EKS-GAG-00226

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00226

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	448.7	1.3E-134	151	471	321

Status

Unreviewed

Ensembl Protein

ENSGALP00000025819

UniProt Accession

F1P0S9;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1A

Gene Synonyms/Alias

DYRK1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000016053	ENSGALP00000025819	ENSGALT00000025866

Organism

Gallus gallus

Functional Description

Protein Length

756

Protein Sequence
(FASTA)

IFLGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMSHSHQQ YSDRRQQNIN DQQVSASSYT 60

DRIQQPLTNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN EVYYAKKKRR HQQGQGDDSS 120

HKKERKVYND GYDDDNYDYI VKNGEKWMDR YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK 180

IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL 240

LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF 300

GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE PLFSGANEVD 360

QMNKIVEVLG IPPAHILDQA PKARKFFEKL PDGTWNLKKT KDGKREYKPP GTRKLHNILG 420

VETGGPGGRR AGESGHTVAD YLKFKDLILR MLDYDPKTRI QPYYALQHSF FKKTADEGTN 480

TSNSVSTSPA MEQSQSSGTT SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA 540

MDCETHSPQV RQQFPPPIGW TATEAPTQVT VENHPVQETT FHVTPQQQNA LHHHHGNSSH 600

HHHHHHHHHH HHGQQALGSR TRPRVYNSPT NSSSTQDSME VGHSHHSMTS LSSSTTSSST 660

SSSSTGNQGN QAYQNRPVAA NTLDFGQNGA MDMNLTVYSN PRQETGIAGH PTYQFSANTG 720

PAHYMTEGHL AMRQGIDREE SPMTGVCVQQ SPVASS 756

Nucleotide Sequence
(FASTA)

ATCTTTCTAG GAGGAGAGAC TTCAGCATGC AAACCTTCAT CTGTTCGGCT TGCACCATCG 60

TTTTCATTCC ATGCTGCTGG CCTTCAGATG GCTGGACAGA TGTCCCATTC ACATCAGCAG 120

TACAGTGATC GTCGGCAGCA GAACATAAAT GACCAACAGG TTTCTGCCTC ATCATACACT 180

GACCGGATTC AGCAACCTCT AACAAACCAG AGGCGGATGC CCCAAACTTT CCGTGATCCA 240

GCTACTGCTC CTTTGAGGAA ACTCTCCGTA GATTTGATTA AAACATACAA GCATATTAAT 300

GAGGTTTACT ATGCAAAAAA AAAACGGCGG CATCAACAGG GCCAAGGAGA TGATTCCAGC 360

CACAAAAAGG AGCGAAAAGT TTACAATGAT GGCTATGATG ATGACAACTA TGACTATATT 420

GTAAAAAATG GGGAGAAGTG GATGGATCGT TATGAAATTG ACTCTTTAAT AGGCAAAGGA 480

TCCTTTGGAC AGGTTGTAAA GGCTTATGAT CGAGTGGAAC AGGAGTGGGT GGCTATCAAA 540

ATAATAAAAA ACAAGAAAGC TTTCTTAAAC CAAGCCCAGA TTGAAGTGCG ACTGCTTGAG 600

CTTATGAACA AACATGACAC TGAGATGAAG TACTATATAG TGCATTTGAA GCGCCACTTC 660

ATGTTCCGAA ACCATCTCTG CTTAGTCTTC GAAATGCTGT CCTACAATCT GTATGATTTG 720

TTGCGGAACA CCAACTTCAG AGGTGTCTCA CTGAATCTGA CAAGAAAATT TGCACAGCAG 780

ATGTGCACTG CACTGCTTTT TCTGGCGACT CCTGAACTTA GTATCATTCA CTGTGACCTA 840

AAACCTGAGA ATATCCTGCT CTGTAACCCC AAACGAAGCG CCATCAAGAT TGTTGATTTT 900

GGCAGTTCTT GTCAACTTGG GCAGAGGATA TACCAATATA TCCAGAGTCG TTTCTATCGA 960

TCACCAGAGG TGCTACTGGG AATGCCTTAT GATCTTGCAA TTGATATGTG GTCTCTTGGG 1020

TGTATTTTAG TTGAGATGCA CACTGGAGAG CCTCTTTTCA GTGGGGCAAA TGAGGTGGAT 1080

CAAATGAATA AAATAGTGGA AGTTTTGGGG ATACCGCCTG CCCATATCCT TGACCAAGCA 1140

CCAAAAGCAA GAAAGTTCTT TGAGAAGTTG CCAGATGGCA CTTGGAACTT GAAGAAGACC 1200

AAAGATGGAA AAAGGGAATA CAAACCACCT GGAACTCGTA AACTTCACAA TATACTAGGA 1260

GTTGAAACAG GAGGACCAGG TGGACGTCGT GCTGGGGAAT CGGGTCATAC TGTAGCTGAC 1320

TACTTGAAGT TCAAAGACCT CATCTTAAGG ATGCTTGATT ATGACCCTAA GACACGAATT 1380

CAACCTTATT ATGCCCTACA GCATAGTTTC TTTAAGAAAA CAGCAGACGA AGGTACCAAC 1440

ACAAGCAACA GTGTGTCTAC GAGTCCTGCC ATGGAGCAGT CACAGTCTTC AGGAACCACC 1500

TCTAGTACAT CTTCAAGCTC AGGTGGATCT TCTGGAACAA GCAACAGCGG AAGGGCACGG 1560

TCAGACCCCA CGCACCAGCA TCGACATAGT GGTGGACACT TCACTGCTGC TGTTCAAGCT 1620

ATGGACTGTG AAACACACAG CCCACAGGTT CGACAACAGT TTCCTCCTCC GATTGGTTGG 1680

ACAGCCACTG AAGCTCCTAC ACAGGTCACT GTTGAAAACC ATCCAGTTCA AGAAACCACC 1740

TTCCATGTAA CCCCTCAACA ACAGAATGCA TTACATCATC ATCACGGAAA TAGCTCTCAC 1800

CACCACCATC ACCACCACCA CCACCACCAT CATCATGGAC AGCAAGCCTT GGGTAGCCGG 1860

ACCAGGCCAA GGGTCTACAA TTCTCCAACA AACAGCTCCT CCACCCAGGA TTCTATGGAG 1920

GTGGGCCACA GTCACCACTC CATGACATCC CTGTCTTCCT CAACTACTTC TTCCTCTACA 1980

TCTTCCTCCT CTACTGGTAA CCAAGGCAAT CAAGCCTATC AGAACCGCCC AGTGGCTGCT 2040

AATACCTTGG ACTTTGGACA AAATGGAGCT ATGGACATGA ATTTAACAGT CTACTCTAAT 2100

CCGCGCCAAG AAACTGGCAT AGCTGGACAT CCAACGTACC AGTTTTCTGC TAATACAGGT 2160

CCTGCTCATT ACATGACTGA AGGACACCTT GCAATGAGGC AAGGGATTGA TAGAGAAGAG 2220

TCTCCCATGA CAGGAGTTTG TGTTCAGCAA AGTCCTGTGG CTAGCTCGTG A 2271

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 151   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  210

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 211   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  270

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 271   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  329

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k

Q: 330   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEK  389

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           + ++ lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 390   LPDGTWNLKKTkdgkreykpPGTRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  444

         ********9997777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 445   KDLILRMLDYDPKTRIQPYYALQHSFF  471

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 240

PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043518	; P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0090312	; P:positive regulation of protein deacetylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013