EKS-GAG-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	446.5	2.7E-134	275	524	250

Status

Unreviewed

Ensembl Protein

ENSGALP00000023934

UniProt Accession

G1K347;

Protein Name

Protein Synonyms/Alias

Tyrosine-protein kinase Yes;

Gene Name

YES1

Gene Synonyms/Alias

YES1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000014860	ENSGALP00000023934	ENSGALT00000023980

Organism

Gallus gallus

Functional Description

Protein Length

541

Protein Sequence
(FASTA)

MGCIKSKEDK GPAMKYRTDN TPEPISSHVS HYGSDSSQAT QSPAIKGSAV NFNSHSMTPF 60

GGPSGMTPFG GASSSFSAVP SPYPSTLTGG VTVFVALYDY EARTTDDLSF KKGERFQIIN 120

NTEGDWWEAR SIATGKTGYI PSNYVAPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF 180

LVRESETTKG AYSLSIRDWD EVRGDNVKHY KIRKLDNGGY YITTRAQFES LQKLVKHYRE 240

HADGLCHKLT TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 300

AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMT KGVLLDFLKE 360

GEGKFLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI LVGDNLVCKI ADFGLARLIE 420

DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILL TELVTKGRVP YPGMVNREVL 480

EQVERGYRMP CPQGCPESLH ELMKLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGDN 540

L 541

Nucleotide Sequence
(FASTA)

ATGGGGTGCA TTAAAAGCAA AGAAGATAAA GGTCCAGCCA TGAAATACAG GACTGATAAC 60

ACTCCAGAAC CTATTAGTTC CCACGTCAGC CATTACGGGT CAGACTCCAG CCAAGCAACA 120

CAGTCACCGG CAATAAAGGG ATCAGCAGTT AATTTTAACA GTCATTCCAT GACTCCTTTT 180

GGAGGGCCCT CAGGAATGAC ACCCTTTGGA GGAGCATCGT CTTCATTTTC AGCTGTGCCA 240

AGTCCATATC CTAGTACTTT AACAGGTGGT GTTACTGTAT TTGTGGCCTT ATACGATTAT 300

GAAGCTAGAA CTACAGATGA CCTTTCATTT AAGAAAGGTG AACGGTTCCA GATAATAAAC 360

AACACGGAAG GCGACTGGTG GGAAGCAAGA TCCATTGCTA CGGGAAAAAC AGGCTACATC 420

CCAAGCAATT ATGTAGCTCC TGCAGACTCC ATTCAAGCGG AAGAGTGGTA CTTTGGTAAA 480

ATGGGCAGGA AGGATGCAGA AAGACTACTT TTAAATCCTG GGAACCAGCG TGGTATTTTC 540

TTAGTAAGAG AGAGCGAAAC CACTAAAGGT GCTTACTCCC TTTCCATACG TGACTGGGAT 600

GAGGTCAGAG GTGATAATGT GAAGCACTAC AAAATCAGAA AACTTGACAA TGGTGGATAC 660

TATATCACAA CCAGAGCACA ATTTGAATCT CTCCAGAAGT TGGTGAAGCA CTACAGAGAA 720

CATGCTGATG GACTGTGTCA TAAGCTAACA ACTGTATGTC CCACGGTGAA ACCACAAACA 780

CAGGGACTAG CAAAAGATGC CTGGGAAATT CCTAGGGAGT CTTTGAGGCT GGAAGTTAAG 840

TTGGGCCAAG GATGTTTTGG TGAAGTATGG ATGGGAACCT GGAATGGAAC CACAAAAGTA 900

GCCATCAAGA CACTTAAACC TGGTACAATG ATGCCCGAAG CTTTCCTTCA GGAGGCTCAG 960

ATCATGAAGA AATTACGACA TGACAAGCTT GTTCCACTGT ATGCCGTTGT TTCTGAGGAA 1020

CCAATCTACA TAGTCACCGA ATTCATGACA AAAGGTGTCT TACTAGACTT CCTGAAGGAA 1080

GGAGAAGGGA AGTTCTTAAA ACTCCCACAG CTGGTGGACA TGGCTGCTCA GATTGCTGAT 1140

GGCATGGCTT ACATTGAAAG AATGAACTAC ATCCACAGGG ATCTCCGGGC AGCCAACATT 1200

CTTGTAGGAG ACAATCTTGT GTGTAAAATA GCAGACTTCG GTCTCGCAAG GTTAATAGAG 1260

GACAATGAGT ACACTGCGAG GCAAGGAGCT AAATTTCCAA TTAAATGGAC TGCTCCAGAA 1320

GCAGCATTGT ATGGTCGGTT TACAATCAAG TCAGATGTGT GGTCGTTTGG AATTTTACTG 1380

ACAGAGCTGG TAACAAAGGG GAGAGTGCCA TATCCAGGAA TGGTGAATCG GGAAGTTCTG 1440

GAACAAGTGG AACGTGGATA TAGGATGCCT TGCCCTCAGG GCTGCCCGGA ATCTCTCCAC 1500

GAGTTAATGA AACTATGTTG GAAGAAGGAC CCTGATGAGA GACCAACATT TGAATATATA 1560

CAGTCTTTCC TGGAGGACTA CTTTACTGCT ACAGAACCAC AGTACCAGCC TGGGGACAAT 1620

TTATAA 1626

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 275   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  334

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kG lldflke egk lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 335   AVVSE-EPIYIVTEFMTKGVLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERMNYIHR  393

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvg++lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 394   DLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  453

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+el++ cwkkdp+e

Q: 454   WSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMKLCWKKDPDE  513

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 514   RPTFEYIQSFL  524

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMTKGVL LDFLKEGEGK FLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGD NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHELMK LCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013