EKS-GAG-00206

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00206

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	334.3	4.5E-100	48	299	252

Status

Unreviewed

Ensembl Protein

ENSGALP00000020639

UniProt Accession

F1P356;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK1

Gene Synonyms/Alias

NUAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000012662	ENSGALP00000020639	ENSGALT00000020668

Organism

Gallus gallus

Functional Description

Protein Length

654

Protein Sequence
(FASTA)

SGGEAAAAAM EEPLGEAASP GVAATAAGPR KQQGVKRHHH KHNLKHRYEL QETLGKGTYG 60

KVKRAIERFS GRVVAIKSIR KDKIKDEQDM VHIRREIEIM SSLSHPHIIT IYEVFENKDK 120

IVIIMEYASK GELYDYISER RRLSERETRH FFRQIVSAVH YCHKNGVVHR DLKLENILLD 180

DNFNIKIADF GLSNLYHKDK FLQTFCGSPL YASPEIVNGR PYRGPEVDSW ALGVLLYTLV 240

YGTMPFDGFD HKNLIRQISS GEYREPTQTS DARGLIRWML MVNPERRATI EDIANHWWVN 300

WGYKSSVCDC DAMRDSESPL LARFIDWHHR STGLQPETDT KMKCLSKPKG PEVTLERQRS 360

LKKSKKENDI AQSIQEGGAE NASKPTSKRP KGILKKRSNS EHRSHSAGFI EGVVSPVLPS 420

AFKLEQELCR TGVAIKTVVE GEVAGKYGTK QSSLMPKKGI LKKTQQRESG YYSSPERSES 480

SELLDNNEET VNSDTSPGVT EPSRNGSYSH SCRRKGILKH NGKYSTSSTE SALISPDTPT 540

LEAMEEVVLP GDALPRSYSR PSSVISDDSI LSSDSFDLLD LQENRPNRQR IRSCVSAENF 600

LQIQDFEGLQ NHPRPQYLKR YRNRLGDSSF SLLADMDDVT QVYKKALEIC NKLN 654

Nucleotide Sequence
(FASTA)

TCCGGCGGCG AGGCGGCGGC AGCGGCCATG GAGGAGCCGC TCGGGGAGGC TGCGTCCCCG 60

GGGGTAGCGG CGACGGCGGC GGGGCCGAGG AAGCAGCAGG GGGTGAAGCG GCATCACCAC 120

AAGCACAACC TGAAGCATCG CTACGAGCTG CAGGAGACCT TGGGCAAAGG CACCTACGGC 180

AAAGTCAAGC GGGCCATCGA GCGGTTTTCC GGCAGAGTGG TTGCAATAAA ATCCATTCGT 240

AAGGACAAAA TTAAGGATGA ACAAGATATG GTTCACATCA GACGGGAGAT TGAGATCATG 300

TCATCCCTCA GCCACCCTCA TATCATCACC ATATATGAAG TGTTTGAAAA TAAGGATAAG 360

ATTGTGATCA TCATGGAGTA CGCAAGTAAG GGAGAGCTGT ATGATTATAT CAGTGAGCGG 420

CGACGACTGA GCGAAAGAGA AACAAGACAC TTCTTCCGAC AAATAGTCTC TGCTGTACAT 480

TACTGCCACA AGAATGGCGT GGTCCACAGG GACCTAAAAT TGGAAAACAT CCTTCTCGAT 540

GACAATTTTA ATATTAAGAT TGCTGATTTT GGACTCTCCA ACCTTTATCA CAAAGACAAA 600

TTTCTGCAAA CCTTTTGTGG AAGCCCACTG TATGCTTCCC CTGAAATTGT TAATGGACGA 660

CCTTACAGAG GCCCAGAGGT TGACAGCTGG GCCCTTGGTG TATTGCTTTA CACTCTGGTT 720

TATGGAACCA TGCCCTTTGA TGGCTTTGAT CACAAAAATC TCATCAGGCA GATCAGCAGT 780

GGAGAATATC GTGAACCAAC GCAGACCTCA GATGCTCGTG GTCTCATCAG ATGGATGCTG 840

ATGGTGAACC CTGAACGCCG AGCAACCATT GAAGACATTG CAAACCACTG GTGGGTTAAC 900

TGGGGTTACA AGAGTAGTGT TTGTGACTGT GATGCCATGA GGGACTCTGA GTCTCCATTG 960

CTAGCAAGGT TCATTGATTG GCATCACCGC TCCACTGGCC TCCAACCAGA GACTGATACA 1020

AAAATGAAGT GCCTTTCTAA GCCCAAAGGT CCCGAAGTCA CGCTAGAGAG ACAGAGGTCT 1080

CTGAAAAAAT CAAAAAAGGA AAATGACATT GCACAGTCCA TCCAGGAAGG AGGAGCTGAA 1140

AATGCATCCA AACCCACTTC CAAAAGACCC AAAGGCATCC TGAAGAAAAG GAGCAACAGC 1200

GAACATCGAT CTCACAGTGC AGGGTTCATT GAAGGTGTGG TCAGCCCAGT GTTACCCTCT 1260

GCTTTTAAGC TGGAGCAGGA GTTGTGTAGG ACTGGTGTAG CCATTAAAAC TGTTGTGGAG 1320

GGAGAGGTAG CTGGCAAATA CGGCACTAAG CAGTCTTCAC TAATGCCAAA AAAAGGAATC 1380

TTAAAGAAGA CTCAGCAGAG GGAGTCTGGC TATTACTCCT CTCCAGAACG AAGTGAATCT 1440

TCTGAACTCT TGGACAATAA TGAGGAAACA GTAAACAGTG ACACCTCTCC GGGGGTCACA 1500

GAACCATCCA GAAATGGGTC TTACAGCCAT TCCTGCAGGC GTAAGGGTAT CTTGAAACAC 1560

AATGGCAAGT ATTCTACTAG CAGCACTGAA TCTGCTTTAA TTAGCCCTGA TACACCAACG 1620

CTGGAAGCCA TGGAAGAAGT AGTCCTGCCT GGAGATGCAT TACCTCGAAG TTACAGCCGC 1680

CCTTCCAGCG TGATTAGTGA TGACAGTATT TTGTCCAGTG ACTCCTTTGA TTTGCTGGAT 1740

TTGCAAGAGA ACAGGCCAAA CAGACAGAGG ATACGGAGCT GTGTCTCTGC TGAAAATTTC 1800

CTACAGATCC AAGACTTCGA AGGACTTCAG AACCACCCAC GGCCACAGTA TCTAAAACGG 1860

TATCGCAACC GTCTGGGGGA CAGCAGTTTT TCCCTTCTCG CAGACATGGA TGATGTGACT 1920

CAGGTCTACA AGAAAGCCCT AGAGATCTGC AACAAGCTCA ACTAG 1965

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+l++tlG+g++gkVk a+++  ++ va+K i+k+k+ +e+ + +i+rEiei+++l+hp+

Q: 48    YELQETLGKGTYGKVKRAIERFSGRVVAIKSIRKDKIkDEQDMVHIRREIEIMSSLSHPH  107

         99**********************************95667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii ++ev+e+k+k+++++eyas+geL+dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 108   IITIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV  167

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld++ nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 168   VHRDLKLENILLDDNFNIKIADFGLSNLYHKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  227

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+lv+g++Pfd+ + k+l ++i++g+++ p++ +++++ L+r +L+v+pe+

Q: 228   DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-TSDARGLIRWMLMVNPER  286

         ****************************************9.6689**************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 287   RATIEDIANHWWV  299

         ************6

Domain Sequence
(FASTA)

YELQETLGKG TYGKVKRAIE RFSGRVVAIK SIRKDKIKDE QDMVHIRREI EIMSSLSHPH 60

IITIYEVFEN KDKIVIIMEY ASKGELYDYI SERRRLSERE TRHFFRQIVS AVHYCHKNGV 120

VHRDLKLENI LLDDNFNIKI ADFGLSNLYH KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLVYGTMPFD GFDHKNLIRQ ISSGEYREPT QTSDARGLIR WMLMVNPERR 240

ATIEDIANHW WV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030155	; P:regulation of cell adhesion
GO:2000772	; P:regulation of cellular senescence
GO:0035507	; P:regulation of myosin-light-chain-phosphatase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013