EKS-GAG-00011
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00011
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph443.42.0E-133587844258
StatusUnreviewed
Ensembl ProteinENSGALP00000023625
UniProt AccessionF1NB88;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA1
Gene Synonyms/Alias EPHA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000014687ENSGALP00000036274ENSGALT00000037062
ENSGALG00000014687ENSGALP00000023625ENSGALT00000023671
OrganismGallus gallus
Functional Description
Protein Length941
Protein Sequence
(FASTA)
VNLLDTSTAQ GELGWLPDPP EIGWSEVQQM INGTPVYMYQ DCSVLSEGDT DHWLRTNWIY 60
RGEAASRIYV ELKFTVRDCK SFKGEAVTCK ETFNLYYMES EQDVGIQFRR PMFIKLNTVA 120
ADRSFTNRDI ESGAMQLNTE VCPIGKLSRR GFYLAFQNSG ACVAMVSVRV YYKTCPEAVQ 180
GLARFPETLA GLEGLTEVPG VCVEYAAEET GSPPRMHCST DGEWLVPMGR CLCAVGFEEV 240
DGSCVACQRG FYRHSLETKR CLKCPPNSLS NELGATSCSC NAGFYRAPSE GQNIACTRPP 300
SAPRNVSFSL TGTQLSLWWQ PPSDHGGRKD LTYTVFCQRC HFLSCDPCEP GVVFSPSSSG 360
LTKTAVDVDG LEAYTNYTFA VEAHNGVSGM GPAPQRTAPA VWVAVGHAAP VTVSQFILTQ 420
RDDSSLSVSW LAPRQRSRTS VEYEVMFFEK GEEARYTVKH LLEPNVTLTD LQPDTTYLLR 480
VRSITPLGPG PYSQEQEFRT LPPGTGALSG GVMASIIFGV LLFIGLLLGI LFFRRKKAHR 540
RQARPDYSTS GFDREKVWLK PYVDLQPYDD PSRGVLEFIK ELDVSCVTME NVIGEGEFFG 600
EVYRGSLRLP GKERIVVAIK TLKSTYSDSQ WWNFLREATI MGQFNHPNIV HLEGVVTKRR 660
PMMIITEYME NGALDTFLRE NEEKFSPVQL VNMLQGIASG MTYLSEHNYV HRDLAARNIL 720
VTRSLQCKVS DFGLSRILEN DAEGTYETKG GKIPIRWTAP EAIAHRIFTS ASDVWSFGIV 780
MWEVLSFGDK PYGNMTNQEV MKSLEDGYRL PPPVDCPSIL YELMKSCWSH DRMRRPHFQE 840
IRAQLQHFSS SPHLLRCVAD FDPRVTLRLP SCSGSDGIPY RSIPEWLESI RMKRYISNFR 900
TAGLDTMESI LDLTAEDLKQ MGVSLPGHQK RILCSIQGFK E 941
Nucleotide Sequence
(FASTA)
GTGAATCTGC TAGACACAAG CACTGCACAG GGTGAGCTGG GCTGGCTTCC AGACCCTCCA 60
GAAATAGGGT GGAGTGAAGT GCAGCAGATG ATAAATGGTA CCCCAGTCTA TATGTACCAG 120
GACTGCAGCG TGCTCTCTGA GGGTGACACT GATCACTGGC TTCGCACCAA CTGGATTTAT 180
CGGGGTGAGG CAGCATCTCG CATTTATGTG GAGCTGAAGT TTACTGTGAG AGACTGCAAG 240
AGCTTCAAAG GTGAAGCGGT GACCTGCAAA GAGACTTTCA ACCTCTACTA CATGGAGTCT 300
GAGCAGGATG TTGGGATCCA GTTCCGCCGC CCAATGTTCA TCAAGCTCAA CACTGTGGCA 360
GCAGATCGAA GTTTCACAAA CAGAGACATC GAATCTGGTG CCATGCAGCT GAACACAGAA 420
GTGTGCCCCA TTGGGAAGCT GTCTCGTCGG GGCTTCTACT TAGCTTTCCA GAACTCTGGG 480
GCTTGTGTAG CAATGGTGTC TGTTCGAGTA TATTACAAGA CTTGCCCAGA GGCAGTGCAG 540
GGCCTTGCCC GTTTTCCAGA GACACTAGCA GGCTTGGAGG GGCTCACAGA AGTGCCTGGT 600
GTATGCGTGG AATATGCAGC TGAAGAAACA GGCTCTCCCC CGAGGATGCA CTGCAGCACA 660
GATGGGGAGT GGCTGGTACC AATGGGCCGA TGCCTTTGTG CTGTGGGGTT TGAGGAAGTC 720
GATGGGAGCT GCGTAGCCTG CCAGCGAGGA TTCTACCGTC ACTCTCTGGA GACTAAACGT 780
TGCCTGAAGT GCCCCCCAAA CAGCTTGTCC AATGAGTTAG GGGCTACATC TTGTTCCTGC 840
AACGCAGGCT TCTATCGGGC ACCTTCGGAG GGCCAAAACA TTGCTTGCAC CCGTCCTCCC 900
TCAGCTCCCC GCAATGTCAG CTTCTCCCTT ACTGGCACAC AGCTCAGTCT GTGGTGGCAG 960
CCACCCAGTG ACCACGGTGG GCGGAAGGAC CTAACTTACA CAGTCTTCTG TCAGCGCTGT 1020
CATTTCCTGT CATGTGATCC ATGTGAGCCT GGTGTGGTAT TCTCCCCAAG TTCTTCAGGT 1080
CTCACCAAAA CTGCTGTGGA TGTGGATGGC CTAGAAGCTT ACACCAACTA CACATTTGCT 1140
GTGGAAGCCC ATAATGGTGT CTCAGGAATG GGACCTGCTC CACAGAGAAC TGCTCCAGCT 1200
GTCTGGGTTG CAGTTGGACA TGCAGCTCCA GTGACAGTAT CCCAGTTTAT CCTGACACAG 1260
AGAGATGACA GTAGTCTGTC TGTTTCTTGG CTTGCCCCAC GGCAGCGCAG CCGGACCTCA 1320
GTGGAGTACG AGGTCATGTT CTTTGAGAAG GGAGAGGAGG CACGTTACAC AGTGAAGCAC 1380
CTTCTTGAGC CAAATGTCAC TCTGACAGAC CTTCAGCCAG ACACAACCTA CCTGCTTCGT 1440
GTGAGATCCA TCACACCCCT TGGGCCTGGG CCCTACTCCC AGGAGCAGGA ATTCCGCACC 1500
CTTCCGCCAG GCACCGGAGC TCTGTCTGGT GGTGTCATGG CATCTATTAT CTTTGGAGTT 1560
CTGCTATTTA TTGGGCTGCT TCTGGGAATT CTGTTCTTTC GACGAAAGAA GGCTCACCGC 1620
AGACAGGCAC GGCCTGATTA CAGTACTTCA GGCTTTGATC GAGAGAAGGT CTGGTTGAAG 1680
CCCTATGTGG ACCTGCAACC ATATGATGAC CCCAGTAGAG GTGTTCTGGA GTTCATTAAG 1740
GAACTGGATG TCTCTTGTGT CACTATGGAG AATGTGATTG GAGAAGGTGA GTTTTTTGGG 1800
GAGGTCTATC GTGGGTCCCT GCGGCTCCCA GGGAAAGAAC GTATTGTGGT TGCCATCAAA 1860
ACCCTCAAGT CAACATATTC AGACTCACAA TGGTGGAACT TCCTGCGTGA GGCAACAATT 1920
ATGGGGCAGT TCAATCACCC AAACATCGTA CATCTGGAAG GAGTTGTCAC CAAAAGAAGG 1980
CCAATGATGA TCATCACTGA GTACATGGAG AATGGAGCTC TGGATACCTT CCTCCGGGAG 2040
AATGAGGAAA AATTTAGCCC TGTGCAGCTT GTGAACATGC TGCAGGGAAT AGCCTCCGGC 2100
ATGACCTACC TTTCAGAACA CAACTATGTG CACCGGGATC TGGCTGCTCG CAACATCCTG 2160
GTAACACGCA GCCTTCAATG CAAGGTGTCT GACTTTGGTC TTTCCCGAAT ATTGGAGAAT 2220
GATGCAGAGG GAACATATGA AACCAAGGGT GGTAAGATTC CCATCCGATG GACAGCCCCA 2280
GAGGCCATTG CTCATCGGAT TTTCACCTCA GCCAGTGATG TCTGGAGCTT TGGAATTGTC 2340
ATGTGGGAGG TGCTGTCATT TGGTGACAAG CCATATGGGA ATATGACCAA TCAAGAGGTG 2400
ATGAAAAGCT TAGAGGACGG GTACCGGCTT CCCCCACCTG TGGACTGCCC ATCCATCCTC 2460
TATGAGCTAA TGAAGAGCTG TTGGTCACAT GATCGAATGA GGAGGCCTCA TTTCCAGGAG 2520
ATCCGGGCAC AGCTGCAACA CTTCAGCTCA AGCCCCCATC TCCTTCGGTG TGTTGCAGAC 2580
TTTGATCCCA GGGTAACGCT CCGGCTCCCC AGCTGCAGCG GATCTGATGG TATCCCTTAT 2640
CGATCTATTC CCGAGTGGCT GGAATCCATT CGCATGAAGC GTTATATCTC CAACTTTCGC 2700
ACTGCTGGCC TTGACACCAT GGAGTCAATT CTGGACCTCA CTGCTGAGGA CTTGAAACAG 2760
ATGGGAGTGT CACTTCCAGG CCACCAGAAG AGGATTCTGT GTAGCATCCA AGGCTTTAAG 2820
GAGTGA 2826
Domain Profile
S: 1     vkiekviGaGe.fGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdh  59
         v++e+viG+Ge fGev++G+l+lpgk+ i+vaiktlk++++++q+++fl+ea+i+Gqf+h
Q: 587   VTMENVIGEGEfFGEVYRGSLRLPGKERIVVAIKTLKSTYSDSQWWNFLREATIMGQFNH  646
         689*******945***********************************************
S: 60    pniirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsd  119
         pni++leGvvtk++p+mi+teymengald+flr+++++f+ +qlv+ml+Giasgm yls+
Q: 647   PNIVHLEGVVTKRRPMMIITEYMENGALDTFLRENEEKFSPVQLVNMLQGIASGMTYLSE  706
         ************************************************************
S: 120   mgyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayr  179
         ++yvhrdlaarnilv  +l ckvsdfGlsr+le+d+e +y+t+ggkipirwtapeaia+r
Q: 707   HNYVHRDLAARNILVTRSLQCKVSDFGLSRILENDAEGTYETKGGKIPIRWTAPEAIAHR  766
         ************************************************************
S: 180   kftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmld  239
          ftsasdvws+Giv+wevls+G++py +m+nq+v+k++e+gyrlppp+dcp+ ly+lm++
Q: 767   IFTSASDVWSFGIVMWEVLSFGDKPYGNMTNQEVMKSLEDGYRLPPPVDCPSILYELMKS  826
         ************************************************************
S: 240   cwqkdraerpkfeqivsi  257
         cw +dr +rp+f++i + 
Q: 827   CWSHDRMRRPHFQEIRAQ  844
         **************9876
Domain Sequence
(FASTA)
VTMENVIGEG EFFGEVYRGS LRLPGKERIV VAIKTLKSTY SDSQWWNFLR EATIMGQFNH 60
PNIVHLEGVV TKRRPMMIIT EYMENGALDT FLRENEEKFS PVQLVNMLQG IASGMTYLSE 120
HNYVHRDLAA RNILVTRSLQ CKVSDFGLSR ILENDAEGTY ETKGGKIPIR WTAPEAIAHR 180
IFTSASDVWS FGIVMWEVLS FGDKPYGNMT NQEVMKSLED GYRLPPPVDC PSILYELMKS 240
CWSHDRMRRP HFQEIRAQ 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00011
EKS-ANC-00010
EKS-BOT-00011
EKS-CAJ-00011
EKS-CAF-00012
EKS-CAP-00009
EKS-DAR-00015
EKS-EQC-00012
EKS-FEC-00009
EKS-GOG-00012
EKS-HOS-00012
EKS-ICT-00011
EKS-LAC-00015
EKS-LOA-00012
EKS-MAM-00010
EKS-MEG-00010
EKS-MOD-00011
EKS-MUM-00012
EKS-MUP-00012
EKS-MYL-00013
EKS-NOL-00011
EKS-OCP-00003
EKS-ORC-00011
EKS-OTG-00012
EKS-PAT-00010
EKS-PES-00009
EKS-POA-00009
EKS-RAN-00011
EKS-SAH-00009
EKS-SUS-00009
EKS-TAG-00011
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0032862; P:activation of Rho GTPase activity
GO:0030336; P:negative regulation of cell migration
GO:0006469; P:negative regulation of protein kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0051496; P:positive regulation of stress fiber assembly
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013