EKS-GAG-00056

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00056

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	348.8	2.2E-104	10	293	284

Status

Unreviewed

Ensembl Protein

ENSGALP00000023830

UniProt Accession

E1C8L2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000014790	ENSGALP00000023830	ENSGALT00000023876

Organism

Gallus gallus

Functional Description

Protein Length

294

Protein Sequence
(FASTA)

MDARARAKRY EKLDFLGEGQ FDTVYKAKDK NTGQIVAIKK IKLGHRSEAK DGINRTALRE 60

IKLLQELSHP NVIGLLDAFG HKSNISLVFD FMETDLEVII KDTSIVLTQS HIKAYMLMTL 120

QGLEYLHQQW ILHRDLKPNN LLLDGNGVLK LADFGLAKSF GSPNRVYTHQ VVTRWYRSPE 180

LLFGARMYGV GVDMWAVGCI LAELLLRVPF LPGDSDLDQL TRIFETLGTP TEEQWPNVSD 240

YLNYVTFKSF PGMPLQHIFS AAGDDLLSLL QGLFTFNPCS RVTATQSLLL KYFR 294

Nucleotide Sequence
(FASTA)

ATGGATGCGC GGGCTCGTGC CAAGCGCTAC GAGAAACTCG ACTTCTTGGG GGAGGGGCAG 60

TTTGATACTG TGTATAAGGC AAAGGACAAG AACACGGGAC AGATCGTGGC TATCAAAAAG 120

ATTAAACTGG GCCATCGATC AGAAGCTAAA GATGGAATCA ACAGAACAGC TCTCAGAGAG 180

ATAAAGTTGT TACAGGAGCT AAGCCATCCA AATGTTATTG GTCTTTTAGA TGCGTTTGGA 240

CACAAATCTA ATATTAGCTT GGTGTTTGAT TTCATGGAAA CAGACCTTGA GGTTATTATA 300

AAGGATACTA GTATTGTGTT GACACAATCT CACATCAAAG CATATATGCT GATGACGCTT 360

CAAGGTTTAG AGTATTTACA TCAACAGTGG ATTCTACACA GGGATCTTAA ACCAAATAAT 420

TTGTTGTTAG ATGGAAATGG TGTTTTGAAA TTGGCTGACT TTGGCTTGGC AAAATCTTTT 480

GGAAGCCCAA ACAGAGTTTA CACGCACCAA GTAGTAACAA GATGGTACCG ATCCCCAGAA 540

CTACTGTTTG GTGCTAGAAT GTATGGTGTC GGTGTTGATA TGTGGGCTGT TGGTTGTATT 600

CTAGCTGAGT TACTTCTCAG GGTTCCTTTT TTGCCAGGAG ACTCTGATCT TGACCAGTTG 660

ACAAGGATTT TTGAAACACT GGGCACTCCA ACAGAAGAAC AGTGGCCTAA TGTATCAGAT 720

TATTTGAATT ACGTCACGTT TAAGTCTTTC CCTGGAATGC CTCTTCAACA TATCTTCAGT 780

GCAGCTGGTG ATGATTTACT TAGTCTTCTA CAAGGATTAT TTACATTTAA TCCTTGTTCT 840

AGAGTTACAG CCACTCAGTC CCTGCTTTTA AAATATTTTC GT 882

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++ +vykakdk+tg++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 10    YEKLDFLGEGQFDTVYKAKDKNTGQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  69

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +n++ Ll+ +  +k+++ Lvf+f+e+dL+ ++k++++  l+++++k ++l+ l+gl+ylH

Q: 70    PNVIGLLDAFG-HKSNISLVFDFMETDLEVIIKDTSI-VLTQSHIKAYMLMTLQGLEYLH  127

         ***********.99***********************.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++ +g+lklaDfGla++f+sp++ yt++vvT+wYr+PelL+ga+

Q: 128   QQWILHRDLKPNNLLLDGNGVLKLADFGLAKSFGSPNRVYTHQVVTRWYRSPELLFGARM  187

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp+vs++ +y  +

Q: 188   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPNVSDYLNYV-T  246

         ********************************************************98.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ ++++ ++ l+ll+ l++++p +R++a++ l  kyf

Q: 247   FKSFPGMPLQHIFSAAGDDLLSLLQGLFTFNPCSRVTATQSLLLKYF  293

         9999999******9999***********************9999987

Domain Sequence
(FASTA)

YEKLDFLGEG QFDTVYKAKD KNTGQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNVIGLLDAF GHKSNISLVF DFMETDLEVI IKDTSIVLTQ SHIKAYMLMT LQGLEYLHQQ 120

WILHRDLKPN NLLLDGNGVL KLADFGLAKS FGSPNRVYTH QVVTRWYRSP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPNVS DYLNYVTFKS 240

FPGMPLQHIF SAAGDDLLSL LQGLFTFNPC SRVTATQSLL LKYF 284

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005675	; C:holo TFIIH complex
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0008094	; F:DNA-dependent ATPase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366	; P:transcription from RNA polymerase II promoter

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013