EKS-GAG-00327
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00327
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11359.91.0E-107537793257
StatusUnreviewed
Ensembl ProteinENSGALP00000022482
UniProt AccessionF1NYS9;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000013892ENSGALP00000022482ENSGALT00000022522
OrganismGallus gallus
Functional Description
Protein Length998
Protein Sequence
(FASTA)
SFLSTDIAVV EMSDAFRQPS LFYHLGVRES FSMANNIILY CDTNSESLQS LKEIICQKNN 60
MCTGNYIFVP YMITPHNKVY CCDSSFMKGL TELMQPSFES LLGPICLPLV DRFIQLLKVA 120
QASSSQYFRE SILNDIRKAR TLYTGKELAA ELARIRQRVD NIEVLSADIV INLLLSYRDI 180
QDYDSIVKLV KTLEKLPTFD LASHHHVRLH YAFALNRRNL PGDRQKALEI MIPLVEQEDQ 240
VASDMYCLVG RIYKDMFLES GFIDTESRDK GTFWFKKAFE SEPTLQSGIN YAVLLLAAGH 300
CFDTSFELRK VGVKISSLLG KKGSLEKLQS YWEVGSFLAA SMLANDHIRV IQASEKLFKL 360
KAPAWYLKSI VDTILIYQHF KKLNPEQHTA KQELVDFWMD FLVEATKTDV SVVLILEPTK 420
IYQPSYLSIN SEAEEKTVSI WHVLPDDKKG IHEWNFSAAS IRGVSISKFE ERCCFLYVLH 480
NSDDFQIYFC TEVHCRRCVT VISKTTLITE EIGKSTEEGE CDGDSLEYDY EYDENGERVV 540
LGKGTYGIVY AGRDLSNQVR IAIKEIPERD SRYSQPLHEE IALHKHLKHK NIVQYLGSLS 600
ENGFIKIFME QVPGGNLSAL LRSKWGPLKN NEQTIGFYTK QILEGLKYLH DNQIVHRDIK 660
GDNVLINTYS GVLKISDFGT SKRLAGINPC TETFTGTLQY MAPEIIDKGP RGYGKAADIW 720
SLGCTIIEMA TGKPPFYELG EPQAAMFKVG MFKIHPEIPE SMSAEAKSFI LRCFEPDPDK 780
RAFAHELLVD EFLKVSSKKR KSPSKLSGKE FLSHKCYCSL KQVFRPLRWR WKISIPGERS 840
IFLFTECLFF SIPDENFEDH SAPPSPEEKD SGFFMLKKDS ERRATLHRIL TEDQEKVVRN 900
LMEALAQPKL KWEHITTLVS SLREFVRSTD RKIIATTLSK LKLELDFDSH GISQVQLVLF 960
GFQDAVNKVL RNHNIKPHWM FALDNIIRKA VQTAITIL 998
Nucleotide Sequence
(FASTA)
TCATTTCTTT CTACAGATAT TGCCGTTGTA GAGATGAGCG ACGCCTTTCG TCAGCCTTCC 60
CTCTTCTACC ACCTGGGAGT CAGAGAGAGC TTCAGTATGG CTAACAACAT TATCCTCTAC 120
TGTGATACGA ATTCTGAGTC TCTGCAGTCA CTGAAGGAAA TTATTTGCCA GAAGAATAAT 180
ATGTGTACTG GTAACTACAT CTTTGTTCCT TACATGATAA CTCCGCATAA CAAGGTGTAC 240
TGCTGTGATA GTAGTTTTAT GAAGGGACTA ACAGAACTGA TGCAGCCAAG TTTTGAATCT 300
CTGCTTGGGC CTATTTGCTT ACCTCTGGTG GATCGATTTA TCCAACTCTT GAAGGTGGCA 360
CAGGCCAGCT CGAGCCAGTA TTTTCGGGAA TCCATCCTTA ATGACATTAG GAAAGCCCGT 420
ACCCTCTACA CTGGCAAAGA GCTTGCAGCA GAGCTGGCAA GGATTCGGCA GCGAGTGGAT 480
AATATTGAGG TCTTGTCTGC TGACATTGTG ATCAACTTGC TGCTGTCCTA CAGAGACATT 540
CAGGATTACG ATTCCATTGT GAAACTGGTG AAAACTTTAG AAAAACTGCC TACTTTTGAC 600
TTGGCTTCCC ACCACCATGT GAGGTTACAT TATGCATTTG CACTGAACAG ACGAAATCTG 660
CCTGGGGACA GACAGAAAGC TCTAGAAATT ATGATTCCTT TAGTAGAACA AGAAGATCAA 720
GTAGCTTCAG ATATGTACTG CTTGGTTGGT CGCATTTACA AGGACATGTT TTTGGAATCT 780
GGGTTCATAG ATACGGAAAG CAGAGACAAA GGTACCTTCT GGTTCAAGAA GGCGTTTGAG 840
TCAGAGCCAA CACTGCAGTC AGGAATCAAT TATGCAGTAC TTCTTCTGGC AGCTGGACAT 900
TGCTTTGATA CTTCTTTTGA GCTTCGGAAA GTTGGGGTAA AGATCAGCAG CCTGCTTGGT 960
AAAAAGGGGA GCTTGGAGAA GCTGCAGAGC TATTGGGAAG TGGGATCTTT CTTGGCAGCC 1020
AGTATGTTGG CTAATGACCA CATAAGAGTG ATCCAGGCTT CAGAAAAGCT GTTTAAGCTA 1080
AAGGCACCAG CATGGTACCT GAAGTCTATT GTAGACACTA TTCTGATATA TCAGCATTTT 1140
AAGAAACTGA ATCCTGAACA GCATACAGCC AAGCAGGAAC TTGTGGACTT CTGGATGGAC 1200
TTCCTTGTTG AAGCCACGAA GACAGATGTG TCTGTAGTTT TAATACTGGA ACCAACCAAA 1260
ATCTATCAGC CCTCGTATCT CTCCATCAAC AGTGAAGCTG AGGAGAAGAC TGTATCTATC 1320
TGGCACGTGC TGCCTGATGA CAAGAAAGGT ATCCATGAGT GGAACTTCAG TGCTGCATCC 1380
ATCAGGGGAG TAAGCATTTC GAAGTTTGAA GAACGGTGCT GTTTTCTGTA TGTGCTGCAC 1440
AATTCTGATG ACTTTCAGAT CTATTTCTGC ACGGAAGTTC ATTGTAGAAG GTGTGTCACA 1500
GTTATTTCAA AAACCACTCT CATCACTGAA GAAATAGGGA AATCTACAGA GGAAGGAGAA 1560
TGCGATGGAG ACTCCCTGGA GTATGACTAT GAATATGATG AAAATGGCGA GCGAGTCGTC 1620
CTGGGGAAAG GAACTTATGG CATTGTGTAT GCAGGACGAG ATTTGAGCAA TCAAGTCAGA 1680
ATCGCTATTA AAGAAATCCC AGAGAGAGAT AGCAGGTACT CCCAGCCTCT GCATGAAGAA 1740
ATAGCTTTGC ATAAGCATCT CAAACACAAG AACATTGTGC AGTATTTGGG GTCTCTTAGC 1800
GAGAACGGTT TCATTAAGAT ATTCATGGAG CAGGTGCCTG GAGGTAACCT TTCTGCTCTT 1860
CTACGATCAA AATGGGGACC ATTAAAAAAT AATGAGCAGA CAATTGGCTT TTACACAAAG 1920
CAGATTCTCG AAGGATTAAA ATACCTCCAT GATAATCAAA TAGTGCATCG AGACATAAAG 1980
GGTGATAACG TGCTTATCAA CACTTACAGT GGAGTGTTAA AGATTTCAGA CTTTGGAACT 2040
TCAAAGAGAC TTGCAGGAAT CAACCCTTGT ACTGAAACTT TCACTGGTAC CCTTCAGTAT 2100
ATGGCACCAG AAATAATTGA CAAAGGGCCT CGTGGTTATG GGAAGGCTGC AGACATCTGG 2160
TCTTTGGGAT GCACTATCAT TGAGATGGCC ACAGGGAAAC CCCCGTTTTA TGAACTGGGA 2220
GAACCGCAAG CAGCTATGTT TAAGGTGGGA ATGTTTAAAA TCCACCCAGA GATTCCTGAG 2280
TCCATGTCTG CAGAGGCCAA GTCATTCATA CTGCGTTGCT TTGAACCAGA TCCTGACAAA 2340
CGAGCTTTTG CTCATGAGCT CCTTGTAGAT GAATTCTTGA AGGTTTCAAG CAAAAAAAGA 2400
AAATCCCCAT CAAAACTCTC AGGTAAAGAA TTTCTATCTC ATAAATGCTA TTGTTCCCTA 2460
AAACAGGTGT TTCGGCCTTT AAGATGGAGA TGGAAGATCT CCATCCCAGG TGAACGTTCA 2520
ATTTTTCTTT TCACTGAGTG CCTTTTCTTC AGCATCCCAG ATGAAAATTT TGAGGATCAC 2580
AGTGCACCTC CTTCACCTGA AGAGAAAGAT TCTGGATTTT TCATGCTGAA GAAGGATAGT 2640
GAGAGGAGAG CAACCCTTCA CAGGATACTG ACTGAGGACC AAGAGAAGGT GGTGAGGAAC 2700
TTGATGGAGG CTTTGGCTCA GCCCAAGCTA AAATGGGAAC ATATTACAAC GCTTGTTTCC 2760
AGCCTCAGAG AGTTTGTACG GTCCACTGAT CGTAAAATTA TTGCAACCAC TCTTTCAAAA 2820
CTGAAACTGG AGTTAGACTT TGACAGCCAC GGTATCAGTC AAGTGCAGCT TGTGTTGTTT 2880
GGTTTTCAAG ATGCTGTCAA TAAAGTTCTC CGAAACCATA ACATCAAGCC ACACTGGATG 2940
TTTGCGTTGG ACAACATAAT TAGAAAAGCT GTGCAGACAG CTATTACTAT TCTG 2994
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 537   ERVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  591
         6899**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gG ls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 592   IVQYLGSLSENGFIKIFMEQVPGGNLSALLRsKWGPLKnnEQTIGFYTKQILEGLKYLHD  651
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k
Q: 652   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  708
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+
Q: 709   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKIHPEIPESMSAEAKS  768
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         f+ +c+e dp+kr+ a+eLL +efl
Q: 769   FILRCFEPDPDKRAFAHELLVDEFL  793
         **********************996
Domain Sequence
(FASTA)
ERVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSLSENGFIK IFMEQVPGGN LSALLRSKWG PLKNNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180
ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKIHP EIPESMSAEA KSFILRCFEP 240
DPDKRAFAHE LLVDEFL 257
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00361
EKS-ANC-00378
EKS-BOT-00387
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-EQC-00380
EKS-FEC-00376
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-ICT-00368
EKS-LAC-00401
EKS-LOA-00395
EKS-MAM-00386
EKS-MAE-00046
EKS-MEG-00320
EKS-MIM-00057
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-NOL-00355
EKS-ORN-00500
EKS-ORA-00336
EKS-ORC-00364
EKS-ORL-00460
EKS-OTG-00390
EKS-PAT-00368
EKS-PES-00346
EKS-POA-00379
EKS-RAN-00402
EKS-SAH-00359
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-TUT-00109
EKS-XET-00502
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013