EKS-GAG-00218
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00218
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK428.69.0E-12966318253
StatusUnreviewed
Ensembl ProteinENSGALP00000023702
UniProt AccessionF1NB57;
Protein Name
Protein Synonyms/Alias
Gene NamePLK2
Gene Synonyms/Alias PLK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000014725ENSGALP00000023702ENSGALT00000023748
OrganismGallus gallus
Functional Description
Protein Length667
Protein Sequence
(FASTA)
RTIAYPPGGG GASSTTAAAR GCEAAVGRAG SAEPRRKKAE EQPHQHAHPA AEVSRIITDP 60
TTGKRYCRGK VLGKGGFAKC YEMTDLTTNK VYAAKIIPHS RVAKPHQREK IDKEIELHRM 120
LNHRHVVQFY HYFEDRENIY ILLEYCSRRS MAHILKARKV LTEPEVRYYL RQIVSGLKYL 180
HEQEILHRDL KLGNFFINEN MELKLGDFGL AARLEPLEHR RRTICGTPNY LSPEVLNKQG 240
HGCESDIWAL GCVMYTMLLG RPPFETTNLK ETYRCIREAR YSLPSSLLAP AKHLIASMLS 300
KNPEDRPSLD EIIRHDFFVQ GFTPDRLSAS CCHTVPDFHL SSPAKNFFKK AAAALFGGKK 360
DKARYFDNHN RLAKEDEEIY KLRHDLKKTS ITQQPQKHRT DEEIQPLITT VAKPGALPET 420
KQIGDSIRMI VRGTLGSCSS SSECLEDSTM GSVADTVARV LRGCLENMPE ADSIPKEQLT 480
TSFQWVTKWV DYSNKYGFGY QLSDHTVGVL FNNGAHMSLL PDKKTVHYYA ELGQCSVFTA 540
AEAPEQFISQ VTVLKYFSHY MEENLMDGGD LPSLTDVRRP RLYLLQWLKS DKALMMLFND 600
GTFQVNFYHD HTKIIICNQS EEYLLTYINE DRISTTFRLT TLLVSGCSLE LKRRMEYALN 660
MLLQRCN 667
Nucleotide Sequence
(FASTA)
CGGACCATCG CCTACCCGCC GGGCGGCGGC GGAGCTTCTA GTACTACCGC CGCTGCCAGA 60
GGCTGCGAGG CGGCCGTGGG GAGGGCCGGC AGTGCCGAGC CGCGAAGAAA GAAGGCGGAG 120
GAACAGCCCC ACCAGCACGC GCACCCTGCC GCCGAGGTGT CCCGGATTAT AACCGATCCC 180
ACGACGGGGA AGCGCTACTG CCGCGGAAAG GTGCTCGGAA AGGGTGGATT CGCCAAGTGC 240
TATGAGATGA CAGATTTGAC AACAAATAAA GTTTATGCTG CGAAAATCAT TCCTCACAGC 300
AGAGTAGCGA AACCTCATCA AAGGGAAAAG ATTGATAAAG AGATCGAGCT GCACAGAATG 360
CTTAATCATA GACACGTTGT GCAGTTCTAC CACTACTTTG AAGACAGAGA GAATATTTAC 420
ATTCTTCTGG AGTACTGCAG TAGAAGGTCA ATGGCTCACA TCTTGAAAGC ACGGAAGGTA 480
TTGACAGAAC CAGAAGTACG ATACTACCTC AGGCAGATTG TGTCAGGGCT AAAGTATCTT 540
CACGAACAGG AAATCTTGCA CAGGGATCTT AAGCTAGGTA ACTTCTTCAT TAATGAGAAT 600
ATGGAACTGA AACTGGGTGA CTTTGGCTTG GCAGCAAGGC TGGAACCACT GGAGCACAGA 660
AGGAGAACAA TATGTGGCAC ACCAAATTAC CTCTCTCCAG AAGTCCTCAA CAAACAAGGG 720
CATGGCTGTG AATCTGACAT CTGGGCCTTA GGCTGTGTAA TGTACACAAT GCTGCTGGGA 780
AGACCCCCAT TTGAGACCAC AAATCTTAAA GAAACATACA GATGTATAAG GGAAGCAAGA 840
TACAGTCTGC CTTCATCTCT CTTGGCACCT GCAAAACACT TAATAGCTAG CATGCTGTCA 900
AAGAATCCTG AAGACCGGCC TAGTTTAGAT GAAATAATTC GACATGATTT TTTTGTACAG 960
GGCTTTACAC CTGACAGACT TTCTGCTAGC TGTTGTCACA CTGTTCCTGA CTTTCATTTG 1020
TCAAGTCCTG CTAAAAATTT CTTCAAAAAA GCAGCTGCTG CTCTTTTTGG TGGTAAAAAG 1080
GATAAAGCCA GATACTTCGA TAATCACAAT AGACTAGCTA AAGAAGATGA AGAAATTTAC 1140
AAGCTCAGGC ATGATTTGAA GAAGACATCG ATAACCCAGC AGCCCCAGAA ACACAGAACA 1200
GATGAGGAGA TCCAGCCCCT TATCACAACA GTAGCCAAGC CAGGAGCATT ACCAGAAACA 1260
AAGCAGATTG GAGACTCTAT TCGGATGATT GTCAGAGGAA CTTTAGGAAG CTGCAGCAGT 1320
AGCAGTGAAT GCCTGGAAGA CAGTACCATG GGAAGTGTTG CAGATACAGT TGCAAGGGTA 1380
TTGCGTGGAT GTCTGGAGAA CATGCCAGAA GCAGACAGCA TTCCCAAAGA GCAGCTGACA 1440
ACATCCTTCC AGTGGGTTAC AAAATGGGTG GACTACTCTA ACAAGTATGG CTTTGGGTAC 1500
CAGTTGTCAG ATCATACTGT CGGTGTCCTT TTCAACAACG GGGCGCACAT GAGCCTTCTG 1560
CCAGATAAGA AGACAGTCCA CTACTATGCT GAGCTAGGCC AGTGCTCTGT CTTCACAGCT 1620
GCAGAGGCTC CTGAACAGTT CATTAGCCAA GTGACTGTAC TCAAGTATTT CTCCCACTAC 1680
ATGGAAGAGA ACCTCATGGA TGGAGGAGAT TTGCCCAGCC TAACAGACGT ACGCAGGCCT 1740
AGGCTTTACC TCCTACAGTG GCTTAAATCT GATAAAGCAT TGATGATGCT CTTTAATGAT 1800
GGCACATTTC AAGTGAACTT TTATCATGAT CACACAAAAA TCATCATTTG CAATCAGAGC 1860
GAGGAGTATC TGCTTACCTA CATCAATGAA GACAGGATAT CCACAACGTT TCGTCTGACA 1920
ACTCTTCTGG TTTCAGGATG CTCACTGGAA CTAAAACGTA GAATGGAATA TGCTTTGAAC 1980
ATGCTGCTGC AGCGATGTAA CTGA 2004
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y+rgk+lGkGgfakcye++dl+t++v+a+k++p+s++ak++qrek++keie+hr l+h++
Q: 66    YCRGKVLGKGGFAKCYEMTDLTTNKVYAAKIIPHSRVAKPHQREKIDKEIELHRMLNHRH  125
         99**********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         +v++y++fed+en+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i
Q: 126   VVQFYHYFEDRENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  185
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+
Q: 186   LHRDLKLGNFFINENMELKLGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  245
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         diW+lGc++yt+l+G+PPfet++lkety++i++a+yslPssl ++ak+lia++l+k+Pe+
Q: 246   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYSLPSSLLAPAKHLIASMLSKNPED  305
         ************************************************************
S: 241   rpsleevlkdefl  253
         rpsl+e+++++f+
Q: 306   RPSLDEIIRHDFF  318
         ************8
Domain Sequence
(FASTA)
YCRGKVLGKG GFAKCYEMTD LTTNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRMLNHRH 60
VVQFYHYFED RENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120
LHRDLKLGNF FINENMELKL GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180
DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYSLPS SLLAPAKHLI ASMLSKNPED 240
RPSLDEIIRH DFF 253
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00243
EKS-ANC-00250
EKS-BOT-00260
EKS-CAF-00267
EKS-CAP-00295
EKS-CHH-00011
EKS-CII-00157
EKS-DAR-00595
EKS-DAN-00009
EKS-ECT-00011
EKS-EQC-00252
EKS-FEC-00246
EKS-GAM-00160
EKS-GOG-00258
EKS-HOS-00267
EKS-ICT-00245
EKS-LAC-00272
EKS-LOA-00270
EKS-MAM-00262
EKS-MEG-00208
EKS-MIM-00016
EKS-MOD-00259
EKS-MUM-00292
EKS-MYL-00263
EKS-NOL-00241
EKS-ORN-00338
EKS-ORA-00229
EKS-ORC-00246
EKS-OTG-00266
EKS-PAT-00247
EKS-PES-00232
EKS-PEM-00136
EKS-POA-00253
EKS-PRC-00018
EKS-RAN-00275
EKS-SUS-00226
EKS-TAG-00276
EKS-TAR-00334
EKS-TEN-00329
EKS-VIP-00009
EKS-XET-00335
EKS-XIM-00330
EKS-SAC-00030
Gene Ontology
GO:0005814; C:centriole
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004871; F:signal transducer activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0007093; P:mitotic cell cycle checkpoint
GO:0007052; P:mitotic spindle organization
GO:0043066; P:negative regulation of apoptotic process
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046599; P:regulation of centriole replication
GO:0048167; P:regulation of synaptic plasticity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013