EKS-GAG-00339
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00339
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR608.64.0E-183593950358
StatusUnreviewed
Ensembl ProteinENSGALP00000022536
UniProt AccessionF1N870;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000013929ENSGALP00000036730ENSGALT00000037522
ENSGALG00000013929ENSGALP00000009175ENSGALT00000009189
ENSGALG00000013929ENSGALP00000022536ENSGALT00000022576
ENSGALG00000013929ENSGALP00000036728ENSGALT00000037520
OrganismGallus gallus
Functional Description
Protein Length1087
Protein Sequence
(FASTA)
MGTPPRTFLI LGCFLTGPLL TLCQLPLPTI VPNRNEMVVQ LNSNFTLKCS GDSEVSWQYP 60
VTEGSHRIDI RHEENNSGLF MTVLEVGNAS AAHTGMYVCY YNHTQVEDGE VEGKDIYIYV 120
PDPDMPFVPS LPEDQFILVE EGDPTVIPCR TSDPSAEVTL VNSLDKPVYA FYDSKQGFVG 180
NFLAGPYTCK TMVKGVEFKS DEFLIYILRA TSQLPVEIEA LKTVYKTGET IVVTCVVFDN 240
EVVNLQWNYP GKVKEKGLIK LDDIKVPSQK LVYTLTIPDA SVKDTGDYEC TARHATKEVK 300
ENKKVVITVH DKGFIHLEPQ FSPLEAVNLH EVKNFVVDVQ AYPAPKMYWL KDNVTLIENL 360
TEIVTSSNRV QETRFQSVLK LIRAKEEDSG YYTLVAENED EIKRYTFSLL IQVPALILDL 420
MDDHQGSAGR QTVRCLAEGT PLPDVEWLVC KDIKKCSNDT SWTLLTNNIS DIHMEAHLDE 480
RNMVESQVTF QKVEETLAVR CVARNDLGAV TRELKLVAPT LRSELTVAAA VLVLLVIVII 540
SLIVLVIIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DNFLSRHPEK PKKDLDIFGM NPADESTRSY 720
VILSFENTGE YMDMKQADTT QYVPMLERKE GSKYSDIQRS VYDRPASYKK KSLSESEVKN 780
LLSDDGSEGL SLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMAKPDH ATNEVYEIMV KCWNSEPEKR PSFYHLSEIV ESLLPGEYKK 960
SYEKIHLDFL KSDHPAVTRM RGDCDNAYIG VTYKNEDKIK DRESGFDEQR LSADSGYIIP 1020
LPDIDPVSED ELGKRNRHSS QTSEESAIET GSSSSTFIKR EDETIEDIDM MDDIGIDSSD 1080
LVEDSFL 1087
Nucleotide Sequence
(FASTA)
ATGGGTACTC CCCCAAGGAC GTTCCTGATC CTGGGATGTT TTCTCACAGG ACCGCTCCTA 60
ACACTTTGCC AGCTTCCTCT GCCGACTATT GTTCCCAATA GAAATGAGAT GGTTGTACAG 120
CTGAATTCCA ATTTCACACT CAAATGCTCT GGAGACAGCG AAGTGAGCTG GCAGTACCCG 180
GTGACCGAGG GAAGCCACAG GATAGACATC AGACACGAGG AGAACAACAG TGGCCTCTTC 240
ATGACAGTGC TTGAAGTCGG AAATGCCTCA GCCGCTCACA CGGGCATGTA TGTTTGCTAT 300
TATAACCACA CGCAAGTGGA GGATGGGGAA GTCGAGGGGA AGGACATCTA CATCTATGTG 360
CCTGACCCAG ACATGCCTTT TGTTCCTTCC TTACCAGAAG ACCAGTTCAT CCTAGTAGAA 420
GAAGGTGATC CCACTGTTAT CCCTTGTCGG ACAAGTGACC CAAGTGCTGA AGTGACTTTA 480
GTTAACAGTT TAGACAAGCC TGTCTATGCT TTCTATGACA GCAAACAGGG CTTCGTAGGG 540
AACTTCCTTG CAGGACCATA CACATGCAAA ACAATGGTTA AAGGCGTGGA GTTCAAGTCC 600
GATGAGTTCC TCATCTATAT TTTAAGAGCT ACTTCACAGC TGCCGGTTGA AATTGAAGCT 660
CTGAAAACTG TCTACAAAAC AGGCGAGACC ATCGTAGTAA CTTGTGTGGT CTTTGACAAT 720
GAGGTGGTTA ATTTACAGTG GAATTATCCT GGGAAAGTGA AAGAAAAAGG TCTGATAAAA 780
CTTGATGATA TCAAAGTCCC ATCACAGAAG TTGGTTTACA CGTTGACCAT ACCTGACGCA 840
TCAGTGAAAG ACACAGGGGA TTATGAATGT ACTGCCCGAC ATGCAACCAA GGAGGTTAAG 900
GAAAATAAGA AAGTAGTCAT TACAGTTCAT GACAAAGGGT TCATTCATCT AGAGCCTCAA 960
TTTAGCCCTT TGGAAGCTGT CAATCTACAT GAAGTCAAAA ATTTTGTCGT CGATGTGCAG 1020
GCGTACCCCG CTCCAAAAAT GTACTGGTTG AAGGATAATG TGACTCTGAT TGAAAACCTT 1080
ACTGAGATTG TTACTAGTTC AAACAGAGTC CAGGAAACAC GGTTTCAAAG TGTACTAAAA 1140
TTGATCCGGG CCAAGGAAGA AGACAGTGGG TACTATACTT TGGTTGCTGA AAATGAAGAT 1200
GAGATTAAGA GATACACCTT CTCGTTGCTA ATACAAGTTC CAGCCTTGAT CTTAGACCTC 1260
ATGGACGACC ACCAAGGCTC TGCTGGCAGG CAGACGGTGA GGTGCTTGGC TGAAGGTACC 1320
CCGCTTCCTG ATGTGGAATG GTTGGTTTGC AAGGACATTA AAAAATGCAG CAATGACACT 1380
TCCTGGACTC TTCTGACTAA CAACATCTCT GATATACACA TGGAAGCCCA CCTGGATGAG 1440
AGGAATATGG TGGAAAGCCA GGTGACCTTC CAGAAGGTAG AAGAAACCCT GGCTGTGAGA 1500
TGTGTAGCAA GAAATGACCT TGGAGCTGTT ACTCGGGAAC TGAAACTTGT GGCTCCCACC 1560
TTGCGATCAG AACTGACGGT GGCTGCTGCT GTCTTAGTAC TGCTGGTGAT TGTGATAATT 1620
TCACTGATTG TCCTGGTCAT CATCTGGAAA CAGAAGCCAA GGTATGAGAT AAGATGGAGA 1680
GTCATTGAGT CTATCAGCCC CGATGGCCAT GAATACATTT ATGTGGACCC AATGCAGCTA 1740
CCTTATGACT CCAGATGGGA GTTTCCTCGA GATGGGCTAG TGCTTGGTCG AATCCTTGGT 1800
TCTGGTGCAT TTGGAAAAGT GGTGGAAGGG ACAGCATATG GATTGAGTCG TTCTCAACCT 1860
GTGATGAAAG TAGCCGTGAA AATGCTGAAA CCTACAGCTA GATCCAGCGA AAAACAGGCG 1920
CTCATGTCTG AACTGAAGAT AATGACACAT CTTGGGCCCC ACCTGAATAT TGTGAACCTG 1980
CTTGGAGCTT GTACGAAATC AGGTCCTATT TACATAATCA CTGAATACTG CTTTTACGGT 2040
GATTTGGTGA ACTATCTGCA CAAGAACAGG GACAACTTCC TCAGCCGACA TCCAGAGAAA 2100
CCAAAGAAAG ATCTGGATAT TTTTGGGATG AACCCAGCTG ATGAAAGCAC AAGAAGCTAT 2160
GTGATTTTAT CATTTGAAAA CACCGGAGAA TATATGGATA TGAAACAAGC TGATACCACT 2220
CAGTATGTGC CAATGCTGGA AAGGAAGGAG GGATCTAAAT ACTCTGATAT TCAGAGATCT 2280
GTATATGATC GACCTGCTTC ATATAAGAAG AAATCTTTGT CAGAATCAGA AGTAAAAAAC 2340
CTTCTTTCAG ATGACGGTTC GGAGGGTCTA AGCCTACTGG ATTTGCTAAG CTTCACCTAC 2400
CAGGTTGCAC GGGGAATGGA ATTCTTGGCT TCTAAAAATT GCGTACACCG TGACTTGGCA 2460
GCTCGTAATG TCCTTCTGGC TCAAGGCAAA ATCGTGAAGA TCTGCGACTT TGGGTTGGCT 2520
AGAGACATCA TGCATGATTC CAACTATGTC TCCAAGGGCA GCACCTTCCT CCCAGTAAAA 2580
TGGATGGCAC CTGAAAGCAT TTTTGACAAT CTGTACACAA CATTAAGTGA TGTCTGGTCT 2640
TATGGCATTC TGCTGTGGGA AATATTTTCT CTTGGTGGCA CACCATATCC TGGCATGATG 2700
GTCGACTCCA CCTTCTACAA TAAGATAAAG AGTGGCTACC GAATGGCAAA ACCTGATCAT 2760
GCTACCAATG AAGTGTATGA GATCATGGTA AAGTGCTGGA ACAGTGAACC AGAGAAAAGA 2820
CCTTCGTTTT ACCATCTGAG TGAAATTGTG GAGAGCTTGT TGCCTGGAGA GTACAAAAAG 2880
AGCTACGAGA AGATTCACCT GGACTTCCTG AAAAGCGATC ACCCAGCTGT CACTCGAATG 2940
AGAGGGGACT GTGACAATGC TTACATTGGT GTCACCTACA AGAATGAAGA CAAGATAAAG 3000
GATAGAGAGA GTGGATTTGA TGAGCAGAGG CTGAGTGCTG ACAGTGGGTA CATCATCCCC 3060
CTGCCTGACA TTGACCCTGT TTCTGAAGAT GAGCTTGGCA AAAGGAACAG GCACAGTTCC 3120
CAGACATCTG AAGAGAGTGC CATTGAAACC GGTTCCAGTA GCTCTACCTT TATAAAGAGA 3180
GAGGATGAGA CCATTGAGGA CATTGACATG ATGGATGACA TTGGAATTGA CTCCTCGGAT 3240
CTTGTAGAGG ACAGCTTCCT GTAA 3264
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r++fl+++ ek   ++++ld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFLSRHPEK---PKKDLDIFG  709
         *********************************************999...899999999
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         + +ad+s+rs+++ls+e+++ey+d+k++                +sd+++s +d++as+k
Q: 710   MnPADESTRSYVILSFENTGEYMDMKQAdttqyvpmlerkegskYSDIQRSVYDRPASYK  769
         99*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+ e+evk+ l+++ se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKSLSESEVKNLLSDDGSEGLSLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATNEVYEIMVKCWNSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDN FLSRHPEKPK KDLDIFGMNP 120
ADESTRSYVI LSFENTGEYM DMKQADTTQY VPMLERKEGS KYSDIQRSVY DRPASYKKKS 180
LSESEVKNLL SDDGSEGLSL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT NEVYEIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0010544; P:negative regulation of platelet activation
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013