EKS-GAG-00143

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00143

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TTK	446.8	2.8E-134	534	801	268

Status

Unreviewed

Ensembl Protein

ENSGALP00000025542

UniProt Accession

E1BQR2;

Protein Name

Protein Synonyms/Alias

Gene Name

TTK

Gene Synonyms/Alias

TTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000015874	ENSGALP00000025542	ENSGALT00000025589

Organism

Gallus gallus

Functional Description

Protein Length

871

Protein Sequence
(FASTA)

MEEEEDLSER GLPRIASIMS RVRDLKNKYR NEDNITDELN CTKISADTTD NSGTVNRIMM 60

TTNNPEDWLC FLLRLEKKGI PQMDLSILNR LIGRYSQAVT ALPAEKHSED ENYARILVRF 120

AELKALQDPE EARDQFHLAR LNCKKFAFVH VAFAQFELSQ GNVKKCRQLL QKAVECSAVP 180

LEMLETALQN LNSQKKQLLS DEEKENFAVS SVQESGLQSI VGNQRNIKRN DSTENSSAVA 240

KHLLGEEKSQ DHDAIVNFHN PLRPLNKSNQ ACPFGRVPVK LVTDFDDVVQ KTDVPLTASV 300

MKRQVSSSKC TALIPPFPLS EPKPSENDSC DPADSKLLQE NSVQLQMLDE NSLETATNST 360

VTLKNKIDTS LVMKREENKL QYQELKIPEP RSMESQQQQS SSAIKLNCVN SRKKWPSQEV 420

MQQNCYREGK RSSLEQSAHP LSRRLSPPDA VSKKNELLYV CGTPSSTCTD YMECFRTPIV 480

RNNFSPGYQI STPYSQLPYF LPHTPATTFQ NQMGLQVSGS IPSNECIAVK GRIYTILKQI 540

GSGGSSKVFQ VLNEKKQLYA VKYVNLEEAD QQTVESYKNE IAHLSKLQEH SDKIIRLYSY 600

EITDQHIYMV MECGNIDLNS WLKKKRNIDP LERKSYWKNM LEAVHTIHEH GIVHSDLKPA 660

NFLIVDGMLK LIDFGIANQM QPDVTSIVKD SQVGTMNYMP PEAIQDMSSS YGENGKSQSK 720

ISPKSDVWSL GCILYCMTYG RTPFQHITNT RKKLYAIVDP HYEIEFPDIA EKDLQDVLKR 780

CLVRNPKQRI SVSELLVHPY VQIQTQCQTG VANAKGATEE VKRILGQLVG LNSPNSISRA 840

ARTLYEQCNS GKSLDVSAFA KSGSQKSWTA K 871

Nucleotide Sequence
(FASTA)

ATGGAGGAGG AGGAGGATCT AAGTGAAAGA GGATTGCCAC GAATTGCTTC AATCATGAGT 60

AGAGTTAGAG ACTTGAAAAA CAAATACAGG AATGAAGACA ATATCACAGA TGAACTGAAC 120

TGTACTAAAA TATCAGCTGA TACAACAGAT AACTCTGGAA CTGTTAATCG AATAATGATG 180

ACAACAAATA ATCCAGAAGA TTGGCTGTGT TTTTTGCTTC GGCTGGAGAA AAAGGGTATT 240

CCTCAGATGG ACCTTAGTAT ACTGAATAGG CTCATTGGTC GCTACAGTCA AGCGGTAACT 300

GCATTACCTG CAGAAAAGCA TAGTGAAGAT GAGAACTATG CTCGCATCCT TGTGAGATTT 360

GCAGAGCTGA AAGCTCTTCA AGATCCAGAG GAGGCACGAG ACCAATTCCA TCTGGCCAGA 420

CTGAACTGCA AGAAATTTGC TTTTGTGCAT GTGGCTTTTG CACAGTTTGA GCTGTCACAA 480

GGAAATGTGA AGAAGTGTAG ACAGCTCCTT CAGAAAGCTG TGGAGTGCTC TGCTGTTCCA 540

CTGGAAATGT TAGAAACTGC TCTACAAAAC TTGAATTCAC AAAAAAAACA GTTGCTTTCA 600

GATGAGGAAA AGGAGAACTT TGCAGTATCA AGTGTACAGG AGTCTGGACT TCAGAGCATA 660

GTTGGAAATC AGAGAAATAT AAAAAGGAAT GATTCTACTG AAAATTCTTC TGCTGTTGCT 720

AAACATCTTC TTGGGGAAGA GAAATCACAA GACCATGATG CTATAGTTAA CTTCCACAAT 780

CCATTAAGAC CACTAAACAA ATCTAACCAG GCCTGCCCTT TTGGGAGGGT TCCTGTTAAA 840

CTAGTAACTG ATTTTGATGA TGTGGTGCAG AAGACGGATG TCCCTCTTAC AGCTAGCGTT 900

ATGAAAAGGC AAGTATCTAG CTCCAAATGT ACAGCCTTGA TTCCACCCTT TCCACTCTCT 960

GAACCAAAAC CTAGTGAGAA TGATTCGTGT GACCCGGCAG ACTCAAAGTT ATTACAAGAA 1020

AATTCTGTGC AGCTGCAGAT GTTGGATGAG AACAGCTTAG AAACAGCTAC CAATTCAACT 1080

GTCACTCTGA AAAACAAAAT AGATACAAGT CTTGTGATGA AAAGAGAAGA AAATAAACTC 1140

CAATATCAAG AGCTGAAGAT ACCAGAGCCA AGGAGCATGG AAAGTCAACA GCAGCAATCC 1200

AGTTCTGCTA TAAAACTGAA CTGTGTTAAC TCCAGAAAGA AATGGCCAAG TCAAGAAGTG 1260

ATGCAGCAAA ACTGCTATAG AGAGGGAAAG CGGTCAAGTC TTGAGCAATC TGCTCATCCC 1320

CTTTCAAGAA GGCTATCACC ACCAGATGCT GTTTCGAAGA AAAATGAGCT GTTGTATGTT 1380

TGTGGAACAC CAAGCTCTAC GTGTACAGAT TATATGGAGT GTTTCAGAAC ACCAATTGTA 1440

AGGAACAACT TTTCACCAGG GTATCAAATT TCTACTCCCT ACAGTCAGCT ACCATATTTT 1500

CTACCGCATA CTCCAGCAAC TACATTTCAA AATCAAATGG GCTTGCAGGT TTCAGGTTCT 1560

ATACCTTCAA ATGAATGCAT TGCTGTTAAA GGAAGAATTT ATACAATATT AAAGCAAATA 1620

GGTAGTGGAG GCTCAAGCAA GGTGTTTCAA GTACTGAATG AAAAGAAGCA GCTGTATGCG 1680

GTCAAGTATG TGAATCTAGA AGAAGCTGAT CAGCAGACTG TTGAAAGCTA TAAGAATGAA 1740

ATTGCTCATT TGAGTAAACT ACAAGAGCAT AGTGATAAGA TAATCCGTCT TTATAGCTAT 1800

GAAATTACTG ATCAGCATAT CTACATGGTA ATGGAGTGTG GAAACATTGA TCTCAATAGC 1860

TGGCTGAAAA AGAAAAGGAA TATTGATCCA TTGGAACGGA AGAGCTATTG GAAAAATATG 1920

TTGGAAGCTG TTCACACAAT CCATGAACAC GGCATTGTCC ACAGTGATCT GAAACCAGCA 1980

AACTTTCTGA TAGTTGACGG AATGTTAAAA CTGATTGACT TTGGCATTGC AAACCAAATG 2040

CAGCCAGATG TGACGAGCAT CGTTAAAGAT TCACAGGTTG GCACAATGAA TTATATGCCA 2100

CCTGAAGCAA TACAAGATAT GTCGTCTTCC TATGGAGAAA ATGGGAAATC ACAATCTAAG 2160

ATAAGTCCAA AAAGTGATGT GTGGTCGTTG GGATGCATTT TATATTGTAT GACGTATGGG 2220

AGGACTCCAT TTCAACATAT AACGAATACA CGTAAAAAAC TGTATGCTAT CGTTGATCCT 2280

CATTATGAAA TAGAATTTCC AGATATTGCC GAGAAAGATC TTCAAGATGT GCTAAAGCGC 2340

TGTTTAGTAA GAAATCCTAA ACAAAGAATA TCAGTTTCAG AGTTGCTGGT ACATCCCTAT 2400

GTTCAAATTC AAACCCAATG CCAAACAGGT GTTGCAAATG CAAAAGGAGC AACAGAGGAA 2460

GTAAAGCGTA TCCTTGGCCA ACTTGTTGGC TTAAATTCTC CCAACTCTAT TTCCAGAGCT 2520

GCTAGGACTT TATATGAACA GTGCAACAGT GGTAAAAGTC TCGATGTATC AGCATTTGCC 2580

AAATCTGGGA GTCAAAAATC ATGGACAGCA AAGTAA 2616

Domain Profile

S: 1     yeilkklGsGGsskvfkvksekkrvyalkvvdleaaddqtidgykneielleklqdqs.k  59

         y+ilk++GsGGsskvf+v++ekk+ ya+k+v+le+ad+qt+++yknei+ l klq++s k

Q: 534   YTILKQIGSGGSSKVFQVLNEKKQLYAVKYVNLEEADQQTVESYKNEIAHLSKLQEHSdK  593

         99********************************************************9*

S: 60    virlydyeledsllylvmecGdidlnkilkkkksiepdyelvsyykemleavkvihqhGi  119

         +irly ye++d+++y+vmecG+idln++lkkk+ i+p  e++sy+k+mleav++ih+hGi

Q: 594   IIRLYSYEITDQHIYMVMECGNIDLNSWLKKKRNIDP-LERKSYWKNMLEAVHTIHEHGI  652

         *************************************.9*********************

S: 120   vhsdlkPanfllvdGilklidfGianavaedttsivkesqvGtvnylaPealkdmsssqs  179

         vhsdlkPanfl+vdG+lklidfGian++++d tsivk+sqvGt+ny++Pea++dmsss

Q: 653   VHSDLKPANFLIVDGMLKLIDFGIANQMQPDVTSIVKDSQVGTMNYMPPEAIQDMSSS--  710

         ********************************************************99..

S: 180   sereaekskikvsrksdvwslGcilylllygktPfgsirnqvskllaiinPdveiefPei  239

            e++ks++k+s+ksdvwslGcily ++yg+tPf++i n  +kl ai++P+ eiefP+i

Q: 711   -YGENGKSQSKISPKSDVWSLGCILYCMTYGRTPFQHITNTRKKLYAIVDPHYEIEFPDI  769

         .8899*******************************************************

S: 240   tsniekslvellkaclkrnPkkrisvdellsspfv  274

         +   ek+l+++lk cl+rnPk+risv+ell +p+v

Q: 770   A---EKDLQDVLKRCLVRNPKQRISVSELLVHPYV  801

         *...*****************************96

Domain Sequence
(FASTA)

YTILKQIGSG GSSKVFQVLN EKKQLYAVKY VNLEEADQQT VESYKNEIAH LSKLQEHSDK 60

IIRLYSYEIT DQHIYMVMEC GNIDLNSWLK KKRNIDPLER KSYWKNMLEA VHTIHEHGIV 120

HSDLKPANFL IVDGMLKLID FGIANQMQPD VTSIVKDSQV GTMNYMPPEA IQDMSSSYGE 180

NGKSQSKISP KSDVWSLGCI LYCMTYGRTP FQHITNTRKK LYAIVDPHYE IEFPDIAEKD 240

LQDVLKRCLV RNPKQRISVS ELLVHPYV 268

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013