EKS-GAG-00025
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00025
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak342.52.0E-1028221095274
StatusUnreviewed
Ensembl ProteinENSGALP00000024189
UniProt AccessionF1NX11;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK2
Gene Synonyms/Alias JAK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000015027ENSGALP00000037587ENSGALT00000038382
ENSGALG00000015027ENSGALP00000037583ENSGALT00000038378
ENSGALG00000015027ENSGALP00000037585ENSGALT00000038380
ENSGALG00000015027ENSGALP00000024189ENSGALT00000024235
OrganismGallus gallus
Functional Description
Protein Length1105
Protein Sequence
(FASTA)
GNTSAPKQTE PMLQVYLYYS PGKTGGDYLQ FPAGEYVAEE ICIVACKACG IMPVYHNMFA 60
LMSETERVWY PPNHIFHVDE ATRLKLLYRI RFYFPHWYCN GTSRAYRYGI IRGSESPVLD 120
DLVMSYLFAQ WRKDFLDGWI QMPVTHETQE ECLGMAVLDM MRVAKEKDQT PLAVYNSVSY 180
KMFLPKCVRA KIQEYHILTR KRIRYRFRKF IQQFGQCKAT ARNLKLKYLI NLETLQSAFY 240
SEVFEVKEPG GDPSGEESFA TIVITGNGGI QCSRGKLKNC ETLAEQDLQT YCDFPDIIDV 300
SIKQASQEGS SERRIVTIHK QDSKNLEAEF QSLREALSFV SLIDGYYRLT ADAHHYLCKE 360
VTPPSVLENI QSNCHGPIVM DFAINKLKKA GNQTGFYVLR CSPKDFKKYF LTFAIERENA 420
TDYKHCLITK NENGEYNLSG TKRSFGNLKD LLTCYQTETV RSDSIIFQFI KCCPPKPKDK 480
SNLLVFRSNS VSDVPSSPTL QRHNVSQMVF HKIRNEDLIF EESLGQGTFT KIFKGIRKEV 540
GDYGQLHQTE VLLKVLDKVH RNYSESFFEA ASMMSQLSYK HLVLNYGVCV CGEENILVQE 600
YVKFGSLDTY LKKNKNVINI LWKLEVAKQL ALAMHFLEDK GLVHGNVCAK NILLIREEDR 660
KSGNLPFIKL SDPGISITVL PRDILLERIP WVPPECIENP RQLSLATDKW SFGTTLWEIC 720
SGGDKPLSAL DSSRKLQFYE DRHQLPAPNW TELANLINNC MDYEPDFRPS FRAIIRDLNS 780
LFTPDYELLT ENDMLPNIRT GALGFSGAFE DRDPTQFEER HLKFLQQLGK GNFGSVEMCR 840
YDPLQDNTGE VVAVKKLQHS TEEHLRDFER EIEILKSLQH DNIVKYKGVC YSAGRRNLRL 900
IMEYLPYGSL RDYLQKHKER LDHKKLLLYA SQICKGMEYL GTKRYVHRDL ATRNILVENE 960
NRVKIGDFGL TKVLPQDKEY YKVKEPGESP IFWYAPESLT ESKFSVASDV WSFGVVLYEL 1020
FTYIEKSKSP PAEFMRMIGN DKQGQMIVFH LIELLKNNGR LPRPDGCPDE IYAIMKECWN 1080
NNVAQRPTFR DLAQRVDQIR DNMGG 1105
Nucleotide Sequence
(FASTA)
GGGAATACTA GTGCACCCAA GCAGACAGAG CCAATGCTTC AAGTGTACCT TTATTATTCA 60
CCTGGGAAGA CGGGAGGAGA TTATCTTCAA TTTCCAGCGG GAGAATATGT TGCAGAAGAG 120
ATTTGCATTG TTGCCTGTAA AGCATGTGGT ATCATGCCAG TGTATCATAA TATGTTTGCA 180
CTCATGAGTG AAACAGAGAG AGTTTGGTAT CCTCCAAATC ACATTTTCCA CGTAGATGAA 240
GCAACCAGAC TAAAGCTACT GTACCGGATA AGGTTTTATT TTCCCCACTG GTATTGCAAT 300
GGCACAAGCA GAGCATATCG CTATGGCATT ATTCGAGGTT CAGAAAGCCC TGTTCTTGAT 360
GATCTTGTCA TGTCTTACCT ATTTGCACAG TGGCGAAAAG ATTTTTTGGA TGGTTGGATA 420
CAGATGCCTG TTACTCATGA AACACAGGAA GAATGCCTTG GAATGGCTGT TCTGGATATG 480
ATGAGGGTGG CCAAGGAAAA GGACCAAACC CCACTGGCTG TTTACAACTC AGTCAGCTAC 540
AAAATGTTTC TGCCTAAATG TGTGCGAGCA AAGATCCAAG AATACCACAT TTTGACCCGA 600
AAAAGAATAA GGTACAGGTT CCGTAAATTC ATACAACAGT TTGGCCAGTG CAAAGCCACT 660
GCCAGGAACT TGAAACTTAA GTATCTCATA AATTTGGAAA CCCTTCAGTC CGCCTTCTAT 720
TCAGAGGTTT TTGAAGTTAA AGAACCTGGT GGAGATCCTT CCGGAGAAGA AAGTTTTGCA 780
ACTATTGTAA TAACTGGAAA TGGTGGAATT CAATGCTCAA GAGGAAAACT TAAAAACTGT 840
GAGACACTGG CAGAGCAGGA TTTACAAACA TATTGTGATT TTCCTGATAT CATTGATGTC 900
AGCATTAAAC AAGCAAGTCA AGAAGGTTCC AGTGAGAGGA GAATTGTCAC CATTCACAAA 960
CAAGACAGCA AGAATCTGGA GGCTGAATTT CAGTCTTTAA GAGAAGCTCT CTCCTTTGTA 1020
TCGTTAATTG ATGGATATTA CAGATTAACT GCAGATGCCC ACCATTATCT CTGCAAAGAA 1080
GTAACACCAC CATCAGTGCT TGAAAATATC CAAAGCAATT GCCATGGACC AATTGTCATG 1140
GACTTTGCTA TCAATAAACT GAAGAAGGCA GGTAATCAGA CTGGCTTCTA CGTTCTTCGT 1200
TGCAGTCCTA AAGATTTTAA AAAATACTTC CTCACATTTG CTATTGAGCG TGAGAATGCC 1260
ACTGACTATA AACACTGCTT AATTACAAAG AATGAGAACG GGGAATATAA TCTTAGTGGA 1320
ACCAAGCGAA GTTTTGGTAA TCTTAAGGAT CTATTGACTT GTTATCAGAC AGAAACTGTC 1380
CGCTCAGACA GCATAATTTT CCAGTTCATC AAGTGCTGTC CTCCAAAACC AAAAGATAAA 1440
TCAAACCTCC TTGTCTTCAG AAGCAATAGT GTCTCTGATG TACCTTCATC ACCAACATTG 1500
CAGAGGCACA ATGTCAGCCA GATGGTCTTT CACAAAATCC GGAATGAGGA CTTGATTTTT 1560
GAAGAGAGTC TTGGGCAGGG CACATTTACA AAGATTTTCA AAGGCATAAG GAAAGAAGTG 1620
GGAGACTACG GCCAGCTTCA CCAAACTGAA GTTCTTTTAA AGGTTTTGGA TAAAGTGCAT 1680
AGAAACTACT CTGAGTCCTT CTTTGAGGCA GCAAGTATGA TGAGCCAGCT TTCTTACAAA 1740
CATTTGGTAT TAAATTATGG AGTCTGTGTG TGTGGAGAGG AGAATATCCT TGTACAAGAG 1800
TATGTGAAAT TTGGATCTTT GGACACATAT TTGAAAAAGA ACAAAAACGT TATTAATATC 1860
TTGTGGAAGC TGGAAGTTGC CAAACAGTTG GCACTAGCCA TGCATTTCCT GGAGGATAAA 1920
GGCCTTGTTC ATGGGAATGT CTGTGCAAAG AACATCTTGC TTATCAGGGA GGAGGACAGG 1980
AAGTCTGGAA ACCTTCCTTT TATAAAACTA AGTGACCCTG GCATCAGTAT CACAGTTTTG 2040
CCAAGAGATA TTCTTCTTGA GAGAATACCA TGGGTTCCAC CTGAATGTAT TGAGAACCCC 2100
AGACAACTAA GCCTAGCTAC AGATAAGTGG AGTTTTGGTA CCACTTTATG GGAAATCTGC 2160
AGTGGAGGAG ACAAACCACT GAGTGCTCTC GATTCTTCAA GAAAACTACA GTTTTATGAA 2220
GATAGACACC AGCTTCCTGC CCCCAACTGG ACAGAGCTAG CAAACCTTAT AAACAACTGT 2280
ATGGATTATG AGCCAGATTT CAGGCCGTCA TTTAGGGCAA TTATACGTGA CTTGAATAGT 2340
TTGTTCACTC CTGATTATGA GTTATTGACA GAAAATGATA TGTTGCCAAA TATACGAACT 2400
GGAGCTCTTG GATTTTCTGG GGCCTTTGAA GATCGGGACC CAACACAATT TGAAGAAAGA 2460
CATCTTAAGT TTTTACAGCA ACTTGGCAAG GGAAACTTTG GCAGTGTTGA GATGTGCCGG 2520
TATGACCCCC TACAGGATAA TACTGGAGAG GTGGTGGCTG TGAAAAAGCT GCAACACAGT 2580
ACAGAAGAGC ACCTTAGGGA CTTTGAAAGA GAAATTGAAA TACTTAAATC TCTGCAGCAT 2640
GATAACATTG TTAAATACAA AGGAGTATGC TACAGTGCAG GTCGTAGGAA TCTGAGATTA 2700
ATTATGGAAT ATCTACCATA TGGAAGTTTA CGAGATTATC TGCAGAAACA CAAAGAGAGG 2760
TTAGACCACA AAAAGCTTTT GCTATATGCA TCTCAGATAT GCAAGGGCAT GGAGTATCTG 2820
GGTACAAAAA GATATGTTCA CCGGGATTTA GCAACAAGAA ATATTTTAGT GGAGAATGAG 2880
AACAGAGTTA AAATTGGAGA TTTTGGATTG ACTAAAGTCT TGCCACAAGA TAAGGAGTAC 2940
TACAAAGTGA AAGAACCTGG TGAAAGCCCT ATATTTTGGT ATGCTCCAGA GTCTCTGACA 3000
GAGAGCAAGT TTTCCGTGGC CTCAGATGTA TGGAGTTTTG GTGTGGTCTT GTATGAACTC 3060
TTCACTTACA TCGAAAAGAG CAAAAGCCCA CCAGCTGAAT TCATGCGCAT GATTGGCAAT 3120
GATAAACAAG GGCAGATGAT TGTATTTCAT TTGATAGAGC TTTTGAAGAA CAATGGACGA 3180
CTGCCAAGAC CAGATGGATG CCCTGATGAG ATTTATGCTA TCATGAAAGA ATGTTGGAAC 3240
AATAATGTTG CCCAGCGGCC CACCTTTAGG GATCTTGCTC AGCGAGTGGA TCAAATAAGG 3300
GACAACATGG GTGGGTGA 3318
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+
Q: 822   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  881
         6899********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke+l++++ll +a+q++k+meYL+
Q: 882   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERLDHKKLLLYASQICKGMEYLG  941
         **********999888********************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         +k++vhrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a
Q: 942   TKRYVHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  995
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224
         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el
Q: 996   PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIEL  1054
         ********.*******************************999999999***********
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrailed  264
         l+++ rlp+p+ cp+e++ +m++c++++  qrp+Fr+++++
Q: 1055  LKNNGRLPRPDgCPDEIYAIMKECWNNNVAQRPTFRDLAQR  1095
         *************************************9775
Domain Sequence
(FASTA)
LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60
NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERL DHKKLLLYAS QICKGMEYLG 120
TKRYVHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180
SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240
PRPDGCPDEI YAIMKECWNN NVAQRPTFRD LAQR 274
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00026
EKS-ANC-00025
EKS-BOT-00031
EKS-CAJ-00030
EKS-CAF-00031
EKS-CAP-00032
EKS-CII-00224
EKS-DAR-00042
EKS-DRM-00011
EKS-EQC-00028
EKS-FEC-00028
EKS-GAM-00013
EKS-GAA-00046
EKS-GOG-00030
EKS-HOS-00032
EKS-ICT-00030
EKS-LAC-00033
EKS-LOA-00030
EKS-MAM-00031
EKS-MEG-00027
EKS-MOD-00030
EKS-MUM-00032
EKS-MUP-00032
EKS-MYL-00032
EKS-NOL-00029
EKS-ORN-00046
EKS-ORA-00025
EKS-ORC-00031
EKS-ORL-00043
EKS-OTG-00031
EKS-PAT-00029
EKS-PES-00027
EKS-POA-00028
EKS-PTV-00030
EKS-RAN-00032
EKS-SAH-00029
EKS-SUS-00028
EKS-TAG-00028
EKS-TAR-00046
EKS-TEN-00052
EKS-XET-00030
EKS-XIM-00044
Gene Ontology
GO:0005901; C:caveola
GO:0005737; C:cytoplasm
GO:0005856; C:cytoskeleton
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0035401; F:histone kinase activity (H3-Y41 specific)
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0030154; P:cell differentiation
GO:0060396; P:growth hormone receptor signaling pathway
GO:0035722; P:interleukin-12-mediated signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0043392; P:negative regulation of DNA binding
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:0050727; P:regulation of inflammatory response
GO:0046677; P:response to antibiotic
GO:0007262; P:STAT protein import into nucleus
GO:0033209; P:tumor necrosis factor-mediated signaling pathway
GO:0007260; P:tyrosine phosphorylation of STAT protein
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693; Tyr_kinase_non-rcpt_Jak2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR01825; JANUSKINASE2.
PR00109; TYRKINASE.
Created Date20-Feb-2013