EKS-GAG-00231
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00231
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR452.85.2E-13627314288
StatusReviewed
Ensembl ProteinENSGALP00000020469
UniProt AccessionQ90ZK6; Q9YH45;
Protein NameActivin receptor type-1
Protein Synonyms/Alias Activin receptor type I; Type I TGF B receptor;
Gene NameACVR1
Gene Synonyms/Alias ACVR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000012551ENSGALP00000020469ENSGALT00000020497
OrganismGallus gallus
Functional DescriptionOn ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity).
Protein Length328
Protein Sequence
(FASTA)
DLLDHSCTSG SGSGLPFLVQ RTVARQITLV ECVGKGRYGE VWRGQWQGEN VAVKIFSSRD 60
EKSWFRETEL YNTVLLRHEN ILGFIASDMT SRNSSTQLWL ITHYHEMGSL YDYLQLTTLD 120
TVSCLRIVLS IASGLAHLHI EIFGTQGKPA ISHRDLKSKN ILVKKNGQCC IADLGLAVMH 180
SQSTNQLDVG NNPRVGTKRY MAPEVLDETI QADCFDSYKR VDIWAFGLVL WEVARRMVSN 240
GIVEDYKPPF YDLVPNDPSF EDMRKVVCVD QQRPNIPNRW FSDPTLTSLA KLMKECWYQN 300
PSARLTALRI KKTLTKIDNS LDKLKADC 328
Nucleotide Sequence
(FASTA)
GATTTATTGG ACCATTCCTG CACATCTGGA AGTGGTTCTG GACTTCCATT CTTGGTGCAA 60
AGAACAGTGG CTCGCCAGAT CACGCTTGTG GAGTGTGTAG GAAAGGGCCG TTATGGAGAA 120
GTCTGGAGGG GTCAGTGGCA AGGAGAGAAT GTTGCTGTGA AGATCTTCTC TTCTAGGGAT 180
GAAAAATCCT GGTTCAGGGA AACTGAATTG TATAACACTG TGTTGCTGCG GCATGAAAAC 240
ATTTTAGGTT TTATTGCATC CGATATGACT TCCAGAAACT CTAGCACCCA GCTGTGGCTA 300
ATTACTCACT ACCACGAGAT GGGGTCTTTG TATGACTATC TGCAGCTCAC CACCCTGGAC 360
ACTGTCAGCT GCCTGCGGAT AGTACTGTCC ATAGCCAGCG GCCTTGCACA TTTGCACATA 420
GAGATATTTG GAACGCAGGG GAAGCCTGCC ATTTCTCATC GGGACTTGAA GAGCAAAAAT 480
ATCCTTGTTA AGAAAAATGG ACAGTGCTGC ATAGCAGACT TAGGCCTCGC AGTCATGCAC 540
TCCCAAAGCA CGAACCAGTT GGATGTGGGG AACAACCCCC GAGTGGGCAC CAAACGCTAC 600
ATGGCTCCGG AGGTCTTGGA CGAAACCATC CAGGCAGACT GCTTCGACTC CTACAAGAGG 660
GTCGATATCT GGGCCTTCGG GCTGGTCCTG TGGGAGGTAG CTAGGCGCAT GGTTAGCAAT 720
GGTATTGTAG AAGACTATAA ACCACCATTT TATGACCTGG TTCCAAATGA TCCCAGTTTT 780
GAAGACATGA GGAAAGTGGT CTGTGTAGAT CAGCAAAGGC CAAACATTCC CAACAGGTGG 840
TTCTCAGACC CTACATTAAC ATCTCTTGCC AAGTTGATGA AAGAATGCTG GTATCAGAAT 900
CCATCAGCGA GACTAACAGC CCTGCGAATC AAAAAGACTT TGACCAAAAT TGATAATTCC 960
TTAGATAAAC TGAAGGCTGA CTGTTGA 987
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         ++l+e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tvllrhenil+fia
Q: 27    ITLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIA  86
         789*********************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+
Q: 87    SDMTSRNSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  146
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         g  Kpai+HRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE
Q: 147   G--KPAISHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  204
         *..*********************************************************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         vl+e+++ ++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++ v++dPs+e+m
Q: 205   VLDETIQADCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDLVPNDPSFEDM  263
         **********************************9.************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l
Q: 264   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  314
         *************************************************97
Domain Sequence
(FASTA)
ITLVECVGKG RYGEVWRGQW QGENVAVKIF SSRDEKSWFR ETELYNTVLL RHENILGFIA 60
SDMTSRNSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120
GKPAISHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180
DETIQADCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDLVPN DPSFEDMRKV 240
VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288
KeywordATP-binding; Complete proteome; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00259
EKS-ANC-00266
EKS-BOT-00277
EKS-CAJ-00284
EKS-CAF-00283
EKS-CAP-00312
EKS-CIS-00045
EKS-DAR-00618
EKS-DRM-00143
EKS-ECT-00031
EKS-EQC-00269
EKS-FEC-00264
EKS-GAM-00173
EKS-GAA-00339
EKS-GOG-00276
EKS-HOS-00284
EKS-ICT-00265
EKS-LAC-00291
EKS-LOA-00287
EKS-MAM-00279
EKS-MAE-00018
EKS-MEG-00221
EKS-MIM-00019
EKS-MOD-00275
EKS-MUM-00310
EKS-MUP-00272
EKS-MYL-00280
EKS-NOL-00254
EKS-ORN-00357
EKS-ORA-00242
EKS-ORC-00261
EKS-ORL-00334
EKS-OTG-00283
EKS-PAT-00261
EKS-PES-00246
EKS-PEM-00149
EKS-POA-00269
EKS-PRC-00026
EKS-RAN-00294
EKS-SAH-00261
EKS-SOA-00026
EKS-SUS-00244
EKS-TAG-00290
EKS-TAR-00359
EKS-TEN-00356
EKS-TUT-00043
EKS-XET-00351
EKS-XIM-00350
Gene Ontology
GO:0045177; C:apical part of cell
GO:0005887; C:integral to plasma membrane
GO:0048185; F:activin binding
GO:0016361; F:activin receptor activity, type I
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005057; F:receptor signaling protein activity
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0050431; F:transforming growth factor beta binding
GO:0005025; F:transforming growth factor beta receptor activity, type I
GO:0002526; P:acute inflammatory response
GO:0030509; P:BMP signaling pathway
GO:0060317; P:cardiac epithelial to mesenchymal transition
GO:0051216; P:cartilage development
GO:0016477; P:cell migration
GO:0042118; P:endothelial cell activation
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0001707; P:mesoderm formation
GO:0032926; P:negative regulation of activin receptor signaling pathway
GO:0043066; P:negative regulation of apoptotic process
GO:0060389; P:pathway-restricted SMAD protein phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0010694; P:positive regulation of alkaline phosphatase activity
GO:0030501; P:positive regulation of bone mineralization
GO:2000017; P:positive regulation of determination of dorsal identity
GO:0010718; P:positive regulation of epithelial to mesenchymal transition
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0030510; P:regulation of BMP signaling pathway
GO:0030500; P:regulation of bone mineralization
GO:0032330; P:regulation of chondrocyte differentiation
GO:0042325; P:regulation of phosphorylation
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
gga:395246;
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013