Tag | Content |
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EKPD ID | EKS-GAG-00235 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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TKL/STKR | 420.2 | 4.2E-126 | 2 | 286 | 285 |
|
Status | Reviewed |
Ensembl Protein | ENSGALP00000037012 |
UniProt Accession | Q90669; Q90745; |
Protein Name | Activin receptor type-2A |
Protein Synonyms/Alias | Activin receptor type IIA; ACTR-IIA; ACTRIIA; |
Gene Name | ACVR2A |
Gene Synonyms/Alias | ACVR2A; |
Ensembl Information | |
Organism | Gallus gallus |
Functional Description | On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. |
Protein Length | 292 |
Protein Sequence (FASTA) | LLEIKARGRF GCVWKAQLLN EYVAVKIFPI QDKQSWQNEY EIYSLPGMKH DNILQFIGAE 60 | KRGTSIDVDL WLITAFHEKG SLTDFLKANV VSWNELCHIA QTMARGLAYL HEDIPGLKDG 120 | HKPAISHRDI KSKNVLLKNN LTACIADFGL ALKFEAGKSA GDTHGQVGTR RYMAPEVLEG 180 | AINFQRDAFL RIDMYAMGLV LWELASRCTA SDGPVDEYML PFEEEIGQHP SLEDMQEVVV 240 | HKKKRPVLRE CWQKHSGMAM LCETIEECWD HDAEARLSAG CVEERIIQMQ KL 292 |
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Nucleotide Sequence (FASTA) | TTGCTAGAGA TCAAAGCCAG GGGACGATTT GGGTGTGTGT GGAAAGCTCA GCTGCTGAAT 60 | GAGTATGTTG CAGTCAAAAT ATTCCCTATC CAGGACAAAC AGTCGTGGCA GAATGAATAT 120 | GAAATTTACA GCCTGCCTGG AATGAAGCAT GACAATATTT TACAGTTCAT CGGTGCAGAG 180 | AAGCGAGGCA CCAGCATTGA TGTGGATCTC TGGTTAATTA CAGCTTTTCA CGAAAAGGGT 240 | TCATTAACTG ACTTCCTCAA GGCTAACGTG GTTTCCTGGA ATGAGCTGTG TCACATTGCT 300 | CAGACTATGG CTCGAGGCTT GGCTTATCTC CATGAGGATA TACCAGGGCT AAAAGACGGA 360 | CATAAACCCG CCATCTCACA CAGGGACATC AAAAGCAAGA ATGTGCTGCT GAAAAACAAC 420 | CTTACAGCTT GCATTGCTGA TTTTGGTCTA GCTTTAAAGT TTGAGGCTGG AAAATCTGCA 480 | GGAGATACAC ATGGACAGGT TGGCACACGA AGGTACATGG CTCCTGAGGT ACTAGAAGGT 540 | GCTATAAACT TCCAAAGGGA TGCGTTTTTG AGAATAGACA TGTATGCCAT GGGCTTGGTC 600 | CTCTGGGAGC TGGCATCGCG CTGCACTGCC TCAGATGGCC CAGTAGATGA GTACATGTTG 660 | CCATTTGAAG AAGAAATTGG CCAGCATCCT TCCCTTGAAG ACATGCAGGA AGTTGTGGTT 720 | CATAAAAAGA AGAGACCTGT TTTAAGAGAG TGTTGGCAAA AGCATTCTGG AATGGCGATG 780 | CTCTGTGAAA CCATCGAGGA GTGCTGGGAT CACGACGCAG AAGCCAGGCT GTCGGCGGGG 840 | TGCGTAGAAG AACGCATTAT TCAGATGCAA AAATTA 876 |
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Domain Profile | S: 4 leligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaadk 63 | le+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E eiy+++ ++h+nilqfi+a+k | Q: 2 LEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEIYSLPGMKHDNILQFIGAEK 61 | 78999******************************************************* |
| S: 64 keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkgkk 123 | + ++ ++l+l+t++hekgsL+d+Lk+++++++el+++a+++a+Gla+LHe+i+g k+ + | Q: 62 RGTSIDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAQTMARGLAYLHEDIPGLKDGH 121 | ************************************************************ |
| S: 124 KpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEvle 183 | Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d ++ qvGt+RYmaPEvle | Q: 122 KPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLE 179 | **************************************888..79*************** |
| S: 184 ealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemkev 243 | +a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m+ev | Q: 180 GAINFQR-DAFLRIDMYAMGLVLWELASRCTASDGPVDEYMLPFEEEIGQHPSLEDMQEV 238 | ******9.9*************************************************** |
| S: 244 vvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl 291 | vv+kk+rP ++e w+k++ +++l++++eecWd+d+eaRl+a +v++r+ | Q: 239 VVHKKKRPVLRECWQKHSGMAMLCETIEECWDHDAEARLSAGCVEERI 286 | *********************************************985 |
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Domain Sequence (FASTA) | LEIKARGRFG CVWKAQLLNE YVAVKIFPIQ DKQSWQNEYE IYSLPGMKHD NILQFIGAEK 60 | RGTSIDVDLW LITAFHEKGS LTDFLKANVV SWNELCHIAQ TMARGLAYLH EDIPGLKDGH 120 | KPAISHRDIK SKNVLLKNNL TACIADFGLA LKFEAGKSAG DTHGQVGTRR YMAPEVLEGA 180 | INFQRDAFLR IDMYAMGLVL WELASRCTAS DGPVDEYMLP FEEEIGQHPS LEDMQEVVVH 240 | KKKRPVLREC WQKHSGMAML CETIEECWDH DAEARLSAGC VEERI 285 |
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Keyword | ATP-binding; Complete proteome; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |