EKS-GAG-00269
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00269
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20344.25.1E-10320277258
StatusUnreviewed
Ensembl ProteinENSGALP00000020106
UniProt AccessionF1NAN8;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K5
Gene Synonyms/Alias MAP4K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000012321ENSGALP00000020106ENSGALT00000020133
OrganismGallus gallus
Functional Description
Protein Length846
Protein Sequence
(FASTA)
PAAMERPSGD IMRRNPQQDY ELIQRVGSGT YGDVYKARNL HTGELAAVKI IKLEPGDDFS 60
LIQQEIYMVK ECKHCNIVAY FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSELQIAYV 120
CRETLQGLAY LHMKGKMHRD IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY 180
WMAPEVAAVE KNGGYNQLCD IWAVGITAIE LAELQPPMFD LHPMRALFLM SKSNFQPPKL 240
KEKAKWSSTF HNFVKIALTK NPKKRPTADR LLAHSFVGQP GLSRSLAVEL LDKVNNPDNH 300
THCSEVDDDD FEPHSVIRHT IRSTNRNVRA ERTASEINFD KLQFEPPLRK ETEARDEMVV 360
AAGTDFASHW NPFVEGGSSK MSTLKRAGPP PLPPKPRINS YPEENLPDDE KSETIKHFPD 420
SQNRAPPAHR RQSIPVCGPQ TDSSPIGNGD GMLKLIEENA EGSGQIPQLP RKKEKRDFPK 480
PAINGLPPTP KVLMGACFSK VFDGCPLKIN CATSWIHPDT KDQYIIFGTE EGIYTLNLNE 540
LHEATMEQLF PRKCTWLYVI NNTLMSLSAG KTFQLYSHNL IALFEQAKKT GLAAHIQTHR 600
FPDRILPRKF ALTTKIPDTK GCHKCCIVRN PYTGHKYLCG ALQSGIVLLQ WYEPMQKFML 660
IKHFDFPLPS PLNVFEMLVI PEQEYPMVCV AISKGAEPNQ VVHFETINLN SASSWFTEIG 720
AGNQQLDAIH VTQLERDTVL VCLDKFVKIV NLQGKLKSSK KLASELSFDF CIESVVCLQD 780
SVLAFWKHGM QGKSFKSDEV TQEISDETRV FRLLGSDRVV VLESRPTENP TAHSNLYILA 840
GHENSY 846
Nucleotide Sequence
(FASTA)
CCCGCCGCCA TGGAGCGGCC GAGCGGGGAC ATCATGCGGC GGAACCCGCA GCAGGACTAC 60
GAGCTGATCC AGCGCGTGGG CAGCGGCACC TACGGCGACG TGTACAAGGC TAGAAATCTT 120
CATACTGGAG AACTGGCTGC TGTAAAAATA ATCAAGTTAG AGCCTGGGGA CGACTTTTCG 180
TTGATCCAGC AGGAAATATA TATGGTAAAA GAATGCAAAC ATTGCAACAT AGTCGCCTAT 240
TTTGGGAGCT ATCTCAGCCG TGAAAAGCTG TGGATATGCA TGGAGTACTG CGGTGGGGGA 300
TCCCTCCAAG ATATCTACCA TGTAACGGGA CCTCTGTCAG AGCTACAAAT TGCATATGTT 360
TGCAGAGAGA CTTTGCAGGG TCTCGCTTAT TTGCATATGA AGGGCAAAAT GCACAGAGAC 420
ATAAAGGGTG CAAATATTCT ACTAACAGAC CATGGAGATG TCAAGTTAGC TGACTTCGGT 480
GTAGCAGCAA AAATAACAGC CACCATTGCA AAGAGGAAAT CATTTATCGG TACCCCTTAC 540
TGGATGGCCC CAGAGGTTGC GGCGGTGGAG AAGAACGGCG GCTACAACCA GCTCTGTGAC 600
ATCTGGGCGG TCGGCATCAC AGCCATCGAG CTGGCGGAGC TTCAGCCCCC CATGTTTGAC 660
CTGCACCCCA TGAGGGCTTT GTTCTTAATG TCCAAAAGTA ATTTTCAACC ACCAAAGCTA 720
AAGGAAAAAG CGAAATGGTC ATCGACATTC CATAACTTTG TCAAAATAGC ACTTACAAAA 780
AATCCAAAGA AGAGACCAAC AGCAGACAGA CTCCTTGCTC ATAGCTTTGT AGGGCAGCCT 840
GGCCTTTCAC GATCTTTAGC AGTTGAGCTG TTGGACAAAG TTAATAATCC TGACAACCAC 900
ACACACTGCA GTGAAGTGGA TGATGATGAT TTTGAGCCTC ATTCTGTTAT TCGCCATACG 960
ATTCGTTCTA CAAACAGGAA TGTTAGGGCA GAAAGAACAG CATCAGAGAT AAACTTTGAT 1020
AAGCTCCAGT TTGAGCCCCC TCTGCGGAAA GAAACAGAAG CTCGGGATGA AATGGTTGTG 1080
GCAGCTGGCA CCGACTTTGC TTCGCATTGG AATCCTTTTG TTGAAGGTGG AAGCAGCAAA 1140
ATGTCAACCC TAAAGCGAGC AGGGCCACCT CCACTACCTC CTAAGCCAAG AATAAACAGT 1200
TACCCTGAGG AAAACCTCCC AGATGATGAG AAATCTGAGA CGATAAAACA CTTCCCTGAC 1260
TCACAGAACA GAGCCCCACC AGCTCATAGG AGGCAGAGTA TTCCTGTCTG TGGGCCTCAG 1320
ACTGACTCTT CCCCCATTGG GAATGGGGAC GGCATGTTGA AACTCATTGA GGAAAATGCA 1380
GAAGGATCTG GACAAATCCC TCAGCTGCCA CGTAAAAAAG AGAAAAGAGA TTTTCCTAAG 1440
CCAGCAATCA ATGGTTTGCC ACCAACGCCA AAGGTGCTGA TGGGAGCGTG TTTCTCCAAA 1500
GTCTTCGATG GGTGCCCTTT GAAGATTAAC TGTGCAACAT CGTGGATTCA TCCAGATACT 1560
AAAGATCAGT ACATCATCTT TGGAACAGAA GAAGGTATCT ATACTTTGAA TTTGAATGAG 1620
CTTCATGAAG CAACAATGGA ACAGTTGTTT CCACGAAAGT GCACCTGGCT GTATGTTATC 1680
AATAACACCT TGATGTCCTT GTCAGCAGGG AAGACGTTCC AGCTCTACTC CCACAATCTG 1740
ATAGCTTTGT TTGAACAAGC CAAAAAAACA GGACTGGCTG CTCACATCCA AACCCATCGG 1800
TTCCCTGACA GAATATTACC AAGGAAGTTT GCCTTAACAA CAAAGATTCC TGACACAAAA 1860
GGGTGTCACA AATGCTGTAT AGTAAGAAAT CCATACACAG GACACAAGTA CCTCTGCGGT 1920
GCGTTGCAGT CTGGAATTGT TCTGCTACAG TGGTATGAGC CAATGCAGAA ATTCATGTTA 1980
ATAAAGCACT TTGATTTTCC TTTGCCGAGC CCTCTGAATG TCTTTGAGAT GCTGGTGATC 2040
CCAGAGCAGG AGTACCCGAT GGTCTGCGTG GCTATCAGTA AAGGCGCTGA GCCAAACCAG 2100
GTCGTTCACT TTGAGACAAT CAACTTGAAC TCTGCTTCCT CGTGGTTTAC AGAAATCGGT 2160
GCAGGCAATC AGCAGCTGGA TGCCATTCAT GTGACACAGC TGGAAAGAGA CACCGTGCTG 2220
GTCTGCCTGG ACAAATTTGT GAAAATAGTG AATTTACAAG GGAAACTGAA GTCAAGCAAG 2280
AAGTTGGCCT CGGAGCTGAG CTTTGATTTC TGCATTGAGT CAGTGGTGTG CCTTCAGGAC 2340
AGTGTGCTGG CCTTCTGGAA ACATGGCATG CAGGGCAAGA GCTTCAAGTC GGATGAAGTT 2400
ACCCAGGAGA TATCAGATGA AACGCGGGTT TTTCGCTTAC TGGGCTCTGA CAGAGTGGTG 2460
GTGCTGGAGA GCAGGCCGAC GGAGAACCCA ACTGCACACA GCAACCTCTA CATCTTGGCT 2520
GGCCATGAAA ACAGTTACTG A 2541
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         yel++++g+G++g+vy+ar+ +tgel+a+k+i+le  ++ +++q+ei ++k++kh niv+
Q: 20    YELIQRVGSGTYGDVYKARNLHTGELAAVKIIKLEPGDDFSLIQQEIYMVKECKHCNIVA  79
         99**********************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E qiay++re+l++L+ylH k+++
Q: 80    YFGSYLSREKLWICMEYCGGGSLQDIYH--VTGPLSELQIAYVCRETLQGLAYLHMKGKM  137
         ****************************..******************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179
         Hrdik++niLlt++g+VkL+dfgvaa++++t +krk+++gtpywmAPEv a+e + gY++
Q: 138   HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEkNGGYNQ  197
         ****************************************************98889***
S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237
          +Diw++GItaielae +pP++dl+p++al++++k++  ppklk+k k+s++f++fv+ +
Q: 198   LCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNfqPPKLKEKAKWSSTFHNFVKIA  257
         ********************************9999988*********************
S: 238   lqknpekRpsasellkhkFl  257
         l+knp+kRp+a++ll h+F+
Q: 258   LTKNPKKRPTADRLLAHSFV  277
         *******************7
Domain Sequence
(FASTA)
YELIQRVGSG TYGDVYKARN LHTGELAAVK IIKLEPGDDF SLIQQEIYMV KECKHCNIVA 60
YFGSYLSREK LWICMEYCGG GSLQDIYHVT GPLSELQIAY VCRETLQGLA YLHMKGKMHR 120
DIKGANILLT DHGDVKLADF GVAAKITATI AKRKSFIGTP YWMAPEVAAV EKNGGYNQLC 180
DIWAVGITAI ELAELQPPMF DLHPMRALFL MSKSNFQPPK LKEKAKWSST FHNFVKIALT 240
KNPKKRPTAD RLLAHSFV 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00313
EKS-ANC-00318
EKS-BOT-00318
EKS-CAJ-00326
EKS-CAF-00321
EKS-CII-00179
EKS-DAR-00675
EKS-EQC-00321
EKS-FEC-00319
EKS-GAA-00398
EKS-GOG-00313
EKS-HOS-00327
EKS-LAC-00327
EKS-LOA-00327
EKS-MAM-00321
EKS-MEG-00270
EKS-MOD-00326
EKS-MUM-00351
EKS-MUP-00312
EKS-MYL-00315
EKS-NOL-00293
EKS-ORN-00412
EKS-ORA-00274
EKS-ORC-00315
EKS-OTG-00338
EKS-PAT-00301
EKS-POA-00307
EKS-PTV-00074
EKS-RAN-00334
EKS-SAH-00311
EKS-TAG-00332
EKS-TAR-00413
EKS-TEN-00411
EKS-XET-00396
EKS-XIM-00409
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
GO:0007243; P:intracellular protein kinase cascade
GO:0006950; P:response to stress
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013