EKS-GAG-00341
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00341
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR563.62.0E-169572907336
StatusUnreviewed
Ensembl ProteinENSGALP00000036735
UniProt AccessionF1NW12;
Protein Name
Protein Synonyms/Alias Mast/stem cell growth factor receptor Kit;
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000013925ENSGALP00000036735ENSGALT00000037527
ENSGALG00000013925ENSGALP00000022531ENSGALT00000022571
OrganismGallus gallus
Functional Description
Protein Length958
Protein Sequence
(FASTA)
LKWTFLIEHC ILCFCFFFLG GSVPHEESSL VVNKGEELRL KCNEEGPVTW NFQNSDPSAK 60
TRISNEKEWH TKNATIRDIG RYECKSKGSI VNSFYVFVKD PNVLFLVDSL IYGKEDSDIL 120
LVCPLTDPDV LNFTLRKCDG KPLPKNMTFI PNPQKGIIIK NVQRSFKGCY QCLAKHNGVE 180
KISEHIFLNV RPVHKALPVI TLSKSYELLK EGEEFEVTCI ITDVDSSVKA SWISYKSAIV 240
TSKSRNLGDY GYERKLTLNI RSVGVNDSGE FTCQAENPFG KTNATVTLKA LAKGFVRLFA 300
TMNTTIDINA GQNGNLTVEY EAYPKPKEEV WMYMNETLQN SSDHYVKFKT VGNNSYTSEL 360
HLTRLKGTEG GIYTFFVSNS DASSSVTFNV YVKTKPEILT LDMLGNDILQ CVATGFPAPT 420
IYWYFCPGTE QRCLDSPTIS PMDVKVSYTN SSVPSFERIL VESTVNASMF KSTGTICCEA 480
SSNGDKSSVF FNFAIKEQIR THTLFTPLLI AFGVAAGLMC IIVMILVYIY LQKPKYEVQW 540
KVVEEINGNN YVYIDPTQLP YDHKWEFPRN RLSFGKTLGA GAFGKVVEAT AYGLFKSDAA 600
MTVAVKMLKP SAHLTEREAL MSELKVLSYL GNHINIVNLL GACTIGGPTL VITEYCCYGD 660
LLNFLRRKRD SFICPKHEEH AEAAVYENLL HQAEPTADAV NEYMDMKPGV SYAVPPKADK 720
KRPVKSGSYT DQDVTLSMLE DDELALDVED LLSFSYQVAK GMSFLASKNC IHRDLAARNI 780
LLTHGRITKI CDFGLARDIR NDSNYVVKGN ARLPPVKWMA PESIFNCVYT FESDVWSYGI 840
LLWELFSLGS SPYPGMPVDS KFYKMIKEGY RMFSPECSPP EMYDIMKSCW DADPLQRPTF 900
KQIVQLIEQQ LSDNAPRVYA NFSTPPSTQG NATDHSVRIN SVGSSASSTQ PLLVREDV 958
Nucleotide Sequence
(FASTA)
TTAAAGTGGA CATTTCTAAT TGAGCATTGT ATTTTGTGCT TTTGTTTTTT TTTTTTAGGT 60
GGTTCAGTGC CTCATGAAGA ATCCTCGCTG GTTGTGAACA AAGGGGAGGA GTTAAGGCTG 120
AAGTGCAATG AGGAAGGACC CGTGACTTGG AATTTCCAGA ACTCAGATCC ATCGGCAAAA 180
ACAAGGATTT CCAATGAGAA GGAATGGCAC ACCAAAAACG CAACAATCAG AGACATAGGC 240
AGATATGAGT GCAAAAGCAA AGGGAGTATT GTCAACTCTT TCTATGTTTT TGTTAAAGAT 300
CCAAATGTGC TCTTCCTTGT TGATTCTCTG ATCTATGGGA AAGAAGACAG TGACATCCTG 360
CTGGTGTGCC CACTAACAGA TCCAGATGTT TTGAACTTCA CCCTGAGAAA ATGCGATGGC 420
AAACCTCTCC CCAAAAACAT GACATTCATT CCCAATCCAC AGAAGGGTAT CATTATCAAG 480
AACGTACAGA GGTCATTCAA GGGCTGCTAC CAGTGCTTGG CAAAGCATAA TGGAGTTGAG 540
AAAATATCAG AACACATTTT CCTGAATGTG AGACCAGTTC ACAAAGCTCT TCCAGTCATT 600
ACCTTATCCA AAAGCTATGA GCTTCTCAAA GAAGGGGAAG AATTTGAAGT TACATGCATA 660
ATCACGGATG TGGATAGCAG CGTAAAAGCT AGTTGGATTT CTTACAAAAG TGCGATTGTT 720
ACAAGCAAAA GCAGAAATTT GGGTGATTAC GGATACGAAA GGAAATTAAC ATTGAACATC 780
CGTTCAGTGG GAGTTAATGA TTCTGGAGAA TTCACATGCC AAGCAGAGAA CCCTTTCGGA 840
AAAACCAATG CCACGGTAAC CTTGAAAGCA CTAGCTAAAG GATTTGTCCG TTTGTTTGCA 900
ACAATGAATA CCACAATTGA CATAAATGCA GGACAAAATG GAAATTTAAC AGTTGAATAT 960
GAGGCGTATC CCAAACCAAA GGAAGAAGTC TGGATGTACA TGAACGAAAC ATTGCAGAAT 1020
TCATCGGACC ATTATGTCAA GTTCAAGACT GTGGGCAATA ACAGTTATAC AAGCGAACTT 1080
CACCTTACCC GATTAAAAGG AACAGAGGGA GGCATTTACA CATTTTTTGT GTCCAACTCA 1140
GATGCCAGCT CCTCTGTAAC ATTTAATGTC TACGTGAAAA CAAAACCAGA GATCCTTACC 1200
TTGGATATGC TCGGCAATGA CATTCTTCAG TGTGTGGCAA CTGGATTCCC AGCCCCTACC 1260
ATTTACTGGT ATTTTTGCCC AGGAACTGAA CAGAGGTGTT TAGACTCACC AACGATATCC 1320
CCCATGGATG TGAAAGTCAG TTACACAAAC TCATCGGTGC CATCCTTTGA GCGGATCCTG 1380
GTCGAGAGCA CTGTGAACGC CAGCATGTTC AAGAGCACTG GTACCATCTG CTGTGAGGCA 1440
TCCAGCAATG GTGACAAGAG CTCTGTTTTC TTTAACTTTG CTATTAAAGA GCAAATCCGT 1500
ACCCACACCC TTTTCACACC TTTACTAATC GCATTTGGGG TCGCCGCTGG ACTGATGTGC 1560
ATCATAGTCA TGATCCTGGT GTACATATAT TTGCAGAAAC CCAAATATGA AGTCCAGTGG 1620
AAAGTTGTTG AAGAAATAAA TGGAAACAAC TATGTTTACA TAGACCCAAC GCAACTTCCT 1680
TATGATCACA AATGGGAGTT TCCTAGAAAC CGGTTGAGTT TTGGTAAAAC CCTTGGTGCT 1740
GGAGCTTTTG GAAAGGTTGT TGAAGCCACT GCTTATGGCC TATTTAAATC TGATGCCGCT 1800
ATGACAGTAG CAGTGAAAAT GTTGAAACCA AGCGCCCATT TAACTGAAAG AGAAGCCTTG 1860
ATGTCAGAGC TAAAAGTTCT CAGTTACCTT GGTAACCACA TTAATATTGT GAATCTACTT 1920
GGAGCTTGCA CTATTGGAGG GCCCACGCTG GTCATTACAG AATATTGCTG CTATGGCGAT 1980
CTCTTAAATT TCCTGAGGCG GAAGCGAGAT TCATTCATTT GTCCAAAGCA TGAAGAGCAC 2040
GCAGAAGCAG CTGTTTATGA GAACCTTTTG CACCAGGCAG AGCCCACAGC GGATGCTGTC 2100
AATGAGTACA TGGACATGAA ACCAGGAGTG TCATATGCTG TTCCCCCAAA AGCTGATAAA 2160
AAAAGGCCGG TGAAATCTGG ATCTTACACC GATCAGGATG TTACCCTTTC CATGTTGGAA 2220
GATGACGAAC TTGCTCTAGA TGTTGAAGAT CTATTAAGCT TCTCTTACCA GGTGGCAAAG 2280
GGCATGAGCT TCCTGGCCTC TAAAAACTGC ATTCATAGGG ATCTGGCAGC AAGAAATATT 2340
CTTCTCACTC ATGGTCGAAT AACAAAAATC TGTGACTTTG GTCTGGCAAG AGATATAAGG 2400
AATGACTCAA ATTACGTGGT TAAAGGAAAT GCTCGTCTCC CTCCTGTGAA GTGGATGGCA 2460
CCTGAAAGCA TTTTCAACTG CGTTTACACC TTCGAGAGTG ATGTCTGGTC TTATGGAATA 2520
TTGCTTTGGG AACTCTTCTC CTTAGGAAGC AGCCCTTACC CAGGGATGCC CGTGGACTCC 2580
AAGTTCTATA AAATGATCAA GGAGGGATAT CGGATGTTCA GCCCCGAGTG CTCACCCCCC 2640
GAAATGTACG ACATAATGAA GAGTTGCTGG GATGCCGATC CCTTGCAGAG ACCCACATTC 2700
AAACAGATCG TGCAGCTGAT AGAACAGCAG CTTTCCGATA ATGCCCCCCG GGTGTATGCA 2760
AACTTTTCCA CTCCGCCTTC CACTCAAGGC AATGCTACAG ATCATTCGGT GAGGATTAAC 2820
TCAGTGGGTA GCAGCGCTTC ATCTACTCAG CCCCTCCTGG TACGCGAAGA TGTTTGA 2877
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 572   LSFGKTLGAGAFGKVVEATAYGLFKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  631
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   + k++e++e++ +++
Q: 632   NHINIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CPKHEEHAEAAVYEN  688
         ******************************************...777788999999998
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l++  + ++++ +ey+d+k++vs+  + kadk++  k  s+++++v+ ++ e+d
Q: 689   L-----LHQ-AEPTADAVNEYMDMKPGVSYAVPPKADKKRPVKSGSYTDQDVTLSMLEDD  742
         8.....444.4456799*******************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l++edllsfsyqvakGm flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 743   ELALDVEDLLSFSYQVAKGMSFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRND  802
         ************************************************************
S: 241   snyvvkGnarl.pvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         snyvvkGnarl pvkwmapesif+++yt++sdvwsyGillwe+fslGs+pypg++vdskf
Q: 803   SNYVVKGNARLpPVKWMAPESIFNCVYTFESDVWSYGILLWELFSLGSSPYPGMPVDSKF  862
         ***********55***********************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         yk+ikeGyrm +p+ ++ e+y+im++cw+a+p +rp+fkq+v+l+
Q: 863   YKMIKEGYRMFSPECSPPEMYDIMKSCWDADPLQRPTFKQIVQLI  907
         ******************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLFKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHINIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICPKHEEHA EAAVYENLLH 120
QAEPTADAVN EYMDMKPGVS YAVPPKADKK RPVKSGSYTD QDVTLSMLED DELALDVEDL 180
LSFSYQVAKG MSFLASKNCI HRDLAARNIL LTHGRITKIC DFGLARDIRN DSNYVVKGNA 240
RLPPVKWMAP ESIFNCVYTF ESDVWSYGIL LWELFSLGSS PYPGMPVDSK FYKMIKEGYR 300
MFSPECSPPE MYDIMKSCWD ADPLQRPTFK QIVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002551; P:mast cell chemotaxis
GO:0043303; P:mast cell degranulation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013