EKS-GAG-00232

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00232

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	450.2	3.2E-135	196	482	287

Status

Unreviewed

Ensembl Protein

ENSGALP00000020464

UniProt Accession

F1NC97;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000012547	ENSGALP00000020464	ENSGALT00000020491

Organism

Gallus gallus

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

RAPNSALRAA LPLLGAAVWL CAGLQCVCQL CEHTNFTCQT EGACWASVML TNGKEEVIKS 60

CVSLPELNAQ VFCHSSKNIT KTECCYTDIC NNITLRLPIA SESPSRAAVG PVVLAVTVAV 120

PICVLSLVAV LAACICQGRR CARGRTKPPN VEEPLSECNL VSSGKTLKDL IYDMTTSGSG 180

SGLPLLVQRT IARTIILQEI VGKGRFGEVW RGKWCGEDVA VKIFSSRDER SWFREAEIYQ 240

TVMLRHENIL GFIAADNKDN GTWTQLWLVS EYHEQGSLFD YLNRGTVTAQ GMVRLALSIA 300

SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKRNESCAIA DLGLAVKHDS VLNTIDIPQN 360

PRVGTRRYMA PEILDDAMNT NIFESFKRAD IYSLGLVYWE IARRCCAGGI TEEYQLPYYD 420

AVPSDPSIED MRRVVCEQKL RPNIPNQWQS CEALRVMGRI MRECWYANGA ARLTALRIKK 480

TISQLCVQED SKT 493

Nucleotide Sequence
(FASTA)

CGGGCACCGA ACTCCGCGCT GCGGGCGGCG CTGCCGCTGC TGGGCGCCGC CGTTTGGCTG 60

TGCGCAGGGC TCCAGTGCGT GTGCCAGCTG TGCGAGCACA CCAACTTCAC CTGCCAGACG 120

GAGGGAGCGT GCTGGGCCTC GGTCATGCTA ACCAACGGCA AGGAGGAGGT GATCAAATCC 180

TGCGTGTCCC TCCCGGAGCT CAACGCCCAG GTCTTCTGCC ACAGCTCCAA GAACATCACC 240

AAGACTGAGT GCTGCTACAC CGACATCTGC AACAACATCA CCCTCCGCCT GCCCATAGCC 300

TCCGAGTCCC CCAGCCGTGC TGCCGTGGGT CCCGTGGTGC TGGCAGTGAC AGTGGCCGTG 360

CCCATCTGCG TTCTGTCCCT CGTGGCAGTG CTGGCTGCCT GCATCTGCCA GGGCCGGCGC 420

TGCGCCCGCG GCAGGACGAA GCCGCCCAAC GTGGAGGAGC CGCTCTCCGA GTGCAACCTG 480

GTCAGCTCGG GCAAGACGCT CAAGGACCTC ATTTATGACA TGACGACGTC TGGCTCTGGC 540

TCTGGCTTAC CTCTGCTCGT ACAGAGAACC ATTGCAAGGA CTATCATTCT GCAGGAGATC 600

GTAGGGAAGG GCCGCTTCGG GGAAGTGTGG CGTGGGAAGT GGTGCGGGGA GGACGTGGCT 660

GTGAAAATCT TCTCCTCGAG AGACGAGCGG TCCTGGTTCC GGGAGGCAGA GATCTATCAG 720

ACGGTTATGC TGAGACACGA GAACATCCTG GGCTTCATTG CTGCTGATAA CAAGGACAAC 780

GGGACCTGGA CCCAGCTGTG GCTCGTCTCT GAGTACCACG AGCAGGGCTC CCTGTTCGAC 840

TACCTGAACA GGGGCACGGT GACGGCGCAG GGCATGGTGA GGCTGGCACT GTCCATCGCC 900

AGCGGCCTGG CACACCTGCA CATGGAGATC GTGGGCACGC AGGGCAAACC AGCGATCGCT 960

CACAGGGACC TGAAGTCCAA GAACATCCTG GTGAAGAGGA ACGAGAGCTG TGCCATCGCA 1020

GACCTGGGGC TGGCAGTGAA GCACGACTCC GTGCTCAACA CCATCGACAT CCCGCAGAAC 1080

CCGCGGGTGG GGACAAGGAG GTACATGGCT CCCGAGATAC TGGATGACGC AATGAACACC 1140

AACATCTTTG AGTCCTTTAA GCGCGCAGAC ATCTACTCTC TTGGACTGGT GTACTGGGAG 1200

ATAGCACGGA GGTGCTGTGC TGGAGGGATC ACTGAGGAGT ACCAGCTGCC TTACTATGAT 1260

GCCGTGCCTT CTGACCCCTC GATAGAAGAT ATGAGAAGGG TGGTTTGTGA GCAGAAGCTC 1320

CGACCGAATA TTCCAAACCA GTGGCAAAGC TGTGAGGCAC TGCGGGTGAT GGGCCGGATC 1380

ATGCGGGAGT GCTGGTACGC CAACGGGGCC GCACGGCTCA CTGCTCTGCG CATCAAGAAG 1440

ACCATTTCAC AGCTCTGTGT GCAGGAAGAC TCCAAAACCT AA 1482

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e++gkGr+geVw++k+ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fiaa

Q: 196   ILQEIVGKGRFGEVWRGKWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAA  255

         5899********************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+k+++++t+l+lv+eyhe+gsL+dyL+r t++++ ++rlals+asGlahLH+eivgt+g

Q: 256   DNKDNGTWTQLWLVSEYHEQGSLFDYLNRGTVTAQGMVRLALSIASGLAHLHMEIVGTQG  315

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRDlkskNilvk++++c+iaDlGLa+k+++  +++d+ +n +vGt+RYmaPE+

Q: 316   --KPAIAHRDLKSKNILVKRNESCAIADLGLAVKHDSVLNTIDIPQNPRVGTRRYMAPEI  373

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l++a+n++ fe+fkraD+YslgLv+WE+a+Rc + ++++eey+lp+++ v+sdPs+e+m+

Q: 374   LDDAMNTNIFESFKRADIYSLGLVYWEIARRCCA-GGITEEYQLPYYDAVPSDPSIEDMR  432

         **********************************.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+e+klrP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 433   RVVCEQKLRPNIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  482

         ***********************************************986

Domain Sequence
(FASTA)

ILQEIVGKGR FGEVWRGKWC GEDVAVKIFS SRDERSWFRE AEIYQTVMLR HENILGFIAA 60

DNKDNGTWTQ LWLVSEYHEQ GSLFDYLNRG TVTAQGMVRL ALSIASGLAH LHMEIVGTQG 120

KPAIAHRDLK SKNILVKRNE SCAIADLGLA VKHDSVLNTI DIPQNPRVGT RRYMAPEILD 180

DAMNTNIFES FKRADIYSLG LVYWEIARRC CAGGITEEYQ LPYYDAVPSD PSIEDMRRVV 240

CEQKLRPNIP NQWQSCEALR VMGRIMRECW YANGAARLTA LRIKKTI 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0019915	; P:lipid storage
GO:0008285	; P:negative regulation of cell proliferation
GO:0046676	; P:negative regulation of insulin secretion
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009749	; P:response to glucose stimulus
GO:0032868	; P:response to insulin stimulus

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013