EKS-GAG-00173

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00173

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	515.4	4.0E-155	4	284	281

Status

Unreviewed

Ensembl Protein

ENSGALP00000026281

UniProt Accession

E1BTD4;

Protein Name

Protein Synonyms/Alias

Gene Name

ICK

Gene Synonyms/Alias

ICK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000016321	ENSGALP00000026281	ENSGALT00000026331

Organism

Gallus gallus

Functional Description

Protein Length

623

Protein Sequence
(FASTA)

MNRYTTIRQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 60

NVVKLKEVIR ENDHLYFVFE YMKENLYQLM KERNKLFPEA TVRNIMYQIL QGLAFIHKHG 120

FFHRDLKPEN LLCMGPELVK IADFGLAREI RSRPPYTDYV STRWYRAPEV LLRSTSYSSP 180

IDIWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KNDWPEGYQL SSSMNFRWPQ 240

CVPNNLKTLI PNASSEAVQL MRDMLQWDPK KRPTASQALR YPYFQVGHAL GLQELTRQKE 300

LHDKSSLHIK PVPPAQPPSK SHTRISSRPF QQSQTSQHLV YTCKTDNSGT EHSKYLQEDK 360

SNQVLLPAIH NKVPQQKAPT GTENINGELK PKARRRWGHL ARPVKNSEEW DDLEDLDFSS 420

SVTRVDLKNK KRQSDETICR FESILDLKPL DAVGSGSSAP SHAIFPRQDT PTLQVSAAKQ 480

HYLRHSRYLP VGVNTRNSVV STSSKESVPS NPWPSSGLPG KASVLGGSIN RINSGPIGST 540

GLTGAYIPSF LKKEVGSAGQ RVQLAPIADP SSNYASLKSA RQHLGRPPFN SPSKSTPGVM 600

PLPPPAQPVH GRVDWSAKYG AHR 623

Nucleotide Sequence
(FASTA)

ATGAATAGGT ACACAACTAT CAGACAGCTT GGTGATGGGA CCTACGGCTC TGTCCTCCTA 60

GGGAGAAGCA TTGAATCTGG GGAGCTAATA GCCATTAAAA AAATGAAGAG AAAGTTTTAT 120

TCCTGGGAGG AATGCATGAA CCTTCGAGAG GTTAAGTCTT TGAAGAAACT AAACCATGCC 180

AATGTAGTAA AGCTGAAAGA AGTTATTAGG GAAAATGATC ATCTCTATTT TGTGTTTGAG 240

TACATGAAGG AAAATCTTTA TCAGTTGATG AAAGAAAGAA ACAAACTGTT TCCTGAGGCT 300

ACAGTTAGAA ATATTATGTA TCAGATCCTG CAAGGGCTTG CATTTATCCA TAAACATGGA 360

TTCTTTCACA GAGACTTGAA ACCTGAAAAC CTCCTTTGTA TGGGACCAGA ACTTGTGAAA 420

ATAGCAGACT TTGGCTTAGC CCGAGAAATC CGATCTAGAC CTCCTTACAC AGATTATGTA 480

TCCACAAGGT GGTACAGGGC TCCTGAAGTC CTTCTGAGGT CCACCAGCTA TAGCTCTCCA 540

ATAGATATTT GGGCTGTTGG TTGTATAATG GCAGAAGTTT ACACACTGAG GCCTCTCTTC 600

CCAGGCGCCA GTGAAATTGA TACAATATTC AAAATTTGCC AAGTTTTGGG GACACCAAAG 660

AAGAATGACT GGCCTGAAGG CTACCAGCTT TCATCCTCCA TGAATTTTCG CTGGCCTCAG 720

TGTGTACCTA ACAACTTAAA AACCCTCATA CCTAATGCTA GCAGTGAGGC AGTGCAACTG 780

ATGAGAGACA TGCTGCAGTG GGACCCCAAA AAGCGGCCAA CAGCTAGCCA GGCACTTCGA 840

TATCCATACT TCCAGGTTGG ACATGCTTTA GGCCTTCAGG AGCTGACGAG GCAAAAGGAA 900

CTCCATGATA AATCATCTCT GCATATCAAG CCTGTCCCTC CAGCACAACC TCCTTCAAAA 960

TCCCACACCC GCATTTCTTC ACGGCCATTT CAGCAAAGTC AGACTTCTCA ACATTTGGTC 1020

TATACGTGTA AGACAGACAA CTCTGGGACT GAACACAGTA AATATTTACA GGAGGACAAG 1080

TCGAACCAGG TTCTTCTGCC TGCAATTCAC AATAAGGTTC CTCAGCAGAA AGCACCTACT 1140

GGGACTGAGA ACATAAATGG TGAACTTAAA CCAAAAGCTA GGCGAAGGTG GGGACATCTT 1200

GCTAGGCCAG TGAAGAATTC TGAAGAGTGG GATGACTTGG AAGACCTGGA TTTCAGCTCT 1260

TCTGTCACGA GGGTTGACTT GAAAAACAAA AAGAGGCAGA GCGATGAAAC TATTTGTAGA 1320

TTTGAAAGCA TTTTGGACCT GAAGCCTTTG GATGCAGTTG GCTCCGGCAG CAGCGCACCA 1380

TCCCATGCTA TCTTCCCACG GCAGGACACT CCCACACTGC AAGTTTCTGC AGCAAAGCAG 1440

CACTACCTGA GACATTCTAG GTATCTACCC GTAGGGGTAA ACACAAGAAA TAGCGTGGTC 1500

TCCACTTCAA GCAAGGAGTC TGTTCCATCT AATCCCTGGC CCAGTTCTGG TTTGCCTGGA 1560

AAAGCTTCAG TTTTGGGAGG AAGTATTAAC AGGATAAATT CAGGTCCCAT AGGATCAACT 1620

GGTCTAACTG GTGCTTACAT CCCTTCGTTT CTGAAGAAGG AAGTCGGCTC TGCTGGGCAG 1680

AGGGTTCAGT TAGCACCAAT TGCAGATCCA TCTTCAAATT ATGCTTCTCT GAAGTCAGCG 1740

AGACAACATC TTGGACGGCC ACCATTCAAT TCACCTTCTA AGAGCACCCC CGGGGTGATG 1800

CCGCTCCCAC CCCCAGCTCA GCCAGTGCAC GGCCGCGTGG ACTGGTCTGC AAAGTACGGA 1860

GCTCACCGGT GA 1872

Domain Profile

S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60

         y++i++lGdGt+g+vll++s+++gel+aikkmkrkf+s+ee++nlrevkslkkln h+n+

Q: 4     YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANV  62

         99*****************************************************.****

S: 61    iklkeviidrendslylvlelmeenlyqlikdrrkllsesklksilyqilkglafihkhg  120

         +klkevi  rend+ly+v+e+m+enlyql+k+r+kl++e ++++i+yqil+glafihkhg

Q: 63    VKLKEVI--RENDHLYFVFEYMKENLYQLMKERNKLFPEATVRNIMYQILQGLAFIHKHG  120

         *******..***************************************************

S: 121   ffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvyssp  180

         ffhrdlkPen+l++g+elvk+adfGlare+rs++PytdyvstrwyraPevllrs++yssp

Q: 121   FFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTSYSSP  180

         ************************************************************

S: 181   ldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkfpq  240

         +d+wavGc++aev++lrplfPGaseid+ifki++vlGtPkk++w+e+y+l+s++n+++pq

Q: 181   IDIWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKNDWPEGYQLSSSMNFRWPQ  240

         ************************************************************

S: 241   vegsslktlvsnaskealellkdllaydPderataqqalkypyf  284

         +++++lktl++nas+ea++l++d+l++dP++r+ta+qal+ypyf

Q: 241   CVPNNLKTLIPNASSEAVQLMRDMLQWDPKKRPTASQALRYPYF  284

         *******************************************9

Domain Sequence
(FASTA)

YTTIRQLGDG TYGSVLLGRS IESGELIAIK KMKRKFYSWE ECMNLREVKS LKKLNHANVV 60

KLKEVIREND HLYFVFEYMK ENLYQLMKER NKLFPEATVR NIMYQILQGL AFIHKHGFFH 120

RDLKPENLLC MGPELVKIAD FGLAREIRSR PPYTDYVSTR WYRAPEVLLR STSYSSPIDI 180

WAVGCIMAEV YTLRPLFPGA SEIDTIFKIC QVLGTPKKND WPEGYQLSSS MNFRWPQCVP 240

NNLKTLIPNA SSEAVQLMRD MLQWDPKKRP TASQALRYPY F 281

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0043231	; C:intracellular membrane-bounded organelle
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013