EKS-GAG-00224
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00224
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK456.94.1E-137204532329
StatusUnreviewed
Ensembl ProteinENSGALP00000020844
UniProt AccessionF1P4G3;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK2
Gene Synonyms/Alias HIPK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000012792ENSGALP00000020844ENSGALT00000020873
ENSGALG00000012792ENSGALP00000036819ENSGALT00000037612
OrganismGallus gallus
Functional Description
Protein Length1208
Protein Sequence
(FASTA)
LLPLYKCMAS HVQVFSPHTL QSSAFCSVKK LKVEPSSNWD MTGYGTHSKV YSQSKSVQSS 60
QAAAAAAVNA SLQIPNPSIP YEQTIIFPAS TGHIVVTSAN STSGVVAVSG QTLGGPHNLM 120
RRSTVSLLDT YQKCGLKRKS EEIENTSSVQ IIEEHPPMIQ NNASGATVAT ATTSTATSKN 180
SGSNSEGDYQ LVQHEVLCSM TNTYEVLEFL GRGTFGQVVK CWKRGTNEIV AIKILKNHPS 240
YARQGQIEVS ILARLSTESA DDYNFVRAYE CFQHKNHTCL VFEMLEQNLY DFLKQNKFSP 300
LPLKYIRPIL QQVATALMKL KSLGLIHADL KPENIMLVDP SRQPYRVKVI DFGSASHVSK 360
AVCSTYLQSR YYRAPEIILG LPFCEAIDMW SLGCVIAELF LGWPLYPGAS EYDQIRYISQ 420
TQGLPAEYLL SAGTKTTRFF NRDTDSPYPL WRLKTPDDHE AETGIKSKEA RKYIFNCLDD 480
MAQVNMTTDL EGSDMLVEKA DRREFIDLLK KMLTIDADKR ITPIETLNHP FVTMTHLLDF 540
PHSTHVKSCF QNMEICKRRV NMYDTVNQSK TPFITHVAPS TSTNLTMTFN NQLNTVHNQT 600
TNLAPTSSSA TISLANPEVS ILNYQSALYQ PSAASMAAVA QRSMPLQTGT AQICARPDPF 660
QQALIVCPPG FQGLQASPSK HAGYSVRMEN AVPIVTQAPG AQPLQIQPGL LAQQAWPSGT 720
QQILLPPAWQ QLTGVATHTS VQHATVIPES MAGTQPLADW RNTHAHGSHY NPIMQQPALL 780
ASHVTLPAAQ PVNVGVAHVM RQPPAAATST RKSKQHQSAP RNASTYEVSS SQSISSPQRS 840
KRVKENTPPR CAMVHNSPAC STAVTCGWGD MATSTTRERQ RQPIIIPDTP SPAVSVITIS 900
SDTDEEEEQK HAPTSTLSKQ RKNVISCVTV HDSPYSDSSS NNSPYAVQHR AGQNNGNTYD 960
TKGVPETHCS GNPRTIIVPP LKTQASEVLV ECDSLAPGTV TTSHHSSSYK SKSSSTVTST 1020
SGHSSGSSSG AVAYRQQRPG AHFQQQQPLN LSQAQQHITT DRTGSHRRQQ AYITPTIAQA 1080
PYSFPHNSPS HGTVHPHLAA AAAAHLPTQP HLYTYTTPAA LGSTGTVAHL VASQGSARHA 1140
VQHTTYPASI VHQVPVSMGP RVLPSPTIHP SQYQAQFAHQ TYISASPAST VYTGYPLSPT 1200
KVNQYPYI 1208
Nucleotide Sequence
(FASTA)
TTATTGCCGC TGTACAAATG TATGGCCTCG CATGTGCAAG TTTTCTCTCC TCACACCCTT 60
CAGTCAAGTG CCTTCTGTAG CGTGAAGAAA CTGAAAGTAG AGCCGAGTTC GAACTGGGAT 120
ATGACTGGGT ACGGCACACA CAGCAAAGTC TACAGCCAGA GCAAGAGCGT ACAGTCCTCC 180
CAAGCAGCCG CCGCAGCCGC CGTCAACGCC TCCCTCCAGA TCCCCAATCC GAGCATCCCT 240
TACGAACAGA CCATCATCTT CCCAGCAAGC ACGGGGCACA TCGTGGTGAC GTCCGCCAAC 300
AGCACTTCCG GTGTGGTGGC AGTGTCTGGG CAAACACTGG GCGGACCACA CAACCTGATG 360
CGTCGCAGCA CTGTGAGCCT TCTGGACACC TACCAAAAAT GTGGACTTAA GCGAAAGAGT 420
GAGGAGATTG AGAACACGAG CAGCGTGCAG ATCATCGAAG AGCATCCACC AATGATTCAG 480
AACAATGCCA GTGGGGCCAC TGTAGCCACC GCCACCACCT CCACGGCCAC CTCCAAAAAC 540
AGTGGCTCCA ACAGCGAAGG GGATTACCAG CTGGTGCAAC ATGAGGTGCT CTGTTCCATG 600
ACCAACACGT ACGAAGTGTT AGAATTTCTT GGCCGGGGAA CCTTCGGACA AGTAGTCAAA 660
TGCTGGAAAC GTGGCACTAA TGAGATTGTG GCCATCAAGA TCCTAAAGAA CCATCCTTCC 720
TATGCCCGGC AAGGCCAGAT TGAAGTGAGC ATCCTGGCAC GGCTGAGCAC AGAAAGTGCG 780
GATGACTACA ACTTTGTCCG TGCGTATGAG TGCTTCCAGC ACAAGAATCA CACGTGCTTG 840
GTCTTTGAAA TGTTAGAGCA GAACCTCTAT GATTTCCTAA AACAAAACAA ATTCAGTCCC 900
TTGCCCCTTA AGTACATTCG ACCAATTCTC CAGCAGGTAG CAACTGCACT AATGAAGTTG 960
AAAAGCTTGG GACTGATTCA TGCTGATCTT AAACCAGAGA ACATCATGTT GGTAGATCCA 1020
TCCCGACAGC CGTATAGGGT CAAGGTCATA GACTTCGGAT CAGCTAGCCA TGTGTCTAAA 1080
GCTGTGTGTT CAACCTACCT TCAATCCAGA TATTACAGAG CCCCTGAAAT CATCCTCGGT 1140
TTACCATTTT GTGAAGCAAT CGATATGTGG TCATTGGGAT GTGTCATTGC AGAGCTGTTC 1200
TTGGGCTGGC CTTTGTACCC AGGAGCTTCA GAGTACGATC AGATTCGCTA TATTTCACAG 1260
ACGCAGGGCT TACCAGCAGA GTATTTGTTA AGTGCAGGGA CAAAGACTAC AAGGTTTTTC 1320
AACAGGGATA CAGACTCACC GTATCCTTTG TGGAGGCTGA AGACACCAGA TGATCATGAG 1380
GCAGAGACGG GGATTAAGTC GAAGGAGGCA AGGAAGTATA TTTTCAACTG TTTGGATGAT 1440
ATGGCACAGG TAAATATGAC AACAGATTTG GAAGGAAGCG ACATGTTGGT GGAAAAGGCG 1500
GACCGACGGG AGTTTATAGA TCTGTTAAAG AAGATGTTGA CGATAGATGC TGATAAGAGA 1560
ATAACACCGA TTGAAACTCT GAACCACCCT TTTGTCACCA TGACGCACTT GCTCGATTTC 1620
CCTCACAGCA CACATGTTAA GTCCTGCTTC CAGAATATGG AGATTTGCAA GCGGCGGGTG 1680
AATATGTATG ACACTGTGAA CCAGAGCAAG ACACCATTCA TCACCCACGT AGCCCCGAGC 1740
ACATCTACCA ACTTGACCAT GACTTTTAAC AACCAGCTGA ACACAGTGCA CAACCAGACC 1800
ACCAACCTGG CTCCCACCTC CTCCAGTGCC ACTATTTCCT TAGCCAACCC CGAAGTCTCC 1860
ATACTAAATT ACCAATCTGC ACTCTACCAG CCCTCAGCGG CGTCCATGGC TGCGGTGGCC 1920
CAGCGGAGCA TGCCCTTGCA GACAGGAACA GCGCAGATCT GTGCCCGGCC CGACCCCTTC 1980
CAGCAAGCTC TCATCGTCTG CCCACCAGGC TTCCAAGGGT TACAAGCTTC CCCTTCGAAG 2040
CACGCTGGGT ATTCCGTTCG GATGGAGAAT GCTGTTCCCA TTGTCACTCA GGCTCCTGGG 2100
GCTCAGCCTC TTCAGATCCA GCCAGGACTC CTCGCACAGC AAGCATGGCC CAGCGGCACA 2160
CAGCAGATCC TGCTCCCTCC TGCCTGGCAG CAGCTGACTG GGGTGGCCAC CCACACTTCT 2220
GTCCAGCACG CGACCGTCAT CCCTGAGTCC ATGGCAGGCA CCCAGCCACT GGCAGACTGG 2280
AGAAACACCC ACGCTCATGG CAGCCACTAT AATCCCATCA TGCAGCAGCC CGCGCTGTTA 2340
GCTAGCCATG TGACTCTCCC CGCAGCCCAG CCCGTCAATG TGGGTGTTGC TCACGTCATG 2400
CGCCAGCCGC CCGCCGCCGC CACCTCCACC AGGAAGAGTA AGCAGCACCA GTCGGCGCCT 2460
CGAAATGCAT CCACCTACGA AGTTTCGTCC TCTCAGTCCA TCAGCTCGCC TCAGCGGTCG 2520
AAACGAGTGA AGGAAAACAC GCCTCCTCGC TGTGCCATGG TGCACAACAG CCCTGCCTGC 2580
AGCACTGCCG TCACCTGCGG CTGGGGTGAC ATGGCCACCA GCACCACGCG GGAGCGGCAG 2640
CGGCAGCCCA TAATCATTCC CGACACCCCC AGCCCCGCTG TGAGCGTCAT CACTATCAGC 2700
AGCGACACCG ATGAAGAGGA GGAGCAGAAG CATGCACCCA CCAGCACCTT GTCCAAGCAA 2760
AGGAAGAACG TCATCAGCTG TGTCACTGTG CATGATTCCC CCTACTCCGA TTCCTCCAGC 2820
AACAACAGCC CTTACGCCGT GCAGCATCGC GCAGGACAGA ATAACGGGAA CACATACGAC 2880
ACCAAAGGGG TTCCAGAGAC TCACTGCAGT GGGAACCCCC GAACGATCAT CGTGCCACCA 2940
CTGAAAACCC AGGCCAGTGA GGTGTTGGTA GAGTGTGATA GCCTGGCACC AGGCACAGTC 3000
ACCACCAGTC ACCACTCATC CTCCTACAAG TCCAAGTCCT CCAGCACCGT GACCTCCACC 3060
AGCGGTCACT CTTCAGGGAG CTCGTCTGGA GCCGTTGCCT ATAGGCAGCA GCGACCAGGA 3120
GCACATTTCC AGCAGCAACA GCCTCTTAAT CTAAGCCAGG CCCAGCAGCA CATCACGACT 3180
GATCGCACAG GGAGTCACCG GAGACAGCAA GCCTACATCA CTCCAACGAT AGCTCAGGCC 3240
CCGTACTCTT TCCCGCACAA TAGTCCCAGC CATGGTACAG TTCATCCTCA CTTGGCCGCG 3300
GCTGCCGCTG CTCACCTGCC CACCCAACCC CACCTCTACA CATACACCAC CCCAGCCGCC 3360
CTGGGCTCCA CGGGCACCGT CGCGCACCTG GTGGCCTCCC AAGGGTCTGC ACGGCACGCC 3420
GTGCAGCACA CCACCTACCC CGCCAGCATC GTCCACCAAG TCCCCGTCAG CATGGGCCCG 3480
CGGGTTCTGC CCTCGCCCAC CATCCACCCG AGTCAATACC AGGCTCAGTT TGCCCATCAG 3540
ACCTATATCA GTGCTTCTCC AGCCTCCACA GTCTACACTG GATACCCACT GAGCCCCACC 3600
AAGGTCAACC AGTACCCTTA CATCTAA 3627
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 204   YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ESADD  262
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr++e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 263   YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  322
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv+++r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 323   LGLIHADLKPENIMLVDPSRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  382
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 383   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  442
         **********************************************************88
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
          t++ +p ++lkt          ks++++k+++n+ +++++++++++ e +++l ek+d+
Q: 443   dTDSPYPLWRLKTPddheaetgiKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADR  502
         87889999999999********************************************99
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + f+dllk+ml++d++kRitp e+l+hpfv
Q: 503   ReFIDLLKKMLTIDADKRITPIETLNHPFV  532
         99***************************7
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTESADDY 60
NFVRAYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPSRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240
TDSPYPLWRL KTPDDHEAET GIKSKEARKY IFNCLDDMAQ VNMTTDLEGS DMLVEKADRR 300
EFIDLLKKML TIDADKRITP IETLNHPFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00249
EKS-ANC-00256
EKS-BOT-00267
EKS-CAJ-00273
EKS-CAF-00274
EKS-CAP-00302
EKS-CII-00160
EKS-DAR-00602
EKS-DAN-00015
EKS-DRM-00137
EKS-EQC-00259
EKS-FEC-00253
EKS-GAA-00331
EKS-GOG-00267
EKS-HOS-00273
EKS-ICT-00252
EKS-LAC-00284
EKS-MAM-00269
EKS-MEG-00212
EKS-MOD-00264
EKS-MUM-00298
EKS-MUP-00264
EKS-MYL-00269
EKS-NOL-00252
EKS-ORN-00344
EKS-ORC-00252
EKS-ORL-00320
EKS-OTG-00273
EKS-PAT-00252
EKS-PES-00237
EKS-PEM-00141
EKS-POA-00263
EKS-RAN-00282
EKS-SAH-00251
EKS-SUS-00240
EKS-TAG-00282
EKS-TAR-00340
EKS-TEN-00334
EKS-TUT-00032
EKS-SAC-00053
Gene Ontology
GO:0005813; C:centrosome
GO:0005737; C:cytoplasm
GO:0031965; C:nuclear membrane
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0001105; F:RNA polymerase II transcription coactivator activity
GO:0003714; F:transcription corepressor activity
GO:0046790; F:virion binding
GO:0009952; P:anterior/posterior pattern specification
GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0030514; P:negative regulation of BMP signaling pathway
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0008284; P:positive regulation of cell proliferation
GO:0043388; P:positive regulation of DNA binding
GO:0046330; P:positive regulation of JNK cascade
GO:0032092; P:positive regulation of protein binding
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0006468; P:protein phosphorylation
GO:0060395; P:SMAD protein signal transduction
GO:0007224; P:smoothened signaling pathway
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013