGGHLVTKG CLGLEGSDFQ CRDTPIPHQR RSIECCTGQD YCNKHLHPTL PPLKNRDFAE 120

GNIHHKALLI SVTVCSILLV LIIIFCYFRY KRQEARPRYS IGLEQDETYI PPGESLKDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKG 300

MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360

TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEI ARRCVSGGIV 420

EEYQLPYHDL VPSDPSYEDM REIVCIKRLR PSFPNRWSSD ECLRQMGKLM MECWAHNPAS 480

RLTALRVKKT LAKMSESQDI KL 502

Nucleotide Sequence
(FASTA)

ATGCCCTTGC TAAGCTCCAG CAAGTTGAGC GTGGAGAGCA GAAAAGAAGA TGGTGAGGGC 60

ACAGCACCTG CCCCTCCACA GAAGAAGCTG TCATGTCAGT GCCACCACCA TTGTCCTGAG 120

GACTCAGTCA ACAGCACCTG CAGCACTGAT GGCTACTGCT TCACCATAAT AGAAGAAGAT 180

GATTCTGGTG GACATTTGGT CACCAAAGGA TGTCTAGGAT TAGAGGGCTC GGACTTCCAA 240

TGTCGGGACA CTCCTATTCC ACACCAAAGA AGATCTATTG AATGCTGCAC AGGCCAAGAT 300

TACTGTAACA AACATCTTCA CCCAACGCTG CCACCACTGA AAAATCGAGA CTTTGCTGAA 360

GGAAACATTC ACCATAAGGC CCTGCTGATC TCGGTGACTG TCTGTAGTAT ACTACTGGTG 420

CTTATCATCA TATTCTGCTA CTTCAGGTAC AAGCGGCAAG AAGCCAGGCC CCGCTACAGC 480

ATCGGGCTGG AGCAGGACGA GACCTACATT CCCCCTGGAG AATCCCTGAA GGATCTGATC 540

GAGCAGTCCC AGAGCTCAGG CAGCGGCTCC GGGCTCCCTC TCCTGGTTCA AAGGACCATA 600

GCAAAACAGA TTCAGATGGT AAAACAGATT GGAAAAGGTC GCTATGGGGA AGTCTGGATG 660

GGAAAGTGGC GTGGCGAAAA GGTAGCTGTC AAAGTGTTTT TTACCACGGA GGAGGCCAGC 720

TGGTTCAGAG AAACAGAAAT CTACCAAACT GTCCTGATGA GGCATGAAAA TATTCTCGGA 780

TTCATTGCGG CAGACATTAA AGGCACAGGC TCTTGGACCC AACTGTATCT CATCACTGAC 840

TATCATGAGA ATGGCTCCCT TTACGATTAC CTAAAATCCA CCACCCTGGA CACAAAAGGC 900

ATGCTAAAAT TGGCTTACTC CTCTGTTAGT GGCTTGTGCC ACCTACATAC AGAGATCTTC 960

AGTACCCAAG GCAAACCGGC TATTGCCCAC CGTGATCTAA AAAGTAAGAA CATCCTGGTG 1020

AAAAAGAACG GAACCTGCTG TATAGCAGAT TTGGGCTTGG CTGTTAAATT TATTAGTGAT 1080

ACAAATGAGG TAGACATCCC TCCAAACACC CGCGTAGGAA CAAAACGCTA TATGCCTCCT 1140

GAGGTGCTGG ATGAAAGCTT GAACAGAAAT CACTTTCAGT CGTACATCAT GGCTGATATG 1200

TACAGCTTTG GACTCATCCT TTGGGAGATA GCCAGGAGAT GTGTGTCAGG AGGAATAGTG 1260

GAAGAATACC AGCTCCCATA TCACGACCTT GTCCCCAGTG ACCCCTCCTA CGAGGACATG 1320

AGGGAGATTG TGTGCATCAA AAGGCTACGT CCTTCATTCC CCAACAGATG GAGCAGCGAT 1380

GAGTGCCTGC GGCAGATGGG GAAGCTCATG ATGGAGTGCT GGGCCCATAA CCCTGCATCC 1440

CGGCTCACAG CCCTACGAGT CAAAAAAACA CTTGCCAAAA TGTCAGAGTC GCAGGACATT 1500

AAGCTCTGA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  263

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++ +l+la+s +sGl+hLH+ei+ t+

Q: 264   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKGMLKLAYSSVSGLCHLHTEIFSTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWE+a+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 382   VLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ k+lrP++p++w+++e+l+++ kl+ ecW+++p++Rltalrvkk+l

Q: 441   REIVCIKRLRPSFPNRWSSDECLRQMGKLMMECWAHNPASRLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKGMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEIARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKRLRPSF PNRWSSDECL RQMGKLMMEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0030154	; P:cell differentiation
GO:0006954	; P:inflammatory response
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013