EKS-GAG-00230

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00230

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	458.2	1.1E-137	182	469	288

Status

Unreviewed

Ensembl Protein

ENSGALP00000020465

UniProt Accession

H9L0L7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000014631	ENSGALP00000020465	ENSGALT00000020492
ENSGALG00000014631	ENSGALP00000023536	ENSGALT00000023582

Organism

Gallus gallus

Functional Description

Protein Length

480

Protein Sequence
(FASTA)

EMTLPTLTCL CSDCKQANST CETDGACMVS VFNLDGVKHH VRTCIPEAKL IPAGKPFYCL 60

SSEDLRNTHC CYSDFCNKID LMVPSGHLKD NEPPSSWGPV ELVAVIAGPV FLVFVVVIIV 120

VFVFHHHQRV YHNRQRLDME DPSCEMCLSK DKTLQDLVYD LSTSGSGSGL PLFVQRTVAR 180

TIVLQEIIGK GRFGEVWRGR WRGGDVAVKI FSSREERSWF REAEIYQTVM LRHENILGFI 240

AADNKDNGTW TQLWLVSDYH EHGSLFDYLN RYTVTIEGMI KLALSAASGL AHLHMEIVGT 300

QGKPGIAHRD LKSKNILVKK NGTCAIADLG LAVRHDSVTD TIDIAPNQRV GTKRYMAPEV 360

LDETINMKHF DSFKCADIYA LGLVYWEIAR RCNAGGIHEE YQLPYYDLVP SDPSIEEMRK 420

VVCDQKLRPN IPNWWQSYEA LRVMGKMMRE CWYANGAARL TALRIKKTLS QLSVQEDVKI 480

Nucleotide Sequence
(FASTA)

GAGATGACCC TCCCAACTCT GACATGTCTG TGCTCTGACT GCAAGCAAGC CAACTCCACC 60

TGCGAGACGG ACGGCGCCTG CATGGTGTCC GTCTTCAACC TGGATGGGGT GAAGCACCAC 120

GTGCGGACCT GCATCCCCGA AGCCAAACTG ATCCCTGCTG GGAAACCCTT CTACTGCCTG 180

AGCTCCGAGG ACCTGCGGAA CACCCACTGC TGCTACTCTG ATTTTTGCAA CAAGATCGAT 240

TTAATGGTTC CCAGCGGACA CCTGAAGGAC AACGAGCCCC CATCAAGCTG GGGTCCGGTG 300

GAGCTGGTGG CAGTGATTGC TGGGCCCGTC TTCCTCGTCT TCGTGGTCGT CATCATTGTT 360

GTCTTCGTGT TTCATCACCA CCAGCGCGTC TATCACAACC GGCAGCGGCT GGACATGGAG 420

GACCCCTCTT GTGAAATGTG CCTGTCGAAG GACAAGACGC TGCAAGATCT CGTCTACGAT 480

CTCTCCACCT CTGGCTCTGG CTCAGGTTTG CCACTTTTTG TGCAGCGGAC CGTGGCTCGG 540

ACGATCGTCC TGCAGGAGAT CATTGGGAAG GGCCGCTTTG GGGAGGTGTG GCGCGGCCGA 600

TGGCGCGGAG GTGACGTGGC TGTGAAGATC TTCTCTTCCC GTGAGGAACG TTCCTGGTTC 660

AGGGAAGCAG AAATCTACCA AACCGTTATG CTGCGACATG AGAACATCCT GGGCTTCATT 720

GCTGCAGACA ACAAAGACAA CGGGACGTGG ACACAGCTGT GGCTCGTCTC CGATTACCAC 780

GAGCACGGAT CTCTCTTTGA CTACCTGAAC CGCTACACGG TGACCATAGA GGGGATGATC 840

AAGCTTGCTC TGTCTGCTGC CAGCGGGCTG GCCCACCTGC ACATGGAGAT CGTGGGTACT 900

CAGGGAAAGC CTGGGATTGC TCACAGAGAC CTGAAATCCA AGAACATCTT GGTGAAGAAG 960

AATGGCACGT GTGCCATTGC TGACCTGGGG CTCGCTGTGC GCCACGACTC CGTCACGGAC 1020

ACCATTGACA TCGCCCCGAA CCAAAGGGTT GGAACCAAAC GATACATGGC TCCCGAGGTC 1080

CTGGATGAAA CCATCAACAT GAAGCACTTT GATTCATTTA AGTGTGCTGA TATCTACGCC 1140

CTGGGTTTGG TCTACTGGGA GATCGCTCGC AGGTGCAACG CAGGAGGGAT CCACGAGGAG 1200

TATCAGCTGC CATACTACGA CCTGGTGCCC TCTGACCCTT CCATCGAGGA GATGCGGAAG 1260

GTGGTGTGCG ATCAGAAGCT GCGGCCGAAC ATCCCCAACT GGTGGCAGAG CTACGAGGCG 1320

CTGCGGGTGA TGGGTAAGAT GATGAGGGAG TGTTGGTACG CCAACGGAGC GGCTCGCCTC 1380

ACCGCCCTGC GCATTAAGAA GACCCTCTCA CAGCTCAGCG TCCAGGAAGA TGTGAAGATC 1440

TAA 1443

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 182   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  241

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 242   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  301

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk++tc+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 302   G--KPGIAHRDLKSKNILVKKNGTCAIADLGLAVRHDSVTDTIDIAPNQRVGTKRYMAPE  359

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 360   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNA-GGIHEEYQLPYYDLVPSDPSIEEM  418

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 419   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  469

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GTCAIADLGL AVRHDSVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNAGGIHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013