EKS-GAG-00361

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00361

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	539.7	1.4E-162	99	356	258

Status

Reviewed

Ensembl Protein

ENSGALP00000031130

UniProt Accession

Q6U1I9;

Protein Name

Serine/threonine-protein kinase Sgk1

Protein Synonyms/Alias

Serum/glucocorticoid-regulated kinase 1;

Gene Name

SGK1

Gene Synonyms/Alias

SGK1; SGK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000013971	ENSGALP00000031130	ENSGALT00000031766

Organism

Gallus gallus

Functional Description

Protein kinase that may play an important role incellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity).

Protein Length

432

Protein Sequence
(FASTA)

MTVKAAEASG PALTYSKMRG MVAILIAFMK QRRMGLNDFI QKIATNSYAC KHPEVQSILK 60

ISQPQEPELM NANPSPPPSP SQQINLGPSS NPHAKPSDFH FLKVIGKGSF GKVLLARHKA 120

EEQFYAVKVL QKKAILKKKE EKHIMSERNV LLKNVKHPFL VGLHFSFQTA DKLYFVLDYI 180

NGGELFYHLQ RERCFLEPRA RFYAAEIASA LGYLHSLNIV YRDLKPENIL LDSQGHIVLT 240

DFGLCKENIE HNGTTSTFCG TPEYLAPEVL HKQPYDRTVD WWCLGAVLYE MLYGLPPFYS 300

RNTAEMYDNI LNKPLQLKPN ITNSARHLLE GLLQKDRTKR LGAKEDFTEI KNHIFFSPIN 360

WDDLINKKIT PPFNPNVSGP SDLRHFDPEF TDEPVPNSIG QSPDSILITA SVKEAAEAFL 420

GFSYAPPVDS FL 432

Nucleotide Sequence
(FASTA)

ATGACAGTGA AGGCGGCCGA AGCTTCGGGT CCCGCTTTGA CTTACTCGAA GATGAGGGGG 60

ATGGTGGCCA TTCTCATCGC TTTCATGAAA CAGAGAAGGA TGGGGCTTAA TGATTTCATT 120

CAGAAGATAG CCACCAACTC CTATGCCTGC AAGCACCCTG AAGTTCAATC TATCTTGAAA 180

ATCTCCCAGC CCCAAGAGCC TGAACTTATG AACGCTAATC CTTCTCCTCC GCCCAGTCCA 240

TCACAACAGA TAAATCTCGG TCCATCATCC AACCCACATG CCAAGCCATC GGACTTTCAT 300

TTCTTAAAAG TTATTGGAAA AGGAAGCTTT GGAAAGGTTC TTCTTGCACG GCATAAGGCA 360

GAAGAGCAGT TTTATGCTGT TAAAGTCCTA CAGAAAAAAG CAATCCTGAA GAAGAAGGAG 420

GAAAAGCACA TCATGTCAGA GCGCAATGTT CTGCTGAAAA ATGTGAAACA CCCCTTCCTG 480

GTCGGCCTTC ACTTCTCCTT CCAAACTGCG GACAAACTGT ATTTTGTCCT GGACTACATC 540

AATGGCGGAG AGTTGTTCTA CCATCTCCAG AGGGAGCGTT GCTTCCTGGA ACCAAGGGCC 600

CGATTTTATG CTGCTGAAAT TGCCAGTGCG CTGGGCTACC TGCACTCCCT GAACATTGTC 660

TATCGTGACT TGAAGCCGGA GAATATTCTG CTTGATTCAC AGGGGCACAT TGTCTTGACT 720

GACTTTGGAC TCTGCAAGGA AAACATAGAG CACAATGGCA CAACCTCCAC CTTCTGTGGC 780

ACACCTGAGT ACCTTGCTCC TGAAGTTCTT CACAAGCAGC CCTATGACAG GACTGTGGAC 840

TGGTGGTGCC TTGGAGCAGT CTTGTATGAG ATGCTTTATG GCCTGCCACC TTTCTACAGC 900

AGAAACACGG CAGAAATGTA TGATAACATC TTGAACAAAC CTTTGCAACT GAAGCCAAAT 960

ATTACCAACT CTGCGAGACA TCTCCTGGAA GGCCTTTTGC AGAAAGACAG GACAAAGAGG 1020

CTTGGTGCCA AGGAGGACTT TACGGAGATT AAGAATCACA TCTTCTTCTC CCCAATTAAC 1080

TGGGATGATC TCATTAATAA GAAGATTACC CCCCCTTTTA ACCCAAATGT GAGTGGCCCC 1140

AGTGACCTGC GGCACTTTGA TCCTGAATTT ACAGATGAGC CAGTCCCCAA CTCTATTGGC 1200

CAGTCTCCAG ACAGCATCCT CATCACCGCC AGCGTCAAAG AAGCTGCTGA GGCTTTTTTG 1260

GGCTTCTCAT ATGCCCCACC TGTGGACTCT TTCTTGTGA 1299

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 99    FHFLKVIGKGSFGKVLLARHKAEEQFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  158

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 159   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  218

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie++ ttstfcgtpeylapevl+k+pydrt

Q: 219   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT  278

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a++lle+ll+kdr+

Q: 279   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRT  338

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgakedf eiknh+ff

Q: 339   KRLGAKEDFTEIKNHIFF  356

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEQFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEHNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHL LEGLLQKDRT 240

KRLGAKEDFT EIKNHIFF 258

Keyword

Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Endoplasmic reticulum; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Stress response; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005783	; C:endoplasmic reticulum
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0006974	; P:response to DNA damage stimulus

KEGG

gga:395133

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013