EKS-GAG-00326

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00326

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	362.7	1.5E-108	535	789	255

Status

Unreviewed

Ensembl Protein

ENSGALP00000026448

UniProt Accession

F1NKW3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000016426	ENSGALP00000026448	ENSGALT00000026498

Organism

Gallus gallus

Functional Description

Protein Length

1207

Protein Sequence
(FASTA)

SDVAVVDMSD ISKQPSLFYH LGVRESFDMA NNVILYHGTD ADTAQSLKDM VSQKNTASSG 60

NYYFIPYIVT PSADYFCCES DAQRRASEYM QPSWDNILGP LCVPLVDRFI SLLKDVHVTS 120

CAYYKETLLN DIRKAREKYQ GDELAKELAR IKLRMDNTEV LTSDIVINLL LSYRDIQDYD 180

AMVKLVETLE MLPTCDLADQ HNIKFHYAFA LNRRNNAGDR EKALQVMLQV LQTCDHPAPD 240

MFCLCGRIYK DMFLDSDCKD INSRDHAIEW YRKGFELQST LYSGINLAVL LLAEGQQFES 300

SMELRKIGVR LNSLLGRKGS LEKMNSYWDV GQFFSVSMLA NDVSKAVQAA EKLFKLKPPV 360

WYLKSLVQNL MLIQRFKKFT IEHSPKQERL TFWLDIIFEA TKETTNGLRF PVLVIEPTKV 420

YQPAYVSINN EEDERSLSLW HVSPTEMKQI HEWNFTASSI RGISISKFDE RCCFLYVHAN 480

SDDFQIYFST ENQCTRFCGL VKEILSDAVG STLELEGEID GETLEYEYDY DEKGDRVVLG 540

KGTYGIVYAG RDLSNQVRIA IKEIPERDSR YSQPLHEEIA LHKYLKHRNV VQYLGSVSED 600

GYIKIFMEQV PGGSLSALLR SKWGPMKEPT IKFYTKQILE GLKYLHENQI VHRDIKGDNV 660

LVNTYSGVVK ISDFGTSKRL AGINPCTETF TGTLQYMAPE IIDKGPRGYG APADIWSLGC 720

TMIEMATGKP PFHELGEPQA AMFKVGMFKI HPEIPESLSA EAKAFILLCF EPDPFKRAAA 780

SDLLRDSFLK QVNKGKKSRI AFKPSDYNRN ASLPLPIHGE QAGSSSSEHG SVSPDSDVQH 840

DVFFERPKRS ISEIQTRHPI AHLLSVPDEG LAPEDRSASP STEDKDSGLF LLRKDSERRA 900

ILYKILKEEQ NKVASNLQDC IAQSSEELRL SMAHIKQIIG ILRDFIHSPE HRVMASTISK 960

LKMDLDFDST SINQIHLVLF GFQDAVNKVL RNHLIRPHWM FAMDNIIRRA VQAAVTILIP 1020

ELQAHFEPAS ETEGGDKDCD EVEDSFRPSE QNGTEDAALT SGVSTLSSVV SHEAQQQLSL 1080

ELGRLKQETI RLLEKLVQKE KEYQTLLQRS LEQKTQELHL LQLKLKPAVK DWQWPASPLK 1140

ENADPELTNW LKQQGADLDT IRRFAEEDYT LSTVLNDITK DDLRCLQLRG GLLCRIWNAI 1200

LIHRQTA 1207

Nucleotide Sequence
(FASTA)

TCAGATGTTG CAGTTGTGGA TATGAGTGAT ATTTCCAAGC AACCATCACT GTTCTACCAC 60

CTTGGTGTGC GGGAAAGCTT TGACATGGCA AATAATGTTA TACTCTACCA CGGCACTGAT 120

GCTGATACTG CTCAGTCTCT CAAAGATATG GTATCTCAGA AAAATACCGC TTCCAGTGGA 180

AATTATTATT TCATTCCATA CATTGTCACC CCTTCTGCTG ACTACTTCTG CTGTGAAAGC 240

GATGCCCAGA GAAGAGCTTC TGAGTATATG CAGCCCAGCT GGGACAATAT CCTGGGGCCA 300

CTCTGTGTCC CTCTGGTGGA CAGGTTTATC AGCCTTCTCA AGGATGTTCA TGTTACATCA 360

TGTGCCTATT ATAAAGAAAC ACTGCTAAAT GATATTAGAA AGGCTAGAGA GAAGTACCAA 420

GGAGATGAAC TGGCAAAGGA GCTGGCTAGA ATTAAGCTTC GTATGGATAA TACTGAAGTT 480

CTGACTTCTG ACATTGTCAT AAACCTGCTT CTTTCTTACC GAGATATACA GGACTATGAT 540

GCTATGGTGA AGCTGGTAGA AACACTAGAA ATGCTTCCTA CCTGTGATCT GGCTGATCAA 600

CACAACATTA AGTTTCATTA TGCTTTTGCT TTGAACAGAA GAAATAATGC AGGTGACAGA 660

GAGAAGGCAC TACAAGTCAT GCTTCAGGTC CTGCAGACAT GTGATCACCC TGCTCCAGAT 720

ATGTTTTGCT TATGTGGAAG GATATACAAG GATATGTTTC TTGACTCTGA CTGTAAAGAT 780

ATCAACAGTC GAGATCATGC CATTGAATGG TACCGCAAGG GGTTTGAACT TCAGTCAACA 840

CTATATTCAG GAATTAACCT TGCAGTTTTA CTACTTGCTG AAGGACAGCA GTTTGAAAGC 900

TCGATGGAAC TGAGAAAAAT AGGTGTACGG TTAAACAGTT TATTGGGAAG AAAGGGGAGT 960

CTGGAAAAAA TGAACAGTTA CTGGGACGTG GGACAGTTCT TCAGTGTGAG CATGTTGGCT 1020

AATGATGTTA GTAAAGCAGT TCAAGCAGCA GAGAAACTAT TTAAGCTGAA ACCTCCAGTA 1080

TGGTACTTGA AATCATTAGT TCAGAATCTG ATGTTAATTC AGCGTTTCAA GAAATTCACC 1140

ATAGAACATT CTCCTAAACA AGAAAGATTG ACTTTCTGGC TAGATATAAT TTTTGAGGCA 1200

ACGAAAGAAA CAACTAATGG ACTGAGATTT CCAGTTTTGG TGATAGAACC AACTAAAGTT 1260

TACCAGCCTG CATATGTTTC AATCAACAAT GAAGAAGATG AGAGATCTCT TTCTTTGTGG 1320

CATGTCTCTC CCACTGAAAT GAAACAGATT CATGAATGGA ACTTTACAGC TTCTTCCATA 1380

AGGGGAATAA GTATTTCCAA GTTTGATGAA CGATGTTGTT TTCTTTATGT GCATGCTAAC 1440

TCTGATGATT TTCAAATCTA CTTTTCTACA GAAAACCAGT GTACTAGGTT CTGTGGGTTG 1500

GTGAAAGAAA TCTTGTCTGA TGCAGTTGGC AGTACTTTGG AACTAGAAGG AGAAATAGAT 1560

GGAGAAACAT TGGAGTACGA ATATGATTAT GATGAGAAGG GTGACAGAGT AGTTCTAGGA 1620

AAAGGTACTT ACGGGATAGT ATATGCTGGA AGAGACCTTA GCAACCAGGT CCGAATAGCC 1680

ATCAAAGAAA TACCTGAGAG AGACAGCAGA TATTCTCAAC CTCTTCATGA AGAGATAGCA 1740

CTGCATAAAT ATTTAAAGCA TCGGAATGTT GTCCAATATC TTGGATCTGT TTCAGAGGAC 1800

GGATACATTA AGATTTTTAT GGAGCAGGTG CCAGGAGGCA GCCTCTCGGC TCTCCTGAGG 1860

TCTAAGTGGG GGCCAATGAA AGAACCCACA ATTAAATTTT ACACCAAGCA GATTCTGGAA 1920

GGCCTTAAGT ATCTCCATGA GAACCAGATT GTACACAGAG ATATAAAGGG GGATAACGTG 1980

TTGGTGAACA CCTATAGTGG CGTGGTAAAG ATATCTGATT TTGGTACTTC CAAACGGCTG 2040

GCAGGAATCA ATCCGTGCAC TGAAACATTT ACGGGCACGT TGCAGTACAT GGCTCCAGAA 2100

ATCATTGACA AGGGACCACG AGGATATGGT GCACCAGCTG ATATCTGGTC GCTAGGCTGT 2160

ACCATGATTG AAATGGCAAC AGGCAAGCCT CCATTTCATG AGCTAGGAGA GCCTCAGGCA 2220

GCAATGTTTA AAGTCGGGAT GTTTAAGATT CATCCTGAAA TTCCAGAATC ACTGTCTGCT 2280

GAGGCAAAAG CTTTTATTTT GCTTTGTTTT GAACCTGATC CTTTTAAACG TGCTGCAGCG 2340

TCTGATTTGC TCAGAGATTC TTTCCTGAAA CAAGTCAACA AGGGCAAGAA AAGCAGAATT 2400

GCATTCAAGC CTTCAGATTA CAATCGGAAC GCGTCCCTCC CACTGCCAAT CCATGGAGAA 2460

CAGGCTGGCA GCAGCAGCAG TGAGCATGGC TCTGTTTCGC CAGACTCCGA TGTGCAGCAC 2520

GATGTGTTTT TCGAGAGGCC GAAGAGATCC ATTTCAGAGA TTCAGACAAG GCATCCCATT 2580

GCCCACTTAT TGAGTGTGCC TGATGAGGGC CTGGCCCCGG AGGACAGAAG TGCCTCTCCT 2640

TCCACTGAGG ATAAGGATTC TGGTCTGTTC CTGCTACGGA AGGACAGTGA ACGCCGGGCA 2700

ATTCTATATA AAATTCTCAA GGAAGAACAG AATAAAGTTG CTTCAAATTT GCAGGATTGT 2760

ATTGCACAGA GCTCTGAGGA ACTGCGGCTT TCAATGGCCC ACATCAAGCA AATTATTGGG 2820

ATTTTAAGGG ACTTCATACA CTCTCCTGAG CACAGAGTGA TGGCGTCTAC CATATCCAAG 2880

TTGAAAATGG ATCTGGACTT TGACAGCACT TCCATCAATC AGATTCATCT GGTGCTGTTT 2940

GGATTTCAGG ATGCGGTGAA CAAAGTGTTA AGAAATCATT TAATAAGGCC CCACTGGATG 3000

TTTGCAATGG ACAATATAAT TCGCCGTGCA GTCCAAGCAG CAGTCACCAT TCTTATTCCA 3060

GAACTTCAAG CTCACTTTGA GCCAGCATCA GAAACTGAAG GTGGCGACAA AGATTGTGAC 3120

GAAGTGGAAG ACAGTTTCCG TCCCTCTGAA CAAAATGGGA CGGAGGATGC TGCTCTCACA 3180

TCAGGAGTCA GCACCCTCAG CTCTGTGGTG TCACACGAGG CTCAGCAGCA GCTTAGCCTG 3240

GAGTTGGGCA GACTCAAACA AGAGACCATA AGGCTTTTGG AGAAACTCGT TCAGAAGGAG 3300

AAGGAGTATC AGACCCTCTT ACAACGATCT TTGGAGCAAA AAACACAGGA ATTGCACTTG 3360

CTTCAATTAA AACTTAAACC CGCAGTTAAA GACTGGCAGT GGCCTGCATC ACCATTAAAA 3420

GAGAATGCAG ACCCAGAGCT CACAAACTGG CTGAAACAAC AAGGGGCAGA CCTGGATACC 3480

ATTAGAAGGT TTGCTGAAGA GGATTATACA CTGAGTACTG TCCTTAATGA CATCACTAAG 3540

GATGATTTGC GATGCCTTCA ACTGCGTGGT GGTCTTCTCT GCAGAATTTG GAATGCGATT 3600

TTAATCCACC GCCAAACGGC T 3621

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k lkH+n

Q: 535   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKYLKHRN  589

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         +v+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+++e +ik+ytkqilegl+yLHe++

Q: 590   VVQYLGSVSEDGYIKIFMEQVPGGSLSALLRsKWGPMKEPTIKFYTKQILEGLKYLHENQ  649

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgvvk+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k+

Q: 650   IVHRDIKGDNVLVNTySGVVKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDKGP  706

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+tgk+Pf+el+e++a+mfkvg+ k++Peipe+ls+e+k+f+

Q: 707   RGYGAPADIWSLGCTMIEMATGKPPFHELGEPQAAMFKVGMFKIHPEIPESLSAEAKAFI  766

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhefl  263

           c+e dp kr++a++LL+++fl

Q: 767   LLCFEPDPFKRAAASDLLRDSFL  789

         ********************996

Domain Sequence
(FASTA)

DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKY LKHRNVVQYL 60

GSVSEDGYIK IFMEQVPGGS LSALLRSKWG PMKEPTIKFY TKQILEGLKY LHENQIVHRD 120

IKGDNVLVNT YSGVVKISDF GTSKRLAGIN PCTETFTGTL QYMAPEIIDK GPRGYGAPAD 180

IWSLGCTMIE MATGKPPFHE LGEPQAAMFK VGMFKIHPEI PESLSAEAKA FILLCFEPDP 240

FKRAAASDLL RDSFL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013