EKS-GAG-00251

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00251

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	499.9	1.5E-150	637	894	258

Status

Reviewed

Ensembl Protein

ENSGALP00000036620

UniProt Accession

P13387;

Protein Name

Epidermal growth factor receptor

Protein Synonyms/Alias

CER;

Gene Name

EGFR

Gene Synonyms/Alias

EGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000012363	ENSGALP00000036616	ENSGALT00000037409
ENSGALG00000012363	ENSGALP00000036620	ENSGALT00000037413
ENSGALG00000012363	ENSGALP00000020166	ENSGALT00000020193
ENSGALG00000012363	ENSGALP00000020165	ENSGALT00000020192
ENSGALG00000012363	ENSGALP00000020167	ENSGALT00000020194

Organism

Gallus gallus

Functional Description

Receptor tyrosine kinase binding ligands of the EGFfamily and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade.

Protein Length

1139

Protein Sequence
(FASTA)

MYNNCEVVLS NLEITYVEHN RDLTFLKTIQ EVAGYVLIAL NMVDVIPLEN LQIIRGNVLY 60

DNSFALAVLS NYHMNKTQGL RELPMKRLSE ILNGGVKISN NPKLCNMDTV LWNDIIDTSR 120

KPLTVLDFAS NLSSLEENGV RKCKKCDGLC SKVCNGIGIG ELKGILSINA TNIDSFKNCT 180

KINGDVSILP VAFLGDAFTK TLPLDPKKLD VFRTVKEISG FLLIQAWPDN ATDLYAFENL 240

EIIRGRTKQH GQYSLAVVNL KIQSLGLRSL KEISDGDIAI MKNKNLCYAD TMNWRSLFAT 300

QSQKTKIIQN RNKNDCSKGC GLYGDHTSCY GHRKCEFATY WECISSGTGC FTVCLVCVHS 360

GFHFNFERPE FAPKIKARSQ VLGIRKIVIT PLLLGSFSFA MLYLPFLWAV HAAHKFMASL 420

FSAADRHVCD PLCSDVGCWG PGPFHCFSCR FFSRQKECVK QCNILQGEPR EFERDSKCLP 480

CHSECLVQNS TAYNTTCSGP GPDHCMKCAH FIDGPHCVKA CPAGVLGEND TLVWKYADAN 540

AVCQLCHPNC TRGCKGPGLE GCPNGSKTPS IAAGVVGGLL CLVVVGLGIG LYLRRRHIVR 600

KRTLRRLLQE RELVEPLTPS GEAPNQAHLR ILKETEFKKV KVLGSGAFGT VYKGLWIPEG 660

EKVKIPVAIK ELREATSPKA NKEILDEAYV MASVDNPHVC RLLGICLTST VQLITQLMPY 720

GCLLDYIREH KDNIGSQYLL NWCVQIAKGM NYLEERRLVH RDLAARNVLV KTPQHVKITD 780

FGLAKLLGAD EKEYHAEGGK VPIKWMALES ILHRIYTHQS DVWSYGVTVW ELMTFGSKPY 840

DGIPASEISS VLEKGERLPQ PPICTIDVYM IMVKCWMIDA DSRPKFRELI AEFSKMARDP 900

PRYLVIQGDE RMHLPSPTDS KFYRTLMEEE DMEDIVDADE YLVPHQGFFN SPSTSRTPLL 960

SSLSATSNNS ATNCIDRNGQ GHPVREDSFV QRYSSDPTGN FLEESIDDGF LPAPEYVNQL 1020

MPKKPSTAMV QNQIYNNISL TAISKLPMDS RYQNSHSTAV DNPEYLNTNQ SPLAKTVFES 1080

SPYWIQSGNH QINLDNPDYQ QDFLPNETKP NGLLKVPAAE NPEYLRVAAP KSEYIEASA 1139

Nucleotide Sequence
(FASTA)

ATGTACAACA ACTGCGAAGT GGTACTGAGT AACCTGGAGA TTACCTACGT GGAGCATAAT 60

CGCGATCTCA CCTTCCTTAA GACCATACAG GAGGTTGCAG GCTATGTGCT CATTGCGCTT 120

AACATGGTGG ACGTCATTCC CTTAGAAAAC CTCCAGATTA TCCGAGGGAA TGTGCTTTAT 180

GACAACTCTT TTGCCCTGGC AGTTTTATCC AATTACCACA TGAATAAAAC CCAGGGACTT 240

CGAGAGCTGC CAATGAAACG GCTATCAGAA ATTCTCAATG GAGGTGTTAA AATCAGCAAC 300

AACCCCAAAC TGTGCAACAT GGACACTGTT CTCTGGAATG ACATCATTGA TACAAGCAGG 360

AAGCCTCTCA CAGTACTTGA CTTTGCAAGC AATCTTTCTT CTTTGGAAGA AAATGGTGTT 420

CGGAAGTGTA AAAAATGTGA TGGGCTATGT AGCAAAGTGT GCAATGGCAT TGGAATAGGT 480

GAACTTAAAG GGATCCTATC CATAAATGCC ACAAACATCG ACTCCTTCAA AAACTGTACG 540

AAGATCAATG GGGATGTCAG CATTCTTCCT GTTGCATTTC TAGGGGATGC CTTCACAAAG 600

ACACTACCCC TTGACCCTAA GAAGCTGGAT GTCTTTAGAA CAGTCAAAGA AATATCAGGA 660

TTTTTGTTGA TTCAGGCCTG GCCTGATAAT GCTACTGATC TCTATGCTTT TGAAAATCTG 720

GAGATTATCC GAGGCCGAAC CAAGCAGCAC GGCCAGTATT CCCTTGCTGT TGTTAACTTG 780

AAAATACAGT CGTTGGGGCT GCGCTCCCTC AAGGAAATAA GTGATGGAGA CATTGCCATT 840

ATGAAGAACA AGAACCTCTG CTATGCTGAC ACCATGAACT GGCGCAGCTT GTTTGCTACT 900

CAGAGTCAGA AAACAAAAAT TATACAGAAC AGAAATAAAA ATGATTGTAG TAAGGGATGT 960

GGGCTTTATG GTGATCATAC ATCCTGTTAT GGACACAGAA AATGTGAATT TGCTACATAT 1020

TGGGAATGTA TCTCCTCTGG TACTGGTTGC TTTACTGTAT GTCTGGTATG TGTTCACAGT 1080

GGATTTCATT TTAATTTTGA AAGGCCAGAA TTTGCTCCAA AAATAAAGGC CAGAAGTCAA 1140

GTTTTGGGAA TTAGGAAAAT TGTCATTACT CCTCTTCTGC TAGGGTCATT CTCATTTGCC 1200

ATGCTGTATC TGCCCTTCTT ATGGGCAGTT CATGCTGCCC ATAAGTTTAT GGCTTCTCTT 1260

TTCTCAGCTG CTGACAGGCA TGTGTGTGAC CCGCTGTGCT CGGACGTGGG CTGCTGGGGC 1320

CCAGGGCCCT TCCACTGCTT TTCCTGCAGG TTTTTCAGTC GCCAGAAGGA GTGTGTAAAA 1380

CAGTGCAACA TCCTGCAAGG GGAGCCACGT GAGTTTGAAA GAGACTCCAA ATGCCTCCCC 1440

TGCCACTCAG AGTGTCTGGT ACAGAACTCC ACTGCATACA ACACAACCTG CTCTGGACCG 1500

GGCCCAGACC ACTGCATGAA GTGTGCCCAT TTTATAGATG GTCCCCACTG TGTGAAGGCC 1560

TGCCCCGCTG GGGTCCTGGG TGAGAATGAT ACCCTGGTCT GGAAGTATGC AGATGCCAAT 1620

GCTGTTTGCC AGCTCTGCCA TCCAAACTGT ACACGAGGGT GCAAAGGACC AGGTCTTGAA 1680

GGATGTCCAA ATGGCTCCAA AACTCCATCT ATCGCGGCTG GTGTTGTCGG AGGACTCCTG 1740

TGCCTGGTTG TGGTTGGTCT AGGCATCGGT CTTTACCTGC GGCGACGTCA TATCGTGCGG 1800

AAGCGCACCC TGCGCAGGCT GCTGCAAGAG AGGGAGCTTG TCGAACCACT GACACCCAGT 1860

GGGGAGGCAC CAAACCAGGC CCACCTGAGA ATTTTAAAGG AAACAGAATT TAAAAAGGTC 1920

AAAGTTTTGG GCTCTGGAGC TTTTGGCACT GTTTATAAGG GACTTTGGAT CCCAGAAGGG 1980

GAAAAGGTTA AAATTCCTGT TGCTATTAAA GAATTGAGAG AGGCTACATC GCCAAAAGCC 2040

AACAAGGAAA TACTTGATGA AGCCTATGTG ATGGCTAGTG TTGACAATCC TCATGTGTGC 2100

CGCTTGCTGG GAATCTGCCT CACTTCCACT GTGCAGCTCA TCACCCAGCT TATGCCTTAT 2160

GGCTGCCTCC TTGACTACAT CCGAGAGCAC AAGGACAACA TTGGCTCCCA GTACCTTCTC 2220

AACTGGTGTG TGCAGATTGC AAAGGGAATG AACTACCTGG AGGAACGTCG CCTGGTGCAC 2280

CGTGACCTTG CTGCCAGGAA CGTCCTTGTT AAGACTCCAC AACATGTGAA AATCACAGAC 2340

TTTGGGCTGG CAAAGCTGCT TGGGGCAGAT GAGAAGGAGT ATCACGCAGA GGGAGGCAAG 2400

GTTCCTATTA AATGGATGGC ATTGGAGTCA ATTTTACACC GAATTTATAC TCATCAAAGT 2460

GATGTCTGGA GTTATGGTGT GACAGTTTGG GAGTTGATGA CATTTGGGTC CAAGCCTTAT 2520

GACGGGATCC CCGCAAGTGA AATCTCCTCC GTCTTGGAGA AGGGAGAGCG TTTGCCCCAG 2580

CCACCCATTT GTACCATTGA TGTGTACATG ATCATGGTCA AATGCTGGAT GATTGATGCA 2640

GACAGCCGTC CCAAGTTTCG TGAGCTGATT GCAGAGTTCT CCAAAATGGC TCGTGACCCT 2700

CCCCGCTATC TTGTTATACA GGGAGATGAA AGGATGCACT TGCCTAGCCC TACAGATTCC 2760

AAGTTTTATC GCACCCTGAT GGAGGAGGAG GACATGGAAG ACATTGTGGA TGCAGATGAG 2820

TATCTTGTCC CACACCAGGG CTTTTTCAAC AGCCCCTCTA CATCTCGGAC TCCTCTTCTG 2880

AGTTCATTGA GCGCTACTAG CAACAATTCT GCTACAAACT GCATTGACAG AAATGGGCAG 2940

GGGCACCCTG TGAGGGAAGA CAGCTTTGTC CAGAGGTACA GCTCAGATCC AACAGGAAAC 3000

TTCTTGGAGG AGAGTATAGA TGATGGCTTC CTGCCTGCTC CAGAGTATGT AAACCAGCTG 3060

ATGCCCAAGA AACCATCTAC TGCCATGGTC CAGAATCAAA TCTACAACAA CATCTCTCTC 3120

ACAGCAATCT CAAAGCTCCC CATGGACTCA AGATACCAGA ATTCCCACAG CACAGCTGTG 3180

GACAACCCTG AGTATCTCAA CACTAACCAG TCCCCACTGG CCAAAACAGT CTTCGAGAGC 3240

TCTCCCTATT GGATCCAATC AGGCAATCAC CAAATAAATC TGGACAATCC TGACTACCAG 3300

CAGGACTTTT TACCAAATGA AACAAAACCT AATGGTCTCT TGAAAGTTCC TGCAGCAGAA 3360

AACCCAGAGT ACTTGAGGGT AGCAGCACCA AAAAGTGAAT ACATTGAAGC TTCAGCATGA 3420

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 637   FKKVKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  696

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldy+rehkd++Gsq+llnwcvqiakGm+ylee+

Q: 697   PHVCRLLGICLTSTVQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEER  756

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll adeke++aeggkvpikw+alesil+r+y

Q: 757   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRIY  816

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw

Q: 817   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCW  876

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el++efs

Q: 877   MIDADSRPKFRELIAEFS  894

         ****************96

Domain Sequence
(FASTA)

FKKVKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLITQ LMPYGCLLDY IREHKDNIGS QYLLNWCVQI AKGMNYLEER 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGADEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSVLEKGE RLPQPPICTI DVYMIMVKCW 240

MIDADSRPKF RELIAEFS 258

Keyword

ATP-binding; Cell membrane; Complete proteome; Disulfide bond; Endoplasmic reticulum; Endosome; Glycoprotein; Golgi apparatus; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005789	; C:endoplasmic reticulum membrane
GO:0010008	; C:endosome membrane
GO:0000139	; C:Golgi membrane
GO:0016021	; C:integral to membrane
GO:0031965	; C:nuclear membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

gga:396494

;

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261

; FU; 5.

Prosites

PS00107	; PROTEIN_KINASE_ATP; PARTIAL.
PS50011	; PROTEIN_KINASE_DOM; PARTIAL.
PS00109	; PROTEIN_KINASE_TYR; PARTIAL.

Prints

Created Date

20-Feb-2013