EKS-GAG-00078

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00078

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	353.9	9.8E-106	3730	4077	348

Status

Unreviewed

Ensembl Protein

ENSGALP00000024527

UniProt Accession

F1NRC7;

Protein Name

Protein Synonyms/Alias

DNA-dependent protein kinase catalytic subunit;

Gene Name

PRKDC

Gene Synonyms/Alias

PRKDC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000012914	ENSGALP00000024527	ENSGALT00000024573
ENSGALG00000012914	ENSGALP00000023428	ENSGALT00000023474
ENSGALG00000012914	ENSGALP00000023373	ENSGALT00000023418
ENSGALG00000012914	ENSGALP00000021030	ENSGALT00000021060

Organism

Gallus gallus

Functional Description

Protein Length

4139

Protein Sequence
(FASTA)

LSGMAGGVQE CLQELHGCLQ PGDAMRGYGL LRGLGEACLT CSAGGALALH VSLVFAPERG 60

LLAFVCRSLG VEEFRECREE ALKFLCVFLE RIGERAHPYA CSLKQTCISV YTKERAAKCK 120

IPALELLIKL LQSLRRSCLM EEMKVGEIFN KFYGELAVRS KISDTVLEKI YELLGVLGEV 180

HPADMINNSE KLFRAYLGEL KTQMTSATRV PKLPIVAGCL RGLTALMYNF TKSVDEDAQT 240

SKEIFDFAVK AIRPQVDQKR YAVHLAGLQL FSWHAAQFGT LLLDSYVMLF ETMCRWCGHT 300

NQELKKAGHN ALDSFLKQMS LMVAKDAELH KSKLKFFMEQ FYGIIRRMDS SNKELSIAIR 360

GYGLFAAPCK AMHPADVDAM YIELLQRCKQ MYLTEAETID DHLYQLPSFL QSIASVIFHL 420

DTIPEVYTPV LEHLVVLQIN SFPRYSEKMQ LVCCRSIIKV FLALSIKGPV LWNFISTVVH 480

QGLIRVFSKP MKFSKDVFGK ETSGSEEFPE SGEVDTARWK VPTYKDYLYL FRSLLSCDTM 540

KESIFEEENF LTGNSPLQSL NRLLYDELIK SILKIIEKLD LTVQKLNVHE QDENETDSAF 600

IGPTSDPASN LQPKKPTDFI AFINLVEFCR DILPDKHVEY FQPWVYSFGY ELIIHSTRLP 660

LISGFYKLLS VTMKIAKKIK YFEGVGPKSL RKATEDPEKS SCFALFAKFG KEVTAKMKQY 720

KDELLASCLN FLLSLPHDIV MLDIKAYIPA LQNAFKLGLS CTPMADLGLD ALEDWSAHIP 780

RHIMQPYYKD VLPLLDGYLK NSASTVEPQN NWEVRKLSRA AQKGFNKIVI QRLRKAKTSS 840

LDDNPSLEAV RTRVARLLGS LGGQINHNLI TGTEGKEMMK KCVSWDTKNH LSFAVPFADM 900

KPVIYLDVFL PRVTDLALSA SDRQTKIAAC ELLHSIVAYM LGKASQMPER QQGPPPMHQL 960

YKRIFPVLLR LACDVDQVTR QLYEPLVMQL IHWFTNNKKF ESQDTVTFLE AILSGIVDPV 1020

DSTLRDFCGQ CVREFLKWSI KQTTPKQQEK SPANTKSLFK RLYSLALHPS AFKRLGAALA 1080

FNSIYREFRE ENSLVEQFVF EALVVFLESL ALTHTDEKSL GTTQQCCDAI NHLKRIIKHK 1140

APALNKEGKR RVPRGFPATK SVCLQDVVMW LLVQCGRPQT ECRHKAMELF YEFVPLLPGN 1200

NSPSSWLADV LKKRDVSFLI NKFEGGGSDA KSPSGILSQP TLRDMQEPFS LLTVMRWMDM 1260

FLAALDCYNT FFELRMIKPH EILGVNERSS FLEAVDFFLE TIALHDIHAA EQCFDCRSRG 1320

NIFSPQEREV YNYSKCTIIV RIMEFVTMIL ETCQQDFWKL LEKELLNANF IELLVMTVCD 1380

PSHIGFNTAD VQVMKNLPDI SVRLLKALMK SPYKEYLQLC LKKRITPQSF EDLCSVDLFN 1440

SDARFDQVRF SAVLSACKQL QKSGLLHSVL HSQDERPHPS IGSKLLSVVY KSIAPGSERS 1500

SLPAVDISSK RLADRLLQLA FAIDDQCEEL VSLLLNTVVL SVPLSKASER NFVDFSHGQY 1560

FYSLFSDTIN QQLLKNLDVI VIQLMESSVS NPQMVGSILN GMLDQSFRER TIRKQQGVKL 1620

VTAVLRNWKR LDSWWAKDSS PESKMAVLTL LAKVLQIDSS VSFNTSHEAF TAVFDTYTSL 1680

LTDQNLGLNL KGHAVIILPF FTNLSGEKLH DLKNALDQLV AFNFPMSSDE FPKGTLKHNN 1740

YVDCTKKFLD ALELSQSPML LQLMTEVLCR DHRHSMEDLF QASFKRISRR SSTDKQVVLL 1800

DTVHKMFQNE DLLSNIVRQA FVDRSLLTLM SHCSLDALRE FFCKIIVQAM DTLNSRFTKS 1860

NECVFDTQIT KKMGYYKMLE VMYIRLSKDD VHSKDSKINQ AYRGSVSVEG NELTKALIKL 1920

CYDAFTENMA GENQLLEKRR QYHCAAYNCA IAVISCVFTE SKFYQGFLFT EKSEKNLLIF 1980

ENLIDLKRQY VFPVEIEVPL ERKKRYIAIR KEAREAWNDG QDEPKYLASA SYMMDSSLSE 2040

EMSQFDFSTG VQGFSYSSQD VTASSAHFRR KETSEYMVLN DEMELEMDEL NQHECMAPLT 2100

TLIKHMQRNQ ITPKVEEGAV PVDLPLWMKF LHSKLGNPSV PLNIRLFIAK LIVNTEDVFR 2160

PYAKQWLGPM LQLVVSGDNG GEGIHYMVVE IAVTVLSWTS VTTPKGNIKD EILANRLLEF 2220

LMKNAFHQKR AVFRHNLEII KTVIECWKNC LSIPYSLIFE KFSSGDPDTK DNSVGIQLLG 2280

IVLANNLPPF DLKCEIDRVR YFQALVSNMG LLRYKEVYAA AAEVLGLALQ YIAERQNILE 2340

DPVYDCVIKQ LKRHQNTQQD KFIICLNKVV KNFPPLADRF MNAVFFLIPK LHGVMKNYCL 2400

EVIMCRAEEI PDLYLQLKSK DFIQIMKHRD DERQRVCLDI IYKMLSTLKP PELKELLPGV 2460

TGFISHPSVI CRQRMYDILM WIYDNYSDPE SQADGDSQEV LSLAKEILLQ GLIDENAELQ 2520

LIVRNFWSDE TRLPANILDR MLMLLNSLYS AKIETQYLSL ITNFLLEMTS KSPDYSRKIF 2580

EHPLSECKFH DFVIDSSWRY RSTMLTPMFV ETQASQSTNR NSSQERSLSI SGSVGGRVRA 2640

TQRQYEFTPT QNVSGRSSFN WLTGNSIDTL AEYTVPSSSE SLSSSMLLVN KRSEKFKQAA 2700

FKPVGPDFGK KRLSLPGDKV DSKTKGLGID ERAEILRLRR RFLKDQEKVS LIYARKGVAE 2760

QKREKEMKSE LKMKFDGQVT LYRSYRVGDL PDIQIEHCSL IAPLQGLAQK DPTFAKQLFS 2820

SLFGGIFHEV KKSKIPSEKK AIIQKLLKDF NHFLSTSVSY FPPFIACIQE ISYKHRELLE 2880

LDSANVSTSC LASLQQPVGI LLLEHALMAL SPAEEPPSKR MRGRTELPPD VVKWLELAKL 2940

YRSLGDYDVL RGIFSGKIGT KDITQQALLA EARSDYAEAA KCYDEALSKE DWEDGEPTEA 3000

EKDFWELASL ECYDHLTEWK SLEYCATVNI DSGKPPDLNK TWSDPFYQET YLPYIIRSKL 3060

KLLLNGENDQ TLLTFIDEAM KTEQKKALIE MHYSQELSLL YILQDDFDRA KYYIGNGIQI 3120

FMQSYSSIDT LLYQSRMSKL QSVQALTEIQ DFINFMTKTS NIASQAKSLK RLLRTWTSRY 3180

PDAKMDPMNI WDDIITNRCF FLDKLQEKFL CDKANDSMEV DEESSVGDQM EVDQQDEDIH 3240

SMIRSCKFNM KLKMIESARK QNSFSIAKKL LKGLRREAKT REDWLVRWNY AYCRFVHSCS 3300

QSQSCPERVL SVLKTISLLE DTKSDYLNKN IMAFRNQNLL LGTTYHIMAN ALSQDPKCCE 3360

QIEEEKTGKI LELSGESSES PEKILAGLNK RAFQCFSSAA RKSEEEVQSL SMEHVDVKGV 3420

IDAYMTLVGF CDQHLRKEEE GSLEINAADL QLFPAIVVEK MIKALKLNSR EARLRFPRLL 3480

QIIERYPAET LGLVTRELPS VPCWQFIGWI SQMMALLDKD EAVAVQHTVE EIVDTYPQAI 3540

IYPFTISSES YCFKDTAAGC RNKEFVASIK NKLDRGGVVQ DFIHALEQLS NPVMLFKDWV 3600

ADVRNELVKT QRNKIILKEM YEGMYKNLGD VKAPGLGWLR KRFVQAFGKD FDSHFGKGGS 3660

KLLDMKISDF NEITTALLTK MNKTHKEPGN LKECSPWMSE FRAEFLRNEL EVPGQYDGKG 3720

KPLPEYHVKI SGFDERIMVL ESLRKPKRIT IRGSDEQEHP FLVKGGEDLR QDQRIEQLFD 3780

VMNIVLSRDA ACSQRNMQLK TYQVIPMTTR LGLIKWLENT CTLKEFLRNS MTEEEDANYN 3840

SLKGPRAAYS DWLSKMGGKA QGLSRYNAMY KNASRTETVI AFKSRESSVP EDLLRRAFVK 3900

MSTSPEAFLA LRSHFVSSHA LMCISHWILG IGDRHLSNFM INKETGGMVG IDFGHAFGSA 3960

TQFLPVPELM PFRLTRQFVN LMMPVKEWGL IYSVMVHALR AYRADPDLLI STMDVFVKEP 4020

SLDWKNFEQR QLKKGGTWIK EINTAEVNWY PLQKVSYVKR KLTGANPARI TCDELRLGYE 4080

KLPFYNDFAA VARGSADHNI RAKEPEDGLS EETQVRCLID QATDPNLLGR VWEGWEPWM 4139

Nucleotide Sequence
(FASTA)

CTGAGCGGGA TGGCGGGCGG CGTTCAGGAG TGCCTCCAGG AGCTGCACGG CTGCCTGCAG 60

CCCGGCGATG CCATGCGCGG CTACGGGCTG CTGCGCGGCC TGGGCGAGGC CTGCCTCACC 120

TGCTCGGCCG GCGGCGCGCT GGCGCTGCAC GTCTCCCTGG TGTTCGCCCC GGAGCGCGGC 180

CTGCTGGCTT TCGTCTGCCG CTCCCTCGGC GTGGAGGAGT TTCGAGAATG CAGGGAAGAA 240

GCGCTGAAGT TTCTGTGCGT CTTTTTGGAA AGGATTGGAG AGAGAGCTCA TCCTTACGCC 300

TGCAGCCTTA AGCAAACTTG CATTAGTGTT TATACAAAAG AGAGGGCAGC AAAATGTAAA 360

ATTCCAGCTC TGGAACTTCT GATTAAGTTG CTCCAAAGTT TACGACGCTC CTGTCTGATG 420

GAGGAGATGA AAGTTGGGGA AATCTTTAAT AAGTTCTATG GGGAGCTTGC TGTAAGAAGT 480

AAAATTTCTG ATACAGTACT GGAGAAGATC TATGAGCTTT TGGGAGTTTT GGGAGAGGTC 540

CATCCTGCTG ACATGATTAA CAACTCTGAA AAACTATTCC GAGCGTATCT GGGAGAGCTT 600

AAAACACAGA TGACATCAGC AACGAGGGTC CCCAAGCTGC CTATTGTAGC AGGATGTCTG 660

AGGGGACTGA CTGCACTCAT GTACAACTTT ACCAAGTCTG TGGATGAAGA TGCTCAAACT 720

TCAAAGGAGA TTTTTGATTT TGCAGTGAAG GCTATCAGGC CACAGGTTGA TCAGAAGCGA 780

TATGCAGTAC ATCTAGCTGG TTTACAGTTG TTCAGCTGGC ATGCTGCTCA GTTTGGTACC 840

CTACTCTTGG ACAGCTATGT CATGCTCTTT GAAACGATGT GTAGATGGTG TGGCCACACA 900

AATCAGGAGC TGAAGAAAGC CGGTCATAAT GCACTGGATT CATTCCTCAA GCAGATGTCT 960

TTAATGGTGG CAAAGGATGC AGAGCTACAC AAGAGCAAAT TGAAGTTCTT CATGGAGCAG 1020

TTCTATGGAA TCATCAGAAG AATGGATTCA AGCAACAAGG AGCTGTCCAT TGCTATTCGT 1080

GGATATGGGC TTTTTGCAGC ACCCTGCAAA GCTATGCATC CTGCAGATGT TGACGCCATG 1140

TACATTGAGC TCCTTCAGCG CTGTAAACAA ATGTACCTCA CAGAGGCAGA GACAATAGAT 1200

GACCATCTGT ATCAGCTTCC AAGTTTCCTC CAGTCCATCG CAAGTGTGAT ATTCCATTTA 1260

GACACAATTC CAGAAGTATA CACTCCAGTT CTTGAACATC TAGTTGTGCT ACAAATCAAT 1320

AGCTTTCCAC GATACAGTGA AAAAATGCAG TTAGTCTGTT GCAGATCTAT AATAAAGGTG 1380

TTTCTAGCCC TCTCAATAAA AGGTCCTGTT CTCTGGAATT TTATTAGCAC TGTTGTGCAT 1440

CAGGGATTGA TCAGAGTATT CTCCAAGCCA ATGAAGTTTT CAAAGGATGT TTTTGGAAAA 1500

GAAACTTCTG GATCAGAAGA ATTCCCAGAA TCTGGAGAGG TTGATACAGC AAGATGGAAA 1560

GTACCAACCT ATAAGGACTA TTTGTATCTC TTCAGAAGTT TACTGAGTTG TGACACGATG 1620

AAGGAATCCA TTTTTGAAGA AGAAAACTTT CTTACTGGAA ATTCACCACT GCAGTCTCTG 1680

AATCGGTTGC TGTATGATGA ACTCATAAAA TCTATTTTGA AGATTATTGA GAAGTTGGAC 1740

CTGACTGTTC AGAAACTGAA TGTCCACGAG CAGGATGAAA ATGAAACTGA CAGTGCTTTT 1800

ATTGGGCCTA CTTCTGACCC TGCTTCCAAC CTTCAGCCAA AGAAACCTAC GGACTTTATT 1860

GCATTTATAA ACCTGGTAGA ATTCTGCAGA GACATACTTC CAGATAAACA TGTTGAATAC 1920

TTTCAGCCTT GGGTGTATTC CTTTGGTTAT GAGCTTATTA TACACTCAAC GAGACTACCT 1980

CTTATCAGTG GATTCTACAA GCTGCTTTCT GTTACAATGA AGATTGCCAA GAAAATTAAA 2040

TACTTTGAGG GTGTCGGTCC AAAGAGTCTC AGAAAAGCTA CTGAAGACCC TGAAAAGAGT 2100

TCTTGCTTTG CCCTGTTTGC AAAGTTTGGA AAAGAGGTTA CAGCAAAAAT GAAACAGTAT 2160

AAAGATGAGT TGTTGGCATC CTGTCTAAAT TTTTTACTCT CTCTACCACA TGACATCGTC 2220

ATGCTTGATA TCAAGGCATA TATTCCTGCA TTGCAGAATG CGTTTAAGCT GGGCCTTAGC 2280

TGTACGCCAA TGGCTGATCT GGGACTGGAT GCTTTGGAAG ACTGGTCTGC TCACATCCCC 2340

AGGCATATAA TGCAACCTTA TTACAAGGAT GTGCTACCCC TTCTTGATGG TTATTTGAAA 2400

AACTCTGCAT CTACAGTTGA ACCCCAGAAT AACTGGGAAG TAAGGAAGCT TTCCCGAGCA 2460

GCCCAGAAAG GATTTAACAA AATCGTGATA CAGCGTTTAA GAAAAGCAAA AACTTCTTCA 2520

TTGGATGACA ATCCCTCCTT GGAAGCAGTA AGGACTAGAG TGGCTCGCCT TCTTGGCTCT 2580

TTAGGAGGGC AGATCAACCA CAACTTAATT ACGGGGACTG AAGGAAAAGA GATGATGAAG 2640

AAGTGTGTGT CCTGGGACAC CAAGAACCAC CTGAGCTTTG CTGTGCCATT TGCAGACATG 2700

AAGCCTGTCA TCTACTTGGA TGTGTTTCTG CCTCGTGTGA CTGACCTGGC TCTTTCTGCA 2760

AGTGACAGAC AAACAAAGAT CGCAGCATGT GAACTGCTAC ATAGCATTGT TGCATATATG 2820

CTGGGGAAAG CATCTCAAAT GCCAGAAAGA CAACAGGGTC CCCCACCCAT GCATCAGTTA 2880

TACAAACGAA TATTTCCAGT ACTGCTTCGT CTTGCCTGTG ATGTAGACCA GGTAACGAGA 2940

CAGTTGTATG AGCCCTTAGT CATGCAGCTC ATTCACTGGT TTACCAACAA CAAGAAATTT 3000

GAGAGTCAAG ATACAGTGAC GTTTCTGGAA GCTATCTTGA GTGGCATAGT GGATCCGGTT 3060

GACAGCACTC TGAGAGATTT CTGCGGTCAG TGTGTACGAG AATTTTTGAA GTGGTCTATT 3120

AAGCAGACAA CACCGAAACA GCAGGAGAAA AGCCCAGCAA ACACCAAGTC TCTTTTTAAA 3180

AGATTATACA GTCTTGCTCT TCATCCCAGT GCTTTCAAGA GACTAGGTGC AGCACTTGCT 3240

TTTAACAGCA TCTACAGAGA ATTCAGGGAA GAGAATTCTC TGGTGGAGCA GTTTGTGTTT 3300

GAAGCATTGG TTGTGTTTCT GGAAAGTCTG GCTTTAACCC ATACAGACGA GAAATCATTA 3360

GGTACCACTC AACAATGTTG CGATGCTATT AATCACCTGA AGCGCATAAT CAAGCATAAA 3420

GCACCCGCTC TGAACAAGGA AGGAAAACGG CGGGTACCAC GAGGATTTCC AGCTACTAAG 3480

TCAGTGTGCC TTCAGGATGT TGTCATGTGG CTCTTAGTGC AGTGTGGGCG ACCTCAGACG 3540

GAGTGCCGAC ATAAAGCCAT GGAGCTCTTT TATGAATTTG TTCCTTTGTT ACCAGGAAAC 3600

AATTCTCCAT CTTCTTGGCT GGCTGATGTT TTAAAAAAGA GAGACGTTTC CTTCCTTATT 3660

AACAAATTTG AAGGAGGTGG CAGTGATGCC AAAAGCCCGT CTGGGATTCT TTCTCAGCCA 3720

ACTCTCCGTG ATATGCAGGA GCCCTTTAGT TTACTGACTG TCATGCGGTG GATGGATATG 3780

TTCTTAGCGG CGCTGGACTG CTACAATACT TTCTTTGAGC TGCGAATGAT CAAGCCTCAT 3840

GAAATACTGG GTGTAAATGA AAGGTCGTCG TTCTTGGAAG CAGTGGATTT CTTCCTCGAA 3900

ACTATCGCCT TGCATGATAT CCATGCAGCA GAGCAGTGCT TTGATTGCAG ATCAAGAGGC 3960

AACATATTCA GTCCACAAGA GAGAGAAGTG TATAATTACA GTAAGTGTAC AATTATCGTG 4020

CGAATCATGG AGTTTGTCAC CATGATCCTG GAAACATGCC AGCAGGATTT CTGGAAGCTA 4080

CTTGAGAAGG AATTGCTTAA TGCAAACTTT ATAGAGCTTC TGGTGATGAC AGTGTGTGAT 4140

CCGTCACATA TAGGATTTAA TACAGCTGAT GTACAAGTCA TGAAAAATCT CCCAGATATC 4200

TCAGTGAGGC TCTTGAAAGC TTTGATGAAA TCTCCCTATA AAGAGTATTT GCAACTATGT 4260

TTAAAAAAAA GAATCACCCC ACAGAGCTTT GAGGACCTCT GTTCTGTTGA TCTGTTTAAT 4320

TCAGATGCAC GTTTTGATCA AGTTAGGTTT AGTGCTGTTC TTTCTGCCTG CAAACAACTC 4380

CAGAAATCTG GTCTGCTTCA TTCTGTTCTT CACAGTCAGG ATGAAAGGCC TCATCCCTCA 4440

ATTGGCTCTA AGCTTCTTTC AGTTGTTTAT AAAAGCATTG CACCTGGGAG TGAAAGGAGC 4500

TCTCTTCCAG CAGTAGACAT CAGCAGTAAG CGATTAGCTG ATAGACTCCT CCAGCTTGCT 4560

TTTGCCATTG ATGACCAGTG TGAGGAGCTA GTAAGTCTGC TGTTGAACAC AGTGGTGTTA 4620

TCTGTACCAC TATCTAAAGC CTCAGAGAGG AACTTTGTCG ATTTTTCTCA TGGACAGTAT 4680

TTCTACAGCC TGTTCTCAGA CACCATTAAT CAGCAGCTGC TAAAAAATCT GGATGTGATT 4740

GTAATCCAGC TTATGGAATC ATCTGTCAGC AATCCCCAAA TGGTTGGAAG CATTTTGAAT 4800

GGCATGTTAG ATCAGAGTTT TAGGGAGCGT ACCATCCGCA AGCAGCAAGG AGTGAAACTG 4860

GTCACAGCAG TACTGAGAAA CTGGAAGAGG CTTGACAGCT GGTGGGCCAA AGATTCCTCT 4920

CCTGAGAGCA AAATGGCAGT CTTGACTCTG CTGGCAAAAG TTCTCCAGAT AGACTCTTCA 4980

GTTTCTTTCA ATACCAGTCA TGAAGCATTT ACAGCTGTTT TTGATACCTA TACCAGTCTA 5040

CTTACTGACC AGAATTTAGG CTTAAATCTG AAGGGCCATG CCGTGATCAT TCTTCCGTTC 5100

TTCACTAATT TGAGTGGAGA AAAACTTCAT GACCTTAAGA ATGCTCTTGA TCAACTTGTA 5160

GCTTTCAATT TTCCTATGAG TTCAGATGAG TTTCCCAAAG GAACCTTGAA GCACAATAAC 5220

TATGTGGACT GCACTAAGAA GTTTTTAGAT GCTTTGGAGT TGTCTCAGAG TCCAATGTTG 5280

TTGCAGCTGA TGACAGAAGT CCTTTGTAGG GACCACAGAC ATTCTATGGA GGACTTATTT 5340

CAAGCCAGCT TCAAAAGAAT TTCCAGAAGG AGCAGCACTG ACAAACAAGT GGTACTGTTG 5400

GACACTGTTC ACAAGATGTT CCAGAATGAA GACCTTCTTT CAAATATTGT CCGTCAAGCT 5460

TTTGTGGATC GCTCCCTCCT CACTCTCATG TCTCACTGCA GCTTGGATGC ATTGAGAGAA 5520

TTCTTTTGCA AGATTATAGT GCAGGCTATG GATACACTTA ATTCCAGGTT TACAAAGTCC 5580

AATGAATGTG TTTTTGATAC CCAAATCACC AAGAAAATGG GTTATTACAA GATGCTGGAA 5640

GTGATGTATA TACGTCTTTC AAAAGATGAT GTTCACTCCA AGGATTCTAA AATTAACCAA 5700

GCTTACCGTG GCTCTGTAAG TGTAGAAGGA AATGAACTTA CCAAGGCACT AATAAAGTTG 5760

TGCTATGATG CATTTACAGA AAACATGGCA GGGGAGAATC AGCTGCTGGA GAAGAGGAGA 5820

CAGTATCACT GTGCAGCATA TAATTGTGCT ATTGCTGTTA TTAGTTGTGT CTTCACTGAA 5880

AGTAAATTTT ATCAAGGCTT TCTCTTTACA GAAAAATCAG AAAAGAACTT GCTGATTTTT 5940

GAAAACTTGA TAGACTTGAA GCGTCAGTAC GTGTTTCCTG TAGAAATTGA GGTTCCCCTG 6000

GAAAGGAAGA AGAGATACAT TGCTATTAGA AAAGAAGCCA GAGAGGCTTG GAATGACGGT 6060

CAGGATGAAC CCAAGTATTT AGCTTCTGCA TCATACATGA TGGATAGCAG TTTGAGTGAG 6120

GAAATGAGTC AGTTTGATTT TTCTACTGGA GTCCAAGGTT TTTCTTATAG CTCCCAGGAT 6180

GTTACAGCAA GCAGTGCTCA CTTCAGGAGA AAGGAGACAT CAGAATACAT GGTTTTAAAT 6240

GATGAGATGG AGCTGGAGAT GGATGAACTT AACCAACATG AGTGTATGGC ACCGTTGACC 6300

ACTCTGATTA AGCATATGCA GAGGAACCAG ATCACACCCA AAGTGGAAGA GGGCGCGGTT 6360

CCCGTAGACC TTCCTCTTTG GATGAAATTT CTGCATAGTA AGTTAGGAAA TCCGTCAGTG 6420

CCATTAAATA TTCGCCTCTT CATAGCAAAA CTTATTGTTA ATACTGAGGA TGTTTTCCGA 6480

CCTTATGCAA AGCAATGGCT TGGTCCGATG CTGCAGCTCG TTGTTTCTGG CGATAATGGA 6540

GGTGAAGGGA TTCATTATAT GGTGGTGGAA ATAGCAGTTA CTGTTCTTTC CTGGACGAGT 6600

GTAACTACTC CCAAAGGAAA TATTAAGGAT GAGATTTTGG CTAACAGATT GCTTGAATTC 6660

TTGATGAAGA ATGCCTTTCA TCAGAAACGA GCTGTGTTCA GACACAATCT GGAAATCATA 6720

AAGACAGTTA TAGAGTGTTG GAAGAACTGC CTCTCCATAC CTTACAGTTT AATATTTGAA 6780

AAGTTTTCTA GTGGAGATCC TGATACAAAG GACAACTCAG TGGGAATTCA GCTGCTGGGA 6840

ATTGTTCTAG CTAACAATTT ACCTCCCTTT GACCTGAAGT GTGAAATAGA TCGTGTCAGG 6900

TATTTTCAGG CTCTGGTCAG TAACATGGGC TTATTAAGGT ATAAAGAAGT TTATGCAGCT 6960

GCAGCAGAAG TGTTGGGACT TGCTCTTCAA TATATAGCTG AGAGACAAAA TATACTTGAA 7020

GATCCAGTTT ATGATTGTGT CATAAAACAA TTAAAACGTC ATCAGAACAC CCAACAGGAT 7080

AAGTTTATAA TATGCTTGAA TAAAGTGGTT AAGAACTTTC CTCCTCTCGC TGACAGGTTT 7140

ATGAATGCAG TATTCTTTTT GATACCAAAA CTTCACGGTG TGATGAAAAA CTACTGTCTG 7200

GAAGTAATCA TGTGCCGAGC AGAGGAAATA CCTGATCTCT ATTTGCAGCT AAAGAGTAAA 7260

GACTTCATCC AGATCATGAA ACACAGGGAT GATGAAAGGC AAAGGGTTTG TTTGGATATA 7320

ATATACAAGA TGCTGTCTAC ACTGAAACCA CCAGAACTTA AAGAACTTCT TCCTGGAGTG 7380

ACAGGGTTCA TTTCTCACCC TTCTGTAATA TGTCGACAGC GCATGTATGA TATTCTCATG 7440

TGGATTTATG ATAATTACAG TGATCCAGAA AGCCAAGCAG ATGGTGATTC TCAGGAAGTG 7500

CTCAGTCTGG CAAAAGAAAT CCTGCTTCAG GGACTGATTG ATGAGAATGC TGAACTGCAA 7560

TTAATTGTTA GGAATTTTTG GAGTGACGAG ACAAGATTAC CTGCAAATAT TCTTGATCGT 7620

ATGCTGATGT TGTTAAATTC TTTATATTCT GCCAAGATTG AAACACAGTA CTTGAGTCTA 7680

ATCACAAATT TTCTGCTTGA AATGACCAGC AAAAGCCCAG ATTATTCCAG AAAAATATTT 7740

GAGCACCCAC TATCTGAATG CAAATTTCAT GACTTTGTAA TTGATTCCAG TTGGCGTTAT 7800

CGAAGTACCA TGCTCACACC TATGTTTGTG GAGACTCAGG CTTCGCAGAG TACTAACAGG 7860

AATTCATCCC AAGAAAGATC CCTTTCCATT TCTGGGTCAG TAGGTGGTCG AGTGAGAGCT 7920

ACCCAAAGGC AATATGAATT TACACCTACA CAGAATGTCA GTGGTAGAAG TTCTTTTAAT 7980

TGGCTAACTG GAAACAGCAT TGACACTTTG GCAGAGTATA CAGTTCCTTC TTCCTCCGAG 8040

TCTTTGTCTT CATCCATGCT GTTAGTTAAC AAAAGGAGTG AAAAATTTAA ACAGGCAGCC 8100

TTTAAACCTG TGGGGCCAGA TTTTGGGAAA AAAAGGCTGA GTTTACCTGG AGATAAGGTG 8160

GACAGCAAAA CTAAAGGCCT AGGTATAGAT GAACGAGCAG AGATTTTGAG ACTGCGGAGG 8220

CGTTTCTTAA AGGATCAAGA GAAAGTCAGT CTGATTTATG CTAGAAAAGG TGTGGCTGAA 8280

CAGAAAAGAG AAAAGGAGAT GAAATCAGAG CTGAAGATGA AGTTTGATGG CCAGGTTACT 8340

TTGTACAGAA GTTACCGTGT AGGAGACCTT CCTGACATCC AGATTGAACA CTGCAGCCTC 8400

ATTGCCCCTC TACAGGGCCT CGCCCAGAAA GATCCAACAT TTGCCAAGCA ACTTTTCAGC 8460

AGTTTGTTTG GTGGAATTTT TCATGAGGTG AAAAAATCTA AAATTCCCTC TGAGAAGAAA 8520

GCCATCATCC AGAAGCTGCT GAAGGACTTC AATCATTTCC TTAGTACAAG CGTTTCTTAC 8580

TTCCCACCAT TCATTGCGTG CATCCAGGAG ATAAGTTACA AGCACAGAGA GCTGCTGGAG 8640

CTGGATTCAG CTAACGTGAG CACGAGCTGC CTTGCCAGCC TACAGCAGCC TGTAGGCATC 8700

CTTCTTCTGG AGCATGCCCT GATGGCACTG TCCCCTGCAG AGGAGCCCCC ATCAAAGCGG 8760

ATGCGTGGCA GGACTGAGCT CCCCCCAGAC GTCGTCAAAT GGCTCGAGCT TGCTAAGCTT 8820

TACCGGTCTC TGGGAGATTA TGATGTCCTT CGTGGTATTT TCAGTGGTAA GATTGGGACT 8880

AAGGACATTA CACAGCAAGC GTTGCTGGCA GAAGCAAGGA GTGATTATGC TGAAGCAGCT 8940

AAATGTTATG ATGAGGCACT CTCCAAAGAA GATTGGGAAG ACGGGGAGCC AACTGAAGCA 9000

GAGAAAGACT TCTGGGAACT TGCATCTCTG GAATGCTATG ACCACCTCAC AGAATGGAAG 9060

TCTCTGGAGT ATTGTGCTAC TGTTAATATT GACAGTGGTA AACCTCCAGA CCTGAACAAA 9120

ACGTGGAGTG ATCCATTTTA TCAGGAGACG TATCTGCCCT ATATAATACG CAGTAAGTTG 9180

AAGCTACTGC TCAATGGGGA AAATGACCAG ACTTTGCTGA CTTTCATTGA TGAGGCAATG 9240

AAGACAGAAC AGAAGAAAGC TCTGATAGAG ATGCATTACA GCCAAGAGCT TAGTCTCCTT 9300

TACATCCTGC AAGATGATTT TGACAGAGCT AAATACTACA TTGGCAACGG CATACAGATC 9360

TTCATGCAGA GCTATTCCAG TATAGATACT TTGTTATACC AAAGTCGAAT GAGCAAACTG 9420

CAGTCTGTAC AGGCTCTGAC AGAAATACAG GATTTCATCA ATTTTATGAC CAAAACAAGT 9480

AACATAGCTT CACAGGCTAA ATCCCTGAAG AGACTTCTCA GAACTTGGAC GAGCAGATAT 9540

CCAGATGCTA AAATGGATCC CATGAACATC TGGGATGATA TCATTACAAA TCGGTGCTTC 9600

TTTCTTGACA AGCTGCAAGA GAAATTTCTC TGTGATAAGG CCAATGATAG TATGGAGGTG 9660

GATGAAGAAA GTAGTGTTGG AGACCAAATG GAAGTAGATC AACAGGATGA AGACATTCAC 9720

TCAATGATTA GAAGCTGCAA ATTTAACATG AAACTGAAGA TGATAGAAAG TGCCAGGAAA 9780

CAGAACAGCT TCTCCATTGC CAAGAAGCTT CTGAAGGGCC TGCGCAGAGA GGCCAAGACG 9840

AGGGAGGACT GGCTGGTGAG GTGGAACTAT GCCTACTGCC GCTTCGTGCA CAGCTGCAGC 9900

CAGAGCCAGA GTTGTCCTGA ACGAGTGCTC TCTGTGTTAA AAACCATCTC CCTGCTTGAA 9960

GATACCAAGT CAGACTACCT TAACAAGAAC ATAATGGCCT TCCGAAACCA GAATCTTCTG 10020

CTGGGTACTA CGTACCACAT CATGGCCAAT GCTCTTAGTC AGGATCCAAA ATGCTGTGAG 10080

CAAATAGAGG AAGAAAAAAC TGGAAAAATA TTGGAACTGT CAGGAGAAAG TTCTGAGAGT 10140

CCTGAAAAGA TATTAGCAGG TCTGAACAAG AGAGCTTTTC AGTGTTTCAG CAGCGCTGCG 10200

AGGAAGTCTG AAGAGGAAGT GCAGTCCCTC TCCATGGAAC ATGTTGATGT GAAGGGAGTT 10260

ATCGATGCGT ATATGACTTT GGTTGGTTTC TGTGACCAAC ACCTGCGAAA GGAAGAAGAA 10320

GGCTCACTTG AAATTAATGC TGCAGATCTG CAGCTATTCC CAGCTATTGT GGTGGAGAAA 10380

ATGATAAAAG CTTTAAAACT GAACTCCAGA GAAGCCAGGC TGAGGTTTCC TCGACTGCTA 10440

CAAATAATTG AAAGATATCC AGCGGAGACG CTGGGTCTGG TGACACGAGA GCTTCCTTCA 10500

GTTCCCTGCT GGCAGTTCAT CGGTTGGATT AGCCAGATGA TGGCACTCCT TGACAAGGAT 10560

GAGGCAGTGG CTGTGCAGCA CACTGTGGAA GAGATCGTGG ATACCTACCC CCAGGCAATC 10620

ATCTACCCGT TCACGATCAG CAGTGAGAGT TACTGCTTCA AAGATACCGC AGCAGGCTGT 10680

AGGAACAAGG AGTTTGTAGC AAGCATCAAG AACAAGTTGG ACAGAGGAGG AGTGGTTCAA 10740

GATTTTATTC ACGCCCTGGA ACAGCTCTCT AATCCCGTAA TGCTTTTTAA GGACTGGGTT 10800

GCGGATGTCA GAAATGAACT GGTAAAAACT CAGAGAAACA AAATTATACT TAAGGAAATG 10860

TATGAAGGAA TGTATAAGAA TTTGGGAGAT GTGAAGGCTC CCGGCCTTGG GTGGCTGAGG 10920

AAACGGTTTG TTCAGGCTTT TGGGAAGGAT TTTGACAGTC ATTTTGGAAA AGGCGGTTCA 10980

AAGCTGTTGG ATATGAAGAT CAGTGATTTC AATGAGATCA CAACAGCTCT TCTCACCAAA 11040

ATGAACAAAA CCCATAAAGA ACCTGGAAAC CTGAAAGAGT GTTCGCCATG GATGAGTGAA 11100

TTCAGAGCTG AGTTCTTGAG GAATGAGCTG GAGGTCCCTG GTCAGTACGA TGGGAAGGGG 11160

AAACCTCTAC CAGAGTACCA TGTGAAGATC TCTGGATTTG ATGAACGGAT AATGGTATTG 11220

GAATCCTTGA GGAAACCCAA GCGCATAACA ATCCGAGGCA GCGATGAGCA GGAGCATCCT 11280

TTTCTTGTCA AAGGTGGAGA AGACCTGCGA CAAGACCAAC GCATTGAGCA GCTGTTTGAT 11340

GTAATGAACA TCGTCCTTTC CCGAGATGCT GCCTGCAGCC AAAGGAATAT GCAGTTGAAA 11400

ACATACCAGG TCATCCCCAT GACCACAAGG CTGGGACTCA TCAAATGGCT GGAAAATACC 11460

TGTACCTTGA AAGAATTCCT GAGGAACAGC ATGACTGAAG AGGAAGATGC CAACTATAAC 11520

AGCCTAAAAG GACCTCGTGC TGCCTATTCT GACTGGCTGT CCAAGATGGG TGGGAAGGCA 11580

CAAGGCTTAT CTCGATACAA TGCTATGTAC AAAAATGCAA GCCGCACAGA AACGGTTATT 11640

GCCTTCAAGA GCAGGGAGAG CAGTGTTCCA GAAGATCTGC TGCGGAGGGC CTTTGTGAAG 11700

ATGAGCACAT CTCCTGAAGC TTTCCTGGCT CTGCGGTCGC ACTTTGTCAG CTCTCATGCA 11760

CTGATGTGCA TCAGTCACTG GATCCTCGGA ATTGGAGACA GACACCTGTC CAACTTCATG 11820

ATTAACAAGG AGACGGGTGG CATGGTGGGA ATAGACTTTG GACACGCGTT TGGCTCAGCC 11880

ACACAGTTTC TGCCCGTGCC AGAGCTGATG CCTTTCCGCC TGACGCGCCA GTTTGTCAAT 11940

CTGATGATGC CAGTGAAGGA GTGGGGCCTC ATTTACAGCG TGATGGTGCA TGCCCTGAGA 12000

GCGTACCGTG CGGATCCCGA TCTCCTCATC AGCACAATGG ATGTGTTTGT AAAAGAGCCT 12060

TCTCTGGACT GGAAGAACTT TGAACAAAGG CAGCTGAAAA AAGGAGGCAC GTGGATTAAG 12120

GAAATAAACA CCGCTGAAGT AAACTGGTAC CCCTTGCAAA AAGTCAGCTA TGTCAAAAGG 12180

AAGCTTACGG GTGCCAATCC TGCACGAATC ACTTGTGATG AGCTGCGCCT GGGCTATGAG 12240

AAGTTGCCTT TTTACAATGA CTTTGCAGCT GTTGCTCGTG GCAGCGCTGA CCATAATATC 12300

AGAGCCAAAG AGCCAGAGGA CGGGCTGTCT GAGGAGACCC AGGTGCGGTG CCTGATAGAC 12360

CAAGCGACAG ACCCCAACCT CCTTGGCAGG GTGTGGGAAG GATGGGAACC TTGGATGTGA 12420

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i gfder+ +l+s++kpk++++rGsd++e+p+Lvkg eDlrqd+r++qlf ++N +L +d

Q: 3730  ISGFDERIMVLESLRKPKRITIRGSDEQEHPFLVKGGEDLRQDQRIEQLFDVMNIVLSRD  3789

         789*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkkl.vekkavlldqpi..syry  117

         +++s+r+++++ty+V+p++tr+gli+w+ent +Lke+l++   e++++++++ +  +  y

Q: 3790  AACSQRNMQLKTYQVIPMTTRLGLIKWLENTCTLKEFLRNSmTEEEDANYNSLKgpRAAY  3849

         ***************************************986788888888666788899

S: 118   kdlstvqarkpk.lkhlkls.........levfkevlenlvpkdllkklllekfpspeew  167

          d+  ++  k + l+ +  +         +  fk +++  vp+dll+++++++++spe++

Q: 3850  SDWLSKMGGKAQgLSRYNAMyknasrtetVIAFKSRESS-VPEDLLRRAFVKMSTSPEAF  3908

         999888877433144444445567888888999999999.********************

S: 168   felrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpe  227

         ++lr+++ +s+A+++++++iLg+gdrhl+n++i++etg +v idfg+af++a+++l+vpe

Q: 3909  LALRSHFVSSHALMCISHWILGIGDRHLSNFMINKETGGMVGIDFGHAFGSATQFLPVPE  3968

         ************************************************************

S: 228   kvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk..  285

          +PFRLTr++vn++ ++++ G++++ ++++lr+ r +++ l ++++vf+++p++dwk+

Q: 3969  LMPFRLTRQFVNLMMPVKEWGLIYSVMVHALRAYRADPDLLISTMDVFVKEPSLDWKNfe  4028

         ************************************************************

S: 286   ....kkktsketeeelaekakaealkikkllskvekaenavatrdllll  330

             kk++++++e++ ae ++++ +k+ ++++k+++a++a +t+d+l+l

Q: 4029  qrqlKKGGTWIKEINTAEVNWYPLQKVSYVKRKLTGANPARITCDELRL  4077

         ***99***************************************99876

Domain Sequence
(FASTA)

ISGFDERIMV LESLRKPKRI TIRGSDEQEH PFLVKGGEDL RQDQRIEQLF DVMNIVLSRD 60

AACSQRNMQL KTYQVIPMTT RLGLIKWLEN TCTLKEFLRN SMTEEEDANY NSLKGPRAAY 120

SDWLSKMGGK AQGLSRYNAM YKNASRTETV IAFKSRESSV PEDLLRRAFV KMSTSPEAFL 180

ALRSHFVSSH ALMCISHWIL GIGDRHLSNF MINKETGGMV GIDFGHAFGS ATQFLPVPEL 240

MPFRLTRQFV NLMMPVKEWG LIYSVMVHAL RAYRADPDLL ISTMDVFVKE PSLDWKNFEQ 300

RQLKKGGTWI KEINTAEVNW YPLQKVSYVK RKLTGANPAR ITCDELRL 348

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005958	; C:DNA-dependent protein kinase-DNA ligase 4 complex
GO:0005667	; C:transcription factor complex
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0006915	; P:apoptotic process
GO:0032869	; P:cellular response to insulin stimulus
GO:0006303	; P:double-strand break repair via nonhomologous end joining
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0031648	; P:protein destabilization
GO:0010332	; P:response to gamma radiation
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR012582	; NUC194.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF08163	; NUC194; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013