EKS-GAG-00229

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00229

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.2	2.1E-140	205	492	288

Status

Unreviewed

Ensembl Protein

ENSGALP00000020569

UniProt Accession

Q06900;

Protein Name

Protein Synonyms/Alias

Activin like receptor kinase 5;

Gene Name

ChALK5

Gene Synonyms/Alias

ChALK5; TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000012617	ENSGALP00000020569	ENSGALT00000020598

Organism

Gallus gallus

Functional Description

Protein Length

503

Protein Sequence
(FASTA)

MALRGTRRLR ALLRLLVAAV LLPRAAALQC YCHLCTKDNF TCVTDGLCFT SVTRTADRVI 60

RNSMCIAEID LIPRDRPFIC APSFRDGVTT LPHCCDRDHC NKIELPIPTP GPTPGRPASS 120

LGPVELAAVI AGPVCFVCIS LMLILYLCHN RTVIHHRVPS EEDPSLDRPF ISEGTTLKDL 180

IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 240

SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 300

GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS 360

ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI 420

HEDYQLPYYD LVPSDPSVEE MKKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA 480

ARLTALRIKK TLSQLSQQEG IKM 503

Nucleotide Sequence
(FASTA)

ATGGCGTTAC GGGGCACTCG GCGGCTCCGG GCCCTGCTGC GCCTGCTGGT AGCCGCGGTC 60

CTGCTGCCCA GGGCGGCCGC ATTACAATGT TACTGCCATC TATGCACAAA GGACAACTTT 120

ACCTGTGTGA CAGATGGGCT TTGTTTTACC TCTGTAACAC GGACTGCAGA TAGAGTCATA 180

CGCAATAGCA TGTGTATAGC AGAAATTGAT CTGATTCCTC GAGACAGGCC ATTTATTTGT 240

GCACCATCCT TCAGAGATGG AGTTACTACT TTGCCTCATT GCTGTGACAG AGACCACTGC 300

AATAAAATAG AACTTCCAAT TCCAACACCA GGTCCTACTC CAGGAAGACC AGCTTCTAGT 360

CTAGGACCTG TGGAACTGGC AGCTGTTATT GCTGGACCTG TCTGCTTTGT CTGCATTTCA 420

TTGATGCTGA TTCTGTATCT TTGTCATAAC CGTACTGTAA TTCATCATCG TGTGCCAAGT 480

GAAGAAGATC CTTCATTGGA TCGTCCCTTT ATATCTGAAG GAACTACTTT GAAGGATTTA 540

ATTTATGATA TGACAACTTC AGGCTCTGGA TCAGGTTTAC CTTTACTTGT GCAAAGAACA 600

ATTGCACGAA CTATAGTACT CCAAGAAAGT ATTGGTAAGG GTCGCTTTGG AGAAGTATGG 660

AGGGGGAAAT GGAGAGGAGA AGAAGTTGCT GTGAAGATCT TCTCTTCAAG AGAAGAGCGC 720

TCATGGTTTC GAGAGGCAGA AATTTATCAA ACAGTTATGC TACGACATGA AAACATTCTT 780

GGATTCATAG CTGCGGACAA CAAAGACAAT GGTACATGGA CGCAGCTGTG GTTGGTGTCA 840

GATTATCACG AACATGGGTC ACTCTTTGAT TACCTGAACA GGTATACAGT AACCGTAGAA 900

GGAATGATAA AATTAGCTTT GTCTACTGCC AGTGGCCTTG CTCATCTTCA CATGGAAATT 960

GTAGGCACAC AAGGCAAACC AGCAATTGCC CACAGAGATT TGAAATCAAA AAACATATTG 1020

GTAAAGAAGA ATGGAACATG CTGCATTGCA GACCTGGGGT TGGCAGTTAG GCATGATTCA 1080

GCTACAGACA CAATTGACAT TGCCCCCAAC CACAGAGTAG GAACAAAAAG GTACATGGCA 1140

CCTGAAGTTT TAGATGATTC CATAAATATG AAACATTTTG AGTCATTCAA ACGAGCAGAC 1200

ATCTATGCAA TGGGATTAGT ATTTTGGGAA ATTGCTCGTC GATGTTCTAT TGGTGGAATC 1260

CATGAAGATT ACCAGTTGCC ATATTATGAC CTAGTTCCTT CAGATCCTTC TGTTGAAGAA 1320

ATGAAAAAAG TTGTTTGTGA GCAGAAGTTA AGGCCCAATA TCCCAAACAG ATGGCAGAGC 1380

TGTGAGGCAT TACGAGTAAT GGCAAAAATC ATGCGGGAAT GCTGGTATGC CAACGGAGCT 1440

GCTAGGCTAA CAGCTTTGCG TATTAAGAAA ACACTATCAC AACTTAGTCA ACAGGAGGGG 1500

ATAAAGATGT AA 1512

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 205   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  264

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 265   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  324

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 325   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  382

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 383   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  441

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 442   KKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMKKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005623	; C:cell
GO:0044459	; C:plasma membrane part
GO:0043235	; C:receptor complex
GO:0005923	; C:tight junction
GO:0005524	; F:ATP binding
GO:0005057	; F:receptor signaling protein activity
GO:0050431	; F:transforming growth factor beta binding
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0000186	; P:activation of MAPKK activity
GO:0060317	; P:cardiac epithelial to mesenchymal transition
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0030199	; P:collagen fibril organization
GO:0042118	; P:endothelial cell activation
GO:0043542	; P:endothelial cell migration
GO:0006917	; P:induction of apoptosis
GO:0043066	; P:negative regulation of apoptotic process
GO:0032331	; P:negative regulation of chondrocyte differentiation
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030307	; P:positive regulation of cell growth
GO:0051272	; P:positive regulation of cellular component movement
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0051491	; P:positive regulation of filopodium assembly
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0010717	; P:regulation of epithelial to mesenchymal transition
GO:0043393	; P:regulation of protein binding
GO:0031396	; P:regulation of protein ubiquitination
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

gga:374094

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013