EKS-GAG-00124

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00124

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	561.8	2.2E-169	471	747	277

Status

Reviewed

Ensembl Protein

ENSGALP00000001710

UniProt Accession

P18460;

Protein Name

Fibroblast growth factor receptor 3

Protein Synonyms/Alias

FGFR-3; Tyrosine kinase receptor CEK2;

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3; CEK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000015708	ENSGALP00000001710	ENSGALT00000001712
ENSGALG00000015708	ENSGALP00000025286	ENSGALT00000025332

Organism

Gallus gallus

Functional Description

Tyrosine-protein kinase that acts as cell-surfacereceptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).

Protein Length

811

Protein Sequence
(FASTA)

MRAAWGSVWC LCLAAAVGAL PAARRRGAER SGGQAAEYLR SETAFLEELV FGSGDTIELS 60

CNTQRNSTTS SSVSVFWFKD GIGIAPSNRT HIGQKLLKII NVSYDDSGLY SCKPRHSNEV 120

LGNFTVRVTD SPSSGDDEDD DDESEDTGVP FWTRPDKMEK KLLAVPAANT VRFRCPAGGN 180

PTPTIYWLKN GKEFKGEHRI GGIKLRHQQW SLVMESVVPS DRGNYTCVVE NKYGNIRHTY 240

QLDVLERSPH RPILQAGLPA NQTVVVGSNV EFHCKVYSDA QPHIQWLKHV EVNGSKYGPD 300

GTPYVTVLKT AGVNTTDKEL EILYLRNVTF EDAGEYTCLA GNSIGFSHHS AWLTVLPAEE 360

LMEMDDSGSV YAGILSYGTG LVLFILVLVI VIICRMKMPN KKAMNTTTVQ KVSKFPLKRQ 420

QVSLESNSSM NSNTPLVRIT RLSSSDGPML ANVSELELPP DPKWELARSR LTLGKPLGEG 480

CFGQVVMAEA IGIDKDKPNK AITVAVKMLK DDATDKDLSD LVSEMEMMKM IGKHKNIINL 540

LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKLPEEQLTF KDLVSCAYQV 600

ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNIDYYKKT TNGRLPVKWM 660

APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPANCTH 720

DLYMIMRECW HAVPSQRPTF KQLVEDLDRV LTMTSTDEYL DLSVPFEQYS PAGQDTHSTC 780

SSGDDSVFAH DLLPDEPCLP KHVPCNGVIR T 811

Nucleotide Sequence
(FASTA)

ATGCGGGCGG CCTGGGGCTC CGTCTGGTGC CTGTGCCTGG CGGCGGCCGT CGGAGCGCTG 60

CCGGCGGCGC GGCGGCGCGG AGCGGAGCGG AGCGGCGGGC AGGCGGCAGA ATACTTGAGG 120

AGCGAGACCG CCTTTCTGGA AGAGTTGGTG TTTGGAAGTG GAGATACCAT TGAACTTTCC 180

TGTAACACCC AGAGGAATTC CACCACAAGC TCTTCTGTGT CAGTTTTCTG GTTTAAAGAT 240

GGTATTGGGA TTGCACCTTC CAACAGAACT CATATTGGAC AAAAACTGTT GAAGATAATC 300

AATGTGTCAT ATGACGATTC GGGGCTGTAC AGTTGCAAGC CAAGGCATTC CAACGAGGTC 360

CTGGGAAACT TTACAGTCAG AGTGACAGAT TCCCCTTCGT CAGGTGATGA TGAAGATGAT 420

GACGATGAGT CAGAGGATAC AGGTGTCCCC TTCTGGACCC GGCCAGATAA GATGGAGAAG 480

AAGCTGCTGG CAGTTCCTGC CGCCAACACC GTTCGCTTCC GATGTCCAGC AGGTGGAAAC 540

CCAACTCCCA CCATTTACTG GCTGAAGAAT GGCAAAGAAT TCAAGGGAGA GCACAGGATC 600

GGGGGCATCA AGTTGCGACA CCAGCAGTGG AGCTTGGTGA TGGAGAGCGT TGTGCCGTCA 660

GATCGAGGAA ACTACACCTG TGTTGTGGAG AACAAATATG GCAATATTAG GCACACATAC 720

CAGCTTGATG TTTTAGAACG GTCACCCCAC CGACCAATCC TGCAAGCAGG ACTCCCTGCC 780

AATCAGACTG TGGTGGTCGG GAGCAATGTG GAATTTCACT GCAAGGTCTA CAGCGATGCC 840

CAGCCTCATA TCCAGTGGCT GAAACACGTA GAAGTCAACG GCAGCAAGTA TGGACCTGAT 900

GGGACACCCT ATGTCACAGT GCTGAAGACG GCAGGTGTTA ACACAACGGA TAAGGAGCTA 960

GAGATTCTGT ACTTGCGAAA TGTTACTTTT GAGGATGCTG GGGAATATAC TTGTCTCGCA 1020

GGGAATTCTA TTGGGTTCTC ACATCACTCT GCTTGGCTGA CGGTGCTACC AGCAGAGGAG 1080

CTGATGGAAA TGGATGATTC GGGCTCAGTG TACGCTGGCA TTCTCAGCTA TGGCACTGGC 1140

TTAGTCCTCT TCATCCTGGT GCTGGTCATT GTGATTATCT GCAGGATGAA AATGCCAAAC 1200

AAAAAGGCCA TGAACACCAC CACTGTACAG AAAGTCTCCA AATTTCCACT CAAGAGACAG 1260

CAGGTGTCGT TGGAGTCCAA CTCTTCCATG AATTCCAACA CACCCCTGGT CCGGATCACT 1320

CGTCTCTCCT CCAGCGATGG GCCGATGCTG GCCAACGTCT CTGAGCTGGA ACTTCCTCCA 1380

GATCCCAAGT GGGAATTGGC ACGTTCTCGC CTGACCCTGG GGAAGCCGCT TGGTGAGGGC 1440

TGTTTTGGCC AAGTGGTGAT GGCGGAAGCA ATTGGGATTG ATAAAGACAA GCCAAACAAG 1500

GCCATCACCG TGGCTGTCAA GATGTTAAAA GATGATGCCA CAGACAAGGA CCTTTCAGAC 1560

CTGGTCTCTG AGATGGAAAT GATGAAGATG ATTGGGAAGC ACAAAAACAT CATTAACCTG 1620

CTCGGTGCTT GCACGCAGGA CGGACCGCTC TACGTGTTGG TTGAATATGC ATCGAAGGGG 1680

AACTTGCGGG AATACCTCAG GGCACGTCGC CCACCTGGCA TGGACTATTC CTTCGACACC 1740

TGCAAGCTGC CCGAGGAGCA GTTGACATTT AAAGACCTGG TTTCCTGCGC CTACCAGGTG 1800

GCCCGGGGCA TGGAGTACTT GGCGTCACAG AAATGCATTC ATCGTGACTT GGCAGCCAGG 1860

AATGTGTTAG TCACTGAGGA CAATGTGATG AAAATAGCTG ATTTTGGCCT TGCTAGAGAC 1920

GTTCACAACA TCGACTATTA CAAGAAAACC ACCAATGGTC GGCTGCCTGT GAAATGGATG 1980

GCTCCAGAAG CATTGTTTGA CCGGGTCTAT ACTCACCAGA GCGATGTCTG GTCTTTTGGA 2040

GTGCTACTAT GGGAGATCTT CACTTTGGGA GGGTCTCCGT ACCCGGGAAT TCCTGTTGAA 2100

GAACTCTTCA AACTCTTGAA AGAAGGCCAT CGGATGGATA AACCCGCCAA CTGCACCCAC 2160

GACCTGTACA TGATCATGCG GGAGTGCTGG CACGCTGTCC CCTCGCAGCG ACCCACATTC 2220

AAGCAGCTGG TGGAAGACCT GGACAGAGTC CTCACCATGA CATCCACTGA TGAGTACCTG 2280

GACCTCTCGG TGCCCTTTGA GCAATACTCA CCCGCTGGCC AGGACACCCA CAGCACCTGC 2340

TCCTCAGGGG ACGACTCGGT TTTTGCACAT GACCTGCTGC CTGATGAGCC CTGCCTGCCC 2400

AAGCACGTGC CCTGTAATGG CGTCATCCGC ACGTGA 2436

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aeaig+dkdk++k++tvavkmlk+datdkdl+dlvseme++k+

Q: 471   LTLGKPLGEGCFGQVVMAEAIGIDKDKPNKAITVAVKMLKDDATDKDLSDLVSEMEMMKM  530

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k +eeqlt+

Q: 531   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTF  590

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh+idyykkt

Q: 591   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKT  650

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh

Q: 651   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  710

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl

Q: 711   RMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  747

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA IGIDKDKPNK AITVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKLPEEQLTF 120

KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTH DLYMIMRECW HAVPSQRPTF KQLVEDL 277

Keyword

Apoptosis; ATP-binding; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0009898	; C:internal side of plasma membrane
GO:0005764	; C:lysosome
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0006915	; P:apoptotic process
GO:0030154	; P:cell differentiation
GO:0000165	; P:MAPK cascade
GO:0043066	; P:negative regulation of apoptotic process
GO:0050680	; P:negative regulation of epithelial cell proliferation
GO:0045839	; P:negative regulation of mitosis
GO:0045879	; P:negative regulation of smoothened signaling pathway
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597	; P:positive regulation of cell differentiation
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518	; P:positive regulation of phospholipase activity
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0042511	; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777	; P:protein autophosphorylation
GO:0048678	; P:response to axon injury

KEGG

gga:396515

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013