EKS-GAG-00161
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00161
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CASK524.74.4E-15815276262
StatusUnreviewed
Ensembl ProteinENSGALP00000026115
UniProt AccessionE1BWL4;
Protein Name
Protein Synonyms/Alias
Gene NameCASK
Gene Synonyms/Alias CASK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000016226ENSGALP00000026115ENSGALT00000026163
OrganismGallus gallus
Functional Description
Protein Length920
Protein Sequence
(FASTA)
MGSMDERFKI LFKYCTQMIW GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK 60
REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120
YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180
GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR 240
QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGA VSQVLDSLEE IHALTDCSEK 360
DLDFLHSVFQ DQHLHTLLDL YDKINTKSSP QIRNPPSDAV QRAKEVLEEI SCYPENNDAK 420
ELKRILTQPH FMALLQTHDV VAHEVYSDEA LRVTPPPTSP YLNGDSPESA NGDMDMENVT 480
RVRLVQFQKN TDEPMGITLK MNELNHCIVA RIMHGGMIHR QGTLHVGDEI REINGISVAN 540
QTVEQLQKML REMRGSITFK IVPSYRTQSS SCERDSPSTS RQSPANGHSS TNNSVSDLPS 600
TTQPKGRQIY VRAQFEYDPA KDDLIPCKEA GIRFRVGDII QIISKDDHNW WQGKLENSKN 660
GTAGLIPSPE LQEWRVACIA MEKTKQEQQA SCTWFGKKKK QYKDKYLAKH NAVFDQLDLV 720
TYEEVVKLPA FKRKTLVLLG AHGVGRRHIK NTLITKHPDR FAYPIPHTTR PPKKDEENGK 780
NYYFVSHDQM MQDISNNEYL EYGSHEDAMY GTKLETIRKI HEQGLIAILD VEPQALKVLR 840
TAEFAPFVVF IAAPTITPGI NEDESLQRLQ KESEILQRTY AHYFDLTIIN NEIDETIRHL 900
EEAIELVCTA SQWVPVSWVY 920
Nucleotide Sequence
(FASTA)
ATGGGCAGCA TGGATGAGAG GTTCAAGATT CTGTTTAAAT ACTGTACTCA AATGATATGG 60
GGTCCATTCA GTGTTGTGCG GCGATGCATC AACAGGGAAA CAGGGCAACA GTTTGCTGTA 120
AAGATTGTCG ATGTAGCAAA ATTCACTTCA AGTCCTGGAT TAAGCACAGA AGATCTGAAG 180
AGGGAAGCCA GTATTTGTCA CATGCTGAAG CATCCTCATA TTGTTGAACT GTTGGAGACA 240
TACAGCTCAG ATGGAATGCT TTATATGGTT TTTGAGTTTA TGGATGGAGC AGATCTGTGT 300
TTTGAAATTG TGAAGAGAGC AGATGCTGGA TTTGTGTACA GCGAGGCTGT AGCCAGTCAT 360
TACATGAGAC AGATATTGGA AGCTCTACGT TACTGTCATG ATAATAATAT AATTCACAGG 420
GATGTGAAGC CACACTGTGT ACTGCTTGCC TCAAAAGAGA ATTCAGCCCC GGTAAAGCTT 480
GGTGGCTTCG GGGTAGCAAT TCAATTAGGA GAATCTGGGC TAGTTGCTGG AGGACGTGTA 540
GGAACACCTC ATTTTATGGC CCCAGAAGTG GTGAAAAGGG AACCTTATGG GAAGCCTGTA 600
GATGTTTGGG GTTGTGGTGT CATCCTTTTT ATCCTGCTAA GTGGTTGTTT GCCTTTTTAT 660
GGAACCAAGG AAAGATTGTT TGAAGGCATT ATTAAAGGAA AATACAAGAT GAATCCTCGG 720
CAGTGGAGCC ATATTTCTGA AAGTGCCAAA GATCTGGTAC GCCGCATGCT TATGCTGGAT 780
CCAGCAGAAA GGATAACAGT ATATGAAGCA CTGAATCATC CCTGGTTGAA GGAGAGAGAT 840
CGCTATGCAT ACAAGATTCA TCTTCCAGAG ACAGTAGAAC AATTGAGAAA ATTCAATGCA 900
AGACGAAAAC TAAAGGGGGC AGTACTAGCA GCTGTGTCAA GCCACAAATT CAACTCCTTC 960
TATGGTGATC CCCCTGAAGA GTTGCCCGAC TTCTCTGAAG ATCCTACCTC CTCAGGAGCA 1020
GTCTCACAGG TGCTGGACAG CCTGGAGGAA ATTCATGCAC TTACAGATTG CAGTGAAAAA 1080
GACTTAGATT TTCTTCACAG TGTTTTCCAG GATCAACATC TTCACACGCT ACTAGATCTT 1140
TATGACAAAA TAAACACAAA ATCTTCACCA CAGATCAGGA ATCCTCCAAG TGATGCTGTA 1200
CAGAGAGCCA AAGAGGTATT GGAAGAAATT TCATGTTACC CAGAAAACAA TGATGCAAAG 1260
GAGCTAAAGC GTATTTTAAC ACAACCTCAT TTCATGGCCT TACTTCAAAC TCATGATGTA 1320
GTGGCACATG AAGTTTACAG TGATGAAGCG CTGAGAGTTA CACCTCCTCC CACCTCTCCA 1380
TACTTAAATG GAGATTCTCC AGAAAGCGCC AACGGCGACA TGGATATGGA GAATGTAACG 1440
CGAGTTCGAC TGGTGCAGTT CCAGAAGAAC ACAGATGAAC CAATGGGAAT CACTTTAAAA 1500
ATGAATGAGC TGAACCATTG CATTGTGGCA AGAATTATGC ACGGAGGAAT GATTCACCGG 1560
CAAGGTACGT TACATGTAGG GGATGAAATC CGAGAAATAA ACGGCATCAG TGTGGCAAAT 1620
CAAACAGTAG AACAACTACA AAAAATGCTT AGGGAAATGC GTGGAAGTAT CACCTTTAAG 1680
ATAGTGCCAA GTTATCGCAC ACAGTCTTCA TCCTGTGAGA GAGATTCCCC CTCTACATCC 1740
AGACAGTCCC CAGCTAATGG CCATAGCAGC ACTAACAATT CTGTTTCGGA CTTGCCGTCG 1800
ACAACACAAC CAAAAGGACG ACAGATATAT GTAAGAGCAC AATTTGAATA TGATCCAGCA 1860
AAGGATGACC TCATTCCTTG CAAAGAAGCT GGCATCAGAT TCCGAGTTGG TGATATTATC 1920
CAAATCATTA GCAAAGACGA TCACAACTGG TGGCAGGGTA AACTGGAGAA CTCCAAAAAC 1980
GGTACTGCAG GTCTTATTCC TTCTCCTGAA CTTCAAGAAT GGCGGGTTGC TTGTATTGCC 2040
ATGGAGAAGA CCAAACAGGA ACAACAGGCC AGCTGTACTT GGTTTGGAAA GAAAAAAAAG 2100
CAGTACAAAG ATAAATATTT GGCAAAGCAC AATGCAGTGT TTGATCAATT AGATCTCGTC 2160
ACATATGAAG AAGTAGTAAA ACTGCCAGCA TTCAAAAGGA AAACACTAGT CTTACTAGGT 2220
GCACATGGTG TTGGAAGACG ACACATAAAA AACACACTCA TCACAAAACA CCCGGACAGA 2280
TTTGCTTACC CCATTCCTCA CACAACCCGA CCTCCAAAGA AAGATGAAGA AAATGGAAAA 2340
AATTACTACT TTGTATCGCA TGACCAAATG ATGCAGGATA TATCAAACAA TGAATATTTG 2400
GAATATGGCA GCCATGAGGA TGCAATGTAT GGGACAAAAC TGGAAACAAT ACGGAAGATC 2460
CATGAGCAGG GACTAATTGC AATACTTGAT GTAGAACCTC AGGCGTTGAA GGTCCTGAGA 2520
ACTGCAGAGT TTGCTCCTTT TGTTGTTTTT ATTGCTGCAC CTACGATTAC CCCAGGCATT 2580
AATGAGGACG AATCTCTTCA GCGCCTGCAA AAGGAGTCTG AAATCTTACA GAGAACATAT 2640
GCACACTACT TTGACCTAAC CATTATCAAC AATGAAATCG ATGAAACAAT CAGGCACCTG 2700
GAGGAAGCCA TCGAGCTCGT TTGTACAGCG TCGCAGTGGG TGCCGGTCTC CTGGGTCTAT 2760
TAG 2763
Domain Profile
S: 4     cevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkhpyi  63
         c  +  Gpfsvvrr+i+re++q+favkivdvakftsspGlstedlkreasichmlkhp+i
Q: 15    CTQMIWGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHI  74
         555667******************************************************
S: 64    velletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealrychd  123
         velletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqilealrychd
Q: 75    VELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHD  134
         ************************************************************
S: 124   nkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapevvkr  183
         n+i+hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfmapevvkr
Q: 135   NNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEVVKR  193
         *************************************.**********************
S: 184   erygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesakdlv  243
         e+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+ws+isesakdlv
Q: 194   EPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLV  253
         ************************************************************
S: 244   rrmlaadpakrisvkealnhewl  266
         rrml++dpa+ri+v+ealnh+wl
Q: 254   RRMLMLDPAERITVYEALNHPWL  276
         **********************7
Domain Sequence
(FASTA)
CTQMIWGPFS VVRRCINRET GQQFAVKIVD VAKFTSSPGL STEDLKREAS ICHMLKHPHI 60
VELLETYSSD GMLYMVFEFM DGADLCFEIV KRADAGFVYS EAVASHYMRQ ILEALRYCHD 120
NNIIHRDVKP HCVLLASKEN SAPVKLGGFG VAIQLGESGL VAGGRVGTPH FMAPEVVKRE 180
PYGKPVDVWG CGVILFILLS GCLPFYGTKE RLFEGIIKGK YKMNPRQWSH ISESAKDLVR 240
RMLMLDPAER ITVYEALNHP WL 262
KeywordComplete proteome; Reference proteome; SH3 domain.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00177
EKS-ANC-00182
EKS-BOT-00189
EKS-CAE-00177
EKS-CAJ-00196
EKS-CAF-00195
EKS-CAP-00214
EKS-CII-00122
EKS-CIS-00227
EKS-DAR-00489
EKS-DRM-00100
EKS-EQC-00184
EKS-FEC-00177
EKS-GAM-00106
EKS-GAA-00233
EKS-GOG-00185
EKS-HOS-00194
EKS-LAC-00199
EKS-LOA-00185
EKS-MAM-00189
EKS-MEG-00146
EKS-MOD-00187
EKS-MUM-00191
EKS-MUP-00191
EKS-MYL-00194
EKS-NOL-00178
EKS-ORN-00241
EKS-ORA-00167
EKS-ORC-00172
EKS-ORL-00225
EKS-OTG-00195
EKS-PAT-00179
EKS-PES-00164
EKS-POA-00183
EKS-SAH-00181
EKS-SUS-00162
EKS-TAG-00214
EKS-TAR-00246
EKS-TEN-00240
EKS-XET-00219
EKS-XIM-00236
Gene Ontology
GO:0005604; C:basement membrane
GO:0016323; C:basolateral plasma membrane
GO:0005911; C:cell-cell junction
GO:0005829; C:cytosol
GO:0005652; C:nuclear lamina
GO:0016363; C:nuclear matrix
GO:0005730; C:nucleolus
GO:0045202; C:synapse
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0070509; P:calcium ion import
GO:0001953; P:negative regulation of cell-matrix adhesion
GO:0090288; P:negative regulation of cellular response to growth factor stimulus
GO:0010839; P:negative regulation of keratinocyte proliferation
GO:0061045; P:negative regulation of wound healing
GO:0090280; P:positive regulation of calcium ion import
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR008144; Guanylate_kin.
IPR008145; Guanylate_kin/L-typ_Ca_channel.
IPR020590; Guanylate_kinase_CS.
IPR011009; Kinase-like_dom.
IPR004172; L27.
IPR014775; L27_C.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR011511; SH3_2.
IPR001452; SH3_domain.
Pfam
PF00625; Guanylate_kin; 1.
PF02828; L27; 2.
PF00595; PDZ; 1.
PF00069; Pkinase; 1.
PF07653; SH3_2; 1.
SMARTs
SM00072; GuKc; 1.
SM00569; L27; 2.
SM00228; PDZ; 1.
SM00220; S_TKc; 1.
SM00326; SH3; 1.
Prosites
PS00856; GUANYLATE_KINASE_1; 1.
PS50052; GUANYLATE_KINASE_2; 1.
PS51022; L27; 2.
PS50106; PDZ; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013