EKS-GAG-00235
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00235
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR420.24.2E-1262286285
StatusReviewed
Ensembl ProteinENSGALP00000037012
UniProt AccessionQ90669; Q90745;
Protein NameActivin receptor type-2A
Protein Synonyms/Alias Activin receptor type IIA; ACTR-IIA; ACTRIIA;
Gene NameACVR2A
Gene Synonyms/Alias ACVR2A;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000012444ENSGALP00000020317ENSGALT00000020344
ENSGALG00000012444ENSGALP00000037012ENSGALT00000037806
OrganismGallus gallus
Functional DescriptionOn ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.
Protein Length292
Protein Sequence
(FASTA)
LLEIKARGRF GCVWKAQLLN EYVAVKIFPI QDKQSWQNEY EIYSLPGMKH DNILQFIGAE 60
KRGTSIDVDL WLITAFHEKG SLTDFLKANV VSWNELCHIA QTMARGLAYL HEDIPGLKDG 120
HKPAISHRDI KSKNVLLKNN LTACIADFGL ALKFEAGKSA GDTHGQVGTR RYMAPEVLEG 180
AINFQRDAFL RIDMYAMGLV LWELASRCTA SDGPVDEYML PFEEEIGQHP SLEDMQEVVV 240
HKKKRPVLRE CWQKHSGMAM LCETIEECWD HDAEARLSAG CVEERIIQMQ KL 292
Nucleotide Sequence
(FASTA)
TTGCTAGAGA TCAAAGCCAG GGGACGATTT GGGTGTGTGT GGAAAGCTCA GCTGCTGAAT 60
GAGTATGTTG CAGTCAAAAT ATTCCCTATC CAGGACAAAC AGTCGTGGCA GAATGAATAT 120
GAAATTTACA GCCTGCCTGG AATGAAGCAT GACAATATTT TACAGTTCAT CGGTGCAGAG 180
AAGCGAGGCA CCAGCATTGA TGTGGATCTC TGGTTAATTA CAGCTTTTCA CGAAAAGGGT 240
TCATTAACTG ACTTCCTCAA GGCTAACGTG GTTTCCTGGA ATGAGCTGTG TCACATTGCT 300
CAGACTATGG CTCGAGGCTT GGCTTATCTC CATGAGGATA TACCAGGGCT AAAAGACGGA 360
CATAAACCCG CCATCTCACA CAGGGACATC AAAAGCAAGA ATGTGCTGCT GAAAAACAAC 420
CTTACAGCTT GCATTGCTGA TTTTGGTCTA GCTTTAAAGT TTGAGGCTGG AAAATCTGCA 480
GGAGATACAC ATGGACAGGT TGGCACACGA AGGTACATGG CTCCTGAGGT ACTAGAAGGT 540
GCTATAAACT TCCAAAGGGA TGCGTTTTTG AGAATAGACA TGTATGCCAT GGGCTTGGTC 600
CTCTGGGAGC TGGCATCGCG CTGCACTGCC TCAGATGGCC CAGTAGATGA GTACATGTTG 660
CCATTTGAAG AAGAAATTGG CCAGCATCCT TCCCTTGAAG ACATGCAGGA AGTTGTGGTT 720
CATAAAAAGA AGAGACCTGT TTTAAGAGAG TGTTGGCAAA AGCATTCTGG AATGGCGATG 780
CTCTGTGAAA CCATCGAGGA GTGCTGGGAT CACGACGCAG AAGCCAGGCT GTCGGCGGGG 840
TGCGTAGAAG AACGCATTAT TCAGATGCAA AAATTA 876
Domain Profile
S: 4     leligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaadk  63
         le+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E eiy+++ ++h+nilqfi+a+k
Q: 2     LEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEIYSLPGMKHDNILQFIGAEK  61
         78999*******************************************************
S: 64    keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkgkk  123
         + ++  ++l+l+t++hekgsL+d+Lk+++++++el+++a+++a+Gla+LHe+i+g k+ +
Q: 62    RGTSIDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAQTMARGLAYLHEDIPGLKDGH  121
         ************************************************************
S: 124   KpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEvle  183
         Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPEvle
Q: 122   KPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLE  179
         **************************************888..79***************
S: 184   ealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemkev  243
         +a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m+ev
Q: 180   GAINFQR-DAFLRIDMYAMGLVLWELASRCTASDGPVDEYMLPFEEEIGQHPSLEDMQEV  238
         ******9.9***************************************************
S: 244   vvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         vv+kk+rP ++e w+k++ +++l++++eecWd+d+eaRl+a +v++r+
Q: 239   VVHKKKRPVLRECWQKHSGMAMLCETIEECWDHDAEARLSAGCVEERI  286
         *********************************************985
Domain Sequence
(FASTA)
LEIKARGRFG CVWKAQLLNE YVAVKIFPIQ DKQSWQNEYE IYSLPGMKHD NILQFIGAEK 60
RGTSIDVDLW LITAFHEKGS LTDFLKANVV SWNELCHIAQ TMARGLAYLH EDIPGLKDGH 120
KPAISHRDIK SKNVLLKNNL TACIADFGLA LKFEAGKSAG DTHGQVGTRR YMAPEVLEGA 180
INFQRDAFLR IDMYAMGLVL WELASRCTAS DGPVDEYMLP FEEEIGQHPS LEDMQEVVVH 240
KKKRPVLREC WQKHSGMAML CETIEECWDH DAEARLSAGC VEERI 285
KeywordATP-binding; Complete proteome; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Homo sapiens"; ?>
EKS-CAJ-00288
EKS-HOS-00288
Gene Ontology
GO:0009986; C:cell surface
GO:0005737; C:cytoplasm
GO:0034673; C:inhibin-betaglycan-ActRII complex
GO:0016021; C:integral to membrane
GO:0017002; F:activin-activated receptor activity
GO:0005524; F:ATP binding
GO:0015026; F:coreceptor activity
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0030509; P:BMP signaling pathway
GO:0032927; P:positive regulation of activin receptor signaling pathway
GO:0030501; P:positive regulation of bone mineralization
GO:0045648; P:positive regulation of erythrocyte differentiation
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510; P:regulation of BMP signaling pathway
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0023014; P:signal transduction by phosphorylation
KEGG
gga:396324;
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR015768; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013