EKS-GAG-00003
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00003
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph517.74.2E-156578835258
StatusUnreviewed
Ensembl ProteinENSGALP00000036084
UniProt AccessionF1NJX6;
Protein Name
Protein Synonyms/Alias Ephrin type-A receptor 3;
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000015403ENSGALP00000036084ENSGALT00000036872
ENSGALG00000015403ENSGALP00000036083ENSGALT00000036871
ENSGALG00000015403ENSGALP00000024798ENSGALT00000024844
OrganismGallus gallus
Functional Description
Protein Length940
Protein Sequence
(FASTA)
MFVARGSWEE ISGVDEHYTP IRTYQVCNVM DHSQNNWLRT NWIPRNSAQK IYVELKFTLR 60
DCNSIPLVLG TCKETFNLYY MESDDDHLAK FREHQFTKID TIAADESFTQ MDLGDRILKL 120
NTEVREVGPV SKKGFYLAFQ DVGACVALVS VRVYFKKCPF TVKNLAMFPD TVPMDSQSLV 180
EVRGSCVNHS KEEEPPKMYC STEGEWLVPI GKCLCNAGYE ERGFACQACR PGFYKASAGN 240
VKCAKCPPHS STYEDASLNC RCEKNYFRSE KDPPSMACTR PPSAPRNVIS NINETSVILD 300
WSWPLDTGGR KDVTFNIICK KCGGSSKICE PCSDNVRFLP RQTGLTNTTV TVVDLLAHTN 360
YTFEIDAVNG VSDLSTLSRQ FAAVSITTNQ AAPSPITVIR KDRTSRNSVS LSWQEPEHPN 420
GIILDYEVKY YEKQEQETSY TILRAKSTNV TISGLKPDTT YVFQIRARTA AGYGTSSRKF 480
EFETSPDSFS ISSENSQVVM IAISAAVAII LLTVVVYVLI GRFCGYKKSK HGTDEKRLHF 540
GNGHLKLPGL RTYVDPHTYE DPNQAVHEFA KELDASNISI DKVVGAGEFG EVCSGRLKLP 600
SKKEISVAIK TLKAGYTEKQ RRDFLGEASI MGQFDHPNII RLEGVVTKSK PVMIVTEYME 660
NGSLDSFLRK HDAQFTVIQL VGMLRGIASG MKYLSDMGYV HRDLAARNIL INSNLVCKVS 720
DFGLSRVLED DPEAAYTTRG GKIPIRWTSP EAIAYRKFTS ASDAWSYGIV LWEVMSYGER 780
PYWEMSNQDV IKAVDEGYRL PPPMDCPAAL YQLMLDCWQK DRNNRPKFEQ IVSILDKLIR 840
NPSSLKIITN AAARPSNLLL DQSNIDISAF RTAGDWLNGF RTGQCKGIFT GVEYSSCDTI 900
AKISTDDMKK VGVTVVGPQK KIVSSIKTLE THTKNSPVPV 940
Nucleotide Sequence
(FASTA)
ATGTTCGTAG CAAGGGGCAG TTGGGAAGAG ATTAGTGGTG TTGATGAGCA TTATACTCCA 60
ATCAGAACTT ACCAAGTGTG CAATGTTATG GATCACAGTC AAAACAATTG GCTGCGAACA 120
AACTGGATTC CACGCAATTC AGCGCAGAAG ATATATGTGG AGCTCAAGTT TACCTTGAGG 180
GACTGCAATA GTATCCCTCT AGTTCTGGGC ACTTGCAAAG AGACTTTCAA TCTGTATTAC 240
ATGGAATCCG ATGATGACCA TTTGGCAAAG TTCAGAGAGC ACCAATTTAC AAAGATTGAC 300
ACCATTGCGG CTGATGAGAG CTTCACCCAG ATGGATCTTG GGGACCGGAT TCTCAAGCTG 360
AATACCGAAG TCCGCGAGGT GGGACCTGTT AGTAAGAAGG GCTTTTACTT GGCTTTCCAA 420
GATGTAGGTG CATGTGTTGC CTTAGTCTCG GTGCGAGTGT ACTTCAAGAA GTGCCCTTTC 480
ACTGTCAAGA ACCTCGCCAT GTTTCCAGAT ACAGTTCCTA TGGACTCCCA GTCCCTGGTG 540
GAGGTGCGGG GTTCTTGTGT CAATCATTCC AAGGAGGAAG AGCCACCCAA GATGTACTGC 600
AGCACGGAAG GAGAATGGCT AGTGCCCATA GGGAAGTGCT TGTGTAATGC TGGCTATGAA 660
GAGAGAGGCT TTGCGTGCCA AGCTTGTCGA CCTGGGTTCT ATAAAGCTTC TGCTGGCAAT 720
GTGAAGTGTG CCAAATGCCC ACCTCACAGC TCTACCTATG AAGATGCATC TCTGAACTGC 780
AGGTGTGAAA AGAATTACTT TCGCTCTGAG AAAGACCCTC CATCCATGGC TTGCACCAGA 840
CCACCATCTG CTCCAAGAAA TGTTATTTCT AACATCAATG AGACATCTGT TATTCTGGAC 900
TGGAGCTGGC CTCTTGACAC AGGAGGTCGA AAAGATGTCA CTTTCAACAT CATTTGCAAA 960
AAATGTGGAG GAAGCAGCAA GATATGTGAG CCTTGCAGTG ACAACGTACG GTTCTTACCC 1020
CGTCAGACTG GCCTCACCAA CACCACAGTG ACAGTAGTGG ACCTTTTGGC ACATACCAAT 1080
TACACTTTTG AGATTGATGC AGTCAACGGG GTATCTGACT TGAGTACACT TTCGAGACAA 1140
TTTGCTGCTG TCAGCATCAC GACTAATCAG GCTGCGCCAT CCCCCATCAC AGTGATAAGG 1200
AAAGACCGGA CATCCAGGAA CAGCGTGTCT CTGTCTTGGC AGGAGCCTGA GCACCCAAAT 1260
GGAATCATCT TGGACTACGA GGTCAAATAC TACGAAAAGC AGGAACAAGA GACAAGCTAT 1320
ACTATTCTGA GAGCCAAAAG CACTAACGTT ACTATCAGCG GCCTCAAACC TGATACCACC 1380
TACGTCTTCC AAATTCGAGC CCGAACTGCA GCTGGATATG GGACAAGCAG CCGCAAGTTT 1440
GAATTTGAAA CCAGTCCAGA TTCATTCTCC ATTTCCAGTG AAAATAGCCA GGTCGTTATG 1500
ATTGCCATTT CAGCTGCAGT TGCCATCATT CTCCTCACGG TTGTTGTGTA CGTCTTGATT 1560
GGGAGATTCT GCGGATACAA GAAGTCTAAA CATGGTACCG ATGAGAAAAG ACTACATTTT 1620
GGGAATGGCC ACTTAAAACT CCCAGGCCTG AGAACTTATG TAGATCCACA TACGTACGAA 1680
GATCCCAATC AAGCTGTACA TGAATTTGCC AAGGAACTAG ATGCTTCTAA TATATCAATT 1740
GATAAAGTTG TTGGAGCAGG GGAATTTGGA GAAGTGTGCA GTGGGCGCCT GAAGCTGCCT 1800
TCTAAAAAGG AAATTTCAGT GGCCATCAAA ACTCTGAAAG CTGGCTACAC AGAAAAACAG 1860
AGAAGGGATT TCCTGGGAGA AGCAAGCATC ATGGGGCAGT TTGACCACCC CAACATCATC 1920
CGACTGGAGG GCGTTGTGAC TAAAAGTAAA CCAGTTATGA TTGTTACTGA ATACATGGAA 1980
AACGGTTCCT TGGACAGCTT CCTACGGAAA CATGATGCCC AGTTCACAGT CATTCAGCTA 2040
GTAGGCATGC TTCGTGGGAT CGCATCTGGC ATGAAATATT TGTCAGATAT GGGTTATGTC 2100
CACCGAGATC TAGCTGCTCG TAATATACTC ATCAATAGTA ACTTGGTGTG CAAAGTCTCA 2160
GATTTTGGTC TTTCTCGTGT ATTGGAAGAT GACCCAGAAG CTGCTTACAC AACAAGGGGG 2220
GGCAAGATTC CCATCCGATG GACGTCACCA GAAGCCATTG CATACCGGAA GTTCACATCA 2280
GCCAGTGATG CGTGGAGCTA TGGGATTGTC CTCTGGGAGG TGATGTCTTA TGGAGAAAGG 2340
CCGTACTGGG AGATGTCCAA CCAGGACGTA ATTAAAGCCG TTGATGAAGG GTATCGCTTG 2400
CCACCTCCTA TGGACTGCCC AGCTGCCTTG TATCAGCTGA TGCTGGACTG CTGGCAGAAA 2460
GACAGAAACA ACAGACCCAA GTTTGAGCAG ATTGTCAGCA TCCTGGATAA GCTGATCCGT 2520
AATCCCAGCA GTCTGAAAAT AATCACCAAT GCGGCAGCAA GGCCATCAAA TCTTCTCCTG 2580
GACCAAAGTA ACATTGACAT TTCAGCGTTC CGCACGGCAG GTGATTGGCT CAATGGTTTT 2640
CGAACAGGAC AGTGCAAAGG CATTTTCACG GGTGTGGAGT ACAGCTCCTG TGATACAATA 2700
GCCAAGATTT CCACTGATGA CATGAAGAAA GTTGGTGTTA CAGTTGTGGG GCCTCAAAAG 2760
AAGATTGTTA GCAGTATCAA AACTCTAGAA ACTCATACGA AGAACAGCCC TGTTCCTGTG 2820
TAA 2823
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlkag+tekqrrdfl easi+Gqfdhp
Q: 578   ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASIMGQFDHP  637
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtkskpvmivteymeng+ldsflrk+d qftviqlvgmlrGiasgmkylsdm
Q: 638   NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM  697
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwt+peaiayrk
Q: 698   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK  757
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasd+wsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpaalyqlmldc
Q: 758   FTSASDAWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC  817
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkfeqivsil
Q: 818   WQKDRNNRPKFEQIVSIL  835
         ***************986
Domain Sequence
(FASTA)
ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKAGYT EKQRRDFLGE ASIMGQFDHP 60
NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK 180
FTSASDAWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP AALYQLMLDC 240
WQKDRNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00002
EKS-ANC-00002
EKS-CAE-00001
EKS-CAJ-00002
EKS-CAF-00003
EKS-EQC-00003
EKS-FEC-00004
EKS-GAA-00003
EKS-GOG-00002
EKS-HOS-00003
EKS-ICT-00002
EKS-LOA-00002
EKS-MAM-00002
EKS-MEG-00002
EKS-MOD-00002
EKS-MUM-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-NOL-00002
EKS-ORN-00002
EKS-ORA-00003
EKS-ORC-00002
EKS-ORL-00003
EKS-OTG-00001
EKS-PAT-00002
EKS-PES-00003
EKS-POA-00002
EKS-PRC-00002
EKS-RAN-00003
EKS-SUS-00002
EKS-TAG-00004
EKS-TAS-00002
EKS-TEN-00001
EKS-TUT-00001
EKS-XET-00001
Gene Ontology
GO:0005769; C:early endosome
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0071300; P:cellular response to retinoic acid
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0051893; P:regulation of focal adhesion assembly
GO:0070507; P:regulation of microtubule cytoskeleton organization
GO:0032319; P:regulation of Rho GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013