EKS-GAG-00315

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00315

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	413.0	4.5E-124	237	488	252

Status

Unreviewed

Ensembl Protein

ENSGALP00000024119

UniProt Accession

E1C2F6;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000014979	ENSGALP00000024119	ENSGALT00000024165

Organism

Gallus gallus

Functional Description

Protein Length

507

Protein Sequence
(FASTA)

MGNFCQKYCT CLEPCIPCLF SGEKDKVNKT KGKPLPALPG QHLMNTCKFV ALFNYEARTE 60

DDLSFQAGDK LEVLDASHEG WWYAKLLLPE GSVCPGRKLQ GYIPANYIAA VQSIEAEPWF 120

FGPIKRADAE RQLLYPGNQA GAFLIRESES LKGEYSLSVF DGQSVKHYRI RRLDGEGFFL 180

SRMKTFKTLN EFVDYYSKNS DGLCVKLGKP CPKVQIPTTF DLSYKTVDQW EIDRKSLKFL 240

KKLGSGQFGE VWEGLWNNTT PVAIKTLKPG SMDPKDFLRE AQIMKNLRHP NLIQLYAVCT 300

LEDPIYIVTE LMKYGSLIEY LQNDAGSHIS LPHQIDMAAQ VASGMAYLES QNYIHRDLAA 360

RNVLVGEHSV YKVADFGLAR VFKVENENIY EARPETKLPV KWTAPEAIRY NKFSVKSDVW 420

SFGILLFEII TYGKMPYAGM PGHQVIQMLD KGYRLPQPET CPKALYELML KCWSTEPSER 480

PTFEALYCQL EDYFDNDSYM DNRATIK 507

Nucleotide Sequence
(FASTA)

ATGGGAAACT TCTGTCAGAA ATACTGCACC TGTTTGGAGC CCTGTATTCC TTGCTTATTC 60

TCAGGAGAGA AGGACAAAGT GAATAAGACA AAAGGGAAGC CCTTACCTGC ACTGCCTGGA 120

CAGCATTTGA TGAACACTTG CAAATTTGTG GCACTCTTCA ACTATGAGGC TCGCACAGAG 180

GATGACTTGA GCTTCCAAGC TGGGGATAAG CTTGAAGTGC TGGACGCATC CCATGAGGGC 240

TGGTGGTATG CTAAGCTCCT CCTGCCAGAA GGGTCAGTCT GTCCTGGCCG CAAGCTCCAG 300

GGCTATATCC CTGCCAACTA CATAGCTGCT GTACAGAGCA TTGAAGCTGA GCCATGGTTT 360

TTTGGACCAA TCAAACGAGC AGATGCTGAG AGACAACTGT TGTATCCTGG AAACCAGGCA 420

GGAGCCTTCC TAATCCGAGA AAGCGAAAGT CTAAAAGGCG AATACTCACT TTCAGTGTTC 480

GATGGTCAAT CAGTGAAGCA CTACAGGATC AGAAGACTGG ATGGAGAAGG CTTTTTCTTA 540

AGTAGAATGA AAACTTTTAA AACTCTGAAT GAGTTTGTTG ACTATTACAG TAAGAACAGT 600

GATGGCCTCT GTGTGAAGCT TGGAAAGCCA TGTCCGAAGG TACAAATTCC TACTACTTTT 660

GATTTGTCAT ACAAAACTGT TGATCAATGG GAGATAGACA GAAAATCTCT GAAATTCTTG 720

AAAAAGTTAG GATCTGGTCA GTTTGGTGAG GTATGGGAAG GACTGTGGAA TAACACCACC 780

CCAGTGGCAA TCAAAACATT AAAACCAGGT TCAATGGATC CAAAGGACTT TCTGAGGGAA 840

GCACAAATAA TGAAGAACTT GAGGCATCCA AATCTTATAC AACTTTATGC TGTTTGCACT 900

TTGGAGGACC CAATTTATAT TGTTACGGAG CTGATGAAAT ATGGAAGTCT TATAGAATAC 960

CTTCAGAATG ATGCAGGCTC CCACATCTCC CTGCCACATC AAATAGACAT GGCTGCTCAG 1020

GTGGCTTCTG GCATGGCTTA TCTTGAATCT CAGAACTATA TCCATCGAGA TTTGGCAGCC 1080

AGGAATGTTC TTGTTGGTGA ACACAGTGTT TACAAAGTGG CAGATTTTGG ACTTGCGAGA 1140

GTTTTTAAGG TAGAAAATGA AAACATATAT GAAGCTAGGC CTGAAACAAA ACTCCCAGTG 1200

AAGTGGACAG CCCCTGAGGC AATCCGCTAT AACAAATTCA GTGTTAAGTC AGATGTGTGG 1260

TCATTTGGAA TACTTCTTTT TGAAATAATC ACGTATGGGA AGATGCCGTA TGCTGGCATG 1320

CCGGGACACC AGGTGATCCA AATGCTGGAC AAGGGATACA GACTCCCTCA GCCTGAGACC 1380

TGCCCCAAGG CACTCTATGA ACTGATGCTG AAGTGCTGGA GTACGGAGCC CAGTGAGAGG 1440

CCCACATTTG AGGCCTTGTA CTGCCAGCTG GAGGACTACT TCGACAATGA CTCCTATATG 1500

GACAACCGTG CCACCATCAA GTGA 1524

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lk++kklG+GqfGevw+g+w+++++va+ktlk+g+++p++fl+eaqi+k+lrh++l++ly

Q: 237   LKFLKKLGSGQFGEVWEGLWNNTTPVAIKTLKPGSMDPKDFLREAQIMKNLRHPNLIQLY  296

         5789********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyivtelm+ Gsl+++l+++ g++++lp+++d+aaqva+Gmayle++n+ihr

Q: 297   AVCTLEDPIYIVTELMKYGSLIEYLQNDAGSHISLPHQIDMAAQVASGMAYLESQNYIHR  356

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++v+kvadfGlar+++   +++y+a+ ++klP+kWtaPeai+++kf++k

Q: 357   DLAARNVLVGEHSVYKVADFGLARVFKvenENIYEARPETKLPVKWTAPEAIRYNKFSVK  416

         ************************99887899****************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py Gm  ++v++++++gyrlp+pe+cp+ lyel+l+cw+++

Q: 417   SDVWSFGILLFEIITYGKMPYAGMPGHQVIQMLDKGYRLPQPETCPKALYELMLKCWSTE  476

         ************************************************************

S: 238   peerPtfetlqe  249

         p+erPtfe+l+

Q: 477   PSERPTFEALYC  488

         ********9975

Domain Sequence
(FASTA)

LKFLKKLGSG QFGEVWEGLW NNTTPVAIKT LKPGSMDPKD FLREAQIMKN LRHPNLIQLY 60

AVCTLEDPIY IVTELMKYGS LIEYLQNDAG SHISLPHQID MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHSVYKVADF GLARVFKVEN ENIYEARPET KLPVKWTAPE AIRYNKFSVK 180

SDVWSFGILL FEIITYGKMP YAGMPGHQVI QMLDKGYRLP QPETCPKALY ELMLKCWSTE 240

PSERPTFEAL YC 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013