EKS-GAG-00089
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00089
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec472.62.6E-142274524251
StatusUnreviewed
Ensembl ProteinENSGALP00000022821
UniProt AccessionE1C035;
Protein Name
Protein Synonyms/Alias
Gene NameTXK
Gene Synonyms/Alias TXK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000014127ENSGALP00000022821ENSGALT00000022861
OrganismGallus gallus
Functional Description
Protein Length530
Protein Sequence
(FASTA)
MFLFTDHTIQ SVFCCCCCCC TVQKRIRATR TKINVDTDAD LETQYSASQS EDSYAPTWKC 60
KRKKKLHVKN KPLPPLPAEA FADYTKNLKV IALYDFFARG PSDLTLKQSE EYIILEQYDP 120
HWWKARDHYG NEGLIPSNYV TENTKSNLET YEWYCKNINR SQAELLLRQK SKEGSFVVRD 180
SSQQGILTLS VYSRSKGSHG GDIRHYQIKK NHLKQYYVAE KYLFSSIPEL IQYHQHNAAG 240
LITRLRHPVR SITSSSPATA GFSYEEWELN PSELTFMKEL GRGQFGIVHL GKWKTTIKVA 300
IKKINEGAMS EDDFMEEAKL MMKLSHPKLV QLYGVCTRQK PLYVVTEFLE NGCLLNYLRQ 360
RRGKLSRDML LGMCLDVCEG MEYLERNNFI HRDLAARNCL VNAEHTVKVS DFGMARYVID 420
DEYVSSSGAK FPIKWSSPEV FHFKKYSSKS DIWSFGVLMW EVFTEGKMPF ESKSNYEVVR 480
EISAGNRLYR PHLASHTVYK VMYSCWHEKP EGRPTFAELV ETLTDIMEMG 530
Nucleotide Sequence
(FASTA)
ATGTTCTTGT TTACAGATCA CACCATCCAG TCTGTTTTCT GCTGCTGCTG CTGCTGCTGC 60
ACGGTGCAAA AACGAATTAG AGCAACGAGA ACAAAGATAA ATGTGGACAC TGACGCTGAC 120
CTGGAGACCC AGTATTCAGC CTCTCAATCA GAGGATTCCT ATGCACCTAC TTGGAAGTGT 180
AAGCGTAAGA AGAAATTGCA TGTAAAGAAC AAGCCGTTAC CTCCTCTACC TGCTGAGGCT 240
TTTGCAGACT ACACAAAAAA CCTCAAAGTT ATTGCTCTAT ATGACTTTTT CGCTAGAGGA 300
CCCTCTGATT TAACACTCAA GCAGTCAGAA GAATACATTA TCCTTGAACA GTATGATCCT 360
CACTGGTGGA AGGCAAGAGA CCATTATGGG AATGAAGGTC TAATTCCTAG CAACTATGTT 420
ACTGAGAACA CAAAAAGTAA TTTGGAAACA TATGAGTGGT ATTGCAAGAA CATCAACAGA 480
AGCCAGGCAG AACTACTCTT GCGACAGAAG TCCAAAGAAG GTTCATTTGT TGTCAGAGAT 540
TCAAGTCAAC AGGGAATCCT GACACTGTCT GTGTATTCAC GGTCTAAAGG AAGTCATGGT 600
GGAGACATTC GACATTATCA AATTAAGAAA AACCACTTGA AACAGTATTA TGTAGCAGAA 660
AAATATCTAT TCTCCTCTAT TCCTGAGCTC ATTCAATATC ATCAACACAA TGCAGCAGGT 720
CTTATCACCC GTCTCCGACA TCCAGTCAGA TCAATCACCA GTTCTTCACC AGCAACAGCA 780
GGATTTAGTT ACGAGGAGTG GGAATTGAAC CCCTCAGAAC TGACGTTTAT GAAAGAGCTT 840
GGGCGAGGGC AATTTGGAAT TGTTCATCTG GGTAAATGGA AAACAACCAT CAAGGTTGCC 900
ATCAAAAAAA TCAATGAAGG TGCGATGTCT GAAGACGATT TCATGGAGGA GGCCAAATTG 960
ATGATGAAAC TATCCCATCC AAAGCTGGTC CAGCTGTATG GGGTGTGCAC ACGCCAGAAG 1020
CCTCTCTATG TGGTGACTGA ATTCCTGGAG AATGGCTGCC TGCTCAACTA CCTGCGGCAG 1080
CGGCGGGGGA AGCTCAGCAG AGACATGCTG CTGGGCATGT GCCTGGATGT GTGTGAAGGG 1140
ATGGAGTATC TGGAAAGAAA CAACTTTATT CACCGTGATT TAGCTGCAAG GAACTGCTTA 1200
GTCAATGCTG AACACACTGT TAAAGTATCC GACTTTGGCA TGGCAAGATA CGTCATTGAT 1260
GATGAATATG TCAGCTCTTC AGGTGCCAAG TTTCCAATCA AGTGGTCATC TCCTGAAGTC 1320
TTTCATTTCA AAAAGTACAG CAGTAAATCT GACATCTGGT CATTTGGTGT ACTGATGTGG 1380
GAAGTTTTCA CAGAAGGCAA AATGCCTTTT GAAAGTAAAT CAAATTACGA AGTTGTCCGT 1440
GAGATTTCTG CAGGTAACCG ACTTTATCGA CCGCATTTGG CGTCACACAC AGTGTACAAA 1500
GTCATGTACA GCTGCTGGCA TGAGAAGCCT GAAGGACGTC CTACTTTTGC AGAATTAGTA 1560
GAAACCCTCA CAGATATAAT GGAGATGGGA TAA 1593
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt++kelg gqfg+v+lgkw++ i+vaik i+egamse+df+eeak mmklshpklvqly
Q: 274   LTFMKELGRGQFGIVHLGKWKTTIKVAIKKINEGAMSEDDFMEEAKLMMKLSHPKLVQLY  333
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++qkp+y+vte+lengcllnylr++++kl++++ll mc dvcegmeyler++fihrd
Q: 334   GVCTRQKPLYVVTEFLENGCLLNYLRQRRGKLSRDMLLGMCLDVCEGMEYLERNNFIHRD  393
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+ e++vkvsdfg+aryv+dd+yvss+gakfp+kws+pev++++kyssksd+w
Q: 394   LAARNCLVNAEHTVKVSDFGMARYVIDDEYVSSSGAKFPIKWSSPEVFHFKKYSSKSDIW  453
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+p+e ksn+evv+++s g rlyrp+las++vy+vm+scw+ekpe+r
Q: 454   SFGVLMWEVFTEGKMPFESKSNYEVVREISAGNRLYRPHLASHTVYKVMYSCWHEKPEGR  513
         ************************************************************
S: 241   ptfkellsale  251
         ptf+el+++l+
Q: 514   PTFAELVETLT  524
         *******9986
Domain Sequence
(FASTA)
LTFMKELGRG QFGIVHLGKW KTTIKVAIKK INEGAMSEDD FMEEAKLMMK LSHPKLVQLY 60
GVCTRQKPLY VVTEFLENGC LLNYLRQRRG KLSRDMLLGM CLDVCEGMEY LERNNFIHRD 120
LAARNCLVNA EHTVKVSDFG MARYVIDDEY VSSSGAKFPI KWSSPEVFHF KKYSSKSDIW 180
SFGVLMWEVF TEGKMPFESK SNYEVVREIS AGNRLYRPHL ASHTVYKVMY SCWHEKPEGR 240
PTFAELVETL T 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00100
EKS-BOT-00109
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-EQC-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MAM-00104
EKS-MEG-00084
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MUP-00112
EKS-MYL-00122
EKS-NOL-00101
EKS-ORC-00100
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-POA-00101
EKS-RAN-00106
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013