EKS-GAG-00309
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00309
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src449.92.4E-135271519249
StatusUnreviewed
Ensembl ProteinENSGALP00000036526
UniProt AccessionE1C362;
Protein Name
Protein Synonyms/Alias Tyrosine-protein kinase Fyn;
Gene NameFYN
Gene Synonyms/Alias FYN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000015022ENSGALP00000036526ENSGALT00000037319
ENSGALG00000015022ENSGALP00000024180ENSGALT00000024226
OrganismGallus gallus
Functional Description
Protein Length537
Protein Sequence
(FASTA)
MGCVQCKDKE ATKLTDERDG SLTQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHATGGQG 60
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120
EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180
TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 240
RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 300
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR 360
ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 420
TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 480
RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQGFL EDYFTATEPQ YQPGDNL 537
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGCAATGTAA GGACAAAGAG GCAACAAAAC TGACTGACGA GAGGGATGGG 60
AGTTTAACGC AAAGCTCAGG CTACCGCTAT GGCACAGATC CCACGCCACA GCACTATCCA 120
AGCTTTGGTG TGACTTCAAT TCCAAACTAC AACAACTTCC ATGCCACAGG AGGCCAAGGA 180
CTGACAGTGT TTGGTGGAGT CAACTCCTCC TCTCATACAG GGACGCTGCG TACAAGAGGA 240
GGAACAGGTG TAACTCTTTT TGTGGCGCTT TATGACTATG AAGCAAGAAC AGAAGATGAC 300
TTAAGTTTTC ATAAAGGAGA AAAATTTCAA ATTCTTAACA GCTCGGAAGG AGACTGGTGG 360
GAGGCTCGGT CCCTGACAAC AGGCGAAACT GGTTACATTC CCAGTAATTA TGTGGCTCCA 420
GTCGATTCCA TCCAAGCAGA GGAGTGGTAC TTCGGCAAAC TTGGCCGAAA AGATGCTGAG 480
AGGCAGCTGT TGTCATTTGG AAACCCAAGA GGTACCTTCC TGATCCGGGA AAGTGAAACT 540
ACCAAAGGTG CCTATTCCCT GTCTATCCGT GACTGGGATG ATATGAAAGG AGATCATGTC 600
AAACATTATA AGATTCGTAA ACTTGACAAT GGTGGATATT ATATCACAAC TCGGGCACAA 660
TTTGAAACTC TTCAACAGCT GGTTCAACAT TATTCAGAGA GAGCTGCAGG TCTTTGCTGC 720
CGCTTAGTAG TCCCCTGTCA TAAAGGAATG CCAAGGCTTA CTGATCTGTC TGTCAAAACC 780
AAAGATGTCT GGGAAATTCC ACGAGAATCC CTACAGTTGA TCAAGAGACT GGGAAATGGG 840
CAGTTTGGGG AAGTATGGAT GGGTACGTGG AATGGAAATA CTAAAGTGGC TATCAAGACT 900
CTGAAGCCTG GCACTATGTC TCCAGAATCA TTCTTGGAGG AAGCCCAAAT CATGAAGAAG 960
CTAAAACATG ACAAACTGGT CCAGCTTTAT GCTGTGGTGT CTGAAGAACC CATCTATATC 1020
GTCACAGAGT ACATGAGCAA AGGGAGCTTG CTAGATTTCT TAAAAGACGG AGAAGGAAGA 1080
GCTCTGAAGC TACCAAACTT AGTGGACATG GCAGCTCAGG TGGCTGCAGG AATGGCATAT 1140
ATTGAACGAA TGAATTACAT ACACAGAGAT CTGAGATCTG CAAACATTCT GGTGGGGAAT 1200
GGACTAATAT GCAAGATTGC TGACTTTGGA TTAGCAAGGC TGATCGAAGA CAACGAGTAT 1260
ACAGCAAGAC AAGGTGCAAA GTTTCCCATT AAATGGACTG CACCAGAAGC GGCATTGTAT 1320
GGAAGGTTCA CAATAAAGTC GGACGTGTGG TCTTTTGGGA TCCTACTGAC AGAGCTGGTA 1380
ACAAAAGGAA GAGTGCCATA CCCAGGCATG AATAACCGTG AAGTCTTGGA GCAAGTAGAA 1440
CGCGGTTATC GGATGCCATG TCCTCAGGAC TGTCCCATCT CCTTGCACGA GCTTATGATC 1500
CACTGCTGGA AAAAAGACCC AGAGGAGCGT CCAACTTTTG AATATTTGCA GGGTTTTCTT 1560
GAAGACTACT TCACTGCAAC AGAACCCCAG TACCAGCCCG GTGACAACCT GTAA 1614
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+ly
Q: 271   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY  330
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr
Q: 331   AVVSE-EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  389
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 390   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  449
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpee
Q: 450   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE  509
         ************************************************************
S: 241   rPtfetlqev  250
         rPtfe+lq +
Q: 510   RPTFEYLQGF  519
         *******976
Domain Sequence
(FASTA)
LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD 120
LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER 240
PTFEYLQGF 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00339
EKS-ANC-00354
EKS-BOT-00365
EKS-CAJ-00369
EKS-CAF-00366
EKS-CAP-00398
EKS-CHH-00039
EKS-DAR-00743
EKS-DAN-00035
EKS-EQC-00367
EKS-FEC-00353
EKS-GAM-00219
EKS-GAA-00446
EKS-GOG-00358
EKS-HOS-00371
EKS-ICT-00346
EKS-LAC-00380
EKS-LOA-00374
EKS-MAM-00365
EKS-MEG-00300
EKS-MOD-00354
EKS-MUM-00397
EKS-MUP-00359
EKS-MYL-00364
EKS-NOL-00335
EKS-ORN-00470
EKS-ORA-00320
EKS-ORC-00343
EKS-ORL-00432
EKS-OTG-00370
EKS-PAT-00345
EKS-PES-00325
EKS-POA-00355
EKS-PRC-00071
EKS-PTV-00093
EKS-RAN-00379
EKS-SAH-00336
EKS-SUS-00322
EKS-TAG-00440
EKS-TAR-00466
EKS-TEN-00462
EKS-TUB-00053
EKS-TUT-00097
EKS-VIP-00051
EKS-XET-00483
EKS-XIM-00460
Gene Ontology
GO:0005768; C:endosome
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050798; P:activated T cell proliferation
GO:0010629; P:negative regulation of gene expression
GO:0042177; P:negative regulation of protein catabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045471; P:response to ethanol
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013