EKS-GAG-00331
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00331
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11327.01.1E-9710791343265
StatusUnreviewed
Ensembl ProteinENSGALP00000023686
UniProt AccessionF1N938;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K1
Gene Synonyms/Alias MAP3K1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000014718ENSGALP00000023686ENSGALT00000023732
ENSGALG00000014718ENSGALP00000038025ENSGALT00000038817
OrganismGallus gallus
Functional Description
Protein Length1348
Protein Sequence
(FASTA)
RDMENKETLR GLQKMDDRPE ERMIREKLKA TCMPAWKHEW LERRSRRGPV VVKPIPVKGD 60
GSEMNKLSLE PQSEGQSSAS SPTQKGRRSP SPSSSSSSSS RTVKSESPGV RRKRVSPVPF 120
QSGRITPPRR APSPDGFSPY SPEETSRRVN KVMRARLYLL QQIGPNSFLI GGDSPDNKYR 180
VFIGPQTCSC GRGTFCIHLL FVMLRVFQLE PSDPMLWRKT LKNFEVESLF QKYHSRRSSR 240
IKAPSRNTIQ KFVSRMSNSH TLSSSTSTSS SENSMKDEEE QMCPICLLGM LDEESLTVCE 300
DGCRNKLHHH CMSIWAEECR RNREPLICPL CRSKWRSHDF YSHELPSPVD SSVLHVVQQQ 360
TQQQSTIGSQ RRTQDSNFNL THYGVQQIPS AYKDLAEPWI QVFGMELVGC LFSRNWNIRE 420
MALRRLSHDV SGALLLANGE STGSSGNSNG NNTSAGALGI ASGSSQATVS GDVVVESCCS 480
VLSMVCADPV YKVYVAALKT LRAMLVYTPC HSLAERTKLQ RLLKPVVETI LVKCADANSR 540
TSQLSVSTLL EMCKGQAGEL AVGREILKSG SIGIGGVDYV LNCILATEIE SSNWQALLGR 600
LCLIDRLLLE FPGEFYPHIV CGDVLQADAI VGRYKKLLSL LNFALLSIDN SHSMVGKLSR 660
RVFLSSARMV ARVPHVFVKL LEMLSVTSST HYTRMRRRLM AIADEMEVAE AIQLGMEEIQ 720
SGECRHEDFL QLPVPDNSPE ATENNTPNNT VQLSGKNGKG LSDKKLSAGP EDISETLTSL 780
VVGHPVSSLT TEQPKPAVQT KGKPYSQCLN SSPSSSHSQS LFPTLLSPSN PSVSAGTVTD 840
VSKLRPQGFI PCKIPSPSPQ TQRKLSLQFQ RSCSENKEPD KLSPVFTQAR PLPSSHIHRP 900
KPSRPTPNDM NKQGETSKNS MTLDLNDTSH CDGNGSNSSA VIPSEETVFT PVDEKCRLDV 960
NAELNSSIED LLEASMPTSD GTVTFKSEVA VLSPERAEND DTYKDDVNHN QKCKEKMEAE 1020
EEEALAIAMA MSASQDALPI IPQLQVENGE DIIIIQQDTP ETLPGHTKAK HHYREDAEWL 1080
KGQQIGLGAF SSCYQAQDVG TGTLMAVKQV TYVRNTSSEQ EEVVEALREE IRMMSHLNHP 1140
NIIRMLGATC EKSNYNLFIE WMAGGSVAHL LSKYGAFKES VIINYTEQLL RGLSYLHENQ 1200
IIHRDVKGAN LLIDSTGHRL RIADFGAAAR LASKGTGAGE FQGQLLGTIA FMAPEVLRGQ 1260
QYGRSCDVWS VGCVVIEMAC AKPPWNAEKH SNHLALIFKI ASATTAPSIP SHLSPGLRDV 1320
TLRCLELQPQ DRPPSRELLK HPVFRTTW 1348
Nucleotide Sequence
(FASTA)
CGTGACATGG AGAATAAAGA AACCCTCAGG GGGTTGCAGA AGATGGATGA CCGCCCAGAA 60
GAGCGCATGA TCAGGGAGAA ACTCAAGGCA ACGTGTATGC CAGCTTGGAA GCATGAATGG 120
CTGGAAAGAA GAAGCAGGAG AGGCCCTGTG GTGGTGAAAC CTATCCCTGT GAAGGGAGAT 180
GGATCTGAAA TGAACAAGCT ATCTCTAGAA CCTCAATCTG AAGGACAAAG CTCTGCTTCT 240
TCACCTACGC AGAAAGGAAG GCGTAGTCCT TCTCCTAGCA GTTCTTCTTC ATCATCCTCT 300
CGGACTGTTA AATCTGAGTC ACCAGGTGTT AGAAGAAAAA GGGTATCTCC AGTACCTTTT 360
CAGAGTGGAC GAATAACACC ACCTCGAAGA GCCCCATCTC CAGATGGTTT CTCTCCATAC 420
AGCCCTGAGG AAACAAGTCG TCGTGTCAAC AAAGTTATGC GAGCCAGGCT GTACCTGCTG 480
CAGCAGATAG GACCCAACTC TTTCTTAATT GGAGGAGATA GCCCTGATAA TAAATACAGA 540
GTGTTTATTG GACCTCAGAC ATGTAGCTGT GGCCGTGGAA CATTTTGTAT TCATCTGCTC 600
TTTGTTATGC TGCGAGTGTT CCAGCTTGAG CCTTCAGACC CAATGCTGTG GAGAAAGACA 660
CTGAAAAACT TTGAGGTTGA GAGTTTGTTC CAGAAATATC ACAGTAGGCG TAGCTCGAGG 720
ATCAAAGCTC CATCTCGTAA CACCATCCAG AAGTTTGTCT CACGCATGTC AAATTCTCAT 780
ACATTATCAT CTAGTACTTC TACATCTAGT TCAGAAAACA GTATGAAAGA TGAAGAGGAG 840
CAGATGTGCC CCATTTGTTT GCTGGGCATG CTGGATGAAG AGAGCCTGAC TGTGTGTGAG 900
GATGGCTGCA GGAACAAATT ACACCACCAC TGCATGTCAA TATGGGCAGA AGAGTGTAGA 960
AGAAACAGAG AGCCACTTAT ATGTCCTCTG TGTAGATCTA AATGGAGATC TCATGATTTC 1020
TACAGTCATG AATTGCCAAG CCCTGTGGAT TCTTCTGTTC TCCATGTGGT TCAACAACAA 1080
ACTCAACAGC AATCAACAAT TGGATCACAG AGGAGAACCC AGGATAGCAA TTTCAACCTT 1140
ACTCATTATG GGGTCCAGCA GATTCCTTCT GCCTATAAAG ATTTAGCTGA GCCATGGATT 1200
CAGGTCTTTG GAATGGAGTT AGTTGGCTGC TTGTTTTCTC GAAACTGGAA TATACGAGAG 1260
ATGGCACTTA GACGTCTTTC CCATGATGTT AGTGGTGCTT TATTACTGGC TAATGGTGAA 1320
AGCACTGGAA GTTCTGGAAA TAGCAATGGA AACAACACGA GTGCTGGAGC TCTGGGAATA 1380
GCGAGTGGGT CATCTCAGGC CACCGTCTCA GGAGATGTTG TGGTGGAATC TTGCTGCAGT 1440
GTGCTATCCA TGGTCTGTGC TGACCCTGTC TACAAAGTGT ATGTTGCTGC TTTAAAAACC 1500
TTAAGAGCCA TGCTGGTCTA TACTCCTTGT CATAGTTTGG CAGAAAGGAC TAAACTACAG 1560
CGACTTCTGA AGCCAGTTGT AGAGACAATA TTAGTTAAAT GTGCAGATGC CAACAGTCGA 1620
ACAAGTCAAC TTTCAGTCTC AACGCTATTG GAGATGTGTA AAGGCCAAGC AGGAGAGTTG 1680
GCAGTTGGGA GAGAAATACT TAAATCTGGG TCCATTGGTA TTGGTGGTGT TGATTATGTC 1740
TTAAATTGTA TTCTTGCAAC TGAAATTGAA TCAAGCAACT GGCAAGCGCT ACTGGGGAGA 1800
CTTTGTCTTA TAGACAGACT TCTGTTGGAA TTTCCTGGTG AATTTTATCC TCACATTGTC 1860
TGTGGAGATG TTTTACAGGC TGATGCCATA GTAGGCAGAT ATAAGAAACT TCTCTCCCTT 1920
CTAAATTTCG CCTTGCTGTC AATTGACAAT TCCCACTCAA TGGTTGGTAA ACTATCACGG 1980
AGAGTATTTT TGAGTTCAGC AAGAATGGTT GCAAGAGTTC CTCACGTGTT TGTAAAGCTG 2040
TTAGAAATGT TGAGTGTGAC AAGCTCAACT CATTACACAA GGATGCGTCG ACGTCTGATG 2100
GCAATAGCAG ATGAAATGGA AGTTGCAGAA GCCATCCAGC TTGGCATGGA AGAAATACAG 2160
TCTGGGGAAT GTCGACATGA AGACTTTCTG CAGCTACCCG TACCAGATAA TTCTCCAGAA 2220
GCTACAGAAA ATAATACTCC TAACAATACT GTCCAGTTAT CAGGGAAAAA TGGGAAAGGC 2280
TTAAGTGACA AAAAACTGAG TGCTGGTCCA GAGGACATTT CTGAGACACT GACTAGCCTA 2340
GTTGTGGGAC ATCCTGTTTC ATCACTAACC ACTGAGCAAC CAAAGCCAGC TGTTCAAACA 2400
AAAGGAAAAC CCTACAGCCA GTGTTTGAAC TCTTCTCCCT CATCCAGTCA TTCCCAGTCA 2460
CTATTCCCAA CACTTCTCTC TCCTTCAAAC CCATCTGTAT CAGCTGGCAC TGTAACAGAT 2520
GTCTCTAAAC TCCGACCTCA GGGATTCATT CCCTGCAAAA TCCCTTCTCC TTCTCCTCAA 2580
ACACAACGGA AGCTTTCCCT CCAGTTTCAG AGAAGCTGCT CTGAAAATAA AGAACCAGAT 2640
AAGCTTTCTC CAGTTTTTAC CCAAGCCAGG CCATTGCCAT CTAGTCACAT ACACAGGCCA 2700
AAGCCATCAC GACCCACTCC AAATGATATG AACAAGCAGG GAGAAACTTC AAAGAACAGC 2760
ATGACACTTG ACCTGAATGA TACTTCACAT TGTGATGGCA ATGGTAGTAA CAGTAGTGCA 2820
GTTATACCAA GTGAAGAGAC AGTGTTCACA CCAGTAGATG AAAAATGTCG GCTGGATGTT 2880
AATGCAGAGC TCAACTCCAG TATTGAGGAC CTCCTTGAGG CCTCCATGCC AACAAGTGAT 2940
GGCACAGTTA CTTTCAAGTC CGAAGTTGCA GTTCTTTCTC CCGAGAGGGC TGAAAATGAT 3000
GATACTTACA AAGATGATGT AAATCATAAT CAAAAATGCA AGGAAAAGAT GGAAGCTGAA 3060
GAAGAGGAAG CTTTAGCTAT TGCTATGGCA ATGTCTGCAT CTCAAGATGC CCTGCCAATA 3120
ATTCCCCAAC TACAGGTCGA AAATGGTGAA GATATCATAA TTATTCAGCA AGATACACCA 3180
GAAACTCTGC CTGGACATAC CAAAGCAAAG CATCATTACA GGGAAGATGC AGAATGGCTT 3240
AAAGGTCAGC AAATTGGTCT TGGAGCTTTC TCTTCCTGTT ACCAAGCTCA AGATGTAGGA 3300
ACAGGGACAT TAATGGCTGT AAAACAGGTG ACATATGTCA GGAACACATC ATCTGAGCAA 3360
GAAGAGGTAG TGGAAGCACT GAGGGAGGAA ATACGGATGA TGAGTCATCT AAACCATCCT 3420
AATATTATTC GCATGTTGGG TGCTACATGT GAGAAGAGCA ACTACAACCT CTTCATTGAA 3480
TGGATGGCAG GGGGATCAGT TGCTCATTTG TTGAGTAAAT ACGGAGCCTT CAAAGAATCA 3540
GTTATTATTA ACTACACAGA GCAACTGTTA CGTGGCCTTT CTTACCTCCA TGAGAATCAG 3600
ATAATTCATA GAGATGTCAA AGGTGCCAAT TTGCTAATTG ACAGCACAGG TCATAGATTA 3660
AGAATTGCTG ATTTTGGAGC TGCAGCCAGG TTGGCATCAA AAGGAACTGG TGCTGGGGAG 3720
TTTCAGGGAC AGTTGTTGGG AACTATTGCA TTTATGGCCC CGGAGGTTCT GAGAGGTCAG 3780
CAGTATGGTA GGAGCTGTGA TGTGTGGAGC GTTGGCTGTG TTGTCATAGA AATGGCTTGT 3840
GCTAAACCTC CCTGGAATGC AGAGAAACAC TCCAATCATC TTGCTCTGAT CTTTAAGATT 3900
GCTAGTGCAA CTACTGCTCC ATCAATCCCT TCACATCTGT CTCCTGGCTT GAGGGATGTG 3960
ACTCTTCGGT GTTTAGAACT TCAACCTCAG GACAGACCCC CATCGAGGGA GCTGCTGAAA 4020
CACCCAGTCT TCCGTACTAC ATGGTAG 4047
Domain Profile
S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59
         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+
Q: 1079  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1138
         899*******************************999998887699**************
S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119
         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esvi +yt+q+l+gl+yLHe
Q: 1139  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVIINYTEQLLRGLSYLHE  1198
         ************************************************************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177
         ++i+HRD+KgaN+l+ds    ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++
Q: 1199  NQIIHRDVKGANLLIDStGHRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1258
         *****************5668******************9996779*************9
S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235
         ++  +ygr++D+Ws+gcvviem+++k+P++  +++++la++fk+++++t+P+ip++ls+ 
Q: 1259  GQ--QYGRSCDVWSVGCVVIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1316
         98..8************************87678899***********************
S: 236   gkdflekcleldpkkrpsaeeLLkhef  262
          +d+  +clel+p++rp ++eLLkh++
Q: 1317  LRDVTLRCLELQPQDRPPSRELLKHPV  1343
         *************************86
Domain Sequence
(FASTA)
WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60
HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVIINYTEQ LLRGLSYLHE 120
NQIIHRDVKG ANLLIDSTGH RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180
GQQYGRSCDV WSVGCVVIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240
DVTLRCLELQ PQDRPPSREL LKHPV 265
KeywordATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>
EKS-AIM-00366
EKS-ANC-00382
EKS-BOT-00393
EKS-CAJ-00396
EKS-CAF-00394
EKS-CAP-00423
EKS-CII-00219
EKS-CIS-00139
EKS-DAR-00775
EKS-DIO-00061
EKS-EQC-00385
EKS-FEC-00380
EKS-GOG-00383
EKS-HOS-00400
EKS-ICT-00371
EKS-LAC-00407
EKS-LOA-00401
EKS-MAM-00391
EKS-MEG-00326
EKS-MOD-00381
EKS-MUM-00425
EKS-MUP-00387
EKS-MYL-00391
EKS-NOL-00358
EKS-ORA-00339
EKS-ORC-00370
EKS-OTG-00395
EKS-PAT-00370
EKS-PES-00350
EKS-PEM-00208
EKS-POA-00383
EKS-RAN-00407
EKS-SAH-00362
EKS-SUS-00344
EKS-TAG-00463
EKS-VIP-00056
Gene Ontology
GO:0005524; F:ATP binding
GO:0008545; F:JUN kinase kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0008270; F:zinc ion binding
GO:0008637; P:apoptotic mitochondrial changes
GO:0071260; P:cellular response to mechanical stimulus
GO:0030838; P:positive regulation of actin filament polymerization
GO:0030334; P:regulation of cell migration
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001841; Znf_RING.
IPR013083; Znf_RING/FYVE/PHD.
IPR007527; Znf_SWIM.
Pfam
PF00069; Pkinase; 1.
PF04434; SWIM; 1.
SMARTs
SM00184; RING; 1.
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50089; ZF_RING_2; 1.
PS50966; ZF_SWIM; 1.
Prints
Created Date20-Feb-2013